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Protein

S-adenosylmethionine synthase

Gene

SAMS

Organism
Solanum palustre (Non-tuber-performing potato) (Solanum brevidens)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.By similarity

Catalytic activityi

ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.By similarity

Cofactori

Protein has several cofactor binding sites:

Pathwayi: S-adenosyl-L-methionine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes S-adenosyl-L-methionine from L-methionine.By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. S-adenosylmethionine synthase (SAMS)
This subpathway is part of the pathway S-adenosyl-L-methionine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes S-adenosyl-L-methionine from L-methionine, the pathway S-adenosyl-L-methionine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9MagnesiumBy similarity1
Binding sitei15ATPBy similarity1
Metal bindingi43PotassiumBy similarity1
Binding sitei56MethionineBy similarity1
Binding sitei99MethionineBy similarity1
Binding sitei246ATPBy similarity1
Binding sitei246Methionine; shared with neighboring subunitBy similarity1
Binding sitei269ATP; via amide nitrogen; shared with neighboring subunitBy similarity1
Binding sitei273ATP; shared with neighboring subunitBy similarity1
Binding sitei277ATP; shared with neighboring subunitBy similarity1
Binding sitei277MethionineBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi167 – 169ATPBy similarity3
Nucleotide bindingi235 – 238ATPBy similarity4
Nucleotide bindingi252 – 253ATPBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processOne-carbon metabolism
LigandATP-binding, Cobalt, Magnesium, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

UniPathwayi
UPA00315;UER00080

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine synthase (EC:2.5.1.6By similarity)
Short name:
AdoMet synthase
Alternative name(s):
Methionine adenosyltransferase
Short name:
MAT
Gene namesi
Name:SAMS
OrganismiSolanum palustre (Non-tuber-performing potato) (Solanum brevidens)
Taxonomic identifieri4115 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003630471 – 393S-adenosylmethionine synthaseAdd BLAST393

Proteomic databases

PRIDEiQ6GV10

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6GV10
SMRiQ6GV10
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AdoMet synthase family.Curated

Family and domain databases

HAMAPiMF_00086 S_AdoMet_synth1, 1 hit
InterProiView protein in InterPro
IPR022631 ADOMET_SYNTHASE_CS
IPR022630 S-AdoMet_synt_C
IPR022629 S-AdoMet_synt_central
IPR022628 S-AdoMet_synt_N
IPR002133 S-AdoMet_synthetase
IPR022636 S-AdoMet_synthetase_sfam
PANTHERiPTHR11964 PTHR11964, 1 hit
PfamiView protein in Pfam
PF02773 S-AdoMet_synt_C, 1 hit
PF02772 S-AdoMet_synt_M, 1 hit
PF00438 S-AdoMet_synt_N, 1 hit
PIRSFiPIRSF000497 MAT, 1 hit
SUPFAMiSSF55973 SSF55973, 3 hits
TIGRFAMsiTIGR01034 metK, 1 hit
PROSITEiView protein in PROSITE
PS00376 ADOMET_SYNTHASE_1, 1 hit
PS00377 ADOMET_SYNTHASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6GV10-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METFLFTSES VNEGHPDKLC DQISDAVLDA CLEQDPESKV ACETCTKTNL
60 70 80 90 100
VMVFGEITTK AIVDYEKIVR DTCRNIGFVS DDVGLDADNC KVLVYIEQQS
110 120 130 140 150
PDIAQGVHGH LTKRPEEIGA GDQGHMFGYA TDETPELMPL SHVLATKLGA
160 170 180 190 200
RLTEVRKNGT CRWLKPDGKT QVTVEYCNDN GAMIPIRVHT VLISTQHDET
210 220 230 240 250
VTNDEIARDL KEHAIKPVIP EKYLDEKTIF HLNPSGRFVI GGPHGDAGLT
260 270 280 290 300
GRKIIIDTYG GWGAHGGGAF SGKDPTKVDR SGAYIVRQAA KSIVASGLAR
310 320 330 340 350
RCIVQVSYAI GVPEPLSVFV DTYGTGKIPD REILKIVKEN FDFRPGMMSI
360 370 380 390
NLDLKRGGNG RFLKTAAYGH FGRDDADFTW EVVKPLKWEN PQD
Length:393
Mass (Da):43,235
Last modified:July 19, 2004 - v1
Checksum:i653F7337FBEE9C56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY635050 mRNA Translation: AAT47716.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY635050 mRNA Translation: AAT47716.1

3D structure databases

ProteinModelPortaliQ6GV10
SMRiQ6GV10
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6GV10

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayi
UPA00315;UER00080

Family and domain databases

HAMAPiMF_00086 S_AdoMet_synth1, 1 hit
InterProiView protein in InterPro
IPR022631 ADOMET_SYNTHASE_CS
IPR022630 S-AdoMet_synt_C
IPR022629 S-AdoMet_synt_central
IPR022628 S-AdoMet_synt_N
IPR002133 S-AdoMet_synthetase
IPR022636 S-AdoMet_synthetase_sfam
PANTHERiPTHR11964 PTHR11964, 1 hit
PfamiView protein in Pfam
PF02773 S-AdoMet_synt_C, 1 hit
PF02772 S-AdoMet_synt_M, 1 hit
PF00438 S-AdoMet_synt_N, 1 hit
PIRSFiPIRSF000497 MAT, 1 hit
SUPFAMiSSF55973 SSF55973, 3 hits
TIGRFAMsiTIGR01034 metK, 1 hit
PROSITEiView protein in PROSITE
PS00376 ADOMET_SYNTHASE_1, 1 hit
PS00377 ADOMET_SYNTHASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMETK_SOLPL
AccessioniPrimary (citable) accession number: Q6GV10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: July 19, 2004
Last modified: March 15, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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