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Protein

Translocated actin-recruiting phosphoprotein

Gene

tarP

Organism
Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Appears to initiate or participate in signaling events that regulate the actin recruitment, which ultimately leads to internalization.1 Publication

Miscellaneous

Transcribed from mid to late cycle in the chlamydial developmental cycle.

GO - Molecular functioni

  • PTB domain binding Source: CAFA
  • SH2 domain binding Source: CAFA

GO - Biological processi

Keywordsi

Biological processVirulence

Enzyme and pathway databases

BioCyciCTRA471472:G1GJT-749-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Translocated actin-recruiting phosphoprotein
Short name:
Tarp protein
Gene namesi
Name:tarP
Ordered Locus Names:CTL0716
OrganismiChlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B)
Taxonomic identifieri471472 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000795 Componenti: Chromosome

Subcellular locationi

  • Secreted
  • Note: Secreted via type III secretion system and translocated into host cell.

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000724361 – 1005Translocated actin-recruiting phosphoproteinAdd BLAST1005

Post-translational modificationi

Phosphorylated on a tyrosine on attachment to the host cell. Tyrosine phosphorylation is temporally and spatially associated with recruitment of actin to the site of chlamydial entry. Phosphorylated Tarp seems to remain cytoplasmically exposed on the inclusion membrane at one side of internalized elementary bodies for several hours after entry.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ6GX35

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ACTA1P681354EBI-15605056,EBI-367540From Oryctolagus cuniculus.

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-61288N
IntActiQ6GX35, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ6GX35
SMRiQ6GX35
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000035088
OMAiCETESTG

Family and domain databases

InterProiView protein in InterPro
IPR011443 DUF1547
PfamiView protein in Pfam
PF07577 DUF1547, 2 hits

Sequencei

Sequence statusi: Complete.

Q6GX35-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTNSISGDQP TVTTFTSSTT SASGASGSLG ASSVSTTANA TVTQTANATN
60 70 80 90 100
SAATSSIQTT GETVVNYTNS ASAPTVTVST SSSSTQATAT SNKTSQAVAG
110 120 130 140 150
KITSPDTSES SETSSTSSSD HIPSDYEPIS TTENIYENIY ESIDDSSTSG
160 170 180 190 200
PENTSGGAAA LNSLRGSSYS NYDDAAADYE PISTTENIYE SIDDSSTSDP
210 220 230 240 250
ENTSGGAAAL NSLRGSSYSN YDDAAADYEP ISTTENIYEN IYESIDDSST
260 270 280 290 300
SGPENTSGGA AALNSLRGSS YSNYDDAAAD YEPISTTENI YESIDDSSTS
310 320 330 340 350
DPENTSGGAA AALNSLRGSS YSNYDDAAAD YEPISTTENI YESIDDSSTS
360 370 380 390 400
DPENTSGGAA ALNSLRGSSY SNYDDAAADY EPISTTENIY ENIYESIDGS
410 420 430 440 450
STSDPENTSG GAAAALNSLR GSSYTTGPRN EGVFGPGPEG LPDMSLPSYD
460 470 480 490 500
PTNKTSLLTF LSNPHVKSKM LENSGHFVFI DTDRSSFILV PNGNWDQVCS
510 520 530 540 550
IKVQNGKTKE DLDIKDLENM CAKFCTGFNK FSGDWDSRVE PMMSAKAGVA
560 570 580 590 600
SGGNLPNTVI INNKFKTCVA YGPWNSREAS SGYTPSAWRR GHQVNFGEIF
610 620 630 640 650
EKANDFNKIN WGTQAGPSSE DDGISFSNET PGAGPAAAPS PTPSSIPVIN
660 670 680 690 700
VNVNVGGTNV NIRDTNVNTT NTTPTTQSTD ASTDTSDIDN INTNNQTDDI
710 720 730 740 750
NTTDKDSDGA GGVNGDISET ESSSGDDSGS VSSSESDKNA SVGNDGPAMK
760 770 780 790 800
DILSAVRKHL DVVYPGDNGG STEGPLQANQ TLGDIVQDME TTGTSQETVV
810 820 830 840 850
SPWKGSTSST GSAGGSGSVQ TLLPSPPPTP STTTLRTGTG ATTTSLMMGG
860 870 880 890 900
PIKADIITTG GGGRIPGGGT LEKLLPRIRA HLDISFDGQG DLVSTEEPQL
910 920 930 940 950
GSIVNKFRKE TGSGGIVASV ESAPGKPGSA QVLTGTGGDK GNLFQAAAAV
960 970 980 990 1000
TQALGNVAGK VNLAIQGQKL SSLVNDDGKG SVGRDLFQAA TQTTQALSSL

IDTVG
Length:1,005
Mass (Da):103,252
Last modified:July 19, 2004 - v1
Checksum:i84097DC88E20F323
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY623902 Genomic DNA Translation: AAT47185.1
AM884176 Genomic DNA Translation: CAP04155.1
RefSeqiWP_009873825.1, NC_010287.1
YP_001654788.1, NC_010287.1

Genome annotation databases

EnsemblBacteriaiCAP04155; CAP04155; CTL0716
GeneIDi5858633
KEGGictb:CTL0716
PATRICifig|471472.4.peg.768

Similar proteinsi

Entry informationi

Entry nameiTARP_CHLT2
AccessioniPrimary (citable) accession number: Q6GX35
Secondary accession number(s): B0B829
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 19, 2004
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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