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Protein

THO complex subunit 7 homolog

Gene

THOC7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.4 Publications
The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.1 Publication

GO - Molecular functioni

GO - Biological processi

  • mRNA 3'-end processing Source: Reactome
  • mRNA export from nucleus Source: UniProtKB
  • RNA export from nucleus Source: Reactome
  • RNA splicing Source: UniProtKB-KW
  • viral mRNA export from host cell nucleus Source: UniProtKB

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing, mRNA transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72187 mRNA 3'-end processing

Names & Taxonomyi

Protein namesi
Recommended name:
THO complex subunit 7 homolog
Alternative name(s):
Functional spliceosome-associated protein 24
Short name:
fSAP24
Ngg1-interacting factor 3-like protein 1-binding protein 1
Short name:
NIF3L1-binding protein 1
hTREX30
Gene namesi
Name:THOC7
Synonyms:NIF3L1BP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163634.11
HGNCiHGNC:29874 THOC7
MIMi611965 gene
neXtProtiNX_Q6I9Y2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi80145
OpenTargetsiENSG00000163634
PharmGKBiPA144596266

Polymorphism and mutation databases

DMDMi229462996

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00003107542 – 204THO complex subunit 7 homologAdd BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycineCombined sources1 Publication1
Modified residuei5PhosphothreonineCombined sources1
Modified residuei36N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6I9Y2
MaxQBiQ6I9Y2
PaxDbiQ6I9Y2
PeptideAtlasiQ6I9Y2
PRIDEiQ6I9Y2
ProteomicsDBi66355

PTM databases

iPTMnetiQ6I9Y2
PhosphoSitePlusiQ6I9Y2

Expressioni

Gene expression databases

BgeeiENSG00000163634
CleanExiHS_THOC7
ExpressionAtlasiQ6I9Y2 baseline and differential
GenevisibleiQ6I9Y2 HS

Organism-specific databases

HPAiHPA044143

Interactioni

Subunit structurei

Component of the THO complex, which is composed of THOC1, THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the transcription/export (TREX) complex which seems to have a dynamic structure involving ATP-dependent remodeling. Interacts with NIF3L1 and THOC5.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
THOC5Q137699EBI-716286,EBI-5280316

Protein-protein interaction databases

BioGridi123138, 62 interactors
CORUMiQ6I9Y2
IntActiQ6I9Y2, 43 interactors
MINTiQ6I9Y2
STRINGi9606.ENSP00000295899

Structurei

3D structure databases

ProteinModelPortaliQ6I9Y2
SMRiQ6I9Y2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni50 – 137Interaction with THOC51 PublicationAdd BLAST88
Regioni105 – 204Interaction with NIF3L11 PublicationAdd BLAST100

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili75 – 194Sequence analysisAdd BLAST120

Sequence similaritiesi

Belongs to the THOC7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3215 Eukaryota
ENOG4111K36 LUCA
GeneTreeiENSGT00390000002873
HOGENOMiHOG000044589
HOVERGENiHBG061300
InParanoidiQ6I9Y2
KOiK13176
OMAiQQHPDRH
OrthoDBiEOG091G0QNR
PhylomeDBiQ6I9Y2
TreeFamiTF319308

Family and domain databases

InterProiView protein in InterPro
IPR008501 THOC7/Mft1
PfamiView protein in Pfam
PF05615 THOC7, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6I9Y2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAVTDDEVI RKRLLIDGDG AGDDRRINLL VKSFIKWCNS GSQEEGYSQY
60 70 80 90 100
QRMLSTLSQC EFSMGKTLLV YDMNLREMEN YEKIYKEIEC SIAGAHEKIA
110 120 130 140 150
ECKKQILQAK RIRKNRQEYD ALAKVIQHHP DRHETLKELE ALGKELEHLS
160 170 180 190 200
HIKESVEDKL ELRRKQFHVL LSTIHELQQT LENDEKLSEV EEAQEASMET

DPKP
Length:204
Mass (Da):23,743
Last modified:May 5, 2009 - v3
Checksum:iCB0D2608A23E5BFC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23D → G in BAB15656 (PubMed:14702039).Curated1
Sequence conflicti187L → P in CAG33654 (Ref. 2) Curated1
Sequence conflicti200T → S in BAB15656 (PubMed:14702039).Curated1
Sequence conflicti200T → S in CAG33654 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027098 mRNA Translation: BAB15656.1
CR457373 mRNA Translation: CAG33654.1
AC104162 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65418.1
BC020599 mRNA Translation: AAH20599.2
BC065012 mRNA Translation: AAH65012.1
CCDSiCCDS2900.1
RefSeqiNP_001272333.1, NM_001285404.1
NP_079351.2, NM_025075.3
UniGeneiHs.288151

Genome annotation databases

EnsembliENST00000295899; ENSP00000295899; ENSG00000163634
GeneIDi80145
KEGGihsa:80145
UCSCiuc003dlt.6 human

Similar proteinsi

Entry informationi

Entry nameiTHOC7_HUMAN
AccessioniPrimary (citable) accession number: Q6I9Y2
Secondary accession number(s): Q6P1L3, Q8WUF2, Q9H5H0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: May 5, 2009
Last modified: July 18, 2018
This is version 109 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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