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UniProtKB - Q6I9R9 (Q6I9R9_HUMAN)
Protein
Submitted name:
RAR-related orphan receptor C
Gene
RORC
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- nuclear receptor activity Source: InterPro
- sequence-specific DNA binding Source: InterPro
- zinc ion binding Source: InterPro
Keywordsi
Molecular function | Developmental proteinARBA annotation, DNA-bindingUniRule annotationARBA annotation, ReceptorUniRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: RAR-related orphan receptor CImportedSubmitted name: RORC proteinImported |
Gene namesi | Name:RORCImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000143365 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Nucleus
- nuclear body Source: HPA
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000143365, Expressed in gastrocnemius and 124 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 103 | Nuclear receptorInterPro annotationAdd BLAST | 76 | |
Domaini | 269 – 508 | NR LBDInterPro annotationAdd BLAST | 240 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 105 – 183 | DisorderedSequence analysisAdd BLAST | 79 | |
Regioni | 238 – 258 | DisorderedSequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 119 – 135 | Polar residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Keywords - Domaini
Zinc-fingerUniRule annotationARBA annotationPhylogenomic databases
OMAi | ILHRDNH |
OrthoDBi | 583704at2759 |
Family and domain databases
CDDi | cd06968, NR_DBD_ROR, 1 hit |
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR044101, NR_DBD_ROR IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003079, ROR_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01293, RORNUCRECPTR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6I9R9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDRAPQRQHR ASRELLAAKK THTSQIEVIP CKICGDKSSG IHYGVITCEG
60 70 80 90 100
CKGFFRRSQR CNAAYSCTRQ QNCPIDRTSR NRCQHCRLQK CLALGMSRDA
110 120 130 140 150
VKFGRMSKKQ RDSLHAEVQK QLQQRQQQQQ EPVVKTPPAG AQGADTLTYT
160 170 180 190 200
LGLPDGQLPL GSSPDLPEAS ACPPGLLKAS GSGPSYSNNL AKAGLNGASC
210 220 230 240 250
HLEYSPERGK AEGRESFYST GSQLTPDRCG LRFEEHRHPG LGELGQGPDS
260 270 280 290 300
YGSPSFRSTP EAPYASLTEI EHLVQSVCKS YRETCQLRLE DLLRQRSNIF
310 320 330 340 350
SREEVTGYQR KSMWEMWERC AHHLTEAIQY VVEFAKRLSG FMELCQNDQI
360 370 380 390 400
VLLKAGAMEV VLVRMCRAYN ADNRTVFFEG KYGGMELFRA LGCSELISSI
410 420 430 440 450
FDFSHSLSAL HFSEDEIALY TALVLINAHR PGLQEKRKVE QLQYNLELAF
460 470 480 490 500
HHHLCKTHRQ SILAKLPPKG KLRSLCSQHV ERLQIFQHLH PIVVQAAFPP
510
LYKELFSTET ESPVGLSK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC110571 mRNA Translation: AAI10572.1 CR457436 mRNA Translation: CAG33717.1 |
RefSeqi | NP_005051.2, NM_005060.3 |
Genome annotation databases
GeneIDi | 6097 |
KEGGi | hsa:6097 |
MANE-Selecti | ENST00000318247.7; ENSP00000327025.6; NM_005060.4; NP_005051.2 |
UCSCi | uc001ezh.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC110571 mRNA Translation: AAI10572.1 CR457436 mRNA Translation: CAG33717.1 |
RefSeqi | NP_005051.2, NM_005060.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q6I9R9, 1 interactor |
Protocols and materials databases
Antibodypediai | 20336, 813 antibodies from 43 providers |
DNASUi | 6097 |
Genome annotation databases
GeneIDi | 6097 |
KEGGi | hsa:6097 |
MANE-Selecti | ENST00000318247.7; ENSP00000327025.6; NM_005060.4; NP_005051.2 |
UCSCi | uc001ezh.4, human |
Organism-specific databases
CTDi | 6097 |
PharmGKBi | PA34632 |
VEuPathDBi | HostDB:ENSG00000143365 |
Phylogenomic databases
OMAi | ILHRDNH |
OrthoDBi | 583704at2759 |
Miscellaneous databases
BioGRID-ORCSi | 6097, 12 hits in 1094 CRISPR screens |
ChiTaRSi | RORC, human |
GenomeRNAii | 6097 |
Gene expression databases
Bgeei | ENSG00000143365, Expressed in gastrocnemius and 124 other tissues |
Family and domain databases
CDDi | cd06968, NR_DBD_ROR, 1 hit |
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR044101, NR_DBD_ROR IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003079, ROR_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01293, RORNUCRECPTR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6I9R9_HUMAN | |
Accessioni | Q6I9R9Primary (citable) accession number: Q6I9R9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | May 25, 2022 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |