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UniProtKB - Q6GQJ2 (JADE1_XENLA)
Protein
Protein Jade-1
Gene
jade1
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 200 – 250 | PHD-type 1PROSITE-ProRule annotationAdd BLAST | 51 | |
Zinc fingeri | 252 – 286 | C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST | 35 | |
Zinc fingeri | 310 – 366 | PHD-type 2PROSITE-ProRule annotationAdd BLAST | 57 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
Keywordsi
Molecular function | Activator |
Biological process | Apoptosis, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Protein Jade-1Alternative name(s): Jade family PHD finger protein 1 PHD finger protein 17 |
Gene namesi | Name:jade1 Synonyms:phf17 |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-949218, jade1.S |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytoskeleton
- cilium basal body By similarity
Other locations
- Chromosome By similarity
Note: Localizes to the ciliary transition zone.By similarity
Cytoskeleton
- cytoskeleton Source: UniProtKB-KW
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- cell projection Source: UniProtKB-KW
- chromosome Source: UniProtKB-SubCell
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell projection, Chromosome, Cytoplasm, Cytoskeleton, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000253532 | 1 – 827 | Protein Jade-1Add BLAST | 827 |
Interactioni
Subunit structurei
Component of the HBO1 complex composed.
By similarityFamily & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 35 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 622 – 705 | DisorderedSequence analysisAdd BLAST | 84 | |
Regioni | 769 – 810 | DisorderedSequence analysisAdd BLAST | 42 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 10 – 29 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 636 – 683 | Basic and acidic residuesSequence analysisAdd BLAST | 48 | |
Compositional biasi | 688 – 705 | Polar residuesSequence analysisAdd BLAST | 18 |
Domaini
The 2 PHD-type zinc fingers are required for transcriptional activity.By similarity
Sequence similaritiesi
Belongs to the JADE family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 200 – 250 | PHD-type 1PROSITE-ProRule annotationAdd BLAST | 51 | |
Zinc fingeri | 252 – 286 | C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST | 35 | |
Zinc fingeri | 310 – 366 | PHD-type 2PROSITE-ProRule annotationAdd BLAST | 57 |
Keywords - Domaini
Repeat, Zinc-fingerFamily and domain databases
CDDi | cd15679, PHD_JADE1, 1 hit |
Gene3Di | 3.30.40.10, 2 hits |
InterProi | View protein in InterPro IPR019542, Enhancer_polycomb-like_N IPR034732, EPHD IPR039546, Jade-1_PHD IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF10513, EPL1, 1 hit |
SMARTi | View protein in SMART SM00249, PHD, 2 hits |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS51805, EPHD, 1 hit PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6GQJ2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKRVCLPSSS EDSDDNGSLS TSWSQHSRSL PSFRHEDRKP SEVFRTDLIT
60 70 80 90 100
AMKLHDSNQL NPEDYYVLAD PWRQEWEKGV QVPVNPEFIP ETIARVIAEK
110 120 130 140 150
DKVVTFTRPR KYIHSSGSEP PEVGYVDIQT LADAVCRYDL NEMDVAWLQL
160 170 180 190 200
INEEFKEMGM QQLDEYTMEQ VLEEFEKKCY DKMNHAIETE EGLGIEYDED
210 220 230 240 250
VVCDVCQSPD GEDGNEMVFC DKCNICVHQA CYGILKVPEG SWLCRTCALG
260 270 280 290 300
VQPKCLLCPK KGGAMKPTRS GTKWVHVSCA LWIPEVSIGS PEKMEPITKV
310 320 330 340 350
SHIPSNRWAL LCSLCNEKVG ACIQCSIKNC RTAFHVTCAF DHGLEMKTIL
360 370 380 390 400
TQEDEVKFKS YCPKHGSTKK PEDSHFCRSA SDGKDTCEAS PTFLGGLRVL
410 420 430 440 450
EASQQNVKHG SQRKLKLQQL EDDFYSFVDV HDISQALKIP LDVTEYIYQY
460 470 480 490 500
WKLRRKANFN EPLITPKKDE EDNLAKKEQD VLIRRLQLFT HLRQDLERVR
510 520 530 540 550
NLTYMVTRRE KMKRSVCRVQ EQIFNLYTKI SEQEKDLGFP LENGLLFNTQ
560 570 580 590 600
PSNPDAPKIE DLKWHSAFFR KRLGSSLRCS MKDSHKKSRE RIIGKSLDTE
610 620 630 640 650
ILLTDRKKEG QTSDVSFPLE KTVAKIKPVQ QKNGGSFPEH RKRRDSRTQG
660 670 680 690 700
DTKFDSKEKP LRQQHRPAKH TEPPERPAEK KRALSQCGGK SATASSNKKQ
710 720 730 740 750
CSSSLPRYSG SLIKIHCNRP SVKVPTSPIK NWGGFRIPKK GEKVQPGSME
760 770 780 790 800
TCQPNLNCQF LGQVSKKGRT KEKVKLDNDN DGYTPDAEMS DSESEPTDKC
810 820
RLQRLTSSSS LSRGYETDFI RRSILAS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC072750 mRNA Translation: AAH72750.1 |
RefSeqi | NP_001085440.1, NM_001091971.1 |
Genome annotation databases
GeneIDi | 443866 |
KEGGi | xla:443866 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC072750 mRNA Translation: AAH72750.1 |
RefSeqi | NP_001085440.1, NM_001091971.1 |
3D structure databases
SMRi | Q6GQJ2 |
ModBasei | Search... |
Protocols and materials databases
DNASUi | 443866 |
Genome annotation databases
GeneIDi | 443866 |
KEGGi | xla:443866 |
Organism-specific databases
CTDi | 443866 |
Xenbasei | XB-GENE-949218, jade1.S |
Family and domain databases
CDDi | cd15679, PHD_JADE1, 1 hit |
Gene3Di | 3.30.40.10, 2 hits |
InterProi | View protein in InterPro IPR019542, Enhancer_polycomb-like_N IPR034732, EPHD IPR039546, Jade-1_PHD IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
Pfami | View protein in Pfam PF10513, EPL1, 1 hit |
SMARTi | View protein in SMART SM00249, PHD, 2 hits |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS51805, EPHD, 1 hit PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | JADE1_XENLA | |
Accessioni | Q6GQJ2Primary (citable) accession number: Q6GQJ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 17, 2006 |
Last sequence update: | July 19, 2004 | |
Last modified: | June 2, 2021 | |
This is version 85 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |