Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acetate kinase

Gene

ackA

Organism
Bacillus thuringiensis subsp. konkukian (strain 97-27)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. no protein annotated in this organism
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8MagnesiumUniRule annotation1
Binding sitei15ATPUniRule annotation1
Binding sitei89SubstrateUniRule annotation1
Active sitei146Proton donor/acceptorUniRule annotation1
Sitei178Transition state stabilizerUniRule annotation1
Sitei239Transition state stabilizerUniRule annotation1
Metal bindingi382MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi206 – 210ATPUniRule annotation5
Nucleotide bindingi281 – 283ATPUniRule annotation3
Nucleotide bindingi329 – 333ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBTHU281309:G1G14-4442-MONOMER
UniPathwayi
UPA00340;UER00458

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:BT9727_4371
OrganismiBacillus thuringiensis subsp. konkukian (strain 97-27)
Taxonomic identifieri281309 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000001301 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001075311 – 397Acetate kinaseAdd BLAST397

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ6HCP0
SMRiQ6HCP0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000288398
KOiK00925
OMAiWKALTGT

Family and domain databases

HAMAPiMF_00020 Acetate_kinase, 1 hit
InterProiView protein in InterPro
IPR004372 Ac/propionate_kinase
IPR000890 Aliphatic_acid_kin_short-chain
IPR023865 Aliphatic_acid_kinase_CS
PANTHERiPTHR21060 PTHR21060, 1 hit
PfamiView protein in Pfam
PF00871 Acetate_kinase, 1 hit
PIRSFiPIRSF000722 Acetate_prop_kin, 1 hit
PRINTSiPR00471 ACETATEKNASE
TIGRFAMsiTIGR00016 ackA, 1 hit
PROSITEiView protein in PROSITE
PS01075 ACETATE_KINASE_1, 1 hit
PS01076 ACETATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6HCP0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKIIAINAG SSSLKFQLFE MPSETVLTKG LVERIGLEDS IFTITVDGEK
60 70 80 90 100
QKEITNIPDH AVAVNMLLKK LTENGIVKSL DEIGGIGHRV VHGGEKFADS
110 120 130 140 150
VLITDEVLAD IEELSDLAPL HNPANVVGIK AFQEVLPNVP AVAVFDTAFH
160 170 180 190 200
QTMPESAFLY SLPYEYYEKF GIRKYGFHGT SHKYVTERAA ELLGRPLESL
210 220 230 240 250
SLLSCHLGNG ASIAAVEGGK SIDTSMGFTP LAGVTMGTRS GNIDPALIPY
260 270 280 290 300
IMEKTGQTVE EVVSVLNKKS GMLGLTGYSS DLRDIIAKEE EGDHRAKVAL
310 320 330 340 350
DVFVSRIHKY IGSYTARMKG VDAIIFTAGV GENSAIIRER VLEGLEYMGV
360 370 380 390
YFDAKRNNVF GEEAFINFPH SPVKIIVIPT DEEVMIARDV LRLGNID
Length:397
Mass (Da):43,263
Last modified:July 19, 2004 - v1
Checksum:iA458160C57B14288
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017355 Genomic DNA Translation: AAT63581.1
RefSeqiWP_000034578.1, NC_005957.1
YP_038686.1, NC_005957.1

Genome annotation databases

EnsemblBacteriaiAAT63581; AAT63581; BT9727_4371
GeneIDi2856499
KEGGibtk:BT9727_4371
PATRICifig|281309.8.peg.4659

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017355 Genomic DNA Translation: AAT63581.1
RefSeqiWP_000034578.1, NC_005957.1
YP_038686.1, NC_005957.1

3D structure databases

ProteinModelPortaliQ6HCP0
SMRiQ6HCP0
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT63581; AAT63581; BT9727_4371
GeneIDi2856499
KEGGibtk:BT9727_4371
PATRICifig|281309.8.peg.4659

Phylogenomic databases

HOGENOMiHOG000288398
KOiK00925
OMAiWKALTGT

Enzyme and pathway databases

UniPathwayi
UPA00340;UER00458

BioCyciBTHU281309:G1G14-4442-MONOMER

Family and domain databases

HAMAPiMF_00020 Acetate_kinase, 1 hit
InterProiView protein in InterPro
IPR004372 Ac/propionate_kinase
IPR000890 Aliphatic_acid_kin_short-chain
IPR023865 Aliphatic_acid_kinase_CS
PANTHERiPTHR21060 PTHR21060, 1 hit
PfamiView protein in Pfam
PF00871 Acetate_kinase, 1 hit
PIRSFiPIRSF000722 Acetate_prop_kin, 1 hit
PRINTSiPR00471 ACETATEKNASE
TIGRFAMsiTIGR00016 ackA, 1 hit
PROSITEiView protein in PROSITE
PS01075 ACETATE_KINASE_1, 1 hit
PS01076 ACETATE_KINASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACKA_BACHK
AccessioniPrimary (citable) accession number: Q6HCP0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: July 19, 2004
Last modified: October 10, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again