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UniProtKB - Q6H3D7 (PA2HH_TRIST)
Protein
Basic phospholipase A2 homolog CTs-R6
Gene
N/A
Organism
Trimeresurus stejnegeri (Chinese green tree viper) (Viridovipera stejnegeri)
Status
Functioni
Snake venom phospholipase A2 homolog that induces local edema a few hours after injection (5-10 µg) in the hind paw, and shows weak anticoagulant and myotoxic activities.
1 PublicationCaution
Does not bind calcium as one of the calcium-binding sites is lost (Asp->Asn in position 64, which corresponds to 'Asn-49' in the current nomenclature).Curated
GO - Molecular functioni
- calcium ion binding Source: InterPro
- phospholipase A2 activity Source: InterPro
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- arachidonic acid secretion Source: InterPro
- lipid catabolic process Source: InterPro
- phospholipid metabolic process Source: InterPro
Keywordsi
Molecular function | Blood coagulation cascade inhibiting toxin, Hemostasis impairing toxin, Myotoxin, Toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Basic phospholipase A2 homolog CTs-R6Short name: svPLA2 homolog |
Organismi | Trimeresurus stejnegeri (Chinese green tree viper) (Viridovipera stejnegeri) |
Taxonomic identifieri | 39682 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Viperidae › Crotalinae › Trimeresurus |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | 1 PublicationAdd BLAST | 16 | |
ChainiPRO_0000419081 | 17 – 137 | Basic phospholipase A2 homolog CTs-R61 PublicationAdd BLAST | 121 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 42 ↔ 130 | Combined sources | ||
Disulfide bondi | 44 ↔ 60 | Combined sources | ||
Disulfide bondi | 59 ↔ 110 | Combined sources | ||
Disulfide bondi | 65 ↔ 137 | Combined sources | ||
Disulfide bondi | 66 ↔ 103 | Combined sources | ||
Disulfide bondi | 73 ↔ 97 | Combined sources | ||
Disulfide bondi | 91 ↔ 101 | Combined sources |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q6H3D7 |
SMRi | Q6H3D7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalFamily and domain databases
CDDi | cd00125, PLA2c, 1 hit |
Gene3Di | 1.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR001211, PLipase_A2 IPR033112, PLipase_A2_Asp_AS IPR016090, PLipase_A2_dom IPR036444, PLipase_A2_dom_sf IPR033113, PLipase_A2_His_AS |
PANTHERi | PTHR11716, PTHR11716, 1 hit |
Pfami | View protein in Pfam PF00068, Phospholip_A2_1, 1 hit |
PRINTSi | PR00389, PHPHLIPASEA2 |
SMARTi | View protein in SMART SM00085, PA2c, 1 hit |
SUPFAMi | SSF48619, SSF48619, 1 hit |
PROSITEi | View protein in PROSITE PS00119, PA2_ASP, 1 hit PS00118, PA2_HIS, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q6H3D7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRTLLIMAVL LLGVEGSLLQ LRKMIKKMTN KEPILSYSKY GCNCGMAGRG
60 70 80 90 100
KPVDATDTCC SIHNCCYGKV TSCSTKWDSY SYSWENGDIV CDEKHPCKDV
110 120 130
CECDKAVATC FRDNLDTYKK RNIFHPTSSC VKVSTPC
Mass spectrometryi
Molecular mass is 13576 Da. Determined by ESI. 1 Publication
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY211932 mRNA Translation: AAP48890.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY211932 mRNA Translation: AAP48890.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4H0S | X-ray | 1.55 | A/B/C | 1-137 | [»] | |
AlphaFoldDBi | Q6H3D7 | |||||
SMRi | Q6H3D7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Family and domain databases
CDDi | cd00125, PLA2c, 1 hit |
Gene3Di | 1.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR001211, PLipase_A2 IPR033112, PLipase_A2_Asp_AS IPR016090, PLipase_A2_dom IPR036444, PLipase_A2_dom_sf IPR033113, PLipase_A2_His_AS |
PANTHERi | PTHR11716, PTHR11716, 1 hit |
Pfami | View protein in Pfam PF00068, Phospholip_A2_1, 1 hit |
PRINTSi | PR00389, PHPHLIPASEA2 |
SMARTi | View protein in SMART SM00085, PA2c, 1 hit |
SUPFAMi | SSF48619, SSF48619, 1 hit |
PROSITEi | View protein in PROSITE PS00119, PA2_ASP, 1 hit PS00118, PA2_HIS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PA2HH_TRIST | |
Accessioni | Q6H3D7Primary (citable) accession number: Q6H3D7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 5, 2012 |
Last sequence update: | July 19, 2004 | |
Last modified: | May 25, 2022 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families