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Entry version 72 (02 Dec 2020)
Sequence version 1 (19 Jul 2004)
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Protein

Zinc finger RNA-binding protein

Gene

zfr

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in postimplantation and gastrulation stages of development. Binds to DNA and RNA (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding, RNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger RNA-binding protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:zfr
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-6067516, zfr.S

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003127241 – 1054Zinc finger RNA-binding proteinAdd BLAST1054

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6GPM1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini683 – 1053DZFPROSITE-ProRule annotationAdd BLAST371

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi35 – 293Ala-richAdd BLAST259
Compositional biasi420 – 475Ser-richAdd BLAST56

Keywords - Domaini

Repeat

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
HDYVEEX

Database of Orthologous Groups

More...
OrthoDBi
612611at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.460.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006561, DZF_dom
IPR003604, Matrin/U1-like-C_Znf_C2H2
IPR043519, NT_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07528, DZF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00572, DZF, 1 hit
SM00355, ZnF_C2H2, 3 hits
SM00451, ZnF_U1, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51703, DZF, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6GPM1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIPICPVVSF TYVPSRLGEE AKMATGNYFG FTHGAAAQYS QQPASGVAYS
60 70 80 90 100
HPTTVASYTV HQAPVAPHTV TAAYAPAVAT VAVARPAPVA MAATAAAYGG
110 120 130 140 150
YPAAHTATDY GYTQRQQEAP PPPPPVTTQN YQDSYSYVRS TAPAVAYDSK
160 170 180 190 200
QYYQQPTATA AAVAAQPQPS IAETYYQTVA PKAGYSQGAA QYTQAQQTRQ
210 220 230 240 250
VTAIKPANPS PASTTFSIYP VSSSVQPVAA AASVVPSYTQ SATYSNTAVT
260 270 280 290 300
YSGAAYSGYE AAVYSAASSY YQQQQQQQQK QAAAAAAAAA TAAWTGTNFT
310 320 330 340 350
KKAPFQNKQL KPKQPPKPPQ IHYCDVCKIS CAGPQTYKEH LEGQKHKKKE
360 370 380 390 400
AALKASQNTT SSSTAVRGTQ NQLRCELCDV SCTGADAYAA HIRGAKHQKV
410 420 430 440 450
VKLHTKLGKP IPSTEPNVVS QSVTSAVSKA SATSSSTSSA NGSSSVASPA
460 470 480 490 500
VKLLTSSSSM STSNSSKVSS ISSTSIVKKV TTPKITFIGG NKLQSTGNKV
510 520 530 540 550
DDSKMSDISK ATPSSAAQTQ EVKIDPMSEA AQTLAALQSD VQPVGHDYVE
560 570 580 590 600
EVRNDEGKVI RFHCKLCECS FNDPNAKEMH LKGRRHRLQY KKKVNPDLQV
610 620 630 640 650
EVKPSIRARK IQEEKMRKQM QKEEYWRRRE EEDQWRMEMR RYEEDMYWRR
660 670 680 690 700
MEEEQHHWDD RRRVPEGGYP HGPPGPPGLL GVRPGMPPQP QGPAPLRRPD
710 720 730 740 750
SSDDRYVMTK HAAIYPTEDE LQAVQKIVSL TERALKLVSD SMTDQDKTKT
760 770 780 790 800
KESDEKKEPT KERALKGVLR VGVLAKGLLL RGDRNVNLVL LCSEKPTRAL
810 820 830 840 850
LSCISESLPT QLAVICPEKF EVTSSIPEAA IILNSCVEPK MQVTITLTSP
860 870 880 890 900
VIREETPRDG DVTPGMVKDP PDVLDRQKCL DALASLRHAK WFQARANGLQ
910 920 930 940 950
SCVIVIRILR DLCQRVPTWS DFPNWALELL VEKAISSSSG PQSPGDALRR
960 970 980 990 1000
VFECISSGII LKGGPGLLDP CEKDPYDTLA TMNDQQREDI TSSAQFALRL
1010 1020 1030 1040 1050
LAFRQIYKVL GMDPLSQTNQ RFNVHSNRKR RRDSDSVDSF EAEGKKDKKD

YENF
Length:1,054
Mass (Da):115,218
Last modified:July 19, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBF6071AF55F5FA4B
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH42260 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH42260 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti460M → L in AAH42260 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC042260 mRNA Translation: AAH42260.1 Sequence problems.
BC073093 mRNA Translation: AAH73093.1

NCBI Reference Sequences

More...
RefSeqi
NP_001083976.1, NM_001090507.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
399224

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:399224

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC042260 mRNA Translation: AAH42260.1 Sequence problems.
BC073093 mRNA Translation: AAH73093.1
RefSeqiNP_001083976.1, NM_001090507.1

3D structure databases

SMRiQ6GPM1
ModBaseiSearch...

Genome annotation databases

GeneIDi399224
KEGGixla:399224

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
399224
XenbaseiXB-GENE-6067516, zfr.S

Phylogenomic databases

OMAiHDYVEEX
OrthoDBi612611at2759

Family and domain databases

Gene3Di3.30.460.10, 1 hit
InterProiView protein in InterPro
IPR006561, DZF_dom
IPR003604, Matrin/U1-like-C_Znf_C2H2
IPR043519, NT_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF07528, DZF, 1 hit
SMARTiView protein in SMART
SM00572, DZF, 1 hit
SM00355, ZnF_C2H2, 3 hits
SM00451, ZnF_U1, 3 hits
SUPFAMiSSF57667, SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS51703, DZF, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZFR_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6GPM1
Secondary accession number(s): Q8AVI6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 19, 2004
Last modified: December 2, 2020
This is version 72 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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