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Protein

Glucoside xylosyltransferase 1

Gene

Gxylt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose.By similarity

Catalytic activityi

UDP-alpha-D-xylose + beta-D-glucosyl-R = UDP + alpha-D-xylose-(1->3)-beta-D-glucosyl-R.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glucoside xylosyltransferase 1 (EC:2.4.2.n2)
Alternative name(s):
Glycosyltransferase 8 domain-containing protein 3
S33-D
Gene namesi
Name:Gxylt1
Synonyms:Glt8d3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1563062 Gxylt1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6CytoplasmicSequence analysis6
Transmembranei7 – 29Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini30 – 435LumenalSequence analysisAdd BLAST406

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002885361 – 435Glucoside xylosyltransferase 1Add BLAST435

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi232N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6GX83
PRIDEiQ6GX83

Expressioni

Inductioni

By E2F1.1 Publication

Gene expression databases

BgeeiENSRNOG00000005234
ExpressionAtlasiQ6GX83 baseline and differential
GenevisibleiQ6GX83 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000055150

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 8 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3765 Eukaryota
ENOG410XRNY LUCA
GeneTreeiENSGT00510000046589
HOGENOMiHOG000264229
HOVERGENiHBG059879
InParanoidiQ6GX83
KOiK13676
OMAiNCFWEAA
OrthoDBiEOG091G07SJ
PhylomeDBiQ6GX83
TreeFamiTF323210

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR002495 Glyco_trans_8
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF01501 Glyco_transf_8, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequencei

Sequence statusi: Complete.

Q6GX83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRYLRVVGL CLACGFCSLL YAFSQLAVSL EEGAAVGRRP QAAVASWLAD
60 70 80 90 100
GGRGTGRGAG SAGPGRTGRC KEVSLSYWNP YWMLPSDVCG VNCFWEAAFR
110 120 130 140 150
YGLKTRPTEK MHLAVVACGD RLEETVTMLK SALIFSIKPL HVHIFAEDQL
160 170 180 190 200
HDSFKDRLDS WSFLQRFNYS LYPITFPSDS AMEWKKLFKP CASQRLFLPL
210 220 230 240 250
ILKGVDSLLY VDTDVLFLRP VDDIWSLLER FNSTQIAAMA PEHEEPRVGW
260 270 280 290 300
YNRFARHPYY GRTGVNSGVM LMNMTRMRRK YFKNDMTTAR LQWGDILMPL
310 320 330 340 350
LKKYKLNITW GDQDLLNIMF YHNPESLFVF PCQWNYRPDH CIYGSNCREA
360 370 380 390 400
EEEGVFILHG NRGVYHDDKQ PAFRAMYEAL RNCSLEDDSV RSLLKPLELE
410 420 430
LQKTVHTYCG KTYKIFIKQL AKSIRNRYDT PPKER
Length:435
Mass (Da):50,243
Last modified:May 29, 2007 - v2
Checksum:i75A51D4A21074747
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03055509 Genomic DNA No translation available.
AABR03055661 Genomic DNA No translation available.
AY623036 mRNA Translation: AAT46050.1
RefSeqiNP_001094357.1, NM_001100887.1
UniGeneiRn.14826

Genome annotation databases

EnsembliENSRNOT00000058349; ENSRNOP00000055150; ENSRNOG00000005234
GeneIDi300173
KEGGirno:300173

Similar proteinsi

Entry informationi

Entry nameiGXLT1_RAT
AccessioniPrimary (citable) accession number: Q6GX83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: June 7, 2017
This is version 83 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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