UniProtKB - Q6GR78 (Q6GR78_MOUSE)
Protein
ABPP
Gene
App
Organism
Mus musculus (Mouse)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- enzyme binding Source: Ensembl
- growth factor receptor binding Source: Ensembl
- heparin binding Source: InterPro
- identical protein binding Source: Ensembl
- peptidase activator activity Source: Ensembl
- PTB domain binding Source: Ensembl
- serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
- transition metal ion binding Source: InterPro
GO - Biological processi
- amyloid fibril formation Source: Ensembl
- astrocyte activation involved in immune response Source: Ensembl
- cellular response to amyloid-beta Source: Ensembl
- cellular response to cAMP Source: Ensembl
- cellular response to copper ion Source: Ensembl
- cellular response to manganese ion Source: Ensembl
- cellular response to nerve growth factor stimulus Source: Ensembl
- cellular response to norepinephrine stimulus Source: Ensembl
- endocytosis Source: UniProtKB-KW
- learning Source: Ensembl
- microglia development Source: Ensembl
- microglial cell activation Source: Ensembl
- modulation of age-related behavioral decline Source: Ensembl
- modulation of excitatory postsynaptic potential Source: Ensembl
- negative regulation of cell population proliferation Source: Ensembl
- negative regulation of gene expression Source: Ensembl
- negative regulation of long-term synaptic potentiation Source: Ensembl
- neuron apoptotic process Source: Ensembl
- neuron projection maintenance Source: Ensembl
- positive regulation of amyloid-beta formation Source: Ensembl
- positive regulation of amyloid fibril formation Source: Ensembl
- positive regulation of chemokine biosynthetic process Source: Ensembl
- positive regulation of ERK1 and ERK2 cascade Source: Ensembl
- positive regulation of glycolytic process Source: Ensembl
- positive regulation of interleukin-1 beta production Source: Ensembl
- positive regulation of interleukin-6 production Source: Ensembl
- positive regulation of JNK cascade Source: Ensembl
- positive regulation of long-term synaptic potentiation Source: Ensembl
- positive regulation of NF-kappaB transcription factor activity Source: Ensembl
- positive regulation of NIK/NF-kappaB signaling Source: Ensembl
- positive regulation of peptidyl-serine phosphorylation Source: Ensembl
- positive regulation of peptidyl-threonine phosphorylation Source: Ensembl
- positive regulation of protein binding Source: Ensembl
- positive regulation of T cell migration Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- positive regulation of tumor necrosis factor biosynthetic process Source: Ensembl
- regulation of long-term neuronal synaptic plasticity Source: Ensembl
- regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
- regulation of presynapse assembly Source: Ensembl
- regulation of spontaneous synaptic transmission Source: Ensembl
- response to interleukin-1 Source: Ensembl
- response to lead ion Source: Ensembl
- response to radiation Source: Ensembl
- synapse organization Source: Ensembl
- tumor necrosis factor production Source: Ensembl
Keywordsi
Molecular function | Protease inhibitor, Serine protease inhibitorARBA annotation |
Biological process | EndocytosisARBA annotation |
Ligand | CopperARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: ABPPARBA annotationAlternative name(s): Amyloid precursor proteinARBA annotation Amyloid-beta A4 proteinARBA annotation Amyloid-beta precursor proteinARBA annotation Amyloid-beta protein 40ARBA annotation Amyloid-beta protein 42ARBA annotation Beta-APP40ARBA annotation Beta-APP42ARBA annotation Gamma-CTF(57)ARBA annotation Gamma-CTF(59)ARBA annotation Gamma-secretase C-terminal fragment 57ARBA annotation Gamma-secretase C-terminal fragment 59ARBA annotation Soluble APP-betaARBA annotation |
Gene namesi | Name:AppImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:88059, App |
Subcellular locationi
Endosome
- Early endosome ARBA annotation
- Endosome ARBA annotation
Plasma membrane
- Cell membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Other locations
- growth cone ARBA annotation
- Cell surface ARBA annotation
- Cytoplasmic vesicle ARBA annotation
- clathrin-coated pit ARBA annotation
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
- Perikaryon ARBA annotation
- Vesicle ARBA annotation
Endoplasmic reticulum
- rough endoplasmic reticulum Source: Ensembl
Endosome
- early endosome Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular space Source: Ensembl
Golgi apparatus
- Golgi apparatus Source: Ensembl
Nucleus
- nuclear envelope lumen Source: Ensembl
Plasma Membrane
- clathrin-coated pit Source: UniProtKB-SubCell
Other locations
- astrocyte projection Source: Ensembl
- cell surface Source: UniProtKB-SubCell
- dendritic shaft Source: Ensembl
- dendritic spine Source: Ensembl
- growth cone filopodium Source: Ensembl
- growth cone lamellipodium Source: Ensembl
- integral component of membrane Source: UniProtKB-KW
- main axon Source: Ensembl
- membrane raft Source: Ensembl
- perikaryon Source: UniProtKB-SubCell
- perinuclear region of cytoplasm Source: Ensembl
- receptor complex Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 626 – 648 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
Coated pitARBA annotation, Cytoplasmic vesicleARBA annotation, EndosomeARBA annotation, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_5014310460 | 18 – 695 | ABPPSequence analysisAdd BLAST | 678 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 73 ↔ 117 | PROSITE-ProRule annotation | ||
Disulfide bondi | 98 ↔ 105 | PROSITE-ProRule annotation | ||
Disulfide bondi | 133 ↔ 187 | PROSITE-ProRule annotation | ||
Disulfide bondi | 144 ↔ 174 | PROSITE-ProRule annotation | ||
Disulfide bondi | 158 ↔ 186 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotationProteomic databases
MaxQBi | Q6GR78 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000022892, Expressed in cingulate cortex and 349 other tissues |
Interactioni
GO - Molecular functioni
- enzyme binding Source: Ensembl
- growth factor receptor binding Source: Ensembl
- identical protein binding Source: Ensembl
- PTB domain binding Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 189 | E1InterPro annotationAdd BLAST | 162 | |
Domaini | 299 – 490 | E2InterPro annotationAdd BLAST | 192 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 28 – 123 | GFLD subdomainPROSITE-ProRule annotationAdd BLAST | 96 | |
Regioni | 131 – 189 | CuBD subdomainPROSITE-ProRule annotationAdd BLAST | 59 | |
Regioni | 193 – 313 | DisorderedSequence analysisAdd BLAST | 121 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 324 – 344 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 350 – 384 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 480 – 500 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 195 – 210 | AcidicSequence analysisAdd BLAST | 16 | |
Compositional biasi | 225 – 263 | AcidicSequence analysisAdd BLAST | 39 | |
Compositional biasi | 267 – 286 | PolarSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysis, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
HOGENOMi | CLU_014607_2_1_1 |
OrthoDBi | 953529at2759 |
Family and domain databases
Gene3Di | 1.20.120.770, 1 hit 2.30.29.30, 1 hit 3.30.1490.140, 1 hit 3.90.570.10, 1 hit 4.10.230.10, 1 hit |
InterProi | View protein in InterPro IPR036669, Amyloid_Cu-bd_sf IPR008155, Amyloid_glyco IPR013803, Amyloid_glyco_Abeta IPR037071, Amyloid_glyco_Abeta_sf IPR011178, Amyloid_glyco_Cu-bd IPR024329, Amyloid_glyco_E2_domain IPR008154, Amyloid_glyco_extra IPR015849, Amyloid_glyco_heparin-bd IPR036454, Amyloid_glyco_heparin-bd_sf IPR019745, Amyloid_glyco_intracell_CS IPR028866, APP IPR019543, APP_amyloid_C IPR019744, APP_CUBD_CS IPR036176, E2_sf IPR011993, PH-like_dom_sf |
PANTHERi | PTHR23103, PTHR23103, 2 hits PTHR23103:SF7, PTHR23103:SF7, 2 hits |
Pfami | View protein in Pfam PF10515, APP_amyloid, 1 hit PF12924, APP_Cu_bd, 1 hit PF12925, APP_E2, 1 hit PF02177, APP_N, 1 hit PF03494, Beta-APP, 1 hit |
PRINTSi | PR00203, AMYLOIDA4 PR00204, BETAAMYLOID |
SMARTi | View protein in SMART SM00006, A4_EXTRA, 1 hit |
SUPFAMi | SSF109843, SSF109843, 1 hit SSF56491, SSF56491, 1 hit SSF89811, SSF89811, 1 hit |
PROSITEi | View protein in PROSITE PS00319, APP_CUBD, 1 hit PS51869, APP_E1, 1 hit PS51870, APP_E2, 1 hit PS00320, APP_INTRA, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6GR78-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLPSLALLLL AAWTVRALEV PTDGNAGLLA EPQIAMFCGK LNMHMNVQNG
60 70 80 90 100
KWESDPSGTK TCIGTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR
110 120 130 140 150
GRKQCKTHTH IVIPYRCLVG EFVSDALLVP DKCKFLHQER MDVCETHLHW
160 170 180 190 200
HTVAKETCSE KSTNLHDYGM LLPCGIDKFR GVEFVCCPLA EESDSVDSAD
210 220 230 240 250
AEEDDSDVWW GGADTDYADG GEDKVVEVAE EEEVADVEEE EADDDEDVED
260 270 280 290 300
GDEVEEEAEE PYEEATERTT STATTTTTTT ESVEEVVRVP TTAASTPDAV
310 320 330 340 350
DKYLETPGDE NEHAHFQKAK ERLEAKHRER MSQVMREWEE AERQAKNLPK
360 370 380 390 400
ADKKAVIQHF QEKVESLEQE AANERQQLVE THMARVEAML NDRRRLALEN
410 420 430 440 450
YITALQAVPP RPHHVFNMLK KYVRAEQKDR QHTLKHFEHV RMVDPKKAAQ
460 470 480 490 500
IRSQVMTHLR VIYERMNQSL SLLYNVPAVA EEIQDEVDEL LQKEQNYSDD
510 520 530 540 550
VLANMISEPR ISYGNDALMP SLTETKTTVE LLPVNGEFSL DDLQPWHPFG
560 570 580 590 600
VDSVPANTEN EVEPVDARPA ADRGLTTRPG SGLTNIKTEE ISEVKMDAEF
610 620 630 640 650
GHDSGFEVRH QKLVFFAEDV GSNKGAIIGL MVGGVVIATV IVITLVMLKK
660 670 680 690
KQYTSIHHGV VEVDAAVTPE ERHLSKMQQN GYENPTYKFF EQMQN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC070409 mRNA Translation: AAH70409.1 AK147543 mRNA Translation: BAE27986.1 |
RefSeqi | NP_001185752.1, NM_001198823.1 NP_001185753.1, NM_001198824.1 NP_001185754.1, NM_001198825.1 NP_001185755.1, NM_001198826.1 NP_031497.2, NM_007471.3 |
Genome annotation databases
GeneIDi | 11820 |
KEGGi | mmu:11820 |
UCSCi | uc007zto.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC070409 mRNA Translation: AAH70409.1 AK147543 mRNA Translation: BAE27986.1 |
RefSeqi | NP_001185752.1, NM_001198823.1 NP_001185753.1, NM_001198824.1 NP_001185754.1, NM_001198825.1 NP_001185755.1, NM_001198826.1 NP_031497.2, NM_007471.3 |
3D structure databases
SMRi | Q6GR78 |
ModBasei | Search... |
Proteomic databases
MaxQBi | Q6GR78 |
Protocols and materials databases
Antibodypediai | 668, 4007 antibodies |
Genome annotation databases
GeneIDi | 11820 |
KEGGi | mmu:11820 |
UCSCi | uc007zto.2, mouse |
Organism-specific databases
CTDi | 351 |
MGIi | MGI:88059, App |
Phylogenomic databases
HOGENOMi | CLU_014607_2_1_1 |
OrthoDBi | 953529at2759 |
Miscellaneous databases
BioGRID-ORCSi | 11820, 0 hits in 17 CRISPR screens |
ChiTaRSi | App, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022892, Expressed in cingulate cortex and 349 other tissues |
Family and domain databases
Gene3Di | 1.20.120.770, 1 hit 2.30.29.30, 1 hit 3.30.1490.140, 1 hit 3.90.570.10, 1 hit 4.10.230.10, 1 hit |
InterProi | View protein in InterPro IPR036669, Amyloid_Cu-bd_sf IPR008155, Amyloid_glyco IPR013803, Amyloid_glyco_Abeta IPR037071, Amyloid_glyco_Abeta_sf IPR011178, Amyloid_glyco_Cu-bd IPR024329, Amyloid_glyco_E2_domain IPR008154, Amyloid_glyco_extra IPR015849, Amyloid_glyco_heparin-bd IPR036454, Amyloid_glyco_heparin-bd_sf IPR019745, Amyloid_glyco_intracell_CS IPR028866, APP IPR019543, APP_amyloid_C IPR019744, APP_CUBD_CS IPR036176, E2_sf IPR011993, PH-like_dom_sf |
PANTHERi | PTHR23103, PTHR23103, 2 hits PTHR23103:SF7, PTHR23103:SF7, 2 hits |
Pfami | View protein in Pfam PF10515, APP_amyloid, 1 hit PF12924, APP_Cu_bd, 1 hit PF12925, APP_E2, 1 hit PF02177, APP_N, 1 hit PF03494, Beta-APP, 1 hit |
PRINTSi | PR00203, AMYLOIDA4 PR00204, BETAAMYLOID |
SMARTi | View protein in SMART SM00006, A4_EXTRA, 1 hit |
SUPFAMi | SSF109843, SSF109843, 1 hit SSF56491, SSF56491, 1 hit SSF89811, SSF89811, 1 hit |
PROSITEi | View protein in PROSITE PS00319, APP_CUBD, 1 hit PS51869, APP_E1, 1 hit PS51870, APP_E2, 1 hit PS00320, APP_INTRA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6GR78_MOUSE | |
Accessioni | Q6GR78Primary (citable) accession number: Q6GR78 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | December 2, 2020 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |