LAMTOR1

Functionⁱ

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.4 Publications

GO - Molecular functionⁱ

GTPase binding
Source: CAFA
Inferred from physical interactionⁱ
- 22424946

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle arrest Source: Reactome
cellular protein localization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20381137
cellular response to amino acid stimulus
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20381137
cholesterol homeostasis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20544018
endosomal transport Source: UniProtKB
endosome organization Source: UniProtKB
lysosome localization Source: UniProtKB
lysosome organization Source: UniProtKB
neutrophil degranulation Source: Reactome
positive regulation of MAPK cascade Source: UniProtKB
positive regulation of TOR signaling
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20381137
regulation of cell growth
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20381137
regulation of cholesterol efflux
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20544018
regulation of cholesterol esterification
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20544018
regulation of cholesterol import
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20544018
regulation of macroautophagy Source: Reactome
regulation of receptor recycling Source: UniProtKB

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1632852 Macroautophagy R-HSA-165159 mTOR signalling R-HSA-166208 mTORC1-mediated signalling R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-5628897 TP53 Regulates Metabolic Genes R-HSA-6798695 Neutrophil degranulation R-HSA-8943724 Regulation of PTEN gene transcription
SIGNORⁱ	Q6IAA8

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ragulator complex protein LAMTOR1 Alternative name(s): Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1 Lipid raft adaptor protein p18 Protein associated with DRMs and endosomes p27Kip1-releasing factor from RhoA Short name: p27RF-Rho
Gene namesⁱ	Name:LAMTOR1 Synonyms:C11orf59, PDRO ORF Names:PP7157
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000149357.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26068 LAMTOR1
MIMⁱ	613510 gene
neXtProtⁱ	NX_Q6IAA8

Keywords - Cellular componentⁱ

Cell membrane, Endosome, Lysosome, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	55004
Open Targets More...OpenTargetsⁱ	ENSG00000149357
PharmGKBⁱ	PA143485354

Polymorphism and mutation databases

BioMutaⁱ	LAMTOR1
DMDMⁱ	125863645

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed2 Publications
ChainⁱPRO_0000274292	2 – 161	Ragulator complex protein LAMTOR1Add BLAST		160

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Lipidationⁱ	2	N-myristoyl glycine2 Publications	1
Modified residueⁱ	27	PhosphoserineCombined sources	1
Modified residueⁱ	42	PhosphoserineCombined sources	1
Modified residueⁱ	56	PhosphoserineCombined sources	1
Modified residueⁱ	98	PhosphoserineCombined sources	1
Modified residueⁱ	141	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDⁱ	Q6IAA8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6IAA8
PaxDbⁱ	Q6IAA8
PeptideAtlas More...PeptideAtlasⁱ	Q6IAA8
PRIDEⁱ	Q6IAA8
ProteomicsDBⁱ	66364
TopDownProteomicsⁱ	Q6IAA8

PTM databases

iPTMnetⁱ	Q6IAA8
PhosphoSitePlusⁱ	Q6IAA8
SwissPalmⁱ	Q6IAA8

Expressionⁱ

Inductionⁱ

Down-regulated by cholesterol (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000149357 Expressed in 200 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_C11orf59
ExpressionAtlasⁱ	Q6IAA8 baseline and differential
Genevisibleⁱ	Q6IAA8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA002997

HPAⁱ

HPA002997

Interactionⁱ

Subunit structureⁱ

Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability (PubMed:20381137, PubMed:22980980). The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, PubMed:25567906). Interacts with LAMTOR2 and LAMTOR3; the interaction is direct. Interacts with RRAGB and RRAGD; the interaction is direct indicating that it probably constitutes the main RAG-interacting subunit of the Ragulator complex (PubMed:22980980). Interacts with MMP14 (PubMed:19654316). Interacts with CDKN1B; prevents the interaction of CDKN1B with RHOA leaving RHOA in a form accessible to activation by ARHGEF2 (PubMed:19654316).5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
RRAGA	Q7L523	11	EBI-715385,EBI-752376
SLC38A9	Q8NBW4	12	EBI-715385,EBI-9978316

GO - Molecular functionⁱ

GTPase binding
Source: CAFA
Inferred from physical interactionⁱ
- 22424946

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	120336, 59 interactors
Database of interacting proteins More...DIPⁱ	DIP-39650N
IntActⁱ	Q6IAA8, 37 interactors
Molecular INTeraction database More...MINTⁱ	Q6IAA8
STRINGⁱ	9606.ENSP00000278671

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	50 – 64	Combined sources	15
Turnⁱ	75 – 77	Combined sources	3
Helixⁱ	78 – 95	Combined sources	18
Helixⁱ	98 – 102	Combined sources	5
Helixⁱ	115 – 120	Combined sources	6
Helixⁱ	126 – 142	Combined sources	17
Helixⁱ	143 – 145	Combined sources	3
Beta strandⁱ	154 – 156	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q6IAA8
SMRⁱ	Q6IAA8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	121 – 161	Interaction with LAMTOR2 and LAMTOR3By similarityAdd BLAST		41

Sequence similaritiesⁱ

Belongs to the LAMTOR1 family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IH39 Eukaryota ENOG4112AMJ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016789
HOVERGENⁱ	HBG081218
InParanoidⁱ	Q6IAA8
KEGG Orthology (KO) More...KOⁱ	K20397
OMAⁱ	HNLEQHE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XGD
PhylomeDBⁱ	Q6IAA8
TreeFamⁱ	TF323788

Family and domain databases

InterProⁱ	View protein in InterPro IPR028209 LAMTOR1/MEH1
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15454 LAMTOR, 1 hit
SMARTⁱ	View protein in SMART SM01262 LAMTOR, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show all Align All

Q6IAA8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGCCYSSENE DSDQDREERK LLLDPSSPPT KALNGAEPNY HSLPSARTDE 
        60         70         80         90        100
QALLSSILAK TASNIIDVSA ADSQGMEQHE YMDRARQYST RLAVLSSSLT 
       110        120        130        140        150
HWKKLPPLPS LTSQPHQVLA SEPIPFSDLQ QVSRIAAYAY SALSQIRVDA 
       160 
KEELVVQFGI P

Length:161

Mass (Da):17,745

Last modified:February 6, 2007 - v2

Checksum:ⁱ610CC6C548356051

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5H3Y3	F5H3Y3_HUMAN	Ragulator complex protein LAMTOR1 Ragulator complex protein LAMTOR1	LAMTOR1	160	Annotation score:
F5H479	F5H479_HUMAN	Ragulator complex protein LAMTOR1 Ragulator complex protein LAMTOR1	LAMTOR1	99	Annotation score:
F5GX19	F5GX19_HUMAN	Ragulator complex protein LAMTOR1 Ragulator complex protein LAMTOR1	LAMTOR1	142	Annotation score:
H0YFI1	H0YFI1_HUMAN	Ragulator complex protein LAMTOR1 Ragulator complex protein LAMTOR1	LAMTOR1	79	Annotation score:
F5H267	F5H267_HUMAN	Ragulator complex protein LAMTOR1 Ragulator complex protein LAMTOR1	LAMTOR1	76	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	50	E → V in CAG33528 (Ref. 2) Curated	1
Sequence conflictⁱ	60	K → R in AAL55767 (PubMed:15498874).Curated	1
Sequence conflictⁱ	69	S → P in CAG33528 (Ref. 2) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_030250	73	S → L. Corresponds to variant dbSNP:rs1053443Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF289583 mRNA Translation: AAL55767.1 CR457247 mRNA Translation: CAG33528.1 AK000632 mRNA Translation: BAA91297.1 BC001706 mRNA Translation: AAH01706.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8209.1
NCBI Reference Sequences More...RefSeqⁱ	NP_060377.1, NM_017907.2
UniGeneⁱ	Hs.731528

Genome annotation databases

Ensemblⁱ	ENST00000278671; ENSP00000278671; ENSG00000149357
GeneIDⁱ	55004
KEGGⁱ	hsa:55004
UCSC genome browser More...UCSCⁱ	uc001ort.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6IAA8	Ragulator complex protein LAMTOR1		PONAB		161	UniRef100_Q6IAA8
Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1		MACMU		161
Ragulator complex protein LAMTOR1		CALJA		161
LAMTOR1 isoform 1		PANTR		161
Macaca fascicularis brain cDNA clone: QbsB-10811, similar to human hypothetical protein FLJ20625 (FLJ20625), mRNA, RefSeq: NM_017907.1		MACFA		161
+23

Protein	Similar proteins		Species	Score	Length	Source
Q6IAA8	Ragulator complex protein LAMTOR1		PONAB		161	UniRef90_Q6IAA8
Ragulator complex protein LAMTOR1		BOVIN		161
Ragulator complex protein LAMTOR1		MOUSE		161
Ragulator complex protein LAMTOR1		RAT		161
Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1		MACMU		161
+78

Protein	Similar proteins		Species	Score	Length	Source
Q6IAA8	Ragulator complex protein LAMTOR1		PONAB		161	UniRef50_Q6IAA8
Ragulator complex protein LAMTOR1		MOUSE		161
Ragulator complex protein LAMTOR1		BOVIN		161
Ragulator complex protein LAMTOR1		RAT		161
Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1		MACMU		161
+83

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF289583 mRNA Translation: AAL55767.1 CR457247 mRNA Translation: CAG33528.1 AK000632 mRNA Translation: BAA91297.1 BC001706 mRNA Translation: AAH01706.1
CCDSⁱ	CCDS8209.1
RefSeqⁱ	NP_060377.1, NM_017907.2
UniGeneⁱ	Hs.731528

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5X6U	X-ray	2.40	E	42-161	[»]
	5X6V	X-ray	2.02	E	42-161	[»]
	5Y39	X-ray	2.65	A/F	76-145	[»]
	5Y3A	X-ray	2.90	A/F	50-161	[»]
	6B9X	X-ray	1.42	A	1-161	[»]
	6EHP	X-ray	2.30	E	21-161	[»]
	6EHR	X-ray	2.90	E	21-161	[»]
ProteinModelPortalⁱ	Q6IAA8
SMRⁱ	Q6IAA8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120336, 59 interactors
DIPⁱ	DIP-39650N
IntActⁱ	Q6IAA8, 37 interactors
MINTⁱ	Q6IAA8
STRINGⁱ	9606.ENSP00000278671

PTM databases

iPTMnetⁱ	Q6IAA8
PhosphoSitePlusⁱ	Q6IAA8
SwissPalmⁱ	Q6IAA8

Polymorphism and mutation databases

BioMutaⁱ	LAMTOR1
DMDMⁱ	125863645

Proteomic databases

EPDⁱ	Q6IAA8
MaxQBⁱ	Q6IAA8
PaxDbⁱ	Q6IAA8
PeptideAtlasⁱ	Q6IAA8
PRIDEⁱ	Q6IAA8
ProteomicsDBⁱ	66364
TopDownProteomicsⁱ	Q6IAA8

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000278671; ENSP00000278671; ENSG00000149357
GeneIDⁱ	55004
KEGGⁱ	hsa:55004
UCSCⁱ	uc001ort.3 human

Organism-specific databases

CTDⁱ	55004
DisGeNETⁱ	55004
EuPathDBⁱ	HostDB:ENSG00000149357.9
GeneCardsⁱ	LAMTOR1
H-InvDBⁱ	HIX0009905
HGNCⁱ	HGNC:26068 LAMTOR1
HPAⁱ	HPA002997
MIMⁱ	613510 gene
neXtProtⁱ	NX_Q6IAA8
OpenTargetsⁱ	ENSG00000149357
PharmGKBⁱ	PA143485354
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IH39 Eukaryota ENOG4112AMJ LUCA
GeneTreeⁱ	ENSGT00390000016789
HOVERGENⁱ	HBG081218
InParanoidⁱ	Q6IAA8
KOⁱ	K20397
OMAⁱ	HNLEQHE
OrthoDBⁱ	EOG091G0XGD
PhylomeDBⁱ	Q6IAA8
TreeFamⁱ	TF323788

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1632852 Macroautophagy R-HSA-165159 mTOR signalling R-HSA-166208 mTORC1-mediated signalling R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-5628897 TP53 Regulates Metabolic Genes R-HSA-6798695 Neutrophil degranulation R-HSA-8943724 Regulation of PTEN gene transcription
SIGNORⁱ	Q6IAA8

Miscellaneous databases

GenomeRNAiⁱ	55004
Protein Ontology More...PROⁱ	PR:Q6IAA8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000149357 Expressed in 200 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_C11orf59
ExpressionAtlasⁱ	Q6IAA8 baseline and differential
Genevisibleⁱ	Q6IAA8 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR028209 LAMTOR1/MEH1
Pfamⁱ	View protein in Pfam PF15454 LAMTOR, 1 hit
SMARTⁱ	View protein in SMART SM01262 LAMTOR, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LTOR1_HUMAN
Accessionⁱ	Q6IAA8Primary (citable) accession number: Q6IAA8 Secondary accession number(s): Q8WZ09, Q9NWT0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
	Last sequence update:	February 6, 2007
	Last modified:	November 7, 2018
	This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6IAA8 (LTOR1_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Ragulator complex protein LAMTOR1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Lysosome

Endosome

Endosome

Extracellular region or secreted

Lysosome

Plasma Membrane

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ