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Protein

Bombesin receptor subtype-3

Gene

BRS3

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  • bombesin receptor activity Source: InterPro
  • G protein-coupled receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Bombesin receptor subtype-3
Short name:
BRS-3
Gene namesi
Name:BRS3
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40ExtracellularSequence analysisAdd BLAST40
Transmembranei41 – 62Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini63 – 81CytoplasmicSequence analysisAdd BLAST19
Transmembranei82 – 102Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini103 – 120ExtracellularSequence analysisAdd BLAST18
Transmembranei121 – 142Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini143 – 162CytoplasmicSequence analysisAdd BLAST20
Transmembranei163 – 183Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini184 – 219ExtracellularSequence analysisAdd BLAST36
Transmembranei220 – 240Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini241 – 271CytoplasmicSequence analysisAdd BLAST31
Transmembranei272 – 292Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini293 – 312ExtracellularSequence analysisAdd BLAST20
Transmembranei313 – 332Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini333 – 398CytoplasmicSequence analysisAdd BLAST66

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691971 – 398Bombesin receptor subtype-3Add BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi119 ↔ 202PROSITE-ProRule annotation
Lipidationi346S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiQ6H2Y3

Interactioni

Subunit structurei

Interacts with C6orf89.By similarity

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000008499

Structurei

3D structure databases

ProteinModelPortaliQ6H2Y3
SMRiQ6H2Y3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000230781
HOVERGENiHBG004898
InParanoidiQ6H2Y3
KOiK04170
OMAiHFIVTIF
OrthoDBiEOG091G085Y
TreeFamiTF331292

Family and domain databases

InterProiView protein in InterPro
IPR001560 Bombesin_rcpt_3
IPR001556 Bombsn_rcpt-like
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00637 BOMBESIN3R
PR00358 BOMBESINR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6H2Y3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQRQPHSPN QTLISITNDT ESSSVVSNDN TNKGRSGDNS PGIEALCAIY
60 70 80 90 100
ITYAVIISVG ILGNAILIKV FFKTKSMQTV PNIFITSLAF GDLLLLLTCV
110 120 130 140 150
PVDATHYLAE GWLFGRIGCK VLSFIRLTSV GVSVFTLTIL SADRYKAVVK
160 170 180 190 200
PLERQPSNAI LKTCIKAGCV WIVSMIFALP EAIFSNVYSF RDPNKNVTFE
210 220 230 240 250
SCTSYPVSKK LLQEIHSLLC FLVFYIIPLS IISVYYSLIA RTLYKSTLNI
260 270 280 290 300
PTEEQGHARK QIESRKRIAR TVLVLVALFA LCWLPNHLLY LYHSFTSQTY
310 320 330 340 350
VDPSAMHFIF TIFSRVLAFS NSCVNPFALY WLSKTFQKHF KAQLFCCKAE
360 370 380 390
QPEPPVADTS LTTLAVMGRV PGTGNMQMSE ISVTSFPGCS VKQAEDRV
Length:398
Mass (Da):44,266
Last modified:July 19, 2004 - v1
Checksum:iB687A36AA9391B92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY350447 mRNA Translation: AAR07972.1
RefSeqiNP_001028074.1, NM_001032902.1
UniGeneiMmu.3770

Genome annotation databases

GeneIDi574261
KEGGimcc:574261

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY350447 mRNA Translation: AAR07972.1
RefSeqiNP_001028074.1, NM_001032902.1
UniGeneiMmu.3770

3D structure databases

ProteinModelPortaliQ6H2Y3
SMRiQ6H2Y3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000008499

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiQ6H2Y3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi574261
KEGGimcc:574261

Organism-specific databases

CTDi680

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000230781
HOVERGENiHBG004898
InParanoidiQ6H2Y3
KOiK04170
OMAiHFIVTIF
OrthoDBiEOG091G085Y
TreeFamiTF331292

Family and domain databases

InterProiView protein in InterPro
IPR001560 Bombesin_rcpt_3
IPR001556 Bombsn_rcpt-like
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00637 BOMBESIN3R
PR00358 BOMBESINR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBRS3_MACMU
AccessioniPrimary (citable) accession number: Q6H2Y3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 19, 2004
Last modified: November 7, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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