UniProtKB - Q6I9T4 (Q6I9T4_HUMAN)
Protein
C-C motif chemokine
Gene
CCL11
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- chemokine activity Source: Ensembl
GO - Biological processi
- actin filament organization Source: Ensembl
- branching involved in mammary gland duct morphogenesis Source: Ensembl
- chronic inflammatory response Source: Ensembl
- eosinophil chemotaxis Source: Ensembl
- ERK1 and ERK2 cascade Source: Ensembl
- immune response Source: InterPro
- learning or memory Source: Ensembl
- mammary duct terminal end bud growth Source: Ensembl
- mast cell chemotaxis Source: Ensembl
- modulation of age-related behavioral decline Source: Ensembl
- negative regulation of neurogenesis Source: Ensembl
- positive regulation of angiogenesis Source: Ensembl
- response to interleukin-13 Source: Ensembl
- response to interleukin-4 Source: Ensembl
Keywordsi
Molecular function | CytokineUniRule annotationARBA annotation |
Biological process | ChemotaxisUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: C-C motif chemokineUniRule annotation |
Gene namesi | Name:CCL11Imported ORF Names:hCG_29299Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000172156.3 |
Subcellular locationi
Extracellular region or secreted
- Secreted UniRule annotationARBA annotation
Extracellular region or secreted
- extracellular space Source: UniProtKB-KW
Keywords - Cellular componenti
SecretedUniRule annotationARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | UniRule annotationAdd BLAST | 23 | |
ChainiPRO_5014205943 | 24 – 97 | C-C motif chemokineUniRule annotationAdd BLAST | 74 |
Expressioni
Gene expression databases
Bgeei | ENSG00000172156, Expressed in fundus of stomach and 105 other tissues |
ExpressionAtlasi | Q6I9T4, baseline and differential |
Interactioni
GO - Molecular functioni
- chemokine activity Source: Ensembl
Chemistry databases
BindingDBi | Q6I9T4 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 29 – 88 | SCYInterPro annotationAdd BLAST | 60 |
Sequence similaritiesi
Keywords - Domaini
SignalUniRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_141716_1_0_1 |
OMAi | GSKCPQK |
OrthoDBi | 1575018at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR039809, Chemokine_b/g/d IPR000827, Chemokine_CC_CS IPR001811, Chemokine_IL8-like_dom IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR12015, PTHR12015, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00472, SMALL_CYTOKINES_CC, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6I9T4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKVSAALLWL LLIAAAFSPQ GLAGPASVPT TCCFNLANRK IPLQRLESYR
60 70 80 90
RITSGKCPQK AVIFKTKLAK DICADPKKKW VQDSMKYLDQ KSPTPKP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF064768 Genomic DNA Translation: ABK41951.1 CR457421 mRNA Translation: CAG33702.1 CH471147 Genomic DNA Translation: EAW80209.1 |
RefSeqi | NP_002977.1, NM_002986.2 |
Genome annotation databases
GeneIDi | 6356 |
KEGGi | hsa:6356 |
UCSCi | uc002hia.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF064768 Genomic DNA Translation: ABK41951.1 CR457421 mRNA Translation: CAG33702.1 CH471147 Genomic DNA Translation: EAW80209.1 |
RefSeqi | NP_002977.1, NM_002986.2 |
3D structure databases
SMRi | Q6I9T4 |
ModBasei | Search... |
Chemistry databases
BindingDBi | Q6I9T4 |
Protocols and materials databases
Antibodypediai | 15485, 393 antibodies |
DNASUi | 6356 |
Genome annotation databases
GeneIDi | 6356 |
KEGGi | hsa:6356 |
UCSCi | uc002hia.2, human |
Organism-specific databases
CTDi | 6356 |
PharmGKBi | PA35543 |
VEuPathDBi | HostDB:ENSG00000172156.3 |
Phylogenomic databases
HOGENOMi | CLU_141716_1_0_1 |
OMAi | GSKCPQK |
OrthoDBi | 1575018at2759 |
Miscellaneous databases
BioGRID-ORCSi | 6356, 6 hits in 977 CRISPR screens |
ChiTaRSi | CCL11, human |
GenomeRNAii | 6356 |
Gene expression databases
Bgeei | ENSG00000172156, Expressed in fundus of stomach and 105 other tissues |
ExpressionAtlasi | Q6I9T4, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR039809, Chemokine_b/g/d IPR000827, Chemokine_CC_CS IPR001811, Chemokine_IL8-like_dom IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR12015, PTHR12015, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00472, SMALL_CYTOKINES_CC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6I9T4_HUMAN | |
Accessioni | Q6I9T4Primary (citable) accession number: Q6I9T4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | April 7, 2021 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |