UniProtKB - Q6IA17 (SIGIR_HUMAN)
Single Ig IL-1-related receptor
SIGIRR
Functioni
GO - Biological processi
- acute-phase response Source: HGNC-UCL
- cellular response to cytokine stimulus Source: Reactome
- negative regulation of chemokine production Source: HGNC-UCL
- negative regulation of cytokine-mediated signaling pathway Source: HGNC-UCL
- negative regulation of DNA-binding transcription factor activity Source: HGNC-UCL
- negative regulation of lipopolysaccharide-mediated signaling pathway Source: HGNC-UCL
- signal transduction Source: InterPro
Enzyme and pathway databases
PathwayCommonsi | Q6IA17 |
Reactomei | R-HSA-166058, MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-9008059, Interleukin-37 signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Single Ig IL-1-related receptorAlternative name(s): Single Ig IL-1R-related molecule Single immunoglobulin domain-containing IL1R-related protein Toll/interleukin-1 receptor 8 Short name: TIR8 |
Gene namesi | Name:SIGIRR ORF Names:UNQ301/PRO342 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30575, SIGIRR |
MIMi | 605478, gene |
neXtProti | NX_Q6IA17 |
VEuPathDBi | HostDB:ENSG00000185187.12 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type III membrane protein Curated
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: HGNC-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 118 | ExtracellularSequence analysisAdd BLAST | 118 | |
Transmembranei | 119 – 139 | Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 140 – 410 | CytoplasmicSequence analysisAdd BLAST | 271 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 59307 |
OpenTargetsi | ENSG00000185187 |
PharmGKBi | PA142670915 |
Miscellaneous databases
Pharosi | Q6IA17, Tbio |
Genetic variation databases
BioMutai | SIGIRR |
DMDMi | 311033538 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000099065 | 1 – 410 | Single Ig IL-1-related receptorAdd BLAST | 410 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 31 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 32 ↔ 98 | PROSITE-ProRule annotation | ||
Glycosylationi | 73 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 86 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 102 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 383 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q6IA17 |
jPOSTi | Q6IA17 |
MassIVEi | Q6IA17 |
MaxQBi | Q6IA17 |
PaxDbi | Q6IA17 |
PeptideAtlasi | Q6IA17 |
PRIDEi | Q6IA17 |
ProteomicsDBi | 66356 [Q6IA17-1] 66357 [Q6IA17-2] |
PTM databases
GlyGeni | Q6IA17, 4 sites |
iPTMneti | Q6IA17 |
PhosphoSitePlusi | Q6IA17 |
SwissPalmi | Q6IA17 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000185187, Expressed in granulocyte and 214 other tissues |
ExpressionAtlasi | Q6IA17, baseline and differential |
Genevisiblei | Q6IA17, HS |
Organism-specific databases
HPAi | ENSG00000185187, Tissue enhanced (liver) |
Interactioni
Subunit structurei
Interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9 and TRAF6. Upon IL-1 stimulation found in a complex at least composed of IL1R1, SIGIRR, MYD88, IRAK1 and TRAF6. Upon stimulation with LPC found in a complex at least composed of TLR4, SIG1IR, MYD88, IRAK1 and TRAF6.
Interacts with PALM3.
3 PublicationsProtein-protein interaction databases
BioGRIDi | 121873, 9 interactors |
IntActi | Q6IA17, 3 interactors |
STRINGi | 9606.ENSP00000403104 |
Miscellaneous databases
RNActi | Q6IA17, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 109 | Ig-like C2-typeAdd BLAST | 101 | |
Domaini | 163 – 307 | TIRPROSITE-ProRule annotationAdd BLAST | 145 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QVF7, Eukaryota |
GeneTreei | ENSGT01010000222421 |
HOGENOMi | CLU_040046_0_0_1 |
InParanoidi | Q6IA17 |
PhylomeDBi | Q6IA17 |
TreeFami | TF325519 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.40.50.10140, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR015621, IL-1_rcpt_fam IPR000157, TIR_dom IPR035897, Toll_tir_struct_dom_sf |
PANTHERi | PTHR11890, PTHR11890, 1 hit |
Pfami | View protein in Pfam PF01582, TIR, 1 hit |
SMARTi | View protein in SMART SM00255, TIR, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF52200, SSF52200, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS50104, TIR, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPGVCDRAPD FLSPSEDQVL RPALGSSVAL NCTAWVVSGP HCSLPSVQWL
60 70 80 90 100
KDGLPLGIGG HYSLHEYSWV KANLSEVLVS SVLGVNVTST EVYGAFTCSI
110 120 130 140 150
QNISFSSFTL QRAGPTSHVA AVLASLLVLL ALLLAALLYV KCRLNVLLWY
160 170 180 190 200
QDAYGEVEIN DGKLYDAYVS YSDCPEDRKF VNFILKPQLE RRRGYKLFLD
210 220 230 240 250
DRDLLPRAEP SADLLVNLSR CRRLIVVLSD AFLSRAWCSH SFREGLCRLL
260 270 280 290 300
ELTRRPIFIT FEGQRRDPAH PALRLLRQHR HLVTLLLWRP GSVTPSSDFW
310 320 330 340 350
KEVQLALPRK VQYRPVEGDP QTQLQDDKDP MLILRGRVPE GRALDSEVDP
360 370 380 390 400
DPEGDLGVRG PVFGEPSAPP HTSGVSLGES RSSEVDVSDL GSRNYSARTD
410
FYCLVSKDDM
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JFX4 | C9JFX4_HUMAN | Single Ig IL-1-related receptor | SIGIRR | 504 | Annotation score: | ||
H0YDF8 | H0YDF8_HUMAN | Single Ig IL-1-related receptor | SIGIRR | 142 | Annotation score: | ||
H0YDR5 | H0YDR5_HUMAN | Single Ig IL-1-related receptor | SIGIRR | 130 | Annotation score: | ||
E9PLG6 | E9PLG6_HUMAN | Single Ig IL-1-related receptor | SIGIRR | 189 | Annotation score: | ||
E9PSD9 | E9PSD9_HUMAN | Single Ig IL-1-related receptor | SIGIRR | 143 | Annotation score: | ||
E9PK23 | E9PK23_HUMAN | Single Ig IL-1-related receptor | SIGIRR | 57 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 410 | M → I in CAG33619 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_074164 | 80 | S → Y1 PublicationCorresponds to variant dbSNP:rs117739035Ensembl. | 1 | |
Natural variantiVAR_074165 | 115 | P → R1 PublicationCorresponds to variant dbSNP:rs111819059Ensembl. | 1 | |
Natural variantiVAR_058702 | 312 | Q → R5 PublicationsCorresponds to variant dbSNP:rs3210908Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015717 | 358 – 410 | VRGPV…SKDDM → MPAQPHSPTGEAQHRAEWGQ AQGTGPGGALGVEDSSRHRE PLHGLCPGGARPSVCLGTSW ASQAITAGGEQGQPLAVGLG QGCGWPPQASRSPHPRCPGA CFWRAISSTAHQWGLAGREP EQRSGRLGSRLAKLQCPHRL LLPGVQG in isoform 2. 1 PublicationAdd BLAST | 53 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358342 mRNA Translation: AAQ88708.1 AK025099 mRNA Translation: BAB15066.1 CR457338 mRNA Translation: CAG33619.1 AC138230 Genomic DNA No translation available. BC003591 mRNA Translation: AAH03591.1 BC025953 mRNA Translation: AAH25953.1 BC106007 mRNA Translation: AAI06008.1 |
CCDSi | CCDS31325.1 [Q6IA17-1] |
RefSeqi | NP_001128525.1, NM_001135053.1 [Q6IA17-1] NP_001128526.1, NM_001135054.1 [Q6IA17-1] NP_068577.2, NM_021805.2 [Q6IA17-1] |
Genome annotation databases
Ensembli | ENST00000332725; ENSP00000333656; ENSG00000185187 [Q6IA17-1] ENST00000397632; ENSP00000380756; ENSG00000185187 [Q6IA17-1] ENST00000431843; ENSP00000403104; ENSG00000185187 [Q6IA17-1] |
GeneIDi | 59307 |
KEGGi | hsa:59307 |
UCSCi | uc001lpd.3, human [Q6IA17-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358342 mRNA Translation: AAQ88708.1 AK025099 mRNA Translation: BAB15066.1 CR457338 mRNA Translation: CAG33619.1 AC138230 Genomic DNA No translation available. BC003591 mRNA Translation: AAH03591.1 BC025953 mRNA Translation: AAH25953.1 BC106007 mRNA Translation: AAI06008.1 |
CCDSi | CCDS31325.1 [Q6IA17-1] |
RefSeqi | NP_001128525.1, NM_001135053.1 [Q6IA17-1] NP_001128526.1, NM_001135054.1 [Q6IA17-1] NP_068577.2, NM_021805.2 [Q6IA17-1] |
3D structure databases
SMRi | Q6IA17 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121873, 9 interactors |
IntActi | Q6IA17, 3 interactors |
STRINGi | 9606.ENSP00000403104 |
PTM databases
GlyGeni | Q6IA17, 4 sites |
iPTMneti | Q6IA17 |
PhosphoSitePlusi | Q6IA17 |
SwissPalmi | Q6IA17 |
Genetic variation databases
BioMutai | SIGIRR |
DMDMi | 311033538 |
Proteomic databases
EPDi | Q6IA17 |
jPOSTi | Q6IA17 |
MassIVEi | Q6IA17 |
MaxQBi | Q6IA17 |
PaxDbi | Q6IA17 |
PeptideAtlasi | Q6IA17 |
PRIDEi | Q6IA17 |
ProteomicsDBi | 66356 [Q6IA17-1] 66357 [Q6IA17-2] |
Protocols and materials databases
Antibodypediai | 9633, 305 antibodies |
DNASUi | 59307 |
Genome annotation databases
Ensembli | ENST00000332725; ENSP00000333656; ENSG00000185187 [Q6IA17-1] ENST00000397632; ENSP00000380756; ENSG00000185187 [Q6IA17-1] ENST00000431843; ENSP00000403104; ENSG00000185187 [Q6IA17-1] |
GeneIDi | 59307 |
KEGGi | hsa:59307 |
UCSCi | uc001lpd.3, human [Q6IA17-1] |
Organism-specific databases
CTDi | 59307 |
DisGeNETi | 59307 |
GeneCardsi | SIGIRR |
HGNCi | HGNC:30575, SIGIRR |
HPAi | ENSG00000185187, Tissue enhanced (liver) |
MIMi | 605478, gene |
neXtProti | NX_Q6IA17 |
OpenTargetsi | ENSG00000185187 |
PharmGKBi | PA142670915 |
VEuPathDBi | HostDB:ENSG00000185187.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QVF7, Eukaryota |
GeneTreei | ENSGT01010000222421 |
HOGENOMi | CLU_040046_0_0_1 |
InParanoidi | Q6IA17 |
PhylomeDBi | Q6IA17 |
TreeFami | TF325519 |
Enzyme and pathway databases
PathwayCommonsi | Q6IA17 |
Reactomei | R-HSA-166058, MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-9008059, Interleukin-37 signaling |
Miscellaneous databases
BioGRID-ORCSi | 59307, 9 hits in 875 CRISPR screens |
ChiTaRSi | SIGIRR, human |
GeneWikii | SIGIRR |
GenomeRNAii | 59307 |
Pharosi | Q6IA17, Tbio |
PROi | PR:Q6IA17 |
RNActi | Q6IA17, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000185187, Expressed in granulocyte and 214 other tissues |
ExpressionAtlasi | Q6IA17, baseline and differential |
Genevisiblei | Q6IA17, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.40.50.10140, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR015621, IL-1_rcpt_fam IPR000157, TIR_dom IPR035897, Toll_tir_struct_dom_sf |
PANTHERi | PTHR11890, PTHR11890, 1 hit |
Pfami | View protein in Pfam PF01582, TIR, 1 hit |
SMARTi | View protein in SMART SM00255, TIR, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF52200, SSF52200, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS50104, TIR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SIGIR_HUMAN | |
Accessioni | Q6IA17Primary (citable) accession number: Q6IA17 Secondary accession number(s): Q3KQY2, Q6UXI3, Q9H733 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 27, 2005 |
Last sequence update: | November 2, 2010 | |
Last modified: | February 10, 2021 | |
This is version 152 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families