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UniProtKB - Q6GQQ9 (OTU7B_HUMAN)

Entry version 168 (10 Feb 2021)
Sequence version 1 (19 Jul 2004)
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Protein

OTU domain-containing protein 7B

Gene

OTUD7B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin.By similarity7 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Deubiquitinase activity is inhibited following interaction with PARK7.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei191By similarity1
Active sitei194Nucleophile4 Publications1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei197Stabilizes the conformation of the regulatory loop1 Publication1
Active sitei358Proton acceptor1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri796 – 831A20-typePROSITE-ProRule annotationAdd BLAST36

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processAdaptive immunity, Immunity, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6GQQ9

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5357786, TNFR1-induced proapoptotic signaling
R-HSA-5357905, Regulation of TNFR1 signaling
R-HSA-5357956, TNFR1-induced NFkappaB signaling pathway
R-HSA-5689896, Ovarian tumor domain proteases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q6GQQ9

Protein family/group databases

MEROPS protease database

More...MEROPSi		C64.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
OTU domain-containing protein 7B (EC:3.4.19.126 Publications)
Alternative name(s):
Cellular zinc finger anti-NF-kappa-B protein1 Publication
Short name:
Cezanne3 Publications
Zinc finger A20 domain-containing protein 1
Zinc finger protein CezanneCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OTUD7B
Synonyms:ZA20D1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16683, OTUD7B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611748, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6GQQ9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000264522.5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi155 – 156LI → GG: Reduces deubiquitinating activity. 1 Publication2
Mutagenesisi157E → K: Reduces deubiquitinating activity with 'Lys-11'-linked ubiquitin chains; no effect on cleavage of 'Lys-48'-linked and 'Lys-63'-linked ubiquitin chains. 1 Publication1
Mutagenesisi193N → L or M: Loss of deubiquitinating activity due to stabilization of the autoinhibited conformation. 1 Publication1
Mutagenesisi194C → A: Loss of deubiquitinating activity. Increased ability to interact with polyubiquitin. 4 Publications1
Mutagenesisi194C → S: Loss of deubiquitinating activity. 3 Publications1
Mutagenesisi194C → S: Loss of deubiquitinating activity; when associated with N-358. 1 Publication1
Mutagenesisi197H → A or E: Strongly reduces deubiquitinating activity. 1 Publication1
Mutagenesisi197H → D or N: Reduces deubiquitinating activity. 1 Publication1
Mutagenesisi210D → A: Reduces deubiquitinating activity. 1 Publication1
Mutagenesisi295E → K: Loss of deubiquitinating activity. 1 Publication1
Mutagenesisi358H → A: Loss of deubiquitinating activity. 1 Publication1
Mutagenesisi358H → N: Loss of deubiquitinating activity; when associated with S-194. 1 Publication1
Mutagenesisi809F → A: Does not affect interaction with EGFR. 1 Publication1
Mutagenesisi810Y → A: Impairs interaction with EGFR. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		56957

Open Targets

More...OpenTargetsi		ENSG00000264522

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134873802

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6GQQ9, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		OTUD7B

Domain mapping of disease mutations (DMDM)

More...DMDMi		51701318

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001887881 – 843OTU domain-containing protein 7BAdd BLAST843

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei100PhosphoserineCombined sources1
Modified residuei464PhosphoserineBy similarity1
Modified residuei467PhosphoserineCombined sources1
Modified residuei471PhosphoserineBy similarity1
Modified residuei729PhosphothreonineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by EGFR.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6GQQ9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6GQQ9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6GQQ9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6GQQ9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6GQQ9

PeptideAtlas

More...PeptideAtlasi		Q6GQQ9

PRoteomics IDEntifications database

More...PRIDEi		Q6GQQ9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		66318 [Q6GQQ9-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6GQQ9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6GQQ9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Abundant in kidney, heart and fetal liver. Expressed differentially among B-cells at distinct developmental stages. Higher expression seen in primary immature B-cells as compared to the mature cells.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By TNF-alpha.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000264522, Expressed in prostate gland and 216 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6GQQ9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6GQQ9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000264522, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ZAP70 in activated T cells, but not in resting T cells (PubMed:26903241).

Interacts with TRAF3 (By similarity).

Interacts with TRAF6 (PubMed:11463333).

Interacts with PARK7, leading to inhibit deubiquitinase activity (PubMed:21097510).

Interacts with EGFR, ITCH and NEDD4 (PubMed:22179831).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q6GQQ9
With#Exp.IntAct
CCDC50 [Q8IVM0]5EBI-527784,EBI-723996
CDIP1 [Q9H305]3EBI-527784,EBI-2876678
DAZAP2 [Q15038]3EBI-527784,EBI-724310
EPM2AIP1 [Q7L775]3EBI-527784,EBI-6255981
HSFY2 [Q96LI6]3EBI-527784,EBI-3957665
OTULIN [Q96BN8]3EBI-527784,EBI-750730
PARK7 [Q99497]3EBI-527784,EBI-1164361
PIK3R3 [Q92569]3EBI-527784,EBI-79893
PPP1R32 - isoform 2 [Q7Z5V6-2]3EBI-527784,EBI-12000762
PSMB1 [P20618]3EBI-527784,EBI-372273
SPART [Q8N0X7]3EBI-527784,EBI-2643803
Isoform 2 [Q6GQQ9-2]
With#Exp.IntAct
A2M [P01023]3EBI-25830200,EBI-640741
ALB - isoform 3 [P02768-3]3EBI-25830200,EBI-25830928
ATXN1 [P54253]6EBI-25830200,EBI-930964
BAG6 - isoform 2 [P46379-2]3EBI-25830200,EBI-10988864
CASP6 [P55212]3EBI-25830200,EBI-718729
DBH [P09172]3EBI-25830200,EBI-8589586
DCTN1 - isoform 5 [Q14203-5]3EBI-25830200,EBI-25840379
DMWD [G5E9A7]3EBI-25830200,EBI-10976677
DNALI1 [O14645]3EBI-25830200,EBI-395638
EIF2S3 [P41091]3EBI-25830200,EBI-1054228
ERN1 - isoform 2 [O75460-2]3EBI-25830200,EBI-25852368
FGFR3 [P22607]3EBI-25830200,EBI-348399
FKBP1A [Q0VDC6]3EBI-25830200,EBI-10226858
GFAP [P14136]3EBI-25830200,EBI-744302
GRIN2C [Q14957]3EBI-25830200,EBI-8285963
GSN [P06396]3EBI-25830200,EBI-351506
HSPA2 [P54652]3EBI-25830200,EBI-356991
HSPB1 [P04792]3EBI-25830200,EBI-352682
HTRA2 [O43464]3EBI-25830200,EBI-517086
JPH3 [Q8WXH2]3EBI-25830200,EBI-1055254
KIF1B - isoform 2 [O60333-2]3EBI-25830200,EBI-10975473
KLF11 [O14901]3EBI-25830200,EBI-948266
LAMP2 - isoform LAMP-2B [P13473-2]3EBI-25830200,EBI-21591415
MAPK3 [P27361]3EBI-25830200,EBI-73995
MECP2 [P51608]3EBI-25830200,EBI-1189067
NDUFV2 [P19404]3EBI-25830200,EBI-713665
NF2 - isoform 4 [P35240-4]3EBI-25830200,EBI-1014514
NUP58 [Q9BVL2]3EBI-25830200,EBI-2811583
PHYH [O14832]3EBI-25830200,EBI-721853
PMP22 [D3DTS7]3EBI-25830200,EBI-25882629
PRKN - isoform 5 [O60260-5]3EBI-25830200,EBI-21251460
PRPF40A - isoform 2 [O75400-2]3EBI-25830200,EBI-5280197
PRPS1 [P60891]3EBI-25830200,EBI-749195
RAN [P62826]3EBI-25830200,EBI-286642
RNF11 [Q9Y3C5]3EBI-25830200,EBI-396669
SNCA [P37840]3EBI-25830200,EBI-985879
SOD1 [P00441]3EBI-25830200,EBI-990792
SPRED1 [Q7Z699]3EBI-25830200,EBI-5235340
TARDBP [Q13148]6EBI-25830200,EBI-372899
TSC1 [Q86WV8]3EBI-25830200,EBI-12806590
TTR [P02766]3EBI-25830200,EBI-711909
UBB [P0CG47]3EBI-25830200,EBI-413034
UBQLN1 [Q9UMX0]3EBI-25830200,EBI-741480
WFS1 [O76024]3EBI-25830200,EBI-720609
Q9Y6493EBI-25830200,EBI-25900580

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121281, 44 interactors

Database of interacting proteins

More...DIPi		DIP-33805N

Protein interaction database and analysis system

More...IntActi		Q6GQQ9, 70 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000462729

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6GQQ9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1843
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6GQQ9

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini183 – 365OTUPROSITE-ProRule annotationAdd BLAST183

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni152 – 401TRAF-bindingAdd BLAST250
Regioni167 – 440CatalyticAdd BLAST274
Regioni187 – 193Regulatory loop1 Publication7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi483 – 498Nuclear localization signalSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The protein undergoes a significant conformation change upon binding to ubiquitinated substrates. The loop that precedes the active site is in an autoinhibitory conformation in the apoprotein. Ubiquitin binding leads to a conformation change; the loop is stabilized in a catalytically competent conformation with the result that the active site Cys can form the reaction state intermediate.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C64 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri796 – 831A20-typePROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4345, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159172

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_013263_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6GQQ9

Identification of Orthologs from Complete Genome Data

More...OMAi		NVKWIPV

Database of Orthologous Groups

More...OrthoDBi		728724at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6GQQ9

TreeFam database of animal gene trees

More...TreeFami		TF323312

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003323, OTU_dom
IPR002653, Znf_A20

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02338, OTU, 1 hit
PF01754, zf-A20, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00259, ZnF_A20, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50802, OTU, 1 hit
PS51036, ZF_A20, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6GQQ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTLDMDAVLS DFVRSTGAEP GLARDLLEGK NWDVNAALSD FEQLRQVHAG 
        60         70         80         90        100
NLPPSFSEGS GGSRTPEKGF SDREPTRPPR PILQRQDDIV QEKRLSRGIS 
       110        120        130        140        150
HASSSIVSLA RSHVSSNGGG GGSNEHPLEM PICAFQLPDL TVYNEDFRSF 
       160        170        180        190        200
IERDLIEQSM LVALEQAGRL NWWVSVDPTS QRLLPLATTG DGNCLLHAAS 
       210        220        230        240        250
LGMWGFHDRD LMLRKALYAL MEKGVEKEAL KRRWRWQQTQ QNKESGLVYT 
       260        270        280        290        300
EDEWQKEWNE LIKLASSEPR MHLGTNGANC GGVESSEEPV YESLEEFHVF 
       310        320        330        340        350
VLAHVLRRPI VVVADTMLRD SGGEAFAPIP FGGIYLPLEV PASQCHRSPL 
       360        370        380        390        400
VLAYDQAHFS ALVSMEQKEN TKEQAVIPLT DSEYKLLPLH FAVDPGKGWE 
       410        420        430        440        450
WGKDDSDNVR LASVILSLEV KLHLLHSYMN VKWIPLSSDA QAPLAQPESP 
       460        470        480        490        500
TASAGDEPRS TPESGDSDKE SVGSSSTSNE GGRRKEKSKR DREKDKKRAD 
       510        520        530        540        550
SVANKLGSFG KTLGSKLKKN MGGLMHSKGS KPGGVGTGLG GSSGTETLEK 
       560        570        580        590        600
KKKNSLKSWK GGKEEAAGDG PVSEKPPAES VGNGGSKYSQ EVMQSLSILR 
       610        620        630        640        650
TAMQGEGKFI FVGTLKMGHR HQYQEEMIQR YLSDAEERFL AEQKQKEAER 
       660        670        680        690        700
KIMNGGIGGG PPPAKKPEPD AREEQPTGPP AESRAMAFST GYPGDFTIPR 
       710        720        730        740        750
PSGGGVHCQE PRRQLAGGPC VGGLPPYATF PRQCPPGRPY PHQDSIPSLE 
       760        770        780        790        800
PGSHSKDGLH RGALLPPPYR VADSYSNGYR EPPEPDGWAG GLRGLPPTQT 
       810        820        830        840 
KCKQPNCSFY GHPETNNFCS CCYREELRRR EREPDGELLV HRF
Length:843
Mass (Da):92,526
Last modified:July 19, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6D386C864B12EE57
GO
Isoform 2 (identifier: Q6GQQ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     805-833: Missing.

Show »
Length:814
Mass (Da):88,947
Checksum:i26C3BFE215BEC0D3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SZ59Q5SZ59_HUMAN
Ubiquitinyl hydrolase 1
OTUD7B RP11-212K13.2-003
427Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB97494 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti243K → E in AAH20622 (PubMed:15489334).Curated1
Sequence conflicti421K → R in AAH20622 (PubMed:15489334).Curated1
Sequence conflicti791G → S in BAH13129 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_046015805 – 833Missing in isoform 2. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ293573 mRNA Translation: CAB97494.1 Different initiation.
AK299790 mRNA Translation: BAH13129.1
AL590487 Genomic DNA Translation: CAI12651.1
CH471121 Genomic DNA Translation: EAW53586.1
CH471121 Genomic DNA Translation: EAW53587.1
BC020622 mRNA Translation: AAH20622.1
BC072681 mRNA Translation: AAH72681.1
AL122102 mRNA Translation: CAB59268.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS72903.1 [Q6GQQ9-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T34535

NCBI Reference Sequences

More...RefSeqi		NP_064590.2, NM_020205.3 [Q6GQQ9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000581312; ENSP00000462729; ENSG00000264522 [Q6GQQ9-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		56957

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:56957

UCSC genome browser

More...UCSCi		uc001etn.5, human [Q6GQQ9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ293573 mRNA Translation: CAB97494.1 Different initiation.
AK299790 mRNA Translation: BAH13129.1
AL590487 Genomic DNA Translation: CAI12651.1
CH471121 Genomic DNA Translation: EAW53586.1
CH471121 Genomic DNA Translation: EAW53587.1
BC020622 mRNA Translation: AAH20622.1
BC072681 mRNA Translation: AAH72681.1
AL122102 mRNA Translation: CAB59268.1
CCDSiCCDS72903.1 [Q6GQQ9-1]
PIRiT34535
RefSeqiNP_064590.2, NM_020205.3 [Q6GQQ9-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LRUX-ray2.20A129-438[»]
5LRVX-ray2.80A129-438[»]
5LRWX-ray2.00A/C129-266[»]
A/C292-438[»]
SMRiQ6GQQ9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi121281, 44 interactors
DIPiDIP-33805N
IntActiQ6GQQ9, 70 interactors
STRINGi9606.ENSP00000462729

Protein family/group databases

MEROPSiC64.001

PTM databases

iPTMnetiQ6GQQ9
PhosphoSitePlusiQ6GQQ9

Genetic variation databases

BioMutaiOTUD7B
DMDMi51701318

Proteomic databases

EPDiQ6GQQ9
jPOSTiQ6GQQ9
MassIVEiQ6GQQ9
MaxQBiQ6GQQ9
PaxDbiQ6GQQ9
PeptideAtlasiQ6GQQ9
PRIDEiQ6GQQ9
ProteomicsDBi66318 [Q6GQQ9-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		72463, 217 antibodies

The DNASU plasmid repository

More...DNASUi		56957

Genome annotation databases

EnsembliENST00000581312; ENSP00000462729; ENSG00000264522 [Q6GQQ9-1]
GeneIDi56957
KEGGihsa:56957
UCSCiuc001etn.5, human [Q6GQQ9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		56957
DisGeNETi56957

GeneCards: human genes, protein and diseases

More...GeneCardsi		OTUD7B
HGNCiHGNC:16683, OTUD7B
HPAiENSG00000264522, Low tissue specificity
MIMi611748, gene
neXtProtiNX_Q6GQQ9
OpenTargetsiENSG00000264522
PharmGKBiPA134873802
VEuPathDBiHostDB:ENSG00000264522.5

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4345, Eukaryota
GeneTreeiENSGT00940000159172
HOGENOMiCLU_013263_0_0_1
InParanoidiQ6GQQ9
OMAiNVKWIPV
OrthoDBi728724at2759
PhylomeDBiQ6GQQ9
TreeFamiTF323312

Enzyme and pathway databases

PathwayCommonsiQ6GQQ9
ReactomeiR-HSA-5357786, TNFR1-induced proapoptotic signaling
R-HSA-5357905, Regulation of TNFR1 signaling
R-HSA-5357956, TNFR1-induced NFkappaB signaling pathway
R-HSA-5689896, Ovarian tumor domain proteases
SignaLinkiQ6GQQ9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		56957, 8 hits in 879 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		OTUD7B, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		OTUD7B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		56957
PharosiQ6GQQ9, Tbio

Protein Ontology

More...PROi		PR:Q6GQQ9
RNActiQ6GQQ9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000264522, Expressed in prostate gland and 216 other tissues
ExpressionAtlasiQ6GQQ9, baseline and differential
GenevisibleiQ6GQQ9, HS

Family and domain databases

InterProiView protein in InterPro
IPR003323, OTU_dom
IPR002653, Znf_A20
PfamiView protein in Pfam
PF02338, OTU, 1 hit
PF01754, zf-A20, 1 hit
SMARTiView protein in SMART
SM00259, ZnF_A20, 1 hit
PROSITEiView protein in PROSITE
PS50802, OTU, 1 hit
PS51036, ZF_A20, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOTU7B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6GQQ9
Secondary accession number(s): B7Z643
, D3DUZ8, Q5SZ60, Q8WWA7, Q9NQ53, Q9UFF4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 19, 2004
Last modified: February 10, 2021
This is version 168 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Peptidase families
    Classification of peptidase families and list of entries
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