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Entry version 135 (02 Jun 2021)
Sequence version 1 (19 Jul 2004)
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Protein

E3 ubiquitin-protein ligase HECW2

Gene

Hecw2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73. Involved in the regulation of mitotic metaphase/anaphase transition.

By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.26

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1546Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase HECW2 (EC:2.3.2.26)
Alternative name(s):
HECT, C2 and WW domain-containing protein 2
HECT-type E3 ubiquitin transferase HECW2
NEDD4-like E3 ubiquitin-protein ligase 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hecw2
Synonyms:Kiaa1301, Nedl2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2685817, Hecw2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002776681 – 1578E3 ubiquitin-protein ligase HECW2Add BLAST1578

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei48PhosphoserineCombined sources1
Modified residuei858PhosphoserineBy similarity1
Modified residuei915PhosphoserineBy similarity1
Modified residuei1181PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6I6G8

PeptideAtlas

More...
PeptideAtlasi
Q6I6G8

PRoteomics IDEntifications database

More...
PRIDEi
Q6I6G8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
269691 [Q6I6G8-1]
269692 [Q6I6G8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6I6G8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6I6G8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000042807, Expressed in lung and 219 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6I6G8, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TP73 (By similarity).

Interacts with FZR1 (By similarity).

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000113283

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6I6G8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
Q6I6G8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6I6G8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini171 – 298C2PROSITE-ProRule annotationAdd BLAST128
Domaini813 – 846WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini991 – 1024WW 2PROSITE-ProRule annotationAdd BLAST34
Domaini1243 – 1578HECTPROSITE-ProRule annotationAdd BLAST336

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni341 – 453DisorderedSequence analysisAdd BLAST113
Regioni496 – 802DisorderedSequence analysisAdd BLAST307
Regioni737 – 1074Interaction with TP73By similarityAdd BLAST338
Regioni1030 – 1075DisorderedSequence analysisAdd BLAST46
Regioni1167 – 1193DisorderedSequence analysisAdd BLAST27

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili853 – 880Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi381 – 412Polar residuesSequence analysisAdd BLAST32
Compositional biasi436 – 453Polar residuesSequence analysisAdd BLAST18
Compositional biasi509 – 534Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi543 – 627Polar residuesSequence analysisAdd BLAST85
Compositional biasi641 – 672Polar residuesSequence analysisAdd BLAST32
Compositional biasi691 – 710Polar residuesSequence analysisAdd BLAST20
Compositional biasi781 – 802Polar residuesSequence analysisAdd BLAST22
Compositional biasi1169 – 1187Polar residuesSequence analysisAdd BLAST19

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0940, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155466

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002173_14_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6I6G8

Identification of Orthologs from Complete Genome Data

More...
OMAi
PYFMESE

Database of Orthologous Groups

More...
OrthoDBi
117748at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6I6G8

TreeFam database of animal gene trees

More...
TreeFami
TF313938

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08691, C2_NEDL1-like, 1 hit
cd00078, HECTc, 1 hit
cd00201, WW, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR037795, C2_HECW
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR040524, HECW1_helix
IPR032348, HECW_N
IPR001202, WW_dom
IPR036020, WW_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168, C2, 1 hit
PF00632, HECT, 1 hit
PF18436, HECW1_helix, 1 hit
PF16562, HECW_N, 1 hit
PF00397, WW, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239, C2, 1 hit
SM00119, HECTc, 1 hit
SM00456, WW, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51045, SSF51045, 2 hits
SSF56204, SSF56204, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004, C2, 1 hit
PS50237, HECT, 1 hit
PS01159, WW_DOMAIN_1, 2 hits
PS50020, WW_DOMAIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6I6G8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASSAREHLL FVRRRNPQMR YTLSPENLQS LAAQNSMPEN MALQRANSDT
60 70 80 90 100
DLVTSESRSS LTASMYEYTL GQAQNLIIFW DIKEEVDPSD WIGLYHIDEN
110 120 130 140 150
SPANFWDSKN RGVTGTQKGQ IVWRIEPGPY FMEPEIKICF KYYHGISGAL
160 170 180 190 200
RATTPCITVK NPAVMMGAEG MEGGASGSLH SRKLVSFTLS DLRAVGLKKG
210 220 230 240 250
MFFNPDPYLK MSIQPGKKSS FPTCAHHGQE RRSTIISNTT NPIWHREKYS
260 270 280 290 300
FFALLTDVLE IEIKDKFAKS RPIIKRFLGK LTIPVQRLLE RQAGDQMLSY
310 320 330 340 350
NLGRRLPADH VSGYLQFKVE VTSSAHEDAS PEAVGTILGV HTVNGDLGSP
360 370 380 390 400
SDEEDMPGSH HDSTICANGP VSEDSVADGT PKHSFRTSST LEIDTEDLIS
410 420 430 440 450
TSSRNSPPRG RQDSLNDYLD AIEHNGPARP GAASSSERSM GASPKLRSSF
460 470 480 490 500
PTDTRLNAML HIDSDEEDHE FQQDLGYPSS LEEEGGLIMC SRASRIDDGS
510 520 530 540 550
LTSQTKPEDD NPVENEDASI HETASLEERL ENLPEVADGS LPSSTAPDEN
560 570 580 590 600
EANLEPQPSA DQGSTELCSS QEVDQPTSGA DAGASDTSGG SRRAASETES
610 620 630 640 650
LDQGSEPSQV SSETEPSDPA RTESVSEAST RPEGESDPEG ADSSCNESVT
660 670 680 690 700
TQLSSVETRC SSLESARFPE TPAFSSQEEE DGACAAEPTS SGPAEGSQES
710 720 730 740 750
VCTPSSLPAV QVPSREEEGS AAEAAALSEQ GELGEVWQRR GSLEGAAAAA
760 770 780 790 800
PAAAATDSQP QEDGDAGDAQ GACEGATAQE EGATGGSQTN GHQPLRSLPS
810 820 830 840 850
VRQDVSRYQR VDEALPPNWE ARIDSHGRIF YVDHVNRTTT WQRPTAPPAP
860 870 880 890 900
QVLQRSNSIQ QMEQLNRRYQ SIRRTMTNER PEENTSAIDG AGEEADFHQA
910 920 930 940 950
SADFRRENVL PHSTSRSRLT LLLQSPPVKF LISPEFFTVL HSNPSAYRMF
960 970 980 990 1000
TNNTCLKHMI TKVRRDTHHF ERYQHNRDLV GFLNMFANKQ LELPRGWEMK
1010 1020 1030 1040 1050
HDHQGKAFFV DHNSRTTTFI DPRLPLQSSR PTSALVHRQH LTRQRSHSAG
1060 1070 1080 1090 1100
EVGEDSRHAG PPVLPRPSST FNTVSRPQYQ DMVPVAYNDK IVAFLRQPNI
1110 1120 1130 1140 1150
LEILQERQPD LARNHSLREK IQFIRTEGTP GLVRLSSDAD LVMLLSLFEE
1160 1170 1180 1190 1200
EIMSYVPPHA LLHPSYCQSP RGSPVSSPQN SPGTQRANAR APAPYKRDFE
1210 1220 1230 1240 1250
AKLRNFYRKL ETKGYGQGPG KLKLIIRRDH LLEDAFNQIM GYSRKDLQRN
1260 1270 1280 1290 1300
KLYVTFVGEE GLDYSGPSRE FFFLVSRELF NPYYGLFEYS ANDTYTVQIS
1310 1320 1330 1340 1350
PMSAFVDNHH EWFRFSGRIL GLALIHQYLL DAFFTRPFYK ALLRILCDLS
1360 1370 1380 1390 1400
DLEYLDEEFH QSLQWMKDND IHDILDLTFT VNEEVFGQIT ERELKPGGAN
1410 1420 1430 1440 1450
IPVTEKNKKE YIERMVKWRI ERGVVQQTES LVRGFYEVVD ARLVSVFDAR
1460 1470 1480 1490 1500
ELELVIAGTA EIDLNDWRNN TEYRGGYHDN HIVIRWFWAA VERFNNEQRL
1510 1520 1530 1540 1550
RLLQFVTGTS SIPYEGFASL RGSNGPRRFC VEKWGKITAL PRAHTCFNRL
1560 1570
DLPPYPSFSM LYEKLLTAVE ETSTFGLE
Length:1,578
Mass (Da):176,235
Last modified:July 19, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6711C52EA0AF9CBF
GO
Isoform 2 (identifier: Q6I6G8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     295-1578: Missing.

Show »
Length:294
Mass (Da):33,267
Checksum:i7030025F69F569BC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti226H → R in BAC31406 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023078295 – 1578Missing in isoform 2. 2 PublicationsAdd BLAST1284

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB182244 mRNA Translation: BAD23960.1
AK042922 mRNA Translation: BAC31406.1
BC107219 mRNA Translation: AAI07220.1
AK129325 mRNA Translation: BAC98135.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14956.1 [Q6I6G8-1]
CCDS14957.1 [Q6I6G8-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001001883.1, NM_001001883.3 [Q6I6G8-1]
NP_766243.2, NM_172655.3 [Q6I6G8-2]
XP_006496129.1, XM_006496066.3 [Q6I6G8-1]
XP_006496130.1, XM_006496067.1 [Q6I6G8-1]
XP_006496131.1, XM_006496068.3 [Q6I6G8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000087659; ENSMUSP00000084942; ENSMUSG00000042807 [Q6I6G8-1]
ENSMUST00000097741; ENSMUSP00000095348; ENSMUSG00000042807 [Q6I6G8-2]
ENSMUST00000120904; ENSMUSP00000113283; ENSMUSG00000042807 [Q6I6G8-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
329152

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:329152

UCSC genome browser

More...
UCSCi
uc007azk.2, mouse [Q6I6G8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB182244 mRNA Translation: BAD23960.1
AK042922 mRNA Translation: BAC31406.1
BC107219 mRNA Translation: AAI07220.1
AK129325 mRNA Translation: BAC98135.1
CCDSiCCDS14956.1 [Q6I6G8-1]
CCDS14957.1 [Q6I6G8-2]
RefSeqiNP_001001883.1, NM_001001883.3 [Q6I6G8-1]
NP_766243.2, NM_172655.3 [Q6I6G8-2]
XP_006496129.1, XM_006496066.3 [Q6I6G8-1]
XP_006496130.1, XM_006496067.1 [Q6I6G8-1]
XP_006496131.1, XM_006496068.3 [Q6I6G8-1]

3D structure databases

BMRBiQ6I6G8
SMRiQ6I6G8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113283

PTM databases

iPTMnetiQ6I6G8
PhosphoSitePlusiQ6I6G8

Proteomic databases

PaxDbiQ6I6G8
PeptideAtlasiQ6I6G8
PRIDEiQ6I6G8
ProteomicsDBi269691 [Q6I6G8-1]
269692 [Q6I6G8-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
34059, 182 antibodies

The DNASU plasmid repository

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DNASUi
329152

Genome annotation databases

EnsembliENSMUST00000087659; ENSMUSP00000084942; ENSMUSG00000042807 [Q6I6G8-1]
ENSMUST00000097741; ENSMUSP00000095348; ENSMUSG00000042807 [Q6I6G8-2]
ENSMUST00000120904; ENSMUSP00000113283; ENSMUSG00000042807 [Q6I6G8-1]
GeneIDi329152
KEGGimmu:329152
UCSCiuc007azk.2, mouse [Q6I6G8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57520
MGIiMGI:2685817, Hecw2

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG0940, Eukaryota
GeneTreeiENSGT00940000155466
HOGENOMiCLU_002173_14_0_1
InParanoidiQ6I6G8
OMAiPYFMESE
OrthoDBi117748at2759
PhylomeDBiQ6I6G8
TreeFamiTF313938

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-MMU-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
329152, 0 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Hecw2, mouse

Protein Ontology

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PROi
PR:Q6I6G8
RNActiQ6I6G8, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000042807, Expressed in lung and 219 other tissues
GenevisibleiQ6I6G8, MM

Family and domain databases

CDDicd08691, C2_NEDL1-like, 1 hit
cd00078, HECTc, 1 hit
cd00201, WW, 2 hits
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR037795, C2_HECW
IPR000569, HECT_dom
IPR035983, Hect_E3_ubiquitin_ligase
IPR040524, HECW1_helix
IPR032348, HECW_N
IPR001202, WW_dom
IPR036020, WW_dom_sf
PfamiView protein in Pfam
PF00168, C2, 1 hit
PF00632, HECT, 1 hit
PF18436, HECW1_helix, 1 hit
PF16562, HECW_N, 1 hit
PF00397, WW, 1 hit
SMARTiView protein in SMART
SM00239, C2, 1 hit
SM00119, HECTc, 1 hit
SM00456, WW, 2 hits
SUPFAMiSSF51045, SSF51045, 2 hits
SSF56204, SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit
PS50237, HECT, 1 hit
PS01159, WW_DOMAIN_1, 2 hits
PS50020, WW_DOMAIN_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHECW2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6I6G8
Secondary accession number(s): Q3KNL8, Q6ZPU4, Q8C956
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 19, 2004
Last modified: June 2, 2021
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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