Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Chymotrypsinogen B2

Gene

CTRB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Tyr-|-Xaa, Trp-|-Xaa, Phe-|-Xaa, Leu-|-Xaa.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei75Charge relay systemBy similarity1
Active sitei120Charge relay systemBy similarity1
Active sitei213Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processDigestion

Enzyme and pathway databases

ReactomeiR-HSA-1592389 Activation of Matrix Metalloproteinases
R-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism

Protein family/group databases

MEROPSiS01.152

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsinogen B2 (EC:3.4.21.1)
Cleaved into the following 3 chains:
Gene namesi
Name:CTRB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000168928.12
HGNCiHGNC:2522 CTRB2
neXtProtiNX_Q6GPI1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168928
PharmGKBiPA27023

Polymorphism and mutation databases

BioMutaiCTRB2
DMDMi290457638

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000028587019 – 263Chymotrypsinogen B2Add BLAST245
ChainiPRO_000028587119 – 31Chymotrypsin B2 chain AAdd BLAST13
ChainiPRO_000028587234 – 164Chymotrypsin B2 chain BAdd BLAST131
ChainiPRO_0000285873167 – 263Chymotrypsin B2 chain CAdd BLAST97

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi19 ↔ 140PROSITE-ProRule annotation
Disulfide bondi60 ↔ 76PROSITE-ProRule annotation
Disulfide bondi154 ↔ 219PROSITE-ProRule annotation
Disulfide bondi186 ↔ 200PROSITE-ProRule annotation
Disulfide bondi209 ↔ 238PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiQ6GPI1
PeptideAtlasiQ6GPI1
PRIDEiQ6GPI1
ProteomicsDBi66317

PTM databases

iPTMnetiQ6GPI1
PhosphoSitePlusiQ6GPI1

Expressioni

Gene expression databases

BgeeiENSG00000168928 Expressed in 123 organ(s), highest expression level in duodenum
CleanExiHS_CTRB2
ExpressionAtlasiQ6GPI1 baseline and differential
GenevisibleiQ6GPI1 HS

Interactioni

Protein-protein interaction databases

BioGridi136533, 1 interactor
STRINGi9606.ENSP00000303963

Structurei

3D structure databases

ProteinModelPortaliQ6GPI1
SMRiQ6GPI1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 261Peptidase S1PROSITE-ProRule annotationAdd BLAST228

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000119027
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiQ6GPI1
KOiK01310
OMAiKLAQPIN
OrthoDBiEOG091G0AH5
PhylomeDBiQ6GPI1
TreeFamiTF330455

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q6GPI1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFLWLLSCW ALLGTTFGCG VPAIHPVLSG LSRIVNGEDA VPGSWPWQVS
60 70 80 90 100
LQDKTGFHFC GGSLISEDWV VTAAHCGVRT SDVVVAGEFD QGSDEENIQV
110 120 130 140 150
LKIAKVFKNP KFSILTVNND ITLLKLATPA RFSQTVSAVC LPSADDDFPA
160 170 180 190 200
GTLCATTGWG KTKYNANKTP DKLQQAALPL LSNAECKKSW GRRITDVMIC
210 220 230 240 250
AGASGVSSCM GDSGGPLVCQ KDGAWTLVGI VSWGSRTCST TTPAVYARVA
260
KLIPWVQKIL AAN
Length:263
Mass (Da):27,923
Last modified:March 2, 2010 - v2
Checksum:i3B1C0549F3488351
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8YCR2A0A2R8YCR2_HUMAN
Chymotrypsinogen B2
CTRB2
263Annotation score:
H3BTQ4H3BTQ4_HUMAN
Chymotrypsinogen B2
CTRB2
114Annotation score:
H3BP92H3BP92_HUMAN
Chymotrypsinogen B2
CTRB2
137Annotation score:
H3BMY1H3BMY1_HUMAN
Chymotrypsinogen B2
CTRB2
168Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3F → S in AAH73145 (PubMed:15489334).Curated1
Sequence conflicti10 – 16WALLGTT → FSLVGAA in AAH73145 (PubMed:15489334).Curated7

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062766250A → T1 PublicationCorresponds to variant dbSNP:rs4737Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291822 mRNA Translation: BAF84511.1
AC009078 Genomic DNA No translation available.
BC073145 mRNA Translation: AAH73145.1
CCDSiCCDS32489.1
RefSeqiNP_001020371.3, NM_001025200.3
UniGeneiHs.610926
Hs.632211

Genome annotation databases

EnsembliENST00000303037; ENSP00000303963; ENSG00000168928
GeneIDi440387
KEGGihsa:440387
UCSCiuc002fdr.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Chymotrypsin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291822 mRNA Translation: BAF84511.1
AC009078 Genomic DNA No translation available.
BC073145 mRNA Translation: AAH73145.1
CCDSiCCDS32489.1
RefSeqiNP_001020371.3, NM_001025200.3
UniGeneiHs.610926
Hs.632211

3D structure databases

ProteinModelPortaliQ6GPI1
SMRiQ6GPI1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi136533, 1 interactor
STRINGi9606.ENSP00000303963

Protein family/group databases

MEROPSiS01.152

PTM databases

iPTMnetiQ6GPI1
PhosphoSitePlusiQ6GPI1

Polymorphism and mutation databases

BioMutaiCTRB2
DMDMi290457638

Proteomic databases

PaxDbiQ6GPI1
PeptideAtlasiQ6GPI1
PRIDEiQ6GPI1
ProteomicsDBi66317

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303037; ENSP00000303963; ENSG00000168928
GeneIDi440387
KEGGihsa:440387
UCSCiuc002fdr.4 human

Organism-specific databases

CTDi440387
EuPathDBiHostDB:ENSG00000168928.12
GeneCardsiCTRB2
HGNCiHGNC:2522 CTRB2
neXtProtiNX_Q6GPI1
OpenTargetsiENSG00000168928
PharmGKBiPA27023
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000119027
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiQ6GPI1
KOiK01310
OMAiKLAQPIN
OrthoDBiEOG091G0AH5
PhylomeDBiQ6GPI1
TreeFamiTF330455

Enzyme and pathway databases

ReactomeiR-HSA-1592389 Activation of Matrix Metalloproteinases
R-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism

Miscellaneous databases

GenomeRNAii440387
PROiPR:Q6GPI1

Gene expression databases

BgeeiENSG00000168928 Expressed in 123 organ(s), highest expression level in duodenum
CleanExiHS_CTRB2
ExpressionAtlasiQ6GPI1 baseline and differential
GenevisibleiQ6GPI1 HS

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCTRB2_HUMAN
AccessioniPrimary (citable) accession number: Q6GPI1
Secondary accession number(s): A8K707
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 2, 2010
Last modified: November 7, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again