UniProtKB - Q6IAA8 (LTOR1_HUMAN)
Ragulator complex protein LAMTOR1
LAMTOR1
Functioni
GO - Molecular functioni
- GTPase binding Source: CAFA
GO - Biological processi
- cell cycle arrest Source: Reactome
- cellular protein localization Source: UniProtKB
- cellular response to amino acid stimulus Source: UniProtKB
- cholesterol homeostasis Source: UniProtKB
- endosomal transport Source: UniProtKB
- endosome organization Source: UniProtKB
- lysosome localization Source: UniProtKB
- lysosome organization Source: UniProtKB
- neutrophil degranulation Source: Reactome
- positive regulation of MAPK cascade Source: UniProtKB
- positive regulation of TOR signaling Source: UniProtKB
- regulation of cell growth Source: UniProtKB
- regulation of cholesterol efflux Source: UniProtKB
- regulation of cholesterol esterification Source: UniProtKB
- regulation of cholesterol import Source: UniProtKB
- regulation of macroautophagy Source: Reactome
- regulation of receptor recycling Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q6IAA8 |
Reactomei | R-HSA-1632852, Macroautophagy R-HSA-165159, MTOR signalling R-HSA-166208, mTORC1-mediated signalling R-HSA-380972, Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-6798695, Neutrophil degranulation R-HSA-8943724, Regulation of PTEN gene transcription R-HSA-9639288, Amino acids regulate mTORC1 |
SIGNORi | Q6IAA8 |
Names & Taxonomyi
Protein namesi | Recommended name: Ragulator complex protein LAMTOR1Alternative name(s): Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1 Lipid raft adaptor protein p18 Protein associated with DRMs and endosomes p27Kip1-releasing factor from RhoA Short name: p27RF-Rho |
Gene namesi | Name:LAMTOR1 Synonyms:C11orf59, PDRO ORF Names:PP7157 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26068, LAMTOR1 |
MIMi | 613510, gene |
neXtProti | NX_Q6IAA8 |
VEuPathDBi | HostDB:ENSG00000149357.9 |
Subcellular locationi
Plasma membrane
Lysosome
- Lysosome membrane 1 Publication; Lipid-anchor ; Cytoplasmic side
Endosome
Endosome
- late endosome membrane Source: UniProtKB
- Ragulator complex Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Lysosome
- azurophil granule membrane Source: Reactome
- lysosomal membrane Source: Reactome
- lysosome Source: UniProtKB
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- ficolin-1-rich granule membrane Source: Reactome
- membrane raft Source: UniProtKB
- specific granule membrane Source: Reactome
Keywords - Cellular componenti
Cell membrane, Endosome, Lysosome, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 55004 |
OpenTargetsi | ENSG00000149357 |
PharmGKBi | PA143485354 |
Miscellaneous databases
Pharosi | Q6IAA8, Tbio |
Genetic variation databases
BioMutai | LAMTOR1 |
DMDMi | 125863645 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed2 Publications | |||
ChainiPRO_0000274292 | 2 – 161 | Ragulator complex protein LAMTOR1Add BLAST | 160 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 2 | N-myristoyl glycine2 Publications | 1 | |
Modified residuei | 27 | PhosphoserineCombined sources | 1 | |
Modified residuei | 42 | PhosphoserineCombined sources | 1 | |
Modified residuei | 56 | PhosphoserineCombined sources | 1 | |
Modified residuei | 98 | PhosphoserineCombined sources | 1 | |
Modified residuei | 141 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Lipoprotein, Myristate, PhosphoproteinProteomic databases
EPDi | Q6IAA8 |
jPOSTi | Q6IAA8 |
MassIVEi | Q6IAA8 |
MaxQBi | Q6IAA8 |
PaxDbi | Q6IAA8 |
PeptideAtlasi | Q6IAA8 |
PRIDEi | Q6IAA8 |
ProteomicsDBi | 66364 |
TopDownProteomicsi | Q6IAA8 |
PTM databases
iPTMneti | Q6IAA8 |
PhosphoSitePlusi | Q6IAA8 |
SwissPalmi | Q6IAA8 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSG00000149357, Expressed in muscle tissue and 215 other tissues |
ExpressionAtlasi | Q6IAA8, baseline and differential |
Genevisiblei | Q6IAA8, HS |
Organism-specific databases
HPAi | ENSG00000149357, Low tissue specificity |
Interactioni
Subunit structurei
Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5 (PubMed:20381137, PubMed:22980980). LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer (PubMed:20381137, PubMed:22980980).
Interacts with LAMTOR2 and LAMTOR3; the interaction is direct (PubMed:20381137, PubMed:22980980). The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability (PubMed:20381137, PubMed:22980980). The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, PubMed:25567906).
Component of the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or FNIP2), RRAGA/RagA or RRAGB/RagB GDP-bound, RRAGC/RagC or RRAGD/RagD GTP-bound, and Ragulator (PubMed:31704029, PubMed:31672913).
Interacts with RRAGB and RRAGD; the interaction is direct indicating that it probably constitutes the main RAG-interacting subunit of the Ragulator complex (PubMed:22980980).
Interacts with MMP14 (PubMed:19654316).
Interacts with CDKN1B; prevents the interaction of CDKN1B with RHOA leaving RHOA in a form accessible to activation by ARHGEF2 (PubMed:19654316).
Interacts with PIP4P1 (PubMed:29644770).
8 PublicationsBinary interactionsi
Hide detailsQ6IAA8
GO - Molecular functioni
- GTPase binding Source: CAFA
Protein-protein interaction databases
BioGRIDi | 120336, 81 interactors |
ComplexPortali | CPX-4741, Ragulator complex |
CORUMi | Q6IAA8 |
DIPi | DIP-39650N |
IntActi | Q6IAA8, 51 interactors |
MINTi | Q6IAA8 |
STRINGi | 9606.ENSP00000278671 |
Miscellaneous databases
RNActi | Q6IAA8, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q6IAA8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 121 – 161 | Interaction with LAMTOR2 and LAMTOR3By similarityAdd BLAST | 41 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502RYX2, Eukaryota |
GeneTreei | ENSGT00390000016789 |
HOGENOMi | CLU_136283_1_0_1 |
InParanoidi | Q6IAA8 |
OMAi | LHETAAN |
OrthoDBi | 1274244at2759 |
PhylomeDBi | Q6IAA8 |
TreeFami | TF323788 |
Family and domain databases
InterProi | View protein in InterPro IPR028209, LAMTOR1/MEH1 |
Pfami | View protein in Pfam PF15454, LAMTOR, 1 hit |
SMARTi | View protein in SMART SM01262, LAMTOR, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MGCCYSSENE DSDQDREERK LLLDPSSPPT KALNGAEPNY HSLPSARTDE
60 70 80 90 100
QALLSSILAK TASNIIDVSA ADSQGMEQHE YMDRARQYST RLAVLSSSLT
110 120 130 140 150
HWKKLPPLPS LTSQPHQVLA SEPIPFSDLQ QVSRIAAYAY SALSQIRVDA
160
KEELVVQFGI P
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5GX19 | F5GX19_HUMAN | Late endosomal/lysosomal adaptor an... | LAMTOR1 | 142 | Annotation score: | ||
F5H479 | F5H479_HUMAN | Late endosomal/lysosomal adaptor an... | LAMTOR1 | 99 | Annotation score: | ||
F5H3Y3 | F5H3Y3_HUMAN | Late endosomal/lysosomal adaptor an... | LAMTOR1 | 160 | Annotation score: | ||
H0YFI1 | H0YFI1_HUMAN | Late endosomal/lysosomal adaptor an... | LAMTOR1 | 79 | Annotation score: | ||
F5H267 | F5H267_HUMAN | Ragulator complex protein LAMTOR1 | LAMTOR1 | 76 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 50 | E → V in CAG33528 (Ref. 2) Curated | 1 | |
Sequence conflicti | 60 | K → R in AAL55767 (PubMed:15498874).Curated | 1 | |
Sequence conflicti | 69 | S → P in CAG33528 (Ref. 2) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_030250 | 73 | S → L. Corresponds to variant dbSNP:rs1053443Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF289583 mRNA Translation: AAL55767.1 CR457247 mRNA Translation: CAG33528.1 AK000632 mRNA Translation: BAA91297.1 BC001706 mRNA Translation: AAH01706.1 |
CCDSi | CCDS8209.1 |
RefSeqi | NP_060377.1, NM_017907.2 |
Genome annotation databases
Ensembli | ENST00000278671; ENSP00000278671; ENSG00000149357 |
GeneIDi | 55004 |
KEGGi | hsa:55004 |
UCSCi | uc001ort.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF289583 mRNA Translation: AAL55767.1 CR457247 mRNA Translation: CAG33528.1 AK000632 mRNA Translation: BAA91297.1 BC001706 mRNA Translation: AAH01706.1 |
CCDSi | CCDS8209.1 |
RefSeqi | NP_060377.1, NM_017907.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5X6U | X-ray | 2.40 | E | 42-161 | [»] | |
5X6V | X-ray | 2.02 | E | 42-161 | [»] | |
5Y39 | X-ray | 2.65 | A/F | 76-145 | [»] | |
5Y3A | X-ray | 2.90 | A/F | 50-161 | [»] | |
6B9X | X-ray | 1.42 | A | 1-161 | [»] | |
6EHP | X-ray | 2.30 | E | 21-161 | [»] | |
6EHR | X-ray | 2.90 | E | 21-161 | [»] | |
6NZD | electron microscopy | 3.60 | A | 5-161 | [»] | |
6U62 | electron microscopy | 3.18 | D | 6-161 | [»] | |
6ULG | electron microscopy | 3.31 | E | 1-161 | [»] | |
6WJ2 | electron microscopy | 3.20 | A | 1-161 | [»] | |
6WJ3 | electron microscopy | 3.90 | A | 1-161 | [»] | |
SMRi | Q6IAA8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120336, 81 interactors |
ComplexPortali | CPX-4741, Ragulator complex |
CORUMi | Q6IAA8 |
DIPi | DIP-39650N |
IntActi | Q6IAA8, 51 interactors |
MINTi | Q6IAA8 |
STRINGi | 9606.ENSP00000278671 |
PTM databases
iPTMneti | Q6IAA8 |
PhosphoSitePlusi | Q6IAA8 |
SwissPalmi | Q6IAA8 |
Genetic variation databases
BioMutai | LAMTOR1 |
DMDMi | 125863645 |
Proteomic databases
EPDi | Q6IAA8 |
jPOSTi | Q6IAA8 |
MassIVEi | Q6IAA8 |
MaxQBi | Q6IAA8 |
PaxDbi | Q6IAA8 |
PeptideAtlasi | Q6IAA8 |
PRIDEi | Q6IAA8 |
ProteomicsDBi | 66364 |
TopDownProteomicsi | Q6IAA8 |
Protocols and materials databases
Antibodypediai | 721, 75 antibodies |
Genome annotation databases
Ensembli | ENST00000278671; ENSP00000278671; ENSG00000149357 |
GeneIDi | 55004 |
KEGGi | hsa:55004 |
UCSCi | uc001ort.3, human |
Organism-specific databases
CTDi | 55004 |
DisGeNETi | 55004 |
GeneCardsi | LAMTOR1 |
HGNCi | HGNC:26068, LAMTOR1 |
HPAi | ENSG00000149357, Low tissue specificity |
MIMi | 613510, gene |
neXtProti | NX_Q6IAA8 |
OpenTargetsi | ENSG00000149357 |
PharmGKBi | PA143485354 |
VEuPathDBi | HostDB:ENSG00000149357.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RYX2, Eukaryota |
GeneTreei | ENSGT00390000016789 |
HOGENOMi | CLU_136283_1_0_1 |
InParanoidi | Q6IAA8 |
OMAi | LHETAAN |
OrthoDBi | 1274244at2759 |
PhylomeDBi | Q6IAA8 |
TreeFami | TF323788 |
Enzyme and pathway databases
PathwayCommonsi | Q6IAA8 |
Reactomei | R-HSA-1632852, Macroautophagy R-HSA-165159, MTOR signalling R-HSA-166208, mTORC1-mediated signalling R-HSA-380972, Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-6798695, Neutrophil degranulation R-HSA-8943724, Regulation of PTEN gene transcription R-HSA-9639288, Amino acids regulate mTORC1 |
SIGNORi | Q6IAA8 |
Miscellaneous databases
BioGRID-ORCSi | 55004, 124 hits in 883 CRISPR screens |
ChiTaRSi | LAMTOR1, human |
GenomeRNAii | 55004 |
Pharosi | Q6IAA8, Tbio |
PROi | PR:Q6IAA8 |
RNActi | Q6IAA8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000149357, Expressed in muscle tissue and 215 other tissues |
ExpressionAtlasi | Q6IAA8, baseline and differential |
Genevisiblei | Q6IAA8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR028209, LAMTOR1/MEH1 |
Pfami | View protein in Pfam PF15454, LAMTOR, 1 hit |
SMARTi | View protein in SMART SM01262, LAMTOR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LTOR1_HUMAN | |
Accessioni | Q6IAA8Primary (citable) accession number: Q6IAA8 Secondary accession number(s): Q8WZ09, Q9NWT0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 6, 2007 |
Last sequence update: | February 6, 2007 | |
Last modified: | February 10, 2021 | |
This is version 142 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families