App

Functionⁱ

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functionⁱ

enzyme binding Source: Ensembl
growth factor receptor binding Source: Ensembl
heparin binding Source: InterPro
identical protein binding Source: Ensembl
peptidase activator activity Source: Ensembl
PTB domain binding Source: Ensembl
serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
transition metal ion binding Source: InterPro

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

amyloid fibril formation Source: Ensembl
astrocyte activation involved in immune response Source: Ensembl
cellular response to amyloid-beta Source: Ensembl
cellular response to cAMP Source: Ensembl
cellular response to copper ion Source: Ensembl
cellular response to manganese ion Source: Ensembl
cellular response to nerve growth factor stimulus Source: Ensembl
cellular response to norepinephrine stimulus Source: Ensembl
endocytosis Source: UniProtKB-KW
learning Source: Ensembl
microglia development Source: Ensembl
microglial cell activation Source: Ensembl
modulation of age-related behavioral decline Source: Ensembl
modulation of excitatory postsynaptic potential Source: Ensembl
negative regulation of cell population proliferation Source: Ensembl
negative regulation of gene expression Source: Ensembl
negative regulation of long-term synaptic potentiation Source: Ensembl
neuron apoptotic process Source: Ensembl
neuron projection maintenance Source: Ensembl
positive regulation of amyloid-beta formation Source: Ensembl
positive regulation of amyloid fibril formation Source: Ensembl
positive regulation of chemokine biosynthetic process Source: Ensembl
positive regulation of ERK1 and ERK2 cascade Source: Ensembl
positive regulation of glycolytic process Source: Ensembl
positive regulation of interleukin-1 beta production Source: Ensembl
positive regulation of interleukin-6 production Source: Ensembl
positive regulation of JNK cascade Source: Ensembl
positive regulation of long-term synaptic potentiation Source: Ensembl
positive regulation of NF-kappaB transcription factor activity Source: Ensembl
positive regulation of NIK/NF-kappaB signaling Source: Ensembl
positive regulation of peptidyl-serine phosphorylation Source: Ensembl
positive regulation of peptidyl-threonine phosphorylation Source: Ensembl
positive regulation of protein binding Source: Ensembl
positive regulation of T cell migration Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: Ensembl
positive regulation of tumor necrosis factor biosynthetic process Source: Ensembl
regulation of long-term neuronal synaptic plasticity Source: Ensembl
regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
regulation of presynapse assembly Source: Ensembl
regulation of spontaneous synaptic transmission Source: Ensembl
response to interleukin-1 Source: Ensembl
response to lead ion Source: Ensembl
response to radiation Source: Ensembl
synapse organization Source: Ensembl
tumor necrosis factor production Source: Ensembl

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Protease inhibitor, Serine protease inhibitorARBA annotation
Biological process	EndocytosisARBA annotation
Ligand	CopperARBA annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: ABPPARBA annotation Alternative name(s): Amyloid precursor proteinARBA annotation Amyloid-beta A4 proteinARBA annotation Amyloid-beta precursor proteinARBA annotation Amyloid-beta protein 40ARBA annotation Amyloid-beta protein 42ARBA annotation Beta-APP40ARBA annotation Beta-APP42ARBA annotation Gamma-CTF(57)ARBA annotation Gamma-CTF(59)ARBA annotation Gamma-secretase C-terminal fragment 57ARBA annotation Gamma-secretase C-terminal fragment 59ARBA annotation Soluble APP-betaARBA annotation
Gene namesⁱ	Name:AppImported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:88059, App

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	626 – 648	HelicalSequence analysisAdd BLAST		23

Keywords - Cellular componentⁱ

Coated pitARBA annotation, Cytoplasmic vesicleARBA annotation, EndosomeARBA annotation, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 17	Sequence analysisAdd BLAST		17
ChainⁱPRO_5014310460	18 – 695	ABPPSequence analysisAdd BLAST		678

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	73 ↔ 117	PROSITE-ProRule annotation
Disulfide bondⁱ	98 ↔ 105	PROSITE-ProRule annotation
Disulfide bondⁱ	133 ↔ 187	PROSITE-ProRule annotation
Disulfide bondⁱ	144 ↔ 174	PROSITE-ProRule annotation
Disulfide bondⁱ	158 ↔ 186	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6GR78

MaxQBⁱ

Q6GR78

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000022892, Expressed in cingulate cortex and 349 other tissues

Bgeeⁱ

ENSMUSG00000022892, Expressed in cingulate cortex and 349 other tissues

Interactionⁱ

GO - Molecular functionⁱ

enzyme binding Source: Ensembl
growth factor receptor binding Source: Ensembl
identical protein binding Source: Ensembl
PTB domain binding Source: Ensembl

Complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

SMRⁱ	Q6GR78
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	28 – 189	E1InterPro annotationAdd BLAST		162
Domainⁱ	299 – 490	E2InterPro annotationAdd BLAST		192

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	28 – 123	GFLD subdomainPROSITE-ProRule annotationAdd BLAST	96
Regionⁱ	131 – 189	CuBD subdomainPROSITE-ProRule annotationAdd BLAST	59
Regionⁱ	193 – 313	DisorderedSequence analysisAdd BLAST	121

Coiled coil

Feature key	Position(s)	DescriptionActions	Length
Coiled coilⁱ	324 – 344	Sequence analysisAdd BLAST	21
Coiled coilⁱ	350 – 384	Sequence analysisAdd BLAST	35
Coiled coilⁱ	480 – 500	Sequence analysisAdd BLAST	21

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	195 – 210	AcidicSequence analysisAdd BLAST	16
Compositional biasⁱ	225 – 263	AcidicSequence analysisAdd BLAST	39
Compositional biasⁱ	267 – 286	PolarSequence analysisAdd BLAST	20

Sequence similaritiesⁱ

Belongs to the APP family.PROSITE-ProRule annotationARBA annotation

Keywords - Domainⁱ

Coiled coilSequence analysis, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

HOGENOMⁱ	CLU_014607_2_1_1
Database of Orthologous Groups More...OrthoDBⁱ	953529at2759

Family and domain databases

Gene3Dⁱ	1.20.120.770, 1 hit 2.30.29.30, 1 hit 3.30.1490.140, 1 hit 3.90.570.10, 1 hit 4.10.230.10, 1 hit
InterProⁱ	View protein in InterPro IPR036669, Amyloid_Cu-bd_sf IPR008155, Amyloid_glyco IPR013803, Amyloid_glyco_Abeta IPR037071, Amyloid_glyco_Abeta_sf IPR011178, Amyloid_glyco_Cu-bd IPR024329, Amyloid_glyco_E2_domain IPR008154, Amyloid_glyco_extra IPR015849, Amyloid_glyco_heparin-bd IPR036454, Amyloid_glyco_heparin-bd_sf IPR019745, Amyloid_glyco_intracell_CS IPR028866, APP IPR019543, APP_amyloid_C IPR019744, APP_CUBD_CS IPR036176, E2_sf IPR011993, PH-like_dom_sf
PANTHERⁱ	PTHR23103, PTHR23103, 2 hits PTHR23103:SF7, PTHR23103:SF7, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10515, APP_amyloid, 1 hit PF12924, APP_Cu_bd, 1 hit PF12925, APP_E2, 1 hit PF02177, APP_N, 1 hit PF03494, Beta-APP, 1 hit
PRINTSⁱ	PR00203, AMYLOIDA4 PR00204, BETAAMYLOID
SMARTⁱ	View protein in SMART SM00006, A4_EXTRA, 1 hit
SUPFAMⁱ	SSF109843, SSF109843, 1 hit SSF56491, SSF56491, 1 hit SSF89811, SSF89811, 1 hit
PROSITEⁱ	View protein in PROSITE PS00319, APP_CUBD, 1 hit PS51869, APP_E1, 1 hit PS51870, APP_E2, 1 hit PS00320, APP_INTRA, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6GR78-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLPSLALLLL AAWTVRALEV PTDGNAGLLA EPQIAMFCGK LNMHMNVQNG 
        60         70         80         90        100
KWESDPSGTK TCIGTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR 
       110        120        130        140        150
GRKQCKTHTH IVIPYRCLVG EFVSDALLVP DKCKFLHQER MDVCETHLHW 
       160        170        180        190        200
HTVAKETCSE KSTNLHDYGM LLPCGIDKFR GVEFVCCPLA EESDSVDSAD 
       210        220        230        240        250
AEEDDSDVWW GGADTDYADG GEDKVVEVAE EEEVADVEEE EADDDEDVED 
       260        270        280        290        300
GDEVEEEAEE PYEEATERTT STATTTTTTT ESVEEVVRVP TTAASTPDAV 
       310        320        330        340        350
DKYLETPGDE NEHAHFQKAK ERLEAKHRER MSQVMREWEE AERQAKNLPK 
       360        370        380        390        400
ADKKAVIQHF QEKVESLEQE AANERQQLVE THMARVEAML NDRRRLALEN 
       410        420        430        440        450
YITALQAVPP RPHHVFNMLK KYVRAEQKDR QHTLKHFEHV RMVDPKKAAQ 
       460        470        480        490        500
IRSQVMTHLR VIYERMNQSL SLLYNVPAVA EEIQDEVDEL LQKEQNYSDD 
       510        520        530        540        550
VLANMISEPR ISYGNDALMP SLTETKTTVE LLPVNGEFSL DDLQPWHPFG 
       560        570        580        590        600
VDSVPANTEN EVEPVDARPA ADRGLTTRPG SGLTNIKTEE ISEVKMDAEF 
       610        620        630        640        650
GHDSGFEVRH QKLVFFAEDV GSNKGAIIGL MVGGVVIATV IVITLVMLKK 
       660        670        680        690 
KQYTSIHHGV VEVDAAVTPE ERHLSKMQQN GYENPTYKFF EQMQN

Length:695

Mass (Da):78,443

Last modified:May 10, 2005 - v1

Checksum:ⁱ0DE93FA56FB20F3A

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC070409 mRNA Translation: AAH70409.1 AK147543 mRNA Translation: BAE27986.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001185752.1, NM_001198823.1 NP_001185753.1, NM_001198824.1 NP_001185754.1, NM_001198825.1 NP_001185755.1, NM_001198826.1 NP_031497.2, NM_007471.3

Genome annotation databases

GeneIDⁱ	11820
KEGGⁱ	mmu:11820
UCSC genome browser More...UCSCⁱ	uc007zto.2, mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6GR78	Isoform APP695 of Amyloid-beta precursor protein		HUMAN		695	UniRef90_P05067-4
ABPP		MACMU		695
ABPP		RHIRO		695
ABPP		PONAB		695
ABPP		PANTR		695
+123

Protein	Similar proteins		Species	Score	Length	Source
Q6GR78	Amyloid-beta precursor protein	)	HUMAN		770	UniRef50_P05067
Amyloid-beta A4 protein	)	MOUSE		770
Amyloid-beta A4 protein		PANTR		770
Amyloid-beta A4 protein	)	RAT		770
Amyloid-beta A4 protein		PIG		770
+1270

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC070409 mRNA Translation: AAH70409.1 AK147543 mRNA Translation: BAE27986.1
RefSeqⁱ	NP_001185752.1, NM_001198823.1 NP_001185753.1, NM_001198824.1 NP_001185754.1, NM_001198825.1 NP_001185755.1, NM_001198826.1 NP_031497.2, NM_007471.3

3D structure databases

SMRⁱ	Q6GR78
ModBaseⁱ	Search...

Proteomic databases

MaxQBⁱ	Q6GR78

MaxQBⁱ

Q6GR78

Protocols and materials databases

Antibodypediaⁱ	668, 4007 antibodies

Antibodypediaⁱ

668, 4007 antibodies

Genome annotation databases

GeneIDⁱ	11820
KEGGⁱ	mmu:11820
UCSCⁱ	uc007zto.2, mouse

Organism-specific databases

CTDⁱ	351
MGIⁱ	MGI:88059, App

Phylogenomic databases

HOGENOMⁱ	CLU_014607_2_1_1
OrthoDBⁱ	953529at2759

Miscellaneous databases

BioGRID-ORCSⁱ	11820, 0 hits in 17 CRISPR screens
ChiTaRSⁱ	App, mouse
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000022892, Expressed in cingulate cortex and 349 other tissues

Bgeeⁱ

ENSMUSG00000022892, Expressed in cingulate cortex and 349 other tissues

Family and domain databases

Gene3Dⁱ	1.20.120.770, 1 hit 2.30.29.30, 1 hit 3.30.1490.140, 1 hit 3.90.570.10, 1 hit 4.10.230.10, 1 hit
InterProⁱ	View protein in InterPro IPR036669, Amyloid_Cu-bd_sf IPR008155, Amyloid_glyco IPR013803, Amyloid_glyco_Abeta IPR037071, Amyloid_glyco_Abeta_sf IPR011178, Amyloid_glyco_Cu-bd IPR024329, Amyloid_glyco_E2_domain IPR008154, Amyloid_glyco_extra IPR015849, Amyloid_glyco_heparin-bd IPR036454, Amyloid_glyco_heparin-bd_sf IPR019745, Amyloid_glyco_intracell_CS IPR028866, APP IPR019543, APP_amyloid_C IPR019744, APP_CUBD_CS IPR036176, E2_sf IPR011993, PH-like_dom_sf
PANTHERⁱ	PTHR23103, PTHR23103, 2 hits PTHR23103:SF7, PTHR23103:SF7, 2 hits
Pfamⁱ	View protein in Pfam PF10515, APP_amyloid, 1 hit PF12924, APP_Cu_bd, 1 hit PF12925, APP_E2, 1 hit PF02177, APP_N, 1 hit PF03494, Beta-APP, 1 hit
PRINTSⁱ	PR00203, AMYLOIDA4 PR00204, BETAAMYLOID
SMARTⁱ	View protein in SMART SM00006, A4_EXTRA, 1 hit
SUPFAMⁱ	SSF109843, SSF109843, 1 hit SSF56491, SSF56491, 1 hit SSF89811, SSF89811, 1 hit
PROSITEⁱ	View protein in PROSITE PS00319, APP_CUBD, 1 hit PS51869, APP_E1, 1 hit PS51870, APP_E2, 1 hit PS00320, APP_INTRA, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q6GR78_MOUSE
Accessionⁱ	Q6GR78Primary (citable) accession number: Q6GR78
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	May 10, 2005
	Last sequence update:	May 10, 2005
	Last modified:	December 2, 2020
	This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

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UniProtKB - Q6GR78 (Q6GR78_MOUSE)

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ABPP

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Plasma membrane

Other locations

Endoplasmic reticulum

Endosome

Extracellular region or secreted

Golgi apparatus

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ