SIGIRR

Functionⁱ

Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.4 Publications

GO - Biological processⁱ

acute-phase response Source: HGNC
cellular response to cytokine stimulus Source: Reactome
negative regulation of chemokine biosynthetic process Source: HGNC
negative regulation of cytokine-mediated signaling pathway Source: HGNC
negative regulation of DNA-binding transcription factor activity
Source: HGNC
Inferred from mutant phenotypeⁱ
- 12925853
negative regulation of lipopolysaccharide-mediated signaling pathway
Source: HGNC
Traceable author statementⁱ
- 15866876
signal transduction Source: InterPro

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane R-HSA-9008059 Interleukin-37 signaling

Reactomeⁱ

R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane
R-HSA-9008059 Interleukin-37 signaling

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Single Ig IL-1-related receptor Alternative name(s): Single Ig IL-1R-related molecule Single immunoglobulin domain-containing IL1R-related protein Toll/interleukin-1 receptor 8 Short name: TIR8
Gene namesⁱ	Name:SIGIRR ORF Names:UNQ301/PRO342
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000185187.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30575 SIGIRR
MIMⁱ	605478 gene
neXtProtⁱ	NX_Q6IA17

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 118	ExtracellularSequence analysisAdd BLAST	118
Transmembraneⁱ	119 – 139	Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	140 – 410	CytoplasmicSequence analysisAdd BLAST	271

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	59307
Open Targets More...OpenTargetsⁱ	ENSG00000185187
PharmGKBⁱ	PA142670915

Polymorphism and mutation databases

BioMutaⁱ	SIGIRR
DMDMⁱ	311033538

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000099065	1 – 410	Single Ig IL-1-related receptorAdd BLAST		410

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	31	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	32 ↔ 98	PROSITE-ProRule annotation
Glycosylationⁱ	73	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	86	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	102	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	383	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q6IA17
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6IA17
PaxDbⁱ	Q6IA17
PeptideAtlas More...PeptideAtlasⁱ	Q6IA17
PRIDEⁱ	Q6IA17
ProteomicsDBⁱ	66356 66357 [Q6IA17-2]

PTM databases

iPTMnetⁱ	Q6IA17
PhosphoSitePlusⁱ	Q6IA17
SwissPalmⁱ	Q6IA17

Expressionⁱ

Tissue specificityⁱ

Mainly expressed in epithelial tissues such as kidney, lung and gut.2 Publications

Inductionⁱ

Down-regulated during inflammation by inhibition of an SP1-mediated pathway.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000185187 Expressed in 200 organ(s), highest expression level in right lobe of liver
CleanExⁱ	HS_SIGIRR
ExpressionAtlasⁱ	Q6IA17 baseline and differential
Genevisibleⁱ	Q6IA17 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA023188

HPAⁱ

HPA023188

Interactionⁱ

Subunit structureⁱ

Interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9 and TRAF6. Upon IL-1 stimulation found in a complex at least composed of IL1R1, SIGIRR, MYD88, IRAK1 and TRAF6. Upon stimulation with LPC found in a complex at least composed of TLR4, SIG1IR, MYD88, IRAK1 and TRAF6. Interacts with PALM3.3 Publications

Protein-protein interaction databases

BioGridⁱ	121873, 8 interactors
IntActⁱ	Q6IA17, 3 interactors
STRINGⁱ	9606.ENSP00000333656

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6IA17
SMRⁱ	Q6IA17
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	9 – 109	Ig-like C2-typeAdd BLAST		101
Domainⁱ	163 – 310	TIRPROSITE-ProRule annotationAdd BLAST		148

Sequence similaritiesⁱ

Belongs to the interleukin-1 receptor family.Curated

Keywords - Domainⁱ

Immunoglobulin domain, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IEXB Eukaryota ENOG410ZFDI LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119071
HOGENOMⁱ	HOG000237348
HOVERGENⁱ	HBG080781
InParanoidⁱ	Q6IA17
KEGG Orthology (KO) More...KOⁱ	K05169
PhylomeDBⁱ	Q6IA17
TreeFamⁱ	TF325519

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit 3.40.50.10140, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR015621 IL-1_rcpt_fam IPR000157 TIR_dom IPR035897 Toll_tir_struct_dom_sf
PANTHERⁱ	PTHR11890 PTHR11890, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01582 TIR, 1 hit
SMARTⁱ	View protein in SMART SM00255 TIR, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit SSF52200 SSF52200, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit PS50104 TIR, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q6IA17-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGVCDRAPD FLSPSEDQVL RPALGSSVAL NCTAWVVSGP HCSLPSVQWL 
        60         70         80         90        100
KDGLPLGIGG HYSLHEYSWV KANLSEVLVS SVLGVNVTST EVYGAFTCSI 
       110        120        130        140        150
QNISFSSFTL QRAGPTSHVA AVLASLLVLL ALLLAALLYV KCRLNVLLWY 
       160        170        180        190        200
QDAYGEVEIN DGKLYDAYVS YSDCPEDRKF VNFILKPQLE RRRGYKLFLD 
       210        220        230        240        250
DRDLLPRAEP SADLLVNLSR CRRLIVVLSD AFLSRAWCSH SFREGLCRLL 
       260        270        280        290        300
ELTRRPIFIT FEGQRRDPAH PALRLLRQHR HLVTLLLWRP GSVTPSSDFW 
       310        320        330        340        350
KEVQLALPRK VQYRPVEGDP QTQLQDDKDP MLILRGRVPE GRALDSEVDP 
       360        370        380        390        400
DPEGDLGVRG PVFGEPSAPP HTSGVSLGES RSSEVDVSDL GSRNYSARTD 
       410
FYCLVSKDDM

Length:410

Mass (Da):45,679

Last modified:November 2, 2010 - v3

Checksum:ⁱBA4564C2ABAB5104

GO

Isoform 2 (identifier: Q6IA17-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
358-410: VRGPVFGEPS...FYCLVSKDDM → MPAQPHSPTG...HRLLLPGVQG

« Hide

        10         20         30         40         50
MPGVCDRAPD FLSPSEDQVL RPALGSSVAL NCTAWVVSGP HCSLPSVQWL 
        60         70         80         90        100
KDGLPLGIGG HYSLHEYSWV KANLSEVLVS SVLGVNVTST EVYGAFTCSI 
       110        120        130        140        150
QNISFSSFTL QRAGPTSHVA AVLASLLVLL ALLLAALLYV KCRLNVLLWY 
       160        170        180        190        200
QDAYGEVEIN DGKLYDAYVS YSDCPEDRKF VNFILKPQLE RRRGYKLFLD 
       210        220        230        240        250
DRDLLPRAEP SADLLVNLSR CRRLIVVLSD AFLSRAWCSH SFREGLCRLL 
       260        270        280        290        300
ELTRRPIFIT FEGQRRDPAH PALRLLRQHR HLVTLLLWRP GSVTPSSDFW 
       310        320        330        340        350
KEVQLALPRK VQYRPVEGDP QTQLQDDKDP MLILRGRVPE GRALDSEVDP 
       360        370        380        390        400
DPEGDLGMPA QPHSPTGEAQ HRAEWGQAQG TGPGGALGVE DSSRHREPLH 
       410        420        430        440        450
GLCPGGARPS VCLGTSWASQ AITAGGEQGQ PLAVGLGQGC GWPPQASRSP 
       460        470        480        490        500
HPRCPGACFW RAISSTAHQW GLAGREPEQR SGRLGSRLAK LQCPHRLLLP 

GVQG

Note: No experimental confirmation available.

Show »

Length:504

Mass (Da):55,271

Checksum:ⁱ1DC974BAC4EC4D2A

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JFX4	C9JFX4_HUMAN	Single Ig IL-1-related receptor Single Ig IL-1-related receptor	SIGIRR	504	Annotation score:
E9PLG6	E9PLG6_HUMAN	Single Ig IL-1-related receptor Single Ig IL-1-related receptor	SIGIRR	189	Annotation score:
E9PSD9	E9PSD9_HUMAN	Single Ig IL-1-related receptor Single Ig IL-1-related receptor	SIGIRR	143	Annotation score:
H0YDF8	H0YDF8_HUMAN	Single Ig IL-1-related receptor Single Ig IL-1-related receptor	SIGIRR	142	Annotation score:
E9PK23	E9PK23_HUMAN	Single Ig IL-1-related receptor Single Ig IL-1-related receptor	SIGIRR	57	Annotation score:
H0YDR5	H0YDR5_HUMAN	Single Ig IL-1-related receptor Single Ig IL-1-related receptor	SIGIRR	130	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	410	M → I in CAG33619 (Ref. 3) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_074164	80	S → Y1 PublicationCorresponds to variant dbSNP:rs117739035Ensembl.	1
Natural variantⁱVAR_074165	115	P → R1 PublicationCorresponds to variant dbSNP:rs111819059Ensembl.	1
Natural variantⁱVAR_058702	312	Q → R5 PublicationsCorresponds to variant dbSNP:rs3210908Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_015717	358 – 410	VRGPV…SKDDM → MPAQPHSPTGEAQHRAEWGQ AQGTGPGGALGVEDSSRHRE PLHGLCPGGARPSVCLGTSW ASQAITAGGEQGQPLAVGLG QGCGWPPQASRSPHPRCPGA CFWRAISSTAHQWGLAGREP EQRSGRLGSRLAKLQCPHRL LLPGVQG in isoform 2. 1 PublicationAdd BLAST		53

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY358342 mRNA Translation: AAQ88708.1 AK025099 mRNA Translation: BAB15066.1 CR457338 mRNA Translation: CAG33619.1 AC138230 Genomic DNA No translation available. BC003591 mRNA Translation: AAH03591.1 BC025953 mRNA Translation: AAH25953.1 BC106007 mRNA Translation: AAI06008.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31325.1 [Q6IA17-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001128525.1, NM_001135053.1 [Q6IA17-1] NP_001128526.1, NM_001135054.1 [Q6IA17-1] NP_068577.2, NM_021805.2 [Q6IA17-1]
UniGeneⁱ	Hs.501624

Genome annotation databases

Ensemblⁱ	ENST00000332725; ENSP00000333656; ENSG00000185187 [Q6IA17-1] ENST00000397632; ENSP00000380756; ENSG00000185187 [Q6IA17-1] ENST00000431843; ENSP00000403104; ENSG00000185187 [Q6IA17-1]
GeneIDⁱ	59307
KEGGⁱ	hsa:59307
UCSC genome browser More...UCSCⁱ	uc001lpd.3 human [Q6IA17-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6IA17	Single Ig and TIR domain containing		RHIBE		410	UniRef90_Q6IA17
Single Ig and TIR domain containing		RHIRO		410
SIGIRR isoform 11		PONAB		410
Uncharacterized protein		MACMU		410
Uncharacterized protein		COLAP		410
+21
Q6IA17-2	SIGIRR isoform 18		PONAB		505	UniRef90_Q6IA17-2
Single Ig IL-1-related receptor		HUMAN		504
Uncharacterized protein		RHIBE		502
Uncharacterized protein		GORGO		498
Uncharacterized protein		PAPAN		495
+5

Protein	Similar proteins		Species	Score	Length	Source
Q6IA17	SIGIRR isoform 11		PONAB		410	UniRef50_Q6IA17
Uncharacterized protein		PAPAN		410
Uncharacterized protein		CERAT		410
Single Ig and TIR domain containing		RHIBE		410
Single Ig and TIR domain containing		RHIRO		410
+31
Q6IA17-2	SIGIRR isoform 18		PONAB		505	UniRef50_Q6IA17-2
Single Ig IL-1-related receptor		HUMAN		504
Uncharacterized protein		RHIBE		502
Uncharacterized protein		GORGO		498
Uncharacterized protein		PAPAN		495
+36

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY358342 mRNA Translation: AAQ88708.1 AK025099 mRNA Translation: BAB15066.1 CR457338 mRNA Translation: CAG33619.1 AC138230 Genomic DNA No translation available. BC003591 mRNA Translation: AAH03591.1 BC025953 mRNA Translation: AAH25953.1 BC106007 mRNA Translation: AAI06008.1
CCDSⁱ	CCDS31325.1 [Q6IA17-1]
RefSeqⁱ	NP_001128525.1, NM_001135053.1 [Q6IA17-1] NP_001128526.1, NM_001135054.1 [Q6IA17-1] NP_068577.2, NM_021805.2 [Q6IA17-1]
UniGeneⁱ	Hs.501624

3D structure databases

ProteinModelPortalⁱ	Q6IA17
SMRⁱ	Q6IA17
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121873, 8 interactors
IntActⁱ	Q6IA17, 3 interactors
STRINGⁱ	9606.ENSP00000333656

PTM databases

iPTMnetⁱ	Q6IA17
PhosphoSitePlusⁱ	Q6IA17
SwissPalmⁱ	Q6IA17

Polymorphism and mutation databases

BioMutaⁱ	SIGIRR
DMDMⁱ	311033538

Proteomic databases

EPDⁱ	Q6IA17
MaxQBⁱ	Q6IA17
PaxDbⁱ	Q6IA17
PeptideAtlasⁱ	Q6IA17
PRIDEⁱ	Q6IA17
ProteomicsDBⁱ	66356 66357 [Q6IA17-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	59307
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000332725; ENSP00000333656; ENSG00000185187 [Q6IA17-1] ENST00000397632; ENSP00000380756; ENSG00000185187 [Q6IA17-1] ENST00000431843; ENSP00000403104; ENSG00000185187 [Q6IA17-1]
GeneIDⁱ	59307
KEGGⁱ	hsa:59307
UCSCⁱ	uc001lpd.3 human [Q6IA17-1]

Organism-specific databases

CTDⁱ	59307
DisGeNETⁱ	59307
EuPathDBⁱ	HostDB:ENSG00000185187.12
GeneCardsⁱ	SIGIRR
H-InvDBⁱ	HIX0021476
HGNCⁱ	HGNC:30575 SIGIRR
HPAⁱ	HPA023188
MIMⁱ	605478 gene
neXtProtⁱ	NX_Q6IA17
OpenTargetsⁱ	ENSG00000185187
PharmGKBⁱ	PA142670915
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEXB Eukaryota ENOG410ZFDI LUCA
GeneTreeⁱ	ENSGT00760000119071
HOGENOMⁱ	HOG000237348
HOVERGENⁱ	HBG080781
InParanoidⁱ	Q6IA17
KOⁱ	K05169
PhylomeDBⁱ	Q6IA17
TreeFamⁱ	TF325519

Enzyme and pathway databases

Reactomeⁱ	R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane R-HSA-9008059 Interleukin-37 signaling

Reactomeⁱ

R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane
R-HSA-9008059 Interleukin-37 signaling

Miscellaneous databases

ChiTaRSⁱ	SIGIRR human
GeneWikiⁱ	SIGIRR
GenomeRNAiⁱ	59307
Protein Ontology More...PROⁱ	PR:Q6IA17
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000185187 Expressed in 200 organ(s), highest expression level in right lobe of liver
CleanExⁱ	HS_SIGIRR
ExpressionAtlasⁱ	Q6IA17 baseline and differential
Genevisibleⁱ	Q6IA17 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit 3.40.50.10140, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR015621 IL-1_rcpt_fam IPR000157 TIR_dom IPR035897 Toll_tir_struct_dom_sf
PANTHERⁱ	PTHR11890 PTHR11890, 1 hit
Pfamⁱ	View protein in Pfam PF01582 TIR, 1 hit
SMARTⁱ	View protein in SMART SM00255 TIR, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit SSF52200 SSF52200, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit PS50104 TIR, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SIGIR_HUMAN
Accessionⁱ	Q6IA17Primary (citable) accession number: Q6IA17 Secondary accession number(s): Q3KQY2, Q6UXI3, Q9H733
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
	Last sequence update:	November 2, 2010
	Last modified:	November 7, 2018
	This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

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UniProtKB - Q6IA17 (SIGIR_HUMAN)

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Single Ig IL-1-related receptor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ