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Protein

Polyprotein p42

Gene

M

Organism
Influenza C virus (strain C/Ann Arbor/1/1950)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ion channel, which might have a role in genome packaging and uncoating processes.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Viral ion channel
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Polyprotein p42
Cleaved into the following 2 chains:
Alternative name(s):
CM1'
p31
Gene namesi
Name:M
OrganismiInfluenza C virus (strain C/Ann Arbor/1/1950)
Taxonomic identifieri11553 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesOrthomyxoviridaeGammainfluenzavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]
Proteomesi
  • UP000008286 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 238Cytoplasmic1 PublicationAdd BLAST238
Transmembranei239 – 259Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini260 – 288Extracellular1 PublicationAdd BLAST29
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Topological domaini310 – 374CytoplasmicSequence analysisAdd BLAST65

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host endoplasmic reticulum, Host membrane, Membrane, Viral matrix protein, Virion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi260C → A: Complete loss of oligomerization; when associated with A-265 and A279. 1 Publication1
Mutagenesisi265C → A: Complete loss of oligomerization; when associated with A-260 and A279. 1 Publication1
Mutagenesisi272T → A: Loss of carbohydrate modification. 1 Publication1
Mutagenesisi279C → A: Complete loss of oligomerization; when associated with A-260 and A265. 1 Publication1
Mutagenesisi324C → A: Complete loss of palmitoylation. 1
Mutagenesisi337S → A: 93% loss of phosphorylation. Complete loss of phosphorylation; when associated with A-362. 1 Publication1
Mutagenesisi362S → A: Complete loss of phosphorylation; when associated with A-337. 1
Mutagenesisi367S → A: No effet on phosphorylation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004088751 – 374Polyprotein p42Add BLAST374
ChainiPRO_00002694551 – 259Protein M1'Add BLAST259
ChainiPRO_0000269903260 – 374Protein CM2Add BLAST115

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi270N-linked (GlcNAc...) asparagine; by host1 Publication1
Lipidationi324S-palmitoyl cysteine; by host1 Publication1
Modified residuei337Phosphoserine; by host1 Publication1
Modified residuei362Phosphoserine; by host1 Publication1

Post-translational modificationi

Palmitoylated.1 Publication
N-glycosylated.1 Publication
Ser-337 is the major site of phosphorylation, Ser-362 being a minor one.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei259 – 260Cleavage; by host signal peptidase2

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

PTM databases

iPTMnetiQ6I7B9

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Homotetramer; disulfide-linked.1 Publication

Structurei

Secondary structure

1374
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SMRiQ6I7B9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the influenza C protein M1 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK22201

Family and domain databases

InterProiView protein in InterPro
IPR004271 CM1
IPR004267 CM2
PfamiView protein in Pfam
PF03026 CM1, 1 hit
PF03021 CM2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform p42 (identifier: Q6I7B9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAHEILIAET EAFLKNVAPE TRTAIISAIT GGKSACKSAA KLIKNEHLPL
60 70 80 90 100
MSGEATTMHI VMRCLYPEIK PWKKASDMLN KATSSLKKSE GRDIRKQMKA
110 120 130 140 150
AGDFLGVESM MKMRAFRDDQ IMEMVEEVYD HPDDYTPDIR IGTITAWLRC
160 170 180 190 200
KNKKSERYRS NVSESGRTAL KIHEVRKAST AMNEIAGITG LGEEALSLQR
210 220 230 240 250
QTESLAILCN HTFGSNIMRP HLEKAIKGVE GRVGEMGRMA MKWLVVIICF
260 270 280 290 300
SITSQPASAC NLKTCLKLFN NTDAVTVHCF NENQGYMLTL ASLGLGIITM
310 320 330 340 350
LYLLVKIIIE LVNGFVLGRW ERWCGDIKTT IMPEIDSMEK DIALSRERLD
360 370
LGEDAPDETD NSPIPFSNDG IFEI
Note: Produced by unspliced mRNA.
Length:374
Mass (Da):41,740
Last modified:January 9, 2007 - v2
Checksum:iD6BD65E9CB55B739
GO
Isoform M1 (identifier: Q6I7B9-2) [UniParc]FASTAAdd to basket
Also known as: CM1

The sequence of this isoform differs from the canonical sequence as follows:
     243-374: Missing.

Show »
Length:242
Mass (Da):26,985
Checksum:iAD39D9054A189D95
GO

Sequence cautioni

The sequence BAD24942 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAD24943 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022111243 – 374Missing in isoform M1. CuratedAdd BLAST132

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB126196 Viral cRNA Translation: BAD24942.1 Different termination.
AB126196 Viral cRNA Translation: BAD24943.1 Different initiation.
RefSeqiYP_089657.1, NC_006312.1 [Q6I7B9-2]
YP_089658.1, NC_006312.1

Genome annotation databases

GeneIDi3077361
3077362
KEGGivg:3077361
vg:3077362

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB126196 Viral cRNA Translation: BAD24942.1 Different termination.
AB126196 Viral cRNA Translation: BAD24943.1 Different initiation.
RefSeqiYP_089657.1, NC_006312.1 [Q6I7B9-2]
YP_089658.1, NC_006312.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5M1MX-ray1.50A1-155[»]
SMRiQ6I7B9
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ6I7B9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3077361
3077362
KEGGivg:3077361
vg:3077362

Phylogenomic databases

KOiK22201

Family and domain databases

InterProiView protein in InterPro
IPR004271 CM1
IPR004267 CM2
PfamiView protein in Pfam
PF03026 CM1, 1 hit
PF03021 CM2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMAT_INCAA
AccessioniPrimary (citable) accession number: Q6I7B9
Secondary accession number(s): Q6I7B8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 56 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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