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Entry version 64 (02 Jun 2021)
Sequence version 1 (19 Jul 2004)
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Protein

Rhomboid-like protease 5

Gene

ROM5

Organism
Toxoplasma gondii
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine protease involved in intramembrane proteolysis. Cleaves microneme adhesins, such as MIC2. This step is essential for efficient invasion of host cells. Catalyzes intramembrane proteolysis of AMA1.

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains. EC:3.4.21.105

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei531NucleophileBy similarity1
Active sitei585By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.21.105, 6411

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S54.023

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rhomboid-like protease 5 (EC:3.4.21.105)
Alternative name(s):
Microneme protein protease 1
Short name:
MPP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ROM5
Synonyms:MPP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiToxoplasma gondii
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5811 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeToxoplasma

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
ToxoDB:TGARI_294690
ToxoDB:TGCAST_294690A
ToxoDB:TGCAST_294690B
ToxoDB:TGCOUG_294690
ToxoDB:TGCOUG_395050
ToxoDB:TGDOM2_294690A
ToxoDB:TGDOM2_294690B
ToxoDB:TGDOM2_294690C
ToxoDB:TGFOU_294690A
ToxoDB:TGFOU_294690B
ToxoDB:TGGT1_294690
ToxoDB:TGMAS_294690
ToxoDB:TGME49_294690
ToxoDB:TGP89_294690
ToxoDB:TGPRC2_294690
ToxoDB:TGRH88_019690
ToxoDB:TGRUB_294690A
ToxoDB:TGRUB_294690B
ToxoDB:TGVAND_294690
ToxoDB:TGVEG_294690

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Transmembranei464 – 484HelicalSequence analysisAdd BLAST21
Transmembranei492 – 512HelicalSequence analysisAdd BLAST21
Transmembranei526 – 546HelicalSequence analysisAdd BLAST21
Transmembranei571 – 590HelicalSequence analysisAdd BLAST20
Transmembranei673 – 693HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi531S → A: Loss of activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002390781 – 841Rhomboid-like protease 5Add BLAST841

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highly expressed in tachyzoites. Detected at low levels in bradyzoites and sporozoites.1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 289DisorderedSequence analysisAdd BLAST289

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi10 – 57Basic and acidic residuesSequence analysisAdd BLAST48
Compositional biasi80 – 136Polar residuesSequence analysisAdd BLAST57
Compositional biasi192 – 206Polar residuesSequence analysisAdd BLAST15
Compositional biasi209 – 229Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi247 – 272Basic and acidic residuesSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S54 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
GPQEPKD

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1540.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017092, Pept_S54_Rhomboid-like_Rom4/5
IPR002610, Peptidase_S54_rhomboid
IPR022764, Peptidase_S54_rhomboid_dom
IPR035952, Rhomboid-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR22936, PTHR22936, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01694, Rhomboid, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037023, Rhomboid-like_ROM4_ROM5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6GV23-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSKGGSSRL GSKDLKKMTS RTERELRDSG RVRGEVERVE KRLRATAKVK
60 70 80 90 100
EQPPTGDYKR RALASPGETA APTFLVDSRG IPRKTSSTAP RKATLRPASS
110 120 130 140 150
SPRLASSSRP TESTLPSSSS RALQGASSSS SSRPRRLHES ASGRGGSGGS
160 170 180 190 200
AGELRQEKKR LPELEAAEAA PASCVVELRD VTARKGRTSP ATPPETAGSS
210 220 230 240 250
VCGQGSHART AEKLEEGTAS HRDGSRRGSV DAETWATPGD GSSSHEFESS
260 270 280 290 300
PQREERMQPQ ETGRRELSSE PRSGDLTKNG GDGGPRRHSC AWRKWREHMI
310 320 330 340 350
QSFDITTHPF PPRGDGSPRR GKFLMIFLTS SVLFFVFLQE LVLNVTTFNG
360 370 380 390 400
RCMSPVLYPS HDAPESERTP RVISFGYGAC EHNLGVSLFR REETKKDPRG
410 420 430 440 450
RWTPGPLTER CASGRCASDD GWPSDLVQRG RAQRSPAAFD SPNPRVFSSL
460 470 480 490 500
GALDTNKVRN YGEMFRVVWG MFLHGGWMHL LLNVSCQAQT LWILEPAWGF
510 520 530 540 550
LRTLSLWIVG GVSGSLLSAV ANPCTVTVGS SGAFYGLLGA LVPFSIEYWD
560 570 580 590 600
HIASPAWFLF CVSVLVMVAQ FGNMVGVQGV DNNAHLGGLI GGLLFGFATI
610 620 630 640 650
RSVHAFRWQG VAERMASSTL FWWMFPAEKR RSLREDNLQR VAREREERSS
660 670 680 690 700
GRIPPPKFVW KFRGHEREWC VRFAAAVGLV TFWSVLWLYL LVPSYYESLS
710 720 730 740 750
SPPGNFSFLG STGCHCCRVQ PFPGEEDKLP AFHPVRVNRG LFWCFVSEGV
760 770 780 790 800
ANLFCGRSSA LNRGADVYGQ TRQFEEALGD LPSARAGEAP LRIAKEEGES
810 820 830 840
ASVWQRLVKS AKKTYNAVLG NTTTPAAPSA AELAQQTRAG Q
Length:841
Mass (Da):92,102
Last modified:July 19, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i455856A0DB72BFFC
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAT84606 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY634626 mRNA Translation: AAT47708.1
AY587208 mRNA Translation: AAT84606.1 Different initiation.

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
TGME49_294690-t26_1; TGME49_294690-t26_1; TGME49_294690

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY634626 mRNA Translation: AAT47708.1
AY587208 mRNA Translation: AAT84606.1 Different initiation.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiS54.023

Genome annotation databases

EnsemblProtistsiTGME49_294690-t26_1; TGME49_294690-t26_1; TGME49_294690

Organism-specific databases

VEuPathDBiToxoDB:TGARI_294690
ToxoDB:TGCAST_294690A
ToxoDB:TGCAST_294690B
ToxoDB:TGCOUG_294690
ToxoDB:TGCOUG_395050
ToxoDB:TGDOM2_294690A
ToxoDB:TGDOM2_294690B
ToxoDB:TGDOM2_294690C
ToxoDB:TGFOU_294690A
ToxoDB:TGFOU_294690B
ToxoDB:TGGT1_294690
ToxoDB:TGMAS_294690
ToxoDB:TGME49_294690
ToxoDB:TGP89_294690
ToxoDB:TGPRC2_294690
ToxoDB:TGRH88_019690
ToxoDB:TGRUB_294690A
ToxoDB:TGRUB_294690B
ToxoDB:TGVAND_294690
ToxoDB:TGVEG_294690

Phylogenomic databases

OMAiGPQEPKD

Enzyme and pathway databases

BRENDAi3.4.21.105, 6411

Family and domain databases

Gene3Di1.20.1540.10, 1 hit
InterProiView protein in InterPro
IPR017092, Pept_S54_Rhomboid-like_Rom4/5
IPR002610, Peptidase_S54_rhomboid
IPR022764, Peptidase_S54_rhomboid_dom
IPR035952, Rhomboid-like_sf
PANTHERiPTHR22936, PTHR22936, 1 hit
PfamiView protein in Pfam
PF01694, Rhomboid, 1 hit
PIRSFiPIRSF037023, Rhomboid-like_ROM4_ROM5, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHBL5_TOXGO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6GV23
Secondary accession number(s): Q696L8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: July 19, 2004
Last modified: June 2, 2021
This is version 64 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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