UniProtKB - Q6GQS1 (SCMC3_MOUSE)
Protein
Calcium-binding mitochondrial carrier protein SCaMC-3
Gene
Slc25a23
Organism
Mus musculus (Mouse)
Status
Functioni
Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria. Acts as a regulator of mitochondrial calcium uptake via interaction with MCU and MICU1.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 22 – 33 | 1PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 89 – 100 | 2PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- ATP transmembrane transporter activity Source: GO_Central
- calcium ion binding Source: InterPro
GO - Biological processi
- adenine nucleotide transport Source: MGI
- calcium import into the mitochondrion Source: UniProtKB
- cellular response to calcium ion Source: MGI
- mitochondrial calcium ion transmembrane transport Source: UniProtKB
- positive regulation of mitochondrial calcium ion concentration Source: UniProtKB
- regulation of cellular hyperosmotic salinity response Source: UniProtKB
- regulation of cellular respiration Source: MGI
- regulation of oxidative phosphorylation Source: MGI
- regulation of sequestering of calcium ion Source: MGI
- urea homeostasis Source: MGI
Keywordsi
Biological process | Transport |
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Calcium-binding mitochondrial carrier protein SCaMC-3Alternative name(s): Small calcium-binding mitochondrial carrier protein 3 Solute carrier family 25 member 23 |
Gene namesi | Name:Slc25a23 Synonyms:Scamc3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1914222, Slc25a23 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
- mitochondrion Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 187 | Mitochondrial intermembraneSequence analysisAdd BLAST | 187 | |
Transmembranei | 188 – 205 | Helical; Name=1Sequence analysisAdd BLAST | 18 | |
Topological domaini | 206 – 242 | Mitochondrial matrixSequence analysisAdd BLAST | 37 | |
Transmembranei | 243 – 262 | Helical; Name=2Sequence analysisAdd BLAST | 20 | |
Topological domaini | 263 – 285 | Mitochondrial intermembraneSequence analysisAdd BLAST | 23 | |
Transmembranei | 286 – 299 | Helical; Name=3Sequence analysisAdd BLAST | 14 | |
Topological domaini | 300 – 335 | Mitochondrial matrixSequence analysisAdd BLAST | 36 | |
Transmembranei | 336 – 355 | Helical; Name=4Sequence analysisAdd BLAST | 20 | |
Topological domaini | 356 – 378 | Mitochondrial intermembraneSequence analysisAdd BLAST | 23 | |
Transmembranei | 379 – 396 | Helical; Name=5Sequence analysisAdd BLAST | 18 | |
Topological domaini | 397 – 435 | Mitochondrial matrixSequence analysisAdd BLAST | 39 | |
Transmembranei | 436 – 455 | Helical; Name=6Sequence analysisAdd BLAST | 20 | |
Topological domaini | 456 – 467 | Mitochondrial intermembraneSequence analysisAdd BLAST | 12 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000317610 | 1 – 467 | Calcium-binding mitochondrial carrier protein SCaMC-3Add BLAST | 467 |
Proteomic databases
EPDi | Q6GQS1 |
MaxQBi | Q6GQS1 |
PaxDbi | Q6GQS1 |
PeptideAtlasi | Q6GQS1 |
PRIDEi | Q6GQS1 |
PTM databases
PhosphoSitePlusi | Q6GQS1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000046329, Expressed in primary visual cortex and 265 other tissues |
ExpressionAtlasi | Q6GQS1, baseline and differential |
Genevisiblei | Q6GQS1, MM |
Interactioni
Subunit structurei
Interacts with MCU.
Interacts with MICU1.
By similarityProtein-protein interaction databases
BioGRIDi | 211846, 7 interactors |
STRINGi | 10090.ENSMUSP00000040198 |
Miscellaneous databases
RNActi | Q6GQS1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 44 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 76 – 111 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 112 – 147 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 | |
Repeati | 182 – 268 | Solcar 1Add BLAST | 87 | |
Repeati | 276 – 361 | Solcar 2Add BLAST | 86 | |
Repeati | 373 – 461 | Solcar 3Add BLAST | 89 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0036, Eukaryota |
GeneTreei | ENSGT00940000159428 |
HOGENOMi | CLU_015166_2_0_1 |
InParanoidi | Q6GQS1 |
OrthoDBi | 442523at2759 |
PhylomeDBi | Q6GQS1 |
TreeFami | TF313492 |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF13499, EF-hand_7, 2 hits PF00153, Mito_carr, 3 hits |
PRINTSi | PR00926, MITOCARRIER |
SMARTi | View protein in SMART SM00054, EFh, 3 hits |
SUPFAMi | SSF103506, SSF103506, 1 hit SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 3 hits PS50920, SOLCAR, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q6GQS1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRGGSSDAER RQRWGRLFEE LDSNKDGRVD VHELRQGLAR LGRGDPDRAQ
60 70 80 90 100
QGVSSDWDAD PDGGLSLEEF TRYLQEREQR LLLMFHSLDR NQDGHIDVSE
110 120 130 140 150
IQQSFRALGI SISLEQAEKI LHSMDRDGTM TIDWQEWRDH FLLHSLENVE
160 170 180 190 200
DVLYFWKHST VLDIGECLTV PDEFSQEEKL TGMWWKQLVA GAVAGAVSRT
210 220 230 240 250
GTAPLDRLKV FMQVHASKSN RLNILGGLRN MIQEGGVLSL WRGNGINVLK
260 270 280 290 300
IAPESAIKFM AYEQIKRAIR GQQETLHVQE RFVAGSLAGA TAQTIIYPME
310 320 330 340 350
VLKTRLTLRR TGQYKGLLDC AKRILEREGP RAFYRGYLPN VLGIIPYAGI
360 370 380 390 400
DLAVYETLKN RWLQQYSHES ANPGILVLLG CGTISSTCGQ IASYPLALVR
410 420 430 440 450
TRMQAQASIE GGPQVSMVGL LRHILSQEGV WGLYRGIAPN FMKVIPAVSI
460
SYVVYENMKQ ALGVTSR
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF6XQ75 | F6XQ75_MOUSE | Calcium-binding mitochondrial carri... | Slc25a23 | 179 | Annotation score: | ||
F7BBH5 | F7BBH5_MOUSE | Calcium-binding mitochondrial carri... | Slc25a23 | 176 | Annotation score: | ||
F6X0P2 | F6X0P2_MOUSE | Calcium-binding mitochondrial carri... | Slc25a23 | 266 | Annotation score: | ||
F7ANR8 | F7ANR8_MOUSE | Calcium-binding mitochondrial carri... | Slc25a23 | 47 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC072660 mRNA Translation: AAH72660.1 |
CCDSi | CCDS28923.1 |
RefSeqi | NP_080153.2, NM_025877.4 |
Genome annotation databases
Ensembli | ENSMUST00000040280; ENSMUSP00000040198; ENSMUSG00000046329 |
GeneIDi | 66972 |
KEGGi | mmu:66972 |
UCSCi | uc008ddu.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC072660 mRNA Translation: AAH72660.1 |
CCDSi | CCDS28923.1 |
RefSeqi | NP_080153.2, NM_025877.4 |
3D structure databases
SMRi | Q6GQS1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 211846, 7 interactors |
STRINGi | 10090.ENSMUSP00000040198 |
PTM databases
PhosphoSitePlusi | Q6GQS1 |
Proteomic databases
EPDi | Q6GQS1 |
MaxQBi | Q6GQS1 |
PaxDbi | Q6GQS1 |
PeptideAtlasi | Q6GQS1 |
PRIDEi | Q6GQS1 |
Protocols and materials databases
Antibodypediai | 24155, 84 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000040280; ENSMUSP00000040198; ENSMUSG00000046329 |
GeneIDi | 66972 |
KEGGi | mmu:66972 |
UCSCi | uc008ddu.2, mouse |
Organism-specific databases
CTDi | 79085 |
MGIi | MGI:1914222, Slc25a23 |
Phylogenomic databases
eggNOGi | KOG0036, Eukaryota |
GeneTreei | ENSGT00940000159428 |
HOGENOMi | CLU_015166_2_0_1 |
InParanoidi | Q6GQS1 |
OrthoDBi | 442523at2759 |
PhylomeDBi | Q6GQS1 |
TreeFami | TF313492 |
Miscellaneous databases
BioGRID-ORCSi | 66972, 1 hit in 17 CRISPR screens |
ChiTaRSi | Slc25a23, mouse |
PROi | PR:Q6GQS1 |
RNActi | Q6GQS1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000046329, Expressed in primary visual cortex and 265 other tissues |
ExpressionAtlasi | Q6GQS1, baseline and differential |
Genevisiblei | Q6GQS1, MM |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR002067, Mit_carrier IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF13499, EF-hand_7, 2 hits PF00153, Mito_carr, 3 hits |
PRINTSi | PR00926, MITOCARRIER |
SMARTi | View protein in SMART SM00054, EFh, 3 hits |
SUPFAMi | SSF103506, SSF103506, 1 hit SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 3 hits PS50920, SOLCAR, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SCMC3_MOUSE | |
Accessioni | Q6GQS1Primary (citable) accession number: Q6GQS1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | July 19, 2004 | |
Last modified: | December 2, 2020 | |
This is version 134 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families