UniProtKB - Q6GPH4 (XAF1_HUMAN)
XIAP-associated factor 1
XAF1
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 22 – 99 | TRAF-typePROSITE-ProRule annotationAdd BLAST | 78 |
GO - Molecular functioni
- zinc ion binding Source: InterPro
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- response to interferon-beta Source: BHF-UCL
- type I interferon signaling pathway Source: Reactome
Keywordsi
Biological process | Apoptosis |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q6GPH4 |
Reactomei | R-HSA-909733, Interferon alpha/beta signaling |
SIGNORi | Q6GPH4 |
Names & Taxonomyi
Protein namesi | Recommended name: XIAP-associated factor 1Alternative name(s): BIRC4-binding protein |
Gene namesi | Name:XAF1 Synonyms:BIRC4BP, XIAPAF1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30932, XAF1 |
MIMi | 606717, gene |
neXtProti | NX_Q6GPH4 |
VEuPathDBi | HostDB:ENSG00000132530.16 |
Subcellular locationi
Cytoplasm and Cytosol
Mitochondrion
Nucleus
Note: Found in the cytoplasm and nucleus of placental syncytiotrophoblasts. Translocates to mitochondria upon TNF-alpha treatment.
Nucleus
Nucleus
Cytosol
- cytosol Source: Reactome
Mitochondrion
- mitochondrion Source: HPA
Nucleus
- nucleoplasm Source: HPA
Keywords - Cellular componenti
Cytoplasm, Mitochondrion, NucleusPathology & Biotechi
Keywords - Diseasei
Tumor suppressorOrganism-specific databases
DisGeNETi | 54739 |
OpenTargetsi | ENSG00000132530 |
PharmGKBi | PA162409299 |
Miscellaneous databases
Pharosi | Q6GPH4, Tbio |
Genetic variation databases
BioMutai | XAF1 |
DMDMi | 74736479 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000329028 | 1 – 301 | XIAP-associated factor 1Add BLAST | 301 |
Proteomic databases
MassIVEi | Q6GPH4 |
MaxQBi | Q6GPH4 |
PaxDbi | Q6GPH4 |
PeptideAtlasi | Q6GPH4 |
PRIDEi | Q6GPH4 |
ProteomicsDBi | 66307 [Q6GPH4-1] 66308 [Q6GPH4-2] 66309 [Q6GPH4-3] 66310 [Q6GPH4-4] 66311 [Q6GPH4-5] 66312 [Q6GPH4-6] 66313 [Q6GPH4-7] |
PTM databases
iPTMneti | Q6GPH4 |
PhosphoSitePlusi | Q6GPH4 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSG00000132530, Expressed in right ovary and 218 other tissues |
ExpressionAtlasi | Q6GPH4, baseline and differential |
Genevisiblei | Q6GPH4, HS |
Organism-specific databases
HPAi | ENSG00000132530, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with BIRC4; the interaction is not detected in (PubMed:16432762).
Interacts with BIRC1, BIRC2, BIRC3, BIRC7 and BIRC8.
Part of an complex consisting of BIRC4, XAF1 and BIRC5; the complex formation requires IFN-beta stimulation.
Interacts with RNF114, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.
4 PublicationsBinary interactionsi
Hide detailsQ6GPH4
Protein-protein interaction databases
BioGRIDi | 120121, 32 interactors |
IntActi | Q6GPH4, 16 interactors |
STRINGi | 9606.ENSP00000354822 |
Miscellaneous databases
RNActi | Q6GPH4, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q6GPH4 |
SMRi | Q6GPH4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 22 – 99 | TRAF-typePROSITE-ProRule annotationAdd BLAST | 78 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502QQRU, Eukaryota |
GeneTreei | ENSGT00530000063869 |
HOGENOMi | CLU_066148_0_0_1 |
InParanoidi | Q6GPH4 |
OMAi | AQHREVC |
OrthoDBi | 1113262at2759 |
PhylomeDBi | Q6GPH4 |
TreeFami | TF331416 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR031220, XAF1 IPR041386, XAF1_C IPR013083, Znf_RING/FYVE/PHD IPR001293, Znf_TRAF |
PANTHERi | PTHR16295:SF17, PTHR16295:SF17, 1 hit |
Pfami | View protein in Pfam PF18608, XAF1_C, 1 hit |
PROSITEi | View protein in PROSITE PS50145, ZF_TRAF, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEGDFSVCRN CKRHVVSANF TLHEAYCLRF LVLCPECEEP VPKETMEEHC
60 70 80 90 100
KLEHQQVGCT MCQQSMQKSS LEFHKANECQ ERPVECKFCK LDMQLSKLEL
110 120 130 140 150
HESYCGSRTE LCQGCGQFIM HRMLAQHRDV CRSEQAQLGK GERISAPERE
160 170 180 190 200
IYCHYCNQMI PENKYFHHMG KCCPDSEFKK HFPVGNPEIL PSSLPSQAAE
210 220 230 240 250
NQTSTMEKDV RPKTRSINRF PLHSESSSKK APRSKNKTLD PLLMSEPKPR
260 270 280 290 300
TSSPRGDKAA YDILRRCSQC GILLPLPILN QHQEKCRWLA SSKGKQVRNF
S
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J7Z8 | C9J7Z8_HUMAN | XIAP-associated factor 1 | XAF1 | 164 | Annotation score: | ||
I3L3D9 | I3L3D9_HUMAN | XIAP-associated factor 1 | XAF1 | 133 | Annotation score: | ||
I3L509 | I3L509_HUMAN | XIAP-associated factor 1 | XAF1 | 145 | Annotation score: | ||
I3L3B3 | I3L3B3_HUMAN | XIAP-associated factor 1 | XAF1 | 190 | Annotation score: | ||
I3L2B3 | I3L2B3_HUMAN | XIAP-associated factor 1 | XAF1 | 74 | Annotation score: | ||
I3L3Q2 | I3L3Q2_HUMAN | XIAP-associated factor 1 | XAF1 | 63 | Annotation score: | ||
I3L534 | I3L534_HUMAN | XIAP-associated factor 1 | XAF1 | 128 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 132 | R → Q in BAF85537 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 138 | L → R in BAF85537 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 196 | S → R in BAF85537 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_042616 | 85 | E → G. Corresponds to variant dbSNP:rs34195599Ensembl. | 1 | |
Natural variantiVAR_042617 | 132 | R → H. Corresponds to variant dbSNP:rs2271232Ensembl. | 1 | |
Natural variantiVAR_042618 | 188 | E → K. Corresponds to variant dbSNP:rs34625877Ensembl. | 1 | |
Natural variantiVAR_042619 | 219 | R → I. Corresponds to variant dbSNP:rs3736433Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_032918 | 1 – 102 | Missing in isoform 6. 1 PublicationAdd BLAST | 102 | |
Alternative sequenceiVSP_032919 | 57 – 75 | Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST | 19 | |
Alternative sequenceiVSP_032920 | 57 – 74 | VGCTM…SLEFH → GKEFQLLKGKSTVIIATK in isoform 7. 1 PublicationAdd BLAST | 18 | |
Alternative sequenceiVSP_032921 | 103 – 140 | SYCGS…AQLGK → MSLHYGCCCPECTSVAIKEM MWVIRPRVACVVKDAGSA in isoform 6. 1 PublicationAdd BLAST | 38 | |
Alternative sequenceiVSP_032922 | 141 – 301 | GERIS…VRNFS → ETSPDPGKCLSITVAAALSA HLWPFT in isoform 5. CuratedAdd BLAST | 161 | |
Alternative sequenceiVSP_032923 | 142 – 301 | Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST | 160 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X99699 mRNA Translation: CAA68030.1 Frameshift. EF028165 mRNA Translation: ABM74556.1 EF028166 mRNA Translation: ABM74557.1 AK290276 mRNA Translation: BAF82965.1 AK292710 mRNA Translation: BAF85399.1 AK292848 mRNA Translation: BAF85537.1 CH471108 Genomic DNA Translation: EAW90288.1 CH471108 Genomic DNA Translation: EAW90289.1 BC032776 mRNA Translation: AAH32776.1 Different initiation. BC073156 mRNA Translation: AAH73156.1 BX649188 mRNA Translation: CAE46206.1 |
CCDSi | CCDS11080.1 [Q6GPH4-1] CCDS11081.1 [Q6GPH4-2] |
RefSeqi | NP_059993.2, NM_017523.3 [Q6GPH4-1] NP_954590.1, NM_199139.2 [Q6GPH4-2] XP_005256765.1, XM_005256708.2 [Q6GPH4-6] |
Genome annotation databases
Ensembli | ENST00000346752; ENSP00000341029; ENSG00000132530 [Q6GPH4-2] ENST00000361842; ENSP00000354822; ENSG00000132530 [Q6GPH4-1] ENST00000571673; ENSP00000461196; ENSG00000132530 [Q6GPH4-4] ENST00000574962; ENSP00000458229; ENSG00000132530 [Q6GPH4-3] |
GeneIDi | 54739 |
KEGGi | hsa:54739 |
UCSCi | uc002gdn.4, human [Q6GPH4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X99699 mRNA Translation: CAA68030.1 Frameshift. EF028165 mRNA Translation: ABM74556.1 EF028166 mRNA Translation: ABM74557.1 AK290276 mRNA Translation: BAF82965.1 AK292710 mRNA Translation: BAF85399.1 AK292848 mRNA Translation: BAF85537.1 CH471108 Genomic DNA Translation: EAW90288.1 CH471108 Genomic DNA Translation: EAW90289.1 BC032776 mRNA Translation: AAH32776.1 Different initiation. BC073156 mRNA Translation: AAH73156.1 BX649188 mRNA Translation: CAE46206.1 |
CCDSi | CCDS11080.1 [Q6GPH4-1] CCDS11081.1 [Q6GPH4-2] |
RefSeqi | NP_059993.2, NM_017523.3 [Q6GPH4-1] NP_954590.1, NM_199139.2 [Q6GPH4-2] XP_005256765.1, XM_005256708.2 [Q6GPH4-6] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2LXW | NMR | - | A | 251-301 | [»] | |
BMRBi | Q6GPH4 | |||||
SMRi | Q6GPH4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120121, 32 interactors |
IntActi | Q6GPH4, 16 interactors |
STRINGi | 9606.ENSP00000354822 |
PTM databases
iPTMneti | Q6GPH4 |
PhosphoSitePlusi | Q6GPH4 |
Genetic variation databases
BioMutai | XAF1 |
DMDMi | 74736479 |
Proteomic databases
MassIVEi | Q6GPH4 |
MaxQBi | Q6GPH4 |
PaxDbi | Q6GPH4 |
PeptideAtlasi | Q6GPH4 |
PRIDEi | Q6GPH4 |
ProteomicsDBi | 66307 [Q6GPH4-1] 66308 [Q6GPH4-2] 66309 [Q6GPH4-3] 66310 [Q6GPH4-4] 66311 [Q6GPH4-5] 66312 [Q6GPH4-6] 66313 [Q6GPH4-7] |
Protocols and materials databases
Antibodypediai | 23838, 245 antibodies |
Genome annotation databases
Ensembli | ENST00000346752; ENSP00000341029; ENSG00000132530 [Q6GPH4-2] ENST00000361842; ENSP00000354822; ENSG00000132530 [Q6GPH4-1] ENST00000571673; ENSP00000461196; ENSG00000132530 [Q6GPH4-4] ENST00000574962; ENSP00000458229; ENSG00000132530 [Q6GPH4-3] |
GeneIDi | 54739 |
KEGGi | hsa:54739 |
UCSCi | uc002gdn.4, human [Q6GPH4-1] |
Organism-specific databases
CTDi | 54739 |
DisGeNETi | 54739 |
GeneCardsi | XAF1 |
HGNCi | HGNC:30932, XAF1 |
HPAi | ENSG00000132530, Low tissue specificity |
MIMi | 606717, gene |
neXtProti | NX_Q6GPH4 |
OpenTargetsi | ENSG00000132530 |
PharmGKBi | PA162409299 |
VEuPathDBi | HostDB:ENSG00000132530.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQRU, Eukaryota |
GeneTreei | ENSGT00530000063869 |
HOGENOMi | CLU_066148_0_0_1 |
InParanoidi | Q6GPH4 |
OMAi | AQHREVC |
OrthoDBi | 1113262at2759 |
PhylomeDBi | Q6GPH4 |
TreeFami | TF331416 |
Enzyme and pathway databases
PathwayCommonsi | Q6GPH4 |
Reactomei | R-HSA-909733, Interferon alpha/beta signaling |
SIGNORi | Q6GPH4 |
Miscellaneous databases
BioGRID-ORCSi | 54739, 2 hits in 988 CRISPR screens |
ChiTaRSi | XAF1, human |
GeneWikii | XAF1 |
GenomeRNAii | 54739 |
Pharosi | Q6GPH4, Tbio |
PROi | PR:Q6GPH4 |
RNActi | Q6GPH4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000132530, Expressed in right ovary and 218 other tissues |
ExpressionAtlasi | Q6GPH4, baseline and differential |
Genevisiblei | Q6GPH4, HS |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR031220, XAF1 IPR041386, XAF1_C IPR013083, Znf_RING/FYVE/PHD IPR001293, Znf_TRAF |
PANTHERi | PTHR16295:SF17, PTHR16295:SF17, 1 hit |
Pfami | View protein in Pfam PF18608, XAF1_C, 1 hit |
PROSITEi | View protein in PROSITE PS50145, ZF_TRAF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | XAF1_HUMAN | |
Accessioni | Q6GPH4Primary (citable) accession number: Q6GPH4 Secondary accession number(s): A2T931 Q99982 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 8, 2008 |
Last sequence update: | July 19, 2004 | |
Last modified: | April 7, 2021 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references