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Protein

Translocated actin-recruiting phosphoprotein

Gene

tarP

Organism
Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Appears to initiate or participate in signaling events that regulate the actin recruitment, which ultimately leads to internalization.1 Publication

Miscellaneous

Transcribed from mid to late cycle in the chlamydial developmental cycle.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • PTB domain binding Source: CAFA
  • SH2 domain binding Source: CAFA

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processVirulence

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
CTRA471472:G1GJT-749-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Translocated actin-recruiting phosphoprotein
Short name:
Tarp protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tarP
Ordered Locus Names:CTL0716
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiChlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri471472 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000795 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

  • Secreted
  • Note: Secreted via type III secretion system and translocated into host cell.

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000724361 – 1005Translocated actin-recruiting phosphoproteinAdd BLAST1005

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on a tyrosine on attachment to the host cell. Tyrosine phosphorylation is temporally and spatially associated with recruitment of actin to the site of chlamydial entry. Phosphorylated Tarp seems to remain cytoplasmically exposed on the inclusion membrane at one side of internalized elementary bodies for several hours after entry.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q6GX35

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ACTA1P681354EBI-15605056,EBI-367540From Oryctolagus cuniculus.

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-61288N

Protein interaction database and analysis system

More...
IntActi
Q6GX35, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6GX35

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6GX35

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000035088

Identification of Orthologs from Complete Genome Data

More...
OMAi
IYESIDD

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011443 DUF1547

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07577 DUF1547, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6GX35-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTNSISGDQP TVTTFTSSTT SASGASGSLG ASSVSTTANA TVTQTANATN
60 70 80 90 100
SAATSSIQTT GETVVNYTNS ASAPTVTVST SSSSTQATAT SNKTSQAVAG
110 120 130 140 150
KITSPDTSES SETSSTSSSD HIPSDYEPIS TTENIYENIY ESIDDSSTSG
160 170 180 190 200
PENTSGGAAA LNSLRGSSYS NYDDAAADYE PISTTENIYE SIDDSSTSDP
210 220 230 240 250
ENTSGGAAAL NSLRGSSYSN YDDAAADYEP ISTTENIYEN IYESIDDSST
260 270 280 290 300
SGPENTSGGA AALNSLRGSS YSNYDDAAAD YEPISTTENI YESIDDSSTS
310 320 330 340 350
DPENTSGGAA AALNSLRGSS YSNYDDAAAD YEPISTTENI YESIDDSSTS
360 370 380 390 400
DPENTSGGAA ALNSLRGSSY SNYDDAAADY EPISTTENIY ENIYESIDGS
410 420 430 440 450
STSDPENTSG GAAAALNSLR GSSYTTGPRN EGVFGPGPEG LPDMSLPSYD
460 470 480 490 500
PTNKTSLLTF LSNPHVKSKM LENSGHFVFI DTDRSSFILV PNGNWDQVCS
510 520 530 540 550
IKVQNGKTKE DLDIKDLENM CAKFCTGFNK FSGDWDSRVE PMMSAKAGVA
560 570 580 590 600
SGGNLPNTVI INNKFKTCVA YGPWNSREAS SGYTPSAWRR GHQVNFGEIF
610 620 630 640 650
EKANDFNKIN WGTQAGPSSE DDGISFSNET PGAGPAAAPS PTPSSIPVIN
660 670 680 690 700
VNVNVGGTNV NIRDTNVNTT NTTPTTQSTD ASTDTSDIDN INTNNQTDDI
710 720 730 740 750
NTTDKDSDGA GGVNGDISET ESSSGDDSGS VSSSESDKNA SVGNDGPAMK
760 770 780 790 800
DILSAVRKHL DVVYPGDNGG STEGPLQANQ TLGDIVQDME TTGTSQETVV
810 820 830 840 850
SPWKGSTSST GSAGGSGSVQ TLLPSPPPTP STTTLRTGTG ATTTSLMMGG
860 870 880 890 900
PIKADIITTG GGGRIPGGGT LEKLLPRIRA HLDISFDGQG DLVSTEEPQL
910 920 930 940 950
GSIVNKFRKE TGSGGIVASV ESAPGKPGSA QVLTGTGGDK GNLFQAAAAV
960 970 980 990 1000
TQALGNVAGK VNLAIQGQKL SSLVNDDGKG SVGRDLFQAA TQTTQALSSL

IDTVG
Length:1,005
Mass (Da):103,252
Last modified:July 19, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i84097DC88E20F323
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY623902 Genomic DNA Translation: AAT47185.1
AM884176 Genomic DNA Translation: CAP04155.1

NCBI Reference Sequences

More...
RefSeqi
WP_009873825.1, NC_010287.1
YP_001654788.1, NC_010287.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAP04155; CAP04155; CTL0716

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5858633

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ctb:CTL0716

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|471472.4.peg.768

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY623902 Genomic DNA Translation: AAT47185.1
AM884176 Genomic DNA Translation: CAP04155.1
RefSeqiWP_009873825.1, NC_010287.1
YP_001654788.1, NC_010287.1

3D structure databases

ProteinModelPortaliQ6GX35
SMRiQ6GX35
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61288N
IntActiQ6GX35, 1 interactor

Proteomic databases

PRIDEiQ6GX35

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAP04155; CAP04155; CTL0716
GeneIDi5858633
KEGGictb:CTL0716
PATRICifig|471472.4.peg.768

Phylogenomic databases

HOGENOMiHOG000035088
OMAiIYESIDD

Enzyme and pathway databases

BioCyciCTRA471472:G1GJT-749-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR011443 DUF1547
PfamiView protein in Pfam
PF07577 DUF1547, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTARP_CHLT2
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6GX35
Secondary accession number(s): B0B829
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 19, 2004
Last modified: November 7, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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