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UniProtKB - Q6GRK0 (Q6GRK0_HUMAN)
Protein
Cytochrome P450 3A
Gene
CYP3A4
Organism
Homo sapiens (Human)
Status
Functioni
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
UniRule annotationCatalytic activityi
- an organic molecule + O2 + reduced [NADPH—hemoprotein reductase] = an alcohol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]UniRule annotationEC:1.14.14.1UniRule annotation
Cofactori
hemeUniRule annotationARBA annotation
GO - Molecular functioni
- aromatase activity Source: RHEA
- heme binding Source: UniProtKB-UniRule
- iron ion binding Source: UniProtKB-UniRule
Keywordsi
Molecular function | MonooxygenaseUniRule annotation, Oxidoreductase |
Ligand | HemeUniRule annotationARBA annotation, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CYP3A4Imported ORF Names:hCG_17094Imported, tcag7.603Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000160868 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane UniRule annotation
- Microsome membrane UniRule annotation
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 219 – 241 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomeUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000160868, Expressed in jejunal mucosa and 174 other tissues |
Structurei
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
OMAi | TCLEYRK |
OrthoDBi | 467733at2759 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR008072, Cyt_P450_E_CYP3A IPR002402, Cyt_P450_E_grp-II IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00464, EP450II PR01689, EP450IICYP3A PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6GRK0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALIPDLAME TWLLLAVSLV LLYLYGTHSH GLFKKLGIPG PTPLPFLGNI
60 70 80 90 100
LSYHKGFCMF DMECHKKYGK VWGFYDGQQP VLAITDPDMI KTVLVKECYS
110 120 130 140 150
VFTNRRPFGP VGFMKSAISI AEDEEWKRLR SLLSPTFTSG KLKEMVPIIA
160 170 180 190 200
QYGDVLVRNL RREAETGKPV TLKDVFGAYS MDVITSTSFG VNIDSLNNPQ
210 220 230 240 250
DPFVENTKKL LRFDFLDPFF LSITVFPFLI PILEVLNICV FPREVTNFLR
260 270 280 290 300
KSVKRMKESR LEDTQKHRVD FLQLMIDSQN SKETESHKAL SDLELVAQSI
310 320 330 340 350
IFIFAGYETT SSVLSFIMYE LATHPDVQQK LQEEIDAVLP NKAPPTYDTV
360 370 380 390 400
LQMEYLDMVV NETLRLFPIA MRLERVCKKD VEINGMFIPK GVVVMIPSYA
410 420 430 440 450
LHRDPKYWTE PEKFLPERFS KKNKDNIDPY IYTPFGSGPR NCIGMRFALM
460 470 480 490 500
NMKLALIRVL QNFSFKPCKE TQIPLKLSLG GLLQPEKPVV LKVESRDGTV
SGA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC069418 mRNA Translation: AAH69418.1 BC101631 mRNA Translation: AAI01632.1 DQ005611 Genomic DNA Translation: AAY16980.1 DQ924960 mRNA Translation: ABI96208.1 AK312967 mRNA Translation: BAG35806.1 CH236956 Genomic DNA Translation: EAL23866.1 CH471091 Genomic DNA Translation: EAW76635.1 |
RefSeqi | NP_001189784.1, NM_001202855.2 NP_059488.2, NM_017460.5 |
Genome annotation databases
GeneIDi | 1576 |
KEGGi | hsa:1576 |
MANE-Selecti | ENST00000651514.1; ENSP00000498939.1; NM_017460.6; NP_059488.2 |
UCSCi | uc003urv.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC069418 mRNA Translation: AAH69418.1 BC101631 mRNA Translation: AAI01632.1 DQ005611 Genomic DNA Translation: AAY16980.1 DQ924960 mRNA Translation: ABI96208.1 AK312967 mRNA Translation: BAG35806.1 CH236956 Genomic DNA Translation: EAL23866.1 CH471091 Genomic DNA Translation: EAW76635.1 |
RefSeqi | NP_001189784.1, NM_001202855.2 NP_059488.2, NM_017460.5 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 16254, 637 antibodies from 39 providers |
DNASUi | 1576 |
Genome annotation databases
GeneIDi | 1576 |
KEGGi | hsa:1576 |
MANE-Selecti | ENST00000651514.1; ENSP00000498939.1; NM_017460.6; NP_059488.2 |
UCSCi | uc003urv.3, human |
Organism-specific databases
CTDi | 1576 |
PharmGKBi | PA130 |
VEuPathDBi | HostDB:ENSG00000160868 |
Phylogenomic databases
OMAi | TCLEYRK |
OrthoDBi | 467733at2759 |
Miscellaneous databases
BioGRID-ORCSi | 1576, 6 hits in 998 CRISPR screens |
ChiTaRSi | CYP3A4, human |
GenomeRNAii | 1576 |
Gene expression databases
Bgeei | ENSG00000160868, Expressed in jejunal mucosa and 174 other tissues |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR008072, Cyt_P450_E_CYP3A IPR002402, Cyt_P450_E_grp-II IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00464, EP450II PR01689, EP450IICYP3A PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6GRK0_HUMAN | |
Accessioni | Q6GRK0Primary (citable) accession number: Q6GRK0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | May 25, 2022 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |