Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 56 (02 Jun 2021)
Sequence version 1 (19 Jul 2004)
Previous versions | rss
Add a publicationFeedback
Protein

Cytoplasmic FMR1-interacting protein 2

Gene

cyfip2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, Cell adhesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytoplasmic FMR1-interacting protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cyfip2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-922706, cyfip2.S

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002797121 – 1253Cytoplasmic FMR1-interacting protein 2Add BLAST1253

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6GQD1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6GQD1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CYFIP family.Sequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008081, Cytoplasmic_FMR1-int
IPR009828, DUF1394

The PANTHER Classification System

More...
PANTHERi
PTHR12195, PTHR12195, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07159, DUF1394, 1 hit
PF05994, FragX_IP, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF008153, FMR1_interacting, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01698, CYTOFMRPINTP

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6GQD1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTHVTLEDA LSNVDLLEEL PLPDQQPCIE PPPSSIMYQA NFDTNFEDRN
60 70 80 90 100
AFVTGIARYI EQATVHSSMN EMLEEGQEYA VMLYTWRSCS RAIPQVKCNE
110 120 130 140 150
QPNRVEIYEK TVEVLEPEVT KLMKFMYFQR KAIERFCNEV KRLCHTERRK
160 170 180 190 200
DFVSEAYLLT LGKFINMFAV LDELKNMKCS VKNDHSAYKR AAQFLRKMAD
210 220 230 240 250
PQSIQESQNL SMFLANHNRI TQCLHQQLEV IPGYEELLAD IVNICVDYYE
260 270 280 290 300
NKMYLTPSEK HMLLKVMGFG LYLMDGNVSN IYKLDAKKRI NLSKIDKFFK
310 320 330 340 350
QLQVVPLFGD MQIELARYIE TSAHYEENKS KWTCTQSSIS PQYNICEQMV
360 370 380 390 400
QIRDDHIRFI SELARYSNSE VVTGSGLDSQ KSDEEYRELF DLALRGLQLL
410 420 430 440 450
SKWSAHVMEV YSWKLVHPTD KFCNKDCPGT AEEYERATRY NYTSEEKFAF
460 470 480 490 500
VEVIAMVKGL QVLMGRMESV FNQAIRNTIY AALQDFAQSS LREPLRQAVR
510 520 530 540 550
KKKNVLISVL QAIRKTVCDW EAGREPPNDP CLRGEKDPKG GFDINVPRRA
560 570 580 590 600
VGPSSTQLYM VRTMLESLIA DKSGSKKTLR SSLDGPIVQA IEEFHKQSFF
610 620 630 640 650
FTHLLNFSEA LQQCCDLSQL WFREFFLELT MGRRIQFPIE MSMPWILTDH
660 670 680 690 700
ILETKEPSMM EYVLYPLDLY NDSAYYALTK FKKQFLYDEI EAEVNLCFDQ
710 720 730 740 750
FVYKLSDQIF AYYKAMSGSV LLDKRFRAEC KNYGVIIPYP PSNRYETLLK
760 770 780 790 800
QRHVQLLGRS IDLNRLITQR ISAAMYKSLD QAISRFESED LTSIVELEWL
810 820 830 840 850
LDINRLTHRL LSKHLTLDSF DAMFREANHN VSAPYGRNTL HVFWELNFDF
860 870 880 890 900
LPNYCYNGST NRFVRTAIPF TQEPQRDKPA NVQPYYLYGS KPLNIAYSHI
910 920 930 940 950
YSSYRNFVGP PHFKTICRLL GYQGIAVVME ELLKIVKSLL QGTVLQYVKT
960 970 980 990 1000
LIEVMPKICR LPRHEYGSPG ILEFFHHQLK DIIEYAELKT DVFQSLREVG
1010 1020 1030 1040 1050
NAILFCLLIE QALSQEEVCD LLHAAPFQNI LPRVYIKEGE RLEVRMKRLE
1060 1070 1080 1090 1100
AKYAPLHLVP LIERLGTPQQ IAIAREGDLL TKERLCCGLS MFEVILTRIR
1110 1120 1130 1140 1150
SYLQDPIWRG PPPTNGVMHV DECVELHRLW SAMQFVYCIP VGTNEFTAEQ
1160 1170 1180 1190 1200
CFGDGLNWAG CAIIVLLGQQ RRFDLFDFCY HLLKVQRQDG KDEIIKNVPL
1210 1220 1230 1240 1250
KKMADRIRKY QILNNEIFAV LNKYMKSVES DSSTVEHVRC FQPPIHQSLA

TTC
Length:1,253
Mass (Da):145,638
Last modified:July 19, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i306621A4ABBC0E1B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC072814 mRNA Translation: AAH72814.1

NCBI Reference Sequences

More...
RefSeqi
NP_001085471.1, NM_001092002.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
443897

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:443897

Keywords - Coding sequence diversityi

RNA editing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC072814 mRNA Translation: AAH72814.1
RefSeqiNP_001085471.1, NM_001092002.1

3D structure databases

SMRiQ6GQD1
ModBaseiSearch...

Proteomic databases

MaxQBiQ6GQD1

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
443897

Genome annotation databases

GeneIDi443897
KEGGixla:443897

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
443897
XenbaseiXB-GENE-922706, cyfip2.S

Family and domain databases

InterProiView protein in InterPro
IPR008081, Cytoplasmic_FMR1-int
IPR009828, DUF1394
PANTHERiPTHR12195, PTHR12195, 1 hit
PfamiView protein in Pfam
PF07159, DUF1394, 1 hit
PF05994, FragX_IP, 1 hit
PIRSFiPIRSF008153, FMR1_interacting, 1 hit
PRINTSiPR01698, CYTOFMRPINTP

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCYFP2_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6GQD1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: July 19, 2004
Last modified: June 2, 2021
This is version 56 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again