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Entry version 118 (07 Oct 2020)
Sequence version 4 (11 Jan 2011)
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Protein

Astacin-like metalloendopeptidase

Gene

ASTL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding (By similarity).By similarity

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+PROSITE-ProRule annotationNote: Binds 1 zinc ion per subunit.PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by wide spectrum metalloproteinase inhibitor batimastat (BB-94). Also inhibited by EDTA.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Enzymatic activity was assayed using synthetic quenched fluorescent substrates QF-24, QF-35 and QF-41. Astacin displayed the highest Kcat/KM value against QF-35.1 Publication

      pH dependencei

      Optimum pH is 7.5.1 Publication

      Sites

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi182Zinc; via tele nitrogen; catalyticPROSITE-ProRule annotation1
      <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei183PROSITE-ProRule annotation1
      Metal bindingi186Zinc; via tele nitrogen; catalyticPROSITE-ProRule annotation1
      Metal bindingi192Zinc; via tele nitrogen; catalyticPROSITE-ProRule annotation1

      <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

      GO - Biological processi

      <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

      Molecular functionHydrolase, Metalloprotease, Protease
      Biological processFertilization
      LigandMetal-binding, Zinc

      Enzyme and pathway databases

      Pathway Commons web resource for biological pathway data

      More...
      PathwayCommonsi
      Q6HA08

      Protein family/group databases

      MEROPS protease database

      More...
      MEROPSi
      M12.245

      <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
      Recommended name:
      Astacin-like metalloendopeptidase (EC:3.4.-.-)
      Alternative name(s):
      Oocyte astacin
      Ovastacin
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
      Name:ASTLImported
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
      <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
      • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

      Organism-specific databases

      Eukaryotic Pathogen Database Resources

      More...
      EuPathDBi
      HostDB:ENSG00000188886.3

      Human Gene Nomenclature Database

      More...
      HGNCi
      HGNC:31704, ASTL

      Online Mendelian Inheritance in Man (OMIM)

      More...
      MIMi
      608860, gene

      neXtProt; the human protein knowledge platform

      More...
      neXtProti
      NX_Q6HA08

      <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

      Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

      Keywords - Cellular componenti

      Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane

      <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

      Organism-specific databases

      DisGeNET

      More...
      DisGeNETi
      431705

      Open Targets

      More...
      OpenTargetsi
      ENSG00000188886

      The Pharmacogenetics and Pharmacogenomics Knowledge Base

      More...
      PharmGKBi
      PA134922299

      Miscellaneous databases

      Pharos NIH Druggable Genome Knowledgebase

      More...
      Pharosi
      Q6HA08, Tbio

      Polymorphism and mutation databases

      BioMuta curated single-nucleotide variation and disease association database

      More...
      BioMutai
      ASTL

      Domain mapping of disease mutations (DMDM)

      More...
      DMDMi
      317373556

      <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

      Molecule processing

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
      <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004196424 – 431Astacin-like metalloendopeptidaseSequence analysisAdd BLAST408

      Amino acid modifications

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi132 ↔ 281PROSITE-ProRule annotation
      Disulfide bondi153 ↔ 172PROSITE-ProRule annotation

      Keywords - PTMi

      Disulfide bond, Zymogen

      Proteomic databases

      PaxDb, a database of protein abundance averages across all three domains of life

      More...
      PaxDbi
      Q6HA08

      PeptideAtlas

      More...
      PeptideAtlasi
      Q6HA08

      PRoteomics IDEntifications database

      More...
      PRIDEi
      Q6HA08

      ProteomicsDB: a multi-organism proteome resource

      More...
      ProteomicsDBi
      66354

      PTM databases

      iPTMnet integrated resource for PTMs in systems biology context

      More...
      iPTMneti
      Q6HA08

      Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

      More...
      PhosphoSitePlusi
      Q6HA08

      <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

      <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

      Expressed in promyelocytic leukemia HL-60 cells, Burkitt's lymphoma Raji cells, and also in some ovarian carcinomas. Not detected in normal tissues.1 Publication

      Gene expression databases

      Bgee dataBase for Gene Expression Evolution

      More...
      Bgeei
      ENSG00000188886, Expressed in bone marrow and 71 other tissues

      Organism-specific databases

      Human Protein Atlas

      More...
      HPAi
      ENSG00000188886, Tissue enhanced (bone)

      <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

      <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

      Interacts (via N-terminal domain) with SPACA3; the interaction occurs during fertilization.

      By similarity

      <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

      Protein-protein interaction databases

      The Biological General Repository for Interaction Datasets (BioGRID)

      More...
      BioGRIDi
      136111, 7 interactors

      Protein interaction database and analysis system

      More...
      IntActi
      Q6HA08, 4 interactors

      STRING: functional protein association networks

      More...
      STRINGi
      9606.ENSP00000343674

      Miscellaneous databases

      RNAct, Protein-RNA interaction predictions for model organisms.

      More...
      RNActi
      Q6HA08, protein

      <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

      3D structure databases

      SWISS-MODEL Repository - a database of annotated 3D protein structure models

      More...
      SMRi
      Q6HA08

      Database of comparative protein structure models

      More...
      ModBasei
      Search...

      <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

      Domains and Repeats

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini85 – 282Peptidase M12APROSITE-ProRule annotationAdd BLAST198

      Keywords - Domaini

      Signal

      Phylogenomic databases

      evolutionary genealogy of genes: Non-supervised Orthologous Groups

      More...
      eggNOGi
      KOG3714, Eukaryota

      Ensembl GeneTree

      More...
      GeneTreei
      ENSGT00940000154856

      The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

      More...
      HOGENOMi
      CLU_640213_0_0_1

      InParanoid: Eukaryotic Ortholog Groups

      More...
      InParanoidi
      Q6HA08

      KEGG Orthology (KO)

      More...
      KOi
      K08778

      Identification of Orthologs from Complete Genome Data

      More...
      OMAi
      KWPTGGG

      Database of Orthologous Groups

      More...
      OrthoDBi
      681837at2759

      Database for complete collections of gene phylogenies

      More...
      PhylomeDBi
      Q6HA08

      TreeFam database of animal gene trees

      More...
      TreeFami
      TF315280

      Family and domain databases

      Gene3D Structural and Functional Annotation of Protein Families

      More...
      Gene3Di
      3.40.390.10, 1 hit

      Integrated resource of protein families, domains and functional sites

      More...
      InterProi
      View protein in InterPro
      IPR024079, MetalloPept_cat_dom_sf
      IPR001506, Peptidase_M12A
      IPR006026, Peptidase_Metallo

      Pfam protein domain database

      More...
      Pfami
      View protein in Pfam
      PF01400, Astacin, 1 hit

      Protein Motif fingerprint database; a protein domain database

      More...
      PRINTSi
      PR00480, ASTACIN

      Simple Modular Architecture Research Tool; a protein domain database

      More...
      SMARTi
      View protein in SMART
      SM00235, ZnMc, 1 hit

      PROSITE; a protein domain and family database

      More...
      PROSITEi
      View protein in PROSITE
      PS51864, ASTACIN, 1 hit
      PS00142, ZINC_PROTEASE, 1 hit

      <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

      <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

      <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

      Q6HA08-1 [UniParc]FASTAAdd to basket
      « Hide
              10         20         30         40         50
      MEGVGGLWPW VLGLLSLPGV ILGAPLASSC AGACGTSFPD GLTPEGTQAS
      60 70 80 90 100
      GDKDIPAINQ GLILEETPES SFLIEGDIIR PSPFRLLSAT SNKWPMGGSG
      110 120 130 140 150
      VVEVPFLLSS KYDEPSRQVI LEALAEFERS TCIRFVTYQD QRDFISIIPM
      160 170 180 190 200
      YGCFSSVGRS GGMQVVSLAP TCLQKGRGIV LHELMHVLGF WHEHTRADRD
      210 220 230 240 250
      RYIRVNWNEI LPGFEINFIK SQSSNMLTPY DYSSVMHYGR LAFSRRGLPT
      260 270 280 290 300
      ITPLWAPSVH IGQRWNLSAS DITRVLKLYG CSPSGPRPRG RGSHAHSTGR
      310 320 330 340 350
      SPAPASLSLQ RLLEALSAES RSPDPSGSSA GGQPVPAGPG ESPHGWESPA
      360 370 380 390 400
      LKKLSAEASA RQPQTLASSP RSRPGAGAPG VAQEQSWLAG VSTKPTVPSS
      410 420 430
      EAGIQPVPVQ GSPALPGGCV PRNHFKGMSE D
      Length:431
      Mass (Da):45,936
      Last modified:January 11, 2011 - v4
      <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6E1FD4653506AFC1
      GO

      Experimental Info

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti90T → A in CAD61265 (PubMed:15087446).Curated1
      Sequence conflicti300R → K in CAD61265 (PubMed:15087446).Curated1

      Natural variant

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_061734204R → H. Corresponds to variant dbSNP:rs41320144Ensembl.1
      Natural variantiVAR_033491222Q → R2 PublicationsCorresponds to variant dbSNP:rs749458Ensembl.1
      Natural variantiVAR_057063277K → Q1 PublicationCorresponds to variant dbSNP:rs1657502Ensembl.1

      Sequence databases

      Select the link destinations:

      EMBL nucleotide sequence database

      More...
      EMBLi

      GenBank nucleotide sequence database

      More...
      GenBanki

      DNA Data Bank of Japan; a nucleotide sequence database

      More...
      DDBJi
      Links Updated
      AJ537600 mRNA Translation: CAD61265.2
      AC012307 Genomic DNA No translation available.
      BC107127 mRNA Translation: AAI07128.1

      The Consensus CDS (CCDS) project

      More...
      CCDSi
      CCDS33249.1

      NCBI Reference Sequences

      More...
      RefSeqi
      NP_001002036.3, NM_001002036.3

      Genome annotation databases

      Ensembl eukaryotic genome annotation project

      More...
      Ensembli
      ENST00000342380; ENSP00000343674; ENSG00000188886

      Database of genes from NCBI RefSeq genomes

      More...
      GeneIDi
      431705

      KEGG: Kyoto Encyclopedia of Genes and Genomes

      More...
      KEGGi
      hsa:431705

      UCSC genome browser

      More...
      UCSCi
      uc010yui.2, human

      Keywords - Coding sequence diversityi

      Polymorphism

      <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

      <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

      <p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

      Protein Spotlight

      Life's boundaries - Issue 141 of September2012

      Sequence databases

      Select the link destinations:
      EMBLi
      GenBanki
      DDBJi
      Links Updated
      AJ537600 mRNA Translation: CAD61265.2
      AC012307 Genomic DNA No translation available.
      BC107127 mRNA Translation: AAI07128.1
      CCDSiCCDS33249.1
      RefSeqiNP_001002036.3, NM_001002036.3

      3D structure databases

      SMRiQ6HA08
      ModBaseiSearch...

      Protein-protein interaction databases

      BioGRIDi136111, 7 interactors
      IntActiQ6HA08, 4 interactors
      STRINGi9606.ENSP00000343674

      Protein family/group databases

      MEROPSiM12.245

      PTM databases

      iPTMnetiQ6HA08
      PhosphoSitePlusiQ6HA08

      Polymorphism and mutation databases

      BioMutaiASTL
      DMDMi317373556

      Proteomic databases

      PaxDbiQ6HA08
      PeptideAtlasiQ6HA08
      PRIDEiQ6HA08
      ProteomicsDBi66354

      Protocols and materials databases

      Antibodypedia a portal for validated antibodies

      More...
      Antibodypediai
      2745, 49 antibodies

      Genome annotation databases

      EnsembliENST00000342380; ENSP00000343674; ENSG00000188886
      GeneIDi431705
      KEGGihsa:431705
      UCSCiuc010yui.2, human

      Organism-specific databases

      Comparative Toxicogenomics Database

      More...
      CTDi
      431705
      DisGeNETi431705
      EuPathDBiHostDB:ENSG00000188886.3

      GeneCards: human genes, protein and diseases

      More...
      GeneCardsi
      ASTL
      HGNCiHGNC:31704, ASTL
      HPAiENSG00000188886, Tissue enhanced (bone)
      MIMi608860, gene
      neXtProtiNX_Q6HA08
      OpenTargetsiENSG00000188886
      PharmGKBiPA134922299

      GenAtlas: human gene database

      More...
      GenAtlasi
      Search...

      Phylogenomic databases

      eggNOGiKOG3714, Eukaryota
      GeneTreeiENSGT00940000154856
      HOGENOMiCLU_640213_0_0_1
      InParanoidiQ6HA08
      KOiK08778
      OMAiKWPTGGG
      OrthoDBi681837at2759
      PhylomeDBiQ6HA08
      TreeFamiTF315280

      Enzyme and pathway databases

      PathwayCommonsiQ6HA08

      Miscellaneous databases

      BioGRID ORCS database of CRISPR phenotype screens

      More...
      BioGRID-ORCSi
      431705, 9 hits in 871 CRISPR screens

      Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

      More...
      GenomeRNAii
      431705
      PharosiQ6HA08, Tbio

      Protein Ontology

      More...
      PROi
      PR:Q6HA08
      RNActiQ6HA08, protein

      The Stanford Online Universal Resource for Clones and ESTs

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      SOURCEi
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      Gene expression databases

      BgeeiENSG00000188886, Expressed in bone marrow and 71 other tissues

      Family and domain databases

      Gene3Di3.40.390.10, 1 hit
      InterProiView protein in InterPro
      IPR024079, MetalloPept_cat_dom_sf
      IPR001506, Peptidase_M12A
      IPR006026, Peptidase_Metallo
      PfamiView protein in Pfam
      PF01400, Astacin, 1 hit
      PRINTSiPR00480, ASTACIN
      SMARTiView protein in SMART
      SM00235, ZnMc, 1 hit
      PROSITEiView protein in PROSITE
      PS51864, ASTACIN, 1 hit
      PS00142, ZINC_PROTEASE, 1 hit

      ProtoNet; Automatic hierarchical classification of proteins

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      ProtoNeti
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      MobiDB: a database of protein disorder and mobility annotations

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      MobiDBi
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      <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

      <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiASTL_HUMAN
      <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6HA08
      Secondary accession number(s): Q3KNT0
      <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
      Last sequence update: January 11, 2011
      Last modified: October 7, 2020
      This is version 118 of the entry and version 4 of the sequence. See complete history.
      <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
      Annotation programChordata Protein Annotation Program
      DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

      <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

      Keywords - Technical termi

      Reference proteome

      Documents

      1. Human polymorphisms and disease mutations
        Index of human polymorphisms and disease mutations
      2. MIM cross-references
        Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
      3. Human chromosome 2
        Human chromosome 2: entries, gene names and cross-references to MIM
      4. Human entries with polymorphisms or disease mutations
        List of human entries with polymorphisms or disease mutations
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