The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - Q6GQN8 (MECR_DANRE)
Protein
Enoyl-[acyl-carrier-protein] reductase, mitochondrial
Gene
mecr
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro.
By similarityCatalytic activityi
- EC:1.3.1.104By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 96 | Proton donorBy similarity | 1 | |
Binding sitei | 169 | NADPBy similarity | 1 | |
Binding sitei | 372 | NADPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 195 – 198 | NADPBy similarity | 4 | |
Nucleotide bindingi | 218 – 220 | NADPBy similarity | 3 | |
Nucleotide bindingi | 287 – 290 | NADPBy similarity | 4 | |
Nucleotide bindingi | 312 – 314 | NADPBy similarity | 3 |
GO - Molecular functioni
- trans-2-enoyl-CoA reductase (NADPH) activity Source: GO_Central
GO - Biological processi
- fatty acid biosynthetic process Source: UniProtKB-KW
- fatty acid metabolic process Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Ligand | NADP |
Enzyme and pathway databases
Reactomei | R-DRE-77346, Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA |
Names & Taxonomyi
Protein namesi | Recommended name: Enoyl-[acyl-carrier-protein] reductase, mitochondrial (EC:1.3.1.104)Alternative name(s): 2-enoyl thioester reductase |
Gene namesi | Name:mecr ORF Names:zgc:110153 |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-050417-399, mecr |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Mitochondrion
- mitochondrion Source: GO_Central
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 52 | MitochondrionSequence analysisAdd BLAST | 52 | |
ChainiPRO_0000000891 | 53 – 377 | Enoyl-[acyl-carrier-protein] reductase, mitochondrialAdd BLAST | 325 |
Proteomic databases
PaxDbi | Q6GQN8 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000032326, Expressed in testis and 34 other tissues |
ExpressionAtlasi | Q6GQN8, baseline and differential |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
STRINGi | 7955.ENSDARP00000038801 |
Family & Domainsi
Sequence similaritiesi
Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG0025, Eukaryota |
GeneTreei | ENSGT00940000156592 |
HOGENOMi | CLU_026673_17_1_1 |
InParanoidi | Q6GQN8 |
OMAi | HQLCRAW |
PhylomeDBi | Q6GQN8 |
TreeFami | TF312886 |
Family and domain databases
InterProi | View protein in InterPro IPR013149, ADH-like_C IPR013154, ADH_N IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf IPR020843, PKS_ER |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SMARTi | View protein in SMART SM00829, PKS_ER, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q6GQN8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLPSVASLL IRVYRTTGPV SHIQRIRHGA VLNKNYSSVS AVKNCTALLY
60 70 80 90 100
RNHGEPSQVV QLESLDLPQV GAECVLVKML AAPINPSDLN MLQGTYAILP
110 120 130 140 150
ELPAVGGNEG VAQVMEVGDK VKTLKVGDWV IPKDAGIGTW RTAAVLKADD
160 170 180 190 200
LVTLPKDIPV LSAATLGVNP CTAYRMLTDF EELKAGDTVI QNAANSGVGQ
210 220 230 240 250
AVIQIAAAKG IHTINVIRDR PDLRQLSDRL TAMGATHVIT EETLRRPEMK
260 270 280 290 300
ELFKSCPRPK LALNGVGGKS ATELLRHLQS GGSLVTYGGM AKQPVTVPVS
310 320 330 340 350
ALIFKDVRVR GFWVTQWKRD NRHDDEALRH MLDELCILIR AGKLSAPICT
360 370
QVQLQDFRKA LENAMKPYVS TKQVFVM
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF8W5W4 | F8W5W4_DANRE | Enoyl-[acyl-carrier-protein] reduct... | mecr | 107 | Annotation score: |
Sequence cautioni
The sequence AAH72704 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC072704 mRNA Translation: AAH72704.1 Different initiation. |
Genome annotation databases
Ensembli | ENSDART00000039054; ENSDARP00000038801; ENSDARG00000032326 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC072704 mRNA Translation: AAH72704.1 Different initiation. |
3D structure databases
AlphaFoldDBi | Q6GQN8 |
SMRi | Q6GQN8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000038801 |
Proteomic databases
PaxDbi | Q6GQN8 |
Genome annotation databases
Ensembli | ENSDART00000039054; ENSDARP00000038801; ENSDARG00000032326 |
Organism-specific databases
ZFINi | ZDB-GENE-050417-399, mecr |
Phylogenomic databases
eggNOGi | KOG0025, Eukaryota |
GeneTreei | ENSGT00940000156592 |
HOGENOMi | CLU_026673_17_1_1 |
InParanoidi | Q6GQN8 |
OMAi | HQLCRAW |
PhylomeDBi | Q6GQN8 |
TreeFami | TF312886 |
Enzyme and pathway databases
Reactomei | R-DRE-77346, Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA |
Miscellaneous databases
PROi | PR:Q6GQN8 |
Gene expression databases
Bgeei | ENSDARG00000032326, Expressed in testis and 34 other tissues |
ExpressionAtlasi | Q6GQN8, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR013149, ADH-like_C IPR013154, ADH_N IPR011032, GroES-like_sf IPR036291, NAD(P)-bd_dom_sf IPR020843, PKS_ER |
Pfami | View protein in Pfam PF08240, ADH_N, 1 hit PF00107, ADH_zinc_N, 1 hit |
SMARTi | View protein in SMART SM00829, PKS_ER, 1 hit |
SUPFAMi | SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MECR_DANRE | |
Accessioni | Q6GQN8Primary (citable) accession number: Q6GQN8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2005 |
Last sequence update: | April 26, 2005 | |
Last modified: | May 25, 2022 | |
This is version 110 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families