UniProtKB - Q6GTX8 (LAIR1_HUMAN)
Leukocyte-associated immunoglobulin-like receptor 1
LAIR1
Functioni
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- neutrophil degranulation Source: Reactome
- regulation of immune response Source: Reactome
Keywordsi
Molecular function | Receptor |
Biological process | Adaptive immunity, Immunity |
Enzyme and pathway databases
PathwayCommonsi | Q6GTX8 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Leukocyte-associated immunoglobulin-like receptor 1Short name: LAIR-1 Short name: hLAIR1 Alternative name(s): CD_antigen: CD305 |
Gene namesi | Name:LAIR1 Synonyms:CD305 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000167613.15 |
HGNCi | HGNC:6477, LAIR1 |
MIMi | 602992, gene |
neXtProti | NX_Q6GTX8 |
Subcellular locationi
Plasma membrane
- Cell membrane 3 Publications; Single-pass type I membrane protein 3 Publications
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- integral component of membrane Source: UniProtKB-KW
- specific granule membrane Source: Reactome
- tertiary granule membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 165 | ExtracellularSequence analysisAdd BLAST | 144 | |
Transmembranei | 166 – 186 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 187 – 287 | CytoplasmicSequence analysisAdd BLAST | 101 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 251 | Y → F: Reduced tyrosine phosphorylation and loss of binding to PTPN6 and CSK as well as complete loss of inhibitory activity. Loss of phosphorylation and of inhibition of calcium mobilization; when associated with F-281. 3 Publications | 1 | |
Mutagenesisi | 281 | Y → F: Reduced tyrosine phosphorylation and loss of binding to PTPN6. Partial inhibition of cytotoxic activity. 3 Publications | 1 |
Organism-specific databases
DisGeNETi | 3903 |
PharmGKBi | PA30266 |
Miscellaneous databases
Pharosi | Q6GTX8, Tbio |
Polymorphism and mutation databases
BioMutai | LAIR1 |
DMDMi | 74736490 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000250682 | 22 – 287 | Leukocyte-associated immunoglobulin-like receptor 1Add BLAST | 266 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 49 ↔ 101 | 1 Publication | ||
Glycosylationi | 69 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Modified residuei | 251 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 281 | Phosphotyrosine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q6GTX8 |
jPOSTi | Q6GTX8 |
MassIVEi | Q6GTX8 |
MaxQBi | Q6GTX8 |
PaxDbi | Q6GTX8 |
PeptideAtlasi | Q6GTX8 |
PRIDEi | Q6GTX8 |
ProteomicsDBi | 66322 [Q6GTX8-1] 66323 [Q6GTX8-2] 66324 [Q6GTX8-3] 66325 [Q6GTX8-4] |
PTM databases
GlyConnecti | 1998, 10 N-Linked glycans (1 site) |
GlyGeni | Q6GTX8, 2 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q6GTX8 |
PhosphoSitePlusi | Q6GTX8 |
SwissPalmi | Q6GTX8 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSG00000167613, Expressed in granulocyte and 182 other tissues |
ExpressionAtlasi | Q6GTX8, baseline and differential |
Genevisiblei | Q6GTX8, HS |
Organism-specific databases
HPAi | ENSG00000167613, Tissue enhanced (lymphoid) |
Interactioni
Subunit structurei
Interacts with SH2 domains of tyrosine-protein phosphatases PTPN6 and PTPN11. The interaction with PTPN6 is constitutive.
Interacts with the SH2 domain of CSK. Binds with high affinity to extracellular matrix collagens, the interaction is functionally important.
5 PublicationsBinary interactionsi
Q6GTX8
With | #Exp. | IntAct |
---|---|---|
PTPN6 [P29350] | 5 | EBI-965864,EBI-78260 |
Protein-protein interaction databases
BioGRIDi | 110098, 4 interactors |
IntActi | Q6GTX8, 3 interactors |
MINTi | Q6GTX8 |
STRINGi | 9606.ENSP00000375622 |
Miscellaneous databases
RNActi | Q6GTX8, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q6GTX8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q6GTX8 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 29 – 117 | Ig-like C2-typeAdd BLAST | 89 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 249 – 254 | ITIM motif 1 | 6 | |
Motifi | 279 – 284 | ITIM motif 2 | 6 |
Domaini
Keywords - Domaini
Immunoglobulin domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502TBGD, Eukaryota |
HOGENOMi | CLU_021100_3_1_1 |
InParanoidi | Q6GTX8 |
OrthoDBi | 1481318at2759 |
PhylomeDBi | Q6GTX8 |
TreeFami | TF336644 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub |
Pfami | View protein in Pfam PF13895, Ig_2, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 17 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSPHPTALLG LVLCLAQTIH TQEEDLPRPS ISAEPGTVIP LGSHVTFVCR
60 70 80 90 100
GPVGVQTFRL ERESRSTYND TEDVSQASPS ESEARFRIDS VSEGNAGPYR
110 120 130 140 150
CIYYKPPKWS EQSDYLELLV KETSGGPDSP DTEPGSSAGP TQRPSDNSHN
160 170 180 190 200
EHAPASQGLK AEHLYILIGV SVVFLFCLLL LVLFCLHRQN QIKQGPPRSK
210 220 230 240 250
DEEQKPQQRP DLAVDVLERT ADKATVNGLP EKDRETDTSA LAAGSSQEVT
260 270 280
YAQLDHWALT QRTARAVSPQ STKPMAESIT YAAVARH
Computationally mapped potential isoform sequencesi
There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3YTC8 | D3YTC8_HUMAN | Leukocyte-associated immunoglobulin... | LAIR1 | 286 | Annotation score: | ||
A8MZ84 | A8MZ84_HUMAN | Leukocyte-associated immunoglobulin... | LAIR1 | 269 | Annotation score: | ||
A0A0G2JP18 | A0A0G2JP18_HUMAN | Leukocyte-associated immunoglobulin... | LAIR1 | 286 | Annotation score: | ||
A0A0G2JQ50 | A0A0G2JQ50_HUMAN | Leukocyte-associated immunoglobulin... | LAIR1 | 286 | Annotation score: | ||
A0A0G2JLV7 | A0A0G2JLV7_HUMAN | Leukocyte-associated immunoglobulin... | LAIR1 | 287 | Annotation score: | ||
A0A0G2JMI0 | A0A0G2JMI0_HUMAN | Leukocyte-associated immunoglobulin... | LAIR1 | 269 | Annotation score: | ||
A0A0G2JNU6 | A0A0G2JNU6_HUMAN | Leukocyte-associated immunoglobulin... | LAIR1 | 276 | Annotation score: | ||
A0A140T8W3 | A0A140T8W3_HUMAN | Leukocyte-associated immunoglobulin... | LAIR1 | 280 | Annotation score: | ||
A0A0G2JNK8 | A0A0G2JNK8_HUMAN | Leukocyte-associated immunoglobulin... | LAIR1 | 269 | Annotation score: | ||
F8WC07 | F8WC07_HUMAN | Leukocyte-associated immunoglobulin... | LAIR1 | 153 | Annotation score: | ||
There are more potential isoformsShow all |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_027598 | 63 | E → D. Corresponds to variant dbSNP:rs3745442Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_020710 | 23 | Missing in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_020711 | 122 – 138 | Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 17 | |
Alternative sequenceiVSP_020712 | 210 – 287 | Missing in isoform 4. 1 PublicationAdd BLAST | 78 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF013249 mRNA Translation: AAB69324.1 AF109683 mRNA Translation: AAF17107.1 AF251509 mRNA Translation: AAF71274.2 AF251510 mRNA Translation: AAF71275.2 CR542051 mRNA Translation: CAG46848.1 BC027899 mRNA Translation: AAH27899.1 |
CCDSi | CCDS12891.1 [Q6GTX8-1] CCDS12892.1 [Q6GTX8-2] CCDS74448.1 [Q6GTX8-3] |
RefSeqi | NP_001275952.2, NM_001289023.2 NP_001275954.2, NM_001289025.2 NP_002278.2, NM_002287.5 NP_068352.2, NM_021706.4 |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF013249 mRNA Translation: AAB69324.1 AF109683 mRNA Translation: AAF17107.1 AF251509 mRNA Translation: AAF71274.2 AF251510 mRNA Translation: AAF71275.2 CR542051 mRNA Translation: CAG46848.1 BC027899 mRNA Translation: AAH27899.1 |
CCDSi | CCDS12891.1 [Q6GTX8-1] CCDS12892.1 [Q6GTX8-2] CCDS74448.1 [Q6GTX8-3] |
RefSeqi | NP_001275952.2, NM_001289023.2 NP_001275954.2, NM_001289025.2 NP_002278.2, NM_002287.5 NP_068352.2, NM_021706.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3KGR | X-ray | 1.80 | A/B/C | 22-122 | [»] | |
3RP1 | X-ray | 2.60 | A/B/C/D | 22-123 | [»] | |
SMRi | Q6GTX8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110098, 4 interactors |
IntActi | Q6GTX8, 3 interactors |
MINTi | Q6GTX8 |
STRINGi | 9606.ENSP00000375622 |
PTM databases
GlyConnecti | 1998, 10 N-Linked glycans (1 site) |
GlyGeni | Q6GTX8, 2 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q6GTX8 |
PhosphoSitePlusi | Q6GTX8 |
SwissPalmi | Q6GTX8 |
Polymorphism and mutation databases
BioMutai | LAIR1 |
DMDMi | 74736490 |
Proteomic databases
EPDi | Q6GTX8 |
jPOSTi | Q6GTX8 |
MassIVEi | Q6GTX8 |
MaxQBi | Q6GTX8 |
PaxDbi | Q6GTX8 |
PeptideAtlasi | Q6GTX8 |
PRIDEi | Q6GTX8 |
ProteomicsDBi | 66322 [Q6GTX8-1] 66323 [Q6GTX8-2] 66324 [Q6GTX8-3] 66325 [Q6GTX8-4] |
Protocols and materials databases
ABCDi | Q6GTX8, 22 sequenced antibodies |
Antibodypediai | 2596, 765 antibodies |
DNASUi | 3903 |
Genome annotation databases
Organism-specific databases
CTDi | 3903 |
DisGeNETi | 3903 |
EuPathDBi | HostDB:ENSG00000167613.15 |
GeneCardsi | LAIR1 |
HGNCi | HGNC:6477, LAIR1 |
HPAi | ENSG00000167613, Tissue enhanced (lymphoid) |
MIMi | 602992, gene |
neXtProti | NX_Q6GTX8 |
PharmGKBi | PA30266 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502TBGD, Eukaryota |
HOGENOMi | CLU_021100_3_1_1 |
InParanoidi | Q6GTX8 |
OrthoDBi | 1481318at2759 |
PhylomeDBi | Q6GTX8 |
TreeFami | TF336644 |
Enzyme and pathway databases
PathwayCommonsi | Q6GTX8 |
Reactomei | R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 3903, 18 hits in 839 CRISPR screens |
ChiTaRSi | LAIR1, human |
EvolutionaryTracei | Q6GTX8 |
GeneWikii | LAIR1 |
GenomeRNAii | 3903 |
Pharosi | Q6GTX8, Tbio |
PROi | PR:Q6GTX8 |
RNActi | Q6GTX8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000167613, Expressed in granulocyte and 182 other tissues |
ExpressionAtlasi | Q6GTX8, baseline and differential |
Genevisiblei | Q6GTX8, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub |
Pfami | View protein in Pfam PF13895, Ig_2, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LAIR1_HUMAN | |
Accessioni | Q6GTX8Primary (citable) accession number: Q6GTX8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2006 |
Last sequence update: | July 19, 2004 | |
Last modified: | December 2, 2020 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries