UniProtKB - Q6GPK9 (TAOK2_XENLA)
Protein
Serine/threonine-protein kinase TAO2
Gene
taok2
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
Serine/threonine-protein kinase involved in different processes such as apoptotic morphological changes, MAPK8/JNK and MAPK14/p38 MAPK signaling pathway.By similarity
Activates the JNK MAP kinase pathway.By similarity
Catalytic activityi
Cofactori
Mg2+By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 57 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 151 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 34 – 42 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: UniProtKB-EC
- protein threonine kinase activity Source: UniProtKB-EC
GO - Biological processi
- cellular response to DNA damage stimulus Source: UniProtKB
- mitotic G2 DNA damage checkpoint Source: UniProtKB
- positive regulation of stress-activated MAPK cascade Source: UniProtKB
- stress-activated MAPK cascade Source: UniProtKB
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Magnesium, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase TAO2 (EC:2.7.11.1)Alternative name(s): Thousand and one amino acid protein 2 |
Gene namesi | Name:taok2 |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-5714849, taok2.L |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086736 | 1 – 1025 | Serine/threonine-protein kinase TAO2Add BLAST | 1025 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 102250, 1 interactor |
IntActi | Q6GPK9, 2 interactors |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 281 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 254 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 457 – 650 | Sequence analysisAdd BLAST | 194 | |
Coiled coili | 755 – 876 | Sequence analysisAdd BLAST | 122 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 330 – 336 | Poly-Glu | 7 | |
Compositional biasi | 347 – 378 | Ser-richAdd BLAST | 32 | |
Compositional biasi | 955 – 1025 | Ser-richAdd BLAST | 71 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
OrthoDBi | 617606at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6GPK9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPSNARAGNL KDPEVAELFF KDDPEKLFAD LREIGHGSFG AVYFARDIRN
60 70 80 90 100
NEVVAIKKMS YSGKQSNEKW QDIIKEVKFL QKLRHPNTIE YKGCYLREHT
110 120 130 140 150
AWLVMEYCLG SASDLLEVHK KPLQEMEIAA ITHGALQGLA YLHNHNMIHR
160 170 180 190 200
DVKAGNILLT EPGLVKLGDF GSASIMAPAN SFVGTPYWMA PEVILAMDEG
210 220 230 240 250
QYDGKVDVWS LGITSIELAE RKPPLFNMNA MSALYHIAQN ESPVLQSNHW
260 270 280 290 300
SEYFRNFVDS CLQKIPQDRP TSDMLLKHRF LQRERPQTVI MELIQRTKDA
310 320 330 340 350
VRELDNLQYR KMKKILFQDT QNGPNTETTE EEEEAEQFLH CTGTITSMES
360 370 380 390 400
SQSVPSMSIS ASSQSSSVNS LADASDDSGE MAMMQEGEHT VTSNSSVIHR
410 420 430 440 450
LPAHDNIYDD PYQPEMEAQQ SSSAARRRAY CRNRDHFATI RTASLVTRQI
460 470 480 490 500
QEHEQDSALR EQMSGYKRMR RQHQKQLMAL ENKLKSELDE HQQRLDKELE
510 520 530 540 550
AHRSNFSAEN EKISKKHQAI FEKEAKGGMT EEKKFQQHIL GQQKKELTNL
560 570 580 590 600
LESQKRQYKI RKEQLKEELQ ENQSTPKREK QEWLLRQKES MQHYQAEEEA
610 620 630 640 650
NLLRRQRQYF ELQCRQYKRK MLLARHNLDQ DLLREELNKK QTQRDLECAM
660 670 680 690 700
LLRQHECTQE LEFRHLQLLQ HTRSELIRMQ HQTELGNQLE YNKRREQELR
710 720 730 740 750
QKHAAEVRQQ PKSLKSKELQ IKRQFQDTCK IQTRQYKALR NHLLETTPKS
760 770 780 790 800
EHKSILKRLK DEQTRKLAIL AEQYDHSINE MLSTQALRLD ETQEAEYQEL
810 820 830 840 850
RIQLQKELEL LNAYQSKIKI HTDAQHEREL KELEQRVSIR RALLEQRIEE
860 870 880 890 900
EMLALQTERS ERIRSLLERQ AREIEAFDSE SMRLGFSNMA LTGIPAEAFN
910 920 930 940 950
QGYQAPPPGW PSRPVPRSGS HWSHGVQNTG APQLWRQPTL LAPPSASWGL
960 970 980 990 1000
HPPGSSSSLS ALPSSSSSSS SSPSSSSGGR PGLLLLRNSP QPLRRGGSGG
1010 1020
PSEAGLSRST SVTSQLSNGS HLSYS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC073108 mRNA Translation: AAH73108.1 |
RefSeqi | NP_001085661.1, NM_001092192.1 |
Genome annotation databases
GeneIDi | 444087 |
KEGGi | xla:444087 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC073108 mRNA Translation: AAH73108.1 |
RefSeqi | NP_001085661.1, NM_001092192.1 |
3D structure databases
SMRi | Q6GPK9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 102250, 1 interactor |
IntActi | Q6GPK9, 2 interactors |
Genome annotation databases
GeneIDi | 444087 |
KEGGi | xla:444087 |
Organism-specific databases
CTDi | 444087 |
Xenbasei | XB-GENE-5714849, taok2.L |
Phylogenomic databases
OrthoDBi | 617606at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TAOK2_XENLA | |
Accessioni | Q6GPK9Primary (citable) accession number: Q6GPK9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 25, 2005 |
Last sequence update: | July 19, 2004 | |
Last modified: | February 10, 2021 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |