RORC

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	28 – 103	Nuclear receptorPROSITE-ProRule annotationAdd BLAST		76

GO - Molecular functionⁱ

nuclear receptor activity Source: InterPro
sequence-specific DNA binding Source: InterPro
steroid hormone receptor activity Source: InterPro
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

circadian rhythm Source: Ensembl
transcription, DNA-templated Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotationImported
Biological process	Transcription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: RAR-related orphan receptor CImported Submitted name: RORC proteinImported
Gene namesⁱ	Name:RORCImported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000143365.16

EuPathDBⁱ

HostDB:ENSG00000143365.16

Keywords - Cellular componentⁱ

NucleusPROSITE-ProRule annotationSAAS annotation

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA34632

PharmGKBⁱ

PA34632

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000143365
ExpressionAtlasⁱ	Q6I9R9 baseline and differential

Interactionⁱ

Chemistry databases

BindingDBⁱ	Q6I9R9

BindingDBⁱ

Q6I9R9

Structureⁱ

3D structure databases

SMRⁱ	Q6I9R9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	28 – 103	Nuclear receptorInterPro annotationAdd BLAST		76
Domainⁱ	269 – 508	NR LBDInterPro annotationAdd BLAST		240

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	111 – 131	Sequence analysisAdd BLAST		21

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domainⁱ

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG4216 Eukaryota ENOG410XUGR LUCA
HOVERGENⁱ	HBG106848
KEGG Orthology (KO) More...KOⁱ	K08534
OMAⁱ	CRAYNAD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0649

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR003079 ROR_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR01293 RORNUCRECPTR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6I9R9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDRAPQRQHR ASRELLAAKK THTSQIEVIP CKICGDKSSG IHYGVITCEG 
        60         70         80         90        100
CKGFFRRSQR CNAAYSCTRQ QNCPIDRTSR NRCQHCRLQK CLALGMSRDA 
       110        120        130        140        150
VKFGRMSKKQ RDSLHAEVQK QLQQRQQQQQ EPVVKTPPAG AQGADTLTYT 
       160        170        180        190        200
LGLPDGQLPL GSSPDLPEAS ACPPGLLKAS GSGPSYSNNL AKAGLNGASC 
       210        220        230        240        250
HLEYSPERGK AEGRESFYST GSQLTPDRCG LRFEEHRHPG LGELGQGPDS 
       260        270        280        290        300
YGSPSFRSTP EAPYASLTEI EHLVQSVCKS YRETCQLRLE DLLRQRSNIF 
       310        320        330        340        350
SREEVTGYQR KSMWEMWERC AHHLTEAIQY VVEFAKRLSG FMELCQNDQI 
       360        370        380        390        400
VLLKAGAMEV VLVRMCRAYN ADNRTVFFEG KYGGMELFRA LGCSELISSI 
       410        420        430        440        450
FDFSHSLSAL HFSEDEIALY TALVLINAHR PGLQEKRKVE QLQYNLELAF 
       460        470        480        490        500
HHHLCKTHRQ SILAKLPPKG KLRSLCSQHV ERLQIFQHLH PIVVQAAFPP 
       510 
LYKELFSTET ESPVGLSK

Length:518

Mass (Da):58,195

Last modified:May 10, 2005 - v1

Checksum:ⁱ7F423140BD7922BE

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC110571 mRNA Translation: AAI10572.1 CR457436 mRNA Translation: CAG33717.1
NCBI Reference Sequences More...RefSeqⁱ	NP_005051.2, NM_005060.3
UniGeneⁱ	Hs.256022 Hs.607993

Genome annotation databases

GeneIDⁱ	6097
KEGGⁱ	hsa:6097
UCSC genome browser More...UCSCⁱ	uc001ezh.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q6I9R9	Nuclear receptor ROR-gamma	)	HUMAN		518
RAR-related orphan receptor C, isoform CRA_a		HUMAN		574

Protein	Similar proteins		Species	Score	Length
Q6I9R9	Nuclear receptor ROR-gamma	)	HUMAN		518
Nuclear receptor ROR-gamma		PONAB		642
RAR related orphan receptor C		CHLSB		573
UPI000643BA19		MICMU		526
RAR related orphan receptor C		PROCO		520
+53

Protein	Similar proteins		Species	Score	Length
Q6I9R9	Nuclear receptor ROR-gamma	)	HUMAN		518
Nuclear receptor ROR-gamma		PONAB		642
RAR related orphan receptor C		CHLSB		573
UPI000643BA19		MICMU		526
RAR related orphan receptor C		PROCO		520
+94

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC110571 mRNA Translation: AAI10572.1 CR457436 mRNA Translation: CAG33717.1
NCBI Reference Sequences More...RefSeqⁱ	NP_005051.2, NM_005060.3
UniGeneⁱ	Hs.256022 Hs.607993

3D structure databases

SMRⁱ	Q6I9R9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Chemistry databases

BindingDBⁱ	Q6I9R9

BindingDBⁱ

Q6I9R9

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6097
Structural Biology Knowledgebase	Search...

Genome annotation databases

GeneIDⁱ	6097
KEGGⁱ	hsa:6097
UCSC genome browser More...UCSCⁱ	uc001ezh.4 human

Organism-specific databases

CTDⁱ	6097
EuPathDBⁱ	HostDB:ENSG00000143365.16
PharmGKBⁱ	PA34632

Phylogenomic databases

eggNOGⁱ	KOG4216 Eukaryota ENOG410XUGR LUCA
HOVERGENⁱ	HBG106848
KEGG Orthology (KO) More...KOⁱ	K08534
OMAⁱ	CRAYNAD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0649

Miscellaneous databases

GenomeRNAiⁱ	6097

GenomeRNAiⁱ

6097

Gene expression databases

Bgeeⁱ	ENSG00000143365
ExpressionAtlasⁱ	Q6I9R9 baseline and differential

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR003079 ROR_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR01293 RORNUCRECPTR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q6I9R9_HUMAN
Accessionⁱ	Q6I9R9Primary (citable) accession number: Q6I9R9
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 10, 2005
	Last sequence update:	May 10, 2005
	Last modified:	May 23, 2018
	This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - Q6I9R9 (Q6I9R9_HUMAN)

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RAR-related orphan receptor C

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Chemistry databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ