UniProtKB - Q6I9V6 (Q6I9V6_HUMAN)
Protein
Cyclin-dependent kinase inhibitor 1B
Gene
CDKN1B
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- cyclin-dependent protein serine/threonine kinase inhibitor activity Source: InterPro
- kinase activity Source: UniProtKB-KW
GO - Biological processi
- cell cycle arrest Source: InterPro
- regulation of cell population proliferation Source: InterPro
Keywordsi
Molecular function | KinaseImported, Protein kinase inhibitorARBA annotation, Transferase |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclin-dependent kinase inhibitor 1BARBA annotationAlternative name(s): Cyclin-dependent kinase inhibitor p27ARBA annotation p27Kip1ARBA annotation |
Gene namesi | Name:CDKN1BImported ORF Names:hCG_27692Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000111276.10 |
Subcellular locationi
Endosome
- endosome Source: UniProtKB-SubCell
Nucleus
- nucleoplasm Source: HPA
Other locations
- intracellular membrane-bounded organelle Source: HPA
Keywords - Cellular componenti
CytoplasmARBA annotationPTM / Processingi
Keywords - PTMi
PhosphoproteinARBA annotationProteomic databases
MaxQBi | Q6I9V6 |
PRIDEi | Q6I9V6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000111276, Expressed in pigmented layer of retina and 253 other tissues |
ExpressionAtlasi | Q6I9V6, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 79 | CDIInterPro annotationAdd BLAST | 49 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 34 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 85 – 198 | DisorderedSequence analysisAdd BLAST | 114 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 38 – 58 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 158 – 172 | PolyampholyteSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the CDI family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
HOGENOMi | CLU_077692_2_0_1 |
OMAi | EGRYEWQ |
OrthoDBi | 1595421at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR003175, CDI_dom IPR029843, CDKN1B |
PANTHERi | PTHR10265:SF9, PTHR10265:SF9, 1 hit |
Pfami | View protein in Pfam PF02234, CDI, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6I9V6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSNVRVSNGS PSLERMDARQ AEHPKPSACR NLFGPVDHEE LTRDLEKHCR
60 70 80 90 100
DMEEASQRKW NFDFQNHKPL EGKYEWQEVE KGSLPEFYYR PPRPPKGACK
110 120 130 140 150
VPAQESQDVS GSRPAAPLIG APANSEDTHL VDPKTDPSDS QTGLAEQCAG
160 170 180 190
IRKRPATDDS STQNKRANRT EENVSDGSPN AGSVEQTPKK PGLRRRQT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK312461 mRNA Translation: BAG35368.1 AB451291 mRNA Translation: BAG70105.1 AB451423 mRNA Translation: BAG70237.1 CR457399 mRNA Translation: CAG33680.1 CH471094 Genomic DNA Translation: EAW96275.1 |
RefSeqi | NP_004055.1, NM_004064.4 |
Genome annotation databases
GeneIDi | 1027 |
KEGGi | hsa:1027 |
UCSCi | uc001rat.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK312461 mRNA Translation: BAG35368.1 AB451291 mRNA Translation: BAG70105.1 AB451423 mRNA Translation: BAG70237.1 CR457399 mRNA Translation: CAG33680.1 CH471094 Genomic DNA Translation: EAW96275.1 |
RefSeqi | NP_004055.1, NM_004064.4 |
3D structure databases
SMRi | Q6I9V6 |
ModBasei | Search... |
Proteomic databases
MaxQBi | Q6I9V6 |
PRIDEi | Q6I9V6 |
Protocols and materials databases
Antibodypediai | 3295, 2653 antibodies |
DNASUi | 1027 |
Genome annotation databases
GeneIDi | 1027 |
KEGGi | hsa:1027 |
UCSCi | uc001rat.3, human |
Organism-specific databases
CTDi | 1027 |
PharmGKBi | PA105 |
VEuPathDBi | HostDB:ENSG00000111276.10 |
Phylogenomic databases
HOGENOMi | CLU_077692_2_0_1 |
OMAi | EGRYEWQ |
OrthoDBi | 1595421at2759 |
Miscellaneous databases
BioGRID-ORCSi | 1027, 18 hits in 1002 CRISPR screens |
ChiTaRSi | CDKN1B, human |
GenomeRNAii | 1027 |
Gene expression databases
Bgeei | ENSG00000111276, Expressed in pigmented layer of retina and 253 other tissues |
ExpressionAtlasi | Q6I9V6, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR003175, CDI_dom IPR029843, CDKN1B |
PANTHERi | PTHR10265:SF9, PTHR10265:SF9, 1 hit |
Pfami | View protein in Pfam PF02234, CDI, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6I9V6_HUMAN | |
Accessioni | Q6I9V6Primary (citable) accession number: Q6I9V6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | April 7, 2021 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |