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Protein

Cholesterol side-chain cleavage enzyme, mitochondrial

Gene

CYP11A1

Organism
Taeniopygia guttata (Zebra finch) (Poephila guttata)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.UniRule annotation

Catalytic activityi

Cholesterol + 6 reduced adrenodoxin + 3 O2 + 6 H+ = pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H2O.UniRule annotation

Cofactori

hemeUniRule annotation

Pathwayi: C21-steroid hormone metabolism

This protein is involved in the pathway C21-steroid hormone metabolism, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway C21-steroid hormone metabolism and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenaseUniRule annotation, Oxidoreductase
Biological processCholesterol metabolismUniRule annotation, Lipid metabolism, Steroid metabolism, SteroidogenesisUniRule annotation, Sterol metabolism
LigandHemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayi
UPA00229

Names & Taxonomyi

Protein namesi
Recommended name:
Cholesterol side-chain cleavage enzyme, mitochondrialUniRule annotation (EC:1.14.15.6UniRule annotation)
Alternative name(s):
Cholesterol desmolaseUniRule annotation
Gene namesi
Name:CYP11A1Imported
OrganismiTaeniopygia guttata (Zebra finch) (Poephila guttata)Imported
Taxonomic identifieri59729 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePasseriformesPasseroideaEstrildidaeEstrildinaeTaeniopygia

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MembraneUniRule annotation, MitochondrionUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ6GVK8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

HOVERGENiHBG051098
KOiK00498

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR033283 CYP11A1
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PANTHERiPTHR24279:SF3 PTHR24279:SF3, 1 hit
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

Q6GVK8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLARVVTKPG ALRGCPRGAA ARCRRLGGAG GAVPSAPRPF NQVPGEWRAG
60 70 80 90 100
WLNLYRFWRE GGLSALHLSM AQKFRRFGPI YREKLGVHET VNIISPGDAA
110 120 130 140 150
TLFQAEGALP ERFRVPPWVA YRDFRNKPYG VLLKTGEAWR SDRLLLNQEA
160 170 180 190 200
LAPAAVAAFV PLLSAVGEDF VRRARAQARH SGHGCWTGDF SHELFRFALE
210 220 230 240 250
SVCHVLYGQR LGLLQDFVQP EAQRFIEAVA RMFHTTAPML YLPPALLRRL
260 270 280 290 300
RSRTWREHVH AWDAIFCQAD KCIQNVYRDL RLQRKSSQEY MGILGNLILR
310 320 330 340 350
DKLPLDDIRA SVTEMMAGGV DTTSMTLQWA MLELARAPGV QEQLRAEVLA
360 370 380 390 400
AKREAGGDRE KMLKSTRLLK ATIKETLRLH PVAVTLQRYT THEVILQDYR
410 420 430 440 450
IPPGTLVQVG LYAMGRDPDV FPRPERFRPQ RWLAAGPKPF LGLGFGFGPR
460 470 480 490 500
QCLGRRIAEL EMQLFLMHIL ENFKIETMRA VEIGTKFDLI LIPDQPIQLT

LRPLDGQP
Length:508
Mass (Da):57,449
Last modified:July 19, 2004 - v1
Checksum:i06E64EB290D7845D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY633556 mRNA Translation: AAT46359.1
RefSeqiNP_001120846.1, NM_001127374.1
UniGeneiTgu.6759

Genome annotation databases

GeneIDi100151695
KEGGitgu:100151695

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY633556 mRNA Translation: AAT46359.1
RefSeqiNP_001120846.1, NM_001127374.1
UniGeneiTgu.6759

3D structure databases

ProteinModelPortaliQ6GVK8
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100151695
KEGGitgu:100151695

Organism-specific databases

CTDi1583

Phylogenomic databases

HOVERGENiHBG051098
KOiK00498

Enzyme and pathway databases

UniPathwayi
UPA00229

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR033283 CYP11A1
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR036396 Cyt_P450_sf
PANTHERiPTHR24279:SF3 PTHR24279:SF3, 1 hit
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ6GVK8_TAEGU
AccessioniPrimary (citable) accession number: Q6GVK8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 19, 2004
Last sequence update: July 19, 2004
Last modified: July 18, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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