Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

UL-16 binding protein 5

Gene

RAET1G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Isoform 1: Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.3 Publications
Isoform 3: Down-regulates the expression of KLRK1 and stimulates natural killer cells to secrete IFNG.1 Publication
Isoform 2: Stimulates natural killer cells to secrete IFNG.1 Publication

Miscellaneous

UL16-binding proteins (ULBPs) are unusual members of the extended MHC class I superfamily. They do not contain the alpha 3 domain and lack a transmembrane domain.Curated

GO - Molecular functioni

  • natural killer cell lectin-like receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Names & Taxonomyi

Protein namesi
Recommended name:
UL-16 binding protein 5
Alternative name(s):
Retinoic acid early transcript 1G proteinImported
Gene namesi
Name:RAET1G1 PublicationImported
Synonyms:ULBP51 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000203722.7
HGNCiHGNC:16795 RAET1G
MIMi609244 gene
neXtProtiNX_Q6H3X3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 223ExtracellularSequence analysisAdd BLAST198
Transmembranei224 – 243HelicalSequence analysisAdd BLAST20
Topological domaini244 – 334CytoplasmicSequence analysisAdd BLAST91

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi217S → P: Reduced cell surface expression. 1 Publication1

Organism-specific databases

DisGeNETi353091
OpenTargetsiENSG00000203722
PharmGKBiPA134897742

Polymorphism and mutation databases

BioMutaiRAET1G
DMDMi56749591

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25By similarityAdd BLAST25
ChainiPRO_000001902226 – 218UL-16 binding protein 5Add BLAST193
PropeptideiPRO_0000429932219 – 334Removed in mature formSequence analysisAdd BLAST116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 66By similarity
Glycosylationi82N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi127 ↔ 190By similarity
Lipidationi218GPI-anchor amidated glycine1 Publication1

Post-translational modificationi

The functional form is cleaved C-terminally of the GPI-anchor and yields a 28 kDa protein.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ6H3X3
PaxDbiQ6H3X3
PeptideAtlasiQ6H3X3
PRIDEiQ6H3X3
ProteomicsDBi66338
66339 [Q6H3X3-2]
TopDownProteomicsiQ6H3X3-1 [Q6H3X3-1]

PTM databases

iPTMnetiQ6H3X3
PhosphoSitePlusiQ6H3X3

Expressioni

Tissue specificityi

Isoform 1 is highly expressed in colon and in a number of tumor cell lines and highly restricted in normal tissues. Both isoforms are frequently expressed in cell lines derived from epithelial cancers, and in primary breast cancers.3 Publications

Gene expression databases

BgeeiENSG00000203722 Expressed in 81 organ(s), highest expression level in esophagus mucosa
ExpressionAtlasiQ6H3X3 baseline and differential

Organism-specific databases

HPAiHPA062673

Interactioni

Subunit structurei

Interacts with KLRK1/NKG2D.3 Publications
(Microbial infection) In CMV-infected cells, interacts with the viral glycoprotein UL16; this interaction causes RAET1G retention in the endoplasmic reticulum and cis-Golgi and prevents binding to and activation of KLRK1/NKG2D, providing CMV with an immune evasion mechanism.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
KLRK1P267186EBI-458334,EBI-458344

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ6H3X3, 2 interactors
STRINGi9606.ENSP00000356329

Structurei

3D structure databases

ProteinModelPortaliQ6H3X3
SMRiQ6H3X3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 117MHC class I alpha-1 likeAdd BLAST89
Regioni118 – 210MHC class I alpha-2 likeAdd BLAST93

Sequence similaritiesi

Belongs to the MHC class I family.Sequence analysis

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J4VC Eukaryota
ENOG41113ZC LUCA
GeneTreeiENSGT00390000003472
HOGENOMiHOG000070028
InParanoidiQ6H3X3
KOiK07987
OMAiCLLMCSR
OrthoDBiEOG091G0I62
PhylomeDBiQ6H3X3
TreeFamiTF341724

Family and domain databases

Gene3Di3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
PfamiView protein in Pfam
PF00129 MHC_I, 1 hit
SUPFAMiSSF54452 SSF54452, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q6H3X3-1) [UniParc]FASTAAdd to basket
Also known as: RAET1G11 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAASPAFL LRLPLLLLLS SWCRTGLADP HSLCYDITVI PKFRPGPRWC
60 70 80 90 100
AVQGQVDEKT FLHYDCGSKT VTPVSPLGKK LNVTTAWKAQ NPVLREVVDI
110 120 130 140 150
LTEQLLDIQL ENYIPKEPLT LQARMSCEQK AEGHGSGSWQ LSFDGQIFLL
160 170 180 190 200
FDSENRMWTT VHPGARKMKE KWENDKDMTM SFHYISMGDC TGWLEDFLMG
210 220 230 240 250
MDSTLEPSAG APPTMSSGTA QPRATATTLI LCCLLIMCLL ICSRHSLTQS
260 270 280 290 300
HGHHPQSLQP PPHPPLLHPT WLLRRVLWSD SYQIAKRPLS GGHVTRVTLP
310 320 330
IIGDDSHSLP CPLALYTINN GAARYSEPLQ VSIS
Length:334
Mass (Da):37,106
Last modified:July 19, 2004 - v1
Checksum:i3F8350036951BA69
GO
Isoform 21 Publication (identifier: Q6H3X3-2) [UniParc]FASTAAdd to basket
Also known as: RAET1G21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     211-213: APP → GTV
     214-334: Missing.

Show »
Length:213
Mass (Da):23,884
Checksum:i24E4AC61CE0F8854
GO
Isoform 3 (identifier: Q6H3X3-3) [UniParc]FASTAAdd to basket
Also known as: RAET1G31 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     118-154: Missing.
     214-334: Missing.

Show »
Length:176
Mass (Da):19,795
Checksum:iAB9B76BAE27E4665
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JAK3C9JAK3_HUMAN
UL-16-binding protein 5
RAET1G
221Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03344970T → R. Corresponds to variant dbSNP:rs9397449Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_059264118 – 154Missing in isoform 3. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_051621211 – 213APP → GTV in isoform 2. 1 Publication3
Alternative sequenceiVSP_051622214 – 334Missing in isoform 2 and isoform 3. 1 PublicationAdd BLAST121

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY172579 mRNA Translation: AAO22238.1
AY172580 mRNA Translation: AAO22239.1
CCDSiCCDS43514.1 [Q6H3X3-1]
RefSeqiNP_001001788.2, NM_001001788.3 [Q6H3X3-1]
UniGeneiHs.535023
Hs.558792

Genome annotation databases

EnsembliENST00000367360; ENSP00000356329; ENSG00000203722 [Q6H3X3-1]
ENST00000367361; ENSP00000356330; ENSG00000203722 [Q6H3X3-2]
GeneIDi353091
KEGGihsa:353091
UCSCiuc010kii.1 human [Q6H3X3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY172579 mRNA Translation: AAO22238.1
AY172580 mRNA Translation: AAO22239.1
CCDSiCCDS43514.1 [Q6H3X3-1]
RefSeqiNP_001001788.2, NM_001001788.3 [Q6H3X3-1]
UniGeneiHs.535023
Hs.558792

3D structure databases

ProteinModelPortaliQ6H3X3
SMRiQ6H3X3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6H3X3, 2 interactors
STRINGi9606.ENSP00000356329

PTM databases

iPTMnetiQ6H3X3
PhosphoSitePlusiQ6H3X3

Polymorphism and mutation databases

BioMutaiRAET1G
DMDMi56749591

Proteomic databases

MaxQBiQ6H3X3
PaxDbiQ6H3X3
PeptideAtlasiQ6H3X3
PRIDEiQ6H3X3
ProteomicsDBi66338
66339 [Q6H3X3-2]
TopDownProteomicsiQ6H3X3-1 [Q6H3X3-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367360; ENSP00000356329; ENSG00000203722 [Q6H3X3-1]
ENST00000367361; ENSP00000356330; ENSG00000203722 [Q6H3X3-2]
GeneIDi353091
KEGGihsa:353091
UCSCiuc010kii.1 human [Q6H3X3-1]

Organism-specific databases

CTDi353091
DisGeNETi353091
EuPathDBiHostDB:ENSG00000203722.7
GeneCardsiRAET1G
H-InvDBiHIX0025204
HGNCiHGNC:16795 RAET1G
HPAiHPA062673
MIMi609244 gene
neXtProtiNX_Q6H3X3
OpenTargetsiENSG00000203722
PharmGKBiPA134897742
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4VC Eukaryota
ENOG41113ZC LUCA
GeneTreeiENSGT00390000003472
HOGENOMiHOG000070028
InParanoidiQ6H3X3
KOiK07987
OMAiCLLMCSR
OrthoDBiEOG091G0I62
PhylomeDBiQ6H3X3
TreeFamiTF341724

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Miscellaneous databases

GenomeRNAii353091
PROiPR:Q6H3X3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000203722 Expressed in 81 organ(s), highest expression level in esophagus mucosa
ExpressionAtlasiQ6H3X3 baseline and differential

Family and domain databases

Gene3Di3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
PfamiView protein in Pfam
PF00129 MHC_I, 1 hit
SUPFAMiSSF54452 SSF54452, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiULBP5_HUMAN
AccessioniPrimary (citable) accession number: Q6H3X3
Secondary accession number(s): Q6H3X2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 19, 2004
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again