UniProtKB - Q6GQT9 (NOMO1_MOUSE)
Nodal modulator 1
Nomo1
Functioni
GO - Molecular functioni
- carbohydrate binding Source: InterPro
Names & Taxonomyi
Protein namesi | Recommended name: Nodal modulator 1Imported |
Gene namesi | Name:Nomo1Imported |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2385850, Nomo1 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Single-pass membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
- protein-containing complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 1150 | ExtracellularSequence analysisAdd BLAST | 1127 | |
Transmembranei | 1151 – 1167 | HelicalSequence analysisAdd BLAST | 17 | |
Topological domaini | 1168 – 1214 | CytoplasmicSequence analysisAdd BLAST | 47 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000396822 | 24 – 1214 | Nodal modulator 1Sequence analysisAdd BLAST | 1191 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 42 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 210 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 610 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 1196 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1197 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q6GQT9 |
jPOSTi | Q6GQT9 |
MaxQBi | Q6GQT9 |
PaxDbi | Q6GQT9 |
PeptideAtlasi | Q6GQT9 |
PRIDEi | Q6GQT9 |
ProteomicsDBi | 293701 |
PTM databases
GlyConnecti | 2564, 4 N-Linked glycans (3 sites) |
GlyGeni | Q6GQT9, 4 sites |
iPTMneti | Q6GQT9 |
PhosphoSitePlusi | Q6GQT9 |
SwissPalmi | Q6GQT9 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000030835, Expressed in tracheobronchial tree and 315 other tissues |
Genevisiblei | Q6GQT9, MM |
Interactioni
Subunit structurei
Forms a complex with NCLN/Nicalin and TMEM147, resulting in a stabilization of the 3 proteins, which are otherwise quickly degraded by the proteasome. The ribosome-associated ER translocon complex includes SEC61A1, SEC61B, SEC61G, TMCO1, CCDC47, NCLN/Nicalin, NOMO and TMEM147; in the absence of ribosomes, only the complex forms with NCLN/Nicalin, NOMO and TMEM147 remains intact. Due to the strong similarity between NOMO1, NOMO2 and NOMO3, similar interaction pattern probably occur for the three gene copies.
By similarityProtein-protein interaction databases
BioGRIDi | 229243, 6 interactors |
IntActi | Q6GQT9, 2 interactors |
MINTi | Q6GQT9 |
STRINGi | 10090.ENSMUSP00000033121 |
Miscellaneous databases
RNActi | Q6GQT9, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 692 – 720 | Sequence analysisAdd BLAST | 29 |
Keywords - Domaini
Coiled coil, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1948, Eukaryota |
GeneTreei | ENSGT00390000000089 |
HOGENOMi | CLU_007543_2_0_1 |
InParanoidi | Q6GQT9 |
OMAi | GWSFEPE |
OrthoDBi | 839381at2759 |
PhylomeDBi | Q6GQT9 |
TreeFami | TF313696 |
Family and domain databases
InterProi | View protein in InterPro IPR013784, Carb-bd-like_fold IPR008969, CarboxyPept-like_regulatory IPR041033, Prealbumin-like |
Pfami | View protein in Pfam PF17802, SpaA, 1 hit |
SUPFAMi | SSF49452, SSF49452, 3 hits SSF49464, SSF49464, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MRAGRCAAAL LLLLLSGAGR AIGSEDIVVG CGGFVKSDVE INYSLIEIKL
60 70 80 90 100
YTKHGTLKYQ TDCAPNNGYF MIPLYDKGDF ILKIEPPLGW SFEPTNVELR
110 120 130 140 150
VDGVSDICTK GGDINFLFTG FSVNGKVLSK GQPLGPAGVQ VSLRSTGADS
160 170 180 190 200
KIQSTVTQPG GKFAFFKVLP GDYEILATHP TWALKEASTT VRVTNSNANA
210 220 230 240 250
AGPLIVAGYN VSGSVRSDGE PMKGVKFLLF SSLVNKEDVL GCNVSPVSGF
260 270 280 290 300
QPPDESLVYL CYAVSKEDGS FSFYSLPSGG YTVVPFYRGE RITFDVAPSR
310 320 330 340 350
LDFTVEHDSL RIEPVFHVMG FSVTGRVLNG PDGEGVPEAV VTLNNQIKVK
360 370 380 390 400
TKADGSFRLE NITTGTYTIH AQKEHLYFEM VTIKIAPNTP QLADLIATGF
410 420 430 440 450
SICGQIAIVR SPDTIKQMSK YRVVLSSQDK DKALLTVDSD AHGSFCFKAK
460 470 480 490 500
PGAYKVQVVV PEAETRAGLM LKPQVFPLTV TNRPVMDVAF VQFLASVSGK
510 520 530 540 550
VSCLDTCGDL LVTLQSLSRQ GEKRSLQLSG KVNSMTFTFD KVLPGRYKIS
560 570 580 590 600
IMHEDWCWRN KSLEVEVLED DVSAVEFRQT GYMLRCALSH AITLEFHQDG
610 620 630 640 650
NGPENVGIYN LSRGVNRFCL SKPGVYKVTP RSCHRFEQAF YTYDTSSPSI
660 670 680 690 700
LTLTAIRHHV LGTIITDKMM DVTVTIKSSI DSEPALVLGP LKSAQELRRE
710 720 730 740 750
QQLAEIETRR QEREKNGKEE GEEGRARPPG QEMVDELQGP FSYDFSYWAR
760 770 780 790 800
SGEKITVTPS SKELLFYPPS MEATVSGESC PGKLIEIHGK AGLFLEGQIH
810 820 830 840 850
PELEGVEIVI SEKGASSPLI TVFTDDKGAY SVGPLHSDLE YTVNSQKEGY
860 870 880 890 900
VLTAVEGTVG DFKAYALAGV SFEIKAEDDQ PLPGVLLSLS GGVFRSNLLT
910 920 930 940 950
QDNGILTFSN LSPGQYYFKP MMKEFRFEPS SQMIEVQEGQ NLRITITGFR
960 970 980 990 1000
TAYSCYGTVS SLNGEPEQGV AVEAVGQKDC SIYGEDTVTD EEGKFRLRGL
1010 1020 1030 1040 1050
LPGCMYHVQL KAEGNDHIER ALPHHRVIEV GNNDVDDVNI IVFRQINQFD
1060 1070 1080 1090 1100
LSGNVITSSE YLSTLWVKLY KSESLDNPIQ TVSLGQSLFF HFPPLLRDGE
1110 1120 1130 1140 1150
NYVVLLDTTL PRSQYDYVLP QVSFTAVGYH KHITLVFSPT RKLPEQDIAQ
1160 1170 1180 1190 1200
GSYIALPLTL LLLLAGYNHD KLIPLLLQLT SRLQGVRALG QAASDSSGPE
1210
DMKRQTKKQK TRRT
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 6 | C → G in BAC38508 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 62 – 63 | DC → GW in BAC38508 (PubMed:16141072).Curated | 2 | |
Sequence conflicti | 75 | Y → V in BAC38508 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 95 – 97 | TNV → PHG in BAC38508 (PubMed:16141072).Curated | 3 | |
Sequence conflicti | 101 | V → G in BAC38508 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 109 | T → A in BAC38508 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 113 | D → G in BAC38508 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 477 | P → T in BAC38508 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 875 – 878 | KAED → GRVG in AAH24503 (PubMed:15489334).Curated | 4 | |
Sequence conflicti | 1029 | E → G in BAC31513 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 1176 | L → V in BAC31513 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK043279 mRNA Translation: BAC31513.1 AK082495 mRNA Translation: BAC38508.1 AK082963 mRNA Translation: BAC38713.1 Different initiation. AK166764 mRNA Translation: BAE39002.1 BC024503 mRNA Translation: AAH24503.1 Different initiation. BC033923 mRNA Translation: AAH33923.1 Different initiation. BC072630 mRNA Translation: AAH72630.1 |
CCDSi | CCDS21273.1 |
RefSeqi | NP_694697.3, NM_153057.4 |
Genome annotation databases
Ensembli | ENSMUST00000033121; ENSMUSP00000033121; ENSMUSG00000030835 |
GeneIDi | 211548 |
KEGGi | mmu:211548 |
UCSCi | uc009gyb.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK043279 mRNA Translation: BAC31513.1 AK082495 mRNA Translation: BAC38508.1 AK082963 mRNA Translation: BAC38713.1 Different initiation. AK166764 mRNA Translation: BAE39002.1 BC024503 mRNA Translation: AAH24503.1 Different initiation. BC033923 mRNA Translation: AAH33923.1 Different initiation. BC072630 mRNA Translation: AAH72630.1 |
CCDSi | CCDS21273.1 |
RefSeqi | NP_694697.3, NM_153057.4 |
3D structure databases
SMRi | Q6GQT9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 229243, 6 interactors |
IntActi | Q6GQT9, 2 interactors |
MINTi | Q6GQT9 |
STRINGi | 10090.ENSMUSP00000033121 |
PTM databases
GlyConnecti | 2564, 4 N-Linked glycans (3 sites) |
GlyGeni | Q6GQT9, 4 sites |
iPTMneti | Q6GQT9 |
PhosphoSitePlusi | Q6GQT9 |
SwissPalmi | Q6GQT9 |
Proteomic databases
EPDi | Q6GQT9 |
jPOSTi | Q6GQT9 |
MaxQBi | Q6GQT9 |
PaxDbi | Q6GQT9 |
PeptideAtlasi | Q6GQT9 |
PRIDEi | Q6GQT9 |
ProteomicsDBi | 293701 |
Genome annotation databases
Ensembli | ENSMUST00000033121; ENSMUSP00000033121; ENSMUSG00000030835 |
GeneIDi | 211548 |
KEGGi | mmu:211548 |
UCSCi | uc009gyb.2, mouse |
Organism-specific databases
CTDi | 23420 |
MGIi | MGI:2385850, Nomo1 |
Phylogenomic databases
eggNOGi | KOG1948, Eukaryota |
GeneTreei | ENSGT00390000000089 |
HOGENOMi | CLU_007543_2_0_1 |
InParanoidi | Q6GQT9 |
OMAi | GWSFEPE |
OrthoDBi | 839381at2759 |
PhylomeDBi | Q6GQT9 |
TreeFami | TF313696 |
Miscellaneous databases
BioGRID-ORCSi | 211548, 3 hits in 53 CRISPR screens |
ChiTaRSi | Nomo1, mouse |
PROi | PR:Q6GQT9 |
RNActi | Q6GQT9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030835, Expressed in tracheobronchial tree and 315 other tissues |
Genevisiblei | Q6GQT9, MM |
Family and domain databases
InterProi | View protein in InterPro IPR013784, Carb-bd-like_fold IPR008969, CarboxyPept-like_regulatory IPR041033, Prealbumin-like |
Pfami | View protein in Pfam PF17802, SpaA, 1 hit |
SUPFAMi | SSF49452, SSF49452, 3 hits SSF49464, SSF49464, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NOMO1_MOUSE | |
Accessioni | Q6GQT9Primary (citable) accession number: Q6GQT9 Secondary accession number(s): Q3TKZ1 Q8R1I7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 10, 2010 |
Last sequence update: | July 19, 2004 | |
Last modified: | April 7, 2021 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot