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UniProtKB - Q6GPH4 (XAF1_HUMAN)

Entry version 135 (23 Feb 2022)
Sequence version 1 (19 Jul 2004)
Previous versions | rss
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Protein

XIAP-associated factor 1

Gene

XAF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondria, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells.

5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri22 – 99TRAF-typePROSITE-ProRule annotationAdd BLAST78

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6GPH4

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-909733, Interferon alpha/beta signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q6GPH4

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q6GPH4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
XIAP-associated factor 1
Alternative name(s):
BIRC4-binding protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:XAF1
Synonyms:BIRC4BP, XIAPAF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30932, XAF1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606717, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6GPH4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000132530

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNET

More...DisGeNETi		54739

Open Targets

More...OpenTargetsi		ENSG00000132530

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162409299

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6GPH4, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		XAF1

Domain mapping of disease mutations (DMDM)

More...DMDMi		74736479

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003290281 – 301XIAP-associated factor 1Add BLAST301

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6GPH4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6GPH4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6GPH4

PeptideAtlas

More...PeptideAtlasi		Q6GPH4

PRoteomics IDEntifications database

More...PRIDEi		Q6GPH4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		66307 [Q6GPH4-1]
66308 [Q6GPH4-2]
66309 [Q6GPH4-3]
66310 [Q6GPH4-4]
66311 [Q6GPH4-5]
66312 [Q6GPH4-6]
66313 [Q6GPH4-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6GPH4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6GPH4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expression is frequently down-regulated in cancer cell lines. Isoform 5 is widely expressed. Expressed in placenta (at protein level).4 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Selectively expressed in third trimester placenta.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by IFNB1/IFN-beta in cell lines sensitive to the proapoptotic effects of IFNB1 but not in apoptosis-resistant cells. Up-regulated by TNF in trophoblast cells.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000132530, Expressed in right ovary and 219 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6GPH4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6GPH4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000132530, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with BIRC4; the interaction is not detected in (PubMed:16432762).

Interacts with BIRC1, BIRC2, BIRC3, BIRC7 and BIRC8.

Part of an complex consisting of BIRC4, XAF1 and BIRC5; the complex formation requires IFN-beta stimulation.

Interacts with RNF114, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120121, 36 interactors

Protein interaction database and analysis system

More...IntActi		Q6GPH4, 16 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000354822

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6GPH4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1301
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q6GPH4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6GPH4

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni189 – 257DisorderedSequence analysisAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi190 – 205Polar residuesSequence analysisAdd BLAST16

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri22 – 99TRAF-typePROSITE-ProRule annotationAdd BLAST78

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QQRU, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063869

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_066148_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6GPH4

Identification of Orthologs from Complete Genome Data

More...OMAi		WHEAKCQ

Database of Orthologous Groups

More...OrthoDBi		1113262at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6GPH4

TreeFam database of animal gene trees

More...TreeFami		TF331416

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR031220, XAF1
IPR041386, XAF1_C
IPR013083, Znf_RING/FYVE/PHD
IPR001293, Znf_TRAF

The PANTHER Classification System

More...PANTHERi		PTHR16295:SF17, PTHR16295:SF17, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF18608, XAF1_C, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50145, ZF_TRAF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6GPH4-1) [UniParc]FASTAAdd to basket
Also known as: XAF1(A)

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGDFSVCRN CKRHVVSANF TLHEAYCLRF LVLCPECEEP VPKETMEEHC 
        60         70         80         90        100
KLEHQQVGCT MCQQSMQKSS LEFHKANECQ ERPVECKFCK LDMQLSKLEL 
       110        120        130        140        150
HESYCGSRTE LCQGCGQFIM HRMLAQHRDV CRSEQAQLGK GERISAPERE 
       160        170        180        190        200
IYCHYCNQMI PENKYFHHMG KCCPDSEFKK HFPVGNPEIL PSSLPSQAAE 
       210        220        230        240        250
NQTSTMEKDV RPKTRSINRF PLHSESSSKK APRSKNKTLD PLLMSEPKPR 
       260        270        280        290        300
TSSPRGDKAA YDILRRCSQC GILLPLPILN QHQEKCRWLA SSKGKQVRNF 

S
Length:301
Mass (Da):34,626
Last modified:July 19, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFC9D48BD07BE541D
GO
Isoform 2 (identifier: Q6GPH4-2) [UniParc]FASTAAdd to basket
Also known as: XAF1B

The sequence of this isoform differs from the canonical sequence as follows:
     57-75: Missing.

Show »
Length:282
Mass (Da):32,471
Checksum:i6EAC4F7EC6F8E64A
GO
Isoform 3 (identifier: Q6GPH4-3) [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     142-301: Missing.

Show »
Length:141
Mass (Da):16,322
Checksum:iB286A33BC34A10A2
GO
Isoform 4 (identifier: Q6GPH4-4) [UniParc]FASTAAdd to basket
Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     57-75: Missing.
     142-301: Missing.

Show »
Length:122
Mass (Da):14,167
Checksum:i36CC8B71B4DCCD8A
GO
Isoform 5 (identifier: Q6GPH4-5) [UniParc]FASTAAdd to basket
Also known as: XAF1C

The sequence of this isoform differs from the canonical sequence as follows:
     141-301: GERISAPERE...SKGKQVRNFS → ETSPDPGKCLSITVAAALSAHLWPFT

Show »
Length:166
Mass (Da):18,960
Checksum:i0EDD81DA26C30B50
GO
Isoform 6 (identifier: Q6GPH4-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-102: Missing.
     103-140: SYCGSRTELC...CRSEQAQLGK → MSLHYGCCCP...ACVVKDAGSA

Show »
Length:199
Mass (Da):22,507
Checksum:iFCA89ECA5FB0ED46
GO
Isoform 7 (identifier: Q6GPH4-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     57-74: VGCTMCQQSMQKSSLEFH → GKEFQLLKGKSTVIIATK

Show »
Length:301
Mass (Da):34,543
Checksum:i556947EBEFD6B84E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L3D9I3L3D9_HUMAN
XIAP-associated factor 1
XAF1
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J7Z8C9J7Z8_HUMAN
XIAP-associated factor 1
XAF1
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L509I3L509_HUMAN
XIAP-associated factor 1
XAF1
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2B3I3L2B3_HUMAN
XIAP-associated factor 1
XAF1
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3B3I3L3B3_HUMAN
XIAP-associated factor 1
XAF1
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3Q2I3L3Q2_HUMAN
XIAP-associated factor 1
XAF1
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L534I3L534_HUMAN
XIAP-associated factor 1
XAF1
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH32776 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA68030 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti132R → Q in BAF85537 (PubMed:14702039).Curated1
Sequence conflicti138L → R in BAF85537 (PubMed:14702039).Curated1
Sequence conflicti196S → R in BAF85537 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04261685E → G. Corresponds to variant dbSNP:rs34195599Ensembl.1
Natural variantiVAR_042617132R → H. Corresponds to variant dbSNP:rs2271232Ensembl.1
Natural variantiVAR_042618188E → K. Corresponds to variant dbSNP:rs34625877Ensembl.1
Natural variantiVAR_042619219R → I. Corresponds to variant dbSNP:rs3736433Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0329181 – 102Missing in isoform 6. 1 PublicationAdd BLAST102
Alternative sequenceiVSP_03291957 – 75Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST19
Alternative sequenceiVSP_03292057 – 74VGCTM…SLEFH → GKEFQLLKGKSTVIIATK in isoform 7. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_032921103 – 140SYCGS…AQLGK → MSLHYGCCCPECTSVAIKEM MWVIRPRVACVVKDAGSA in isoform 6. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_032922141 – 301GERIS…VRNFS → ETSPDPGKCLSITVAAALSA HLWPFT in isoform 5. CuratedAdd BLAST161
Alternative sequenceiVSP_032923142 – 301Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST160

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X99699 mRNA Translation: CAA68030.1 Frameshift.
EF028165 mRNA Translation: ABM74556.1
EF028166 mRNA Translation: ABM74557.1
AK290276 mRNA Translation: BAF82965.1
AK292710 mRNA Translation: BAF85399.1
AK292848 mRNA Translation: BAF85537.1
CH471108 Genomic DNA Translation: EAW90288.1
CH471108 Genomic DNA Translation: EAW90289.1
BC032776 mRNA Translation: AAH32776.1 Different initiation.
BC073156 mRNA Translation: AAH73156.1
BX649188 mRNA Translation: CAE46206.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11080.1 [Q6GPH4-1]
CCDS11081.1 [Q6GPH4-2]

NCBI Reference Sequences

More...RefSeqi		NP_059993.2, NM_017523.3 [Q6GPH4-1]
NP_954590.1, NM_199139.2 [Q6GPH4-2]
XP_005256765.1, XM_005256708.2 [Q6GPH4-6]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000346752; ENSP00000341029; ENSG00000132530 [Q6GPH4-2]
ENST00000361842; ENSP00000354822; ENSG00000132530
ENST00000571673; ENSP00000461196; ENSG00000132530 [Q6GPH4-4]
ENST00000574962; ENSP00000458229; ENSG00000132530 [Q6GPH4-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54739

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54739

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000361842.8; ENSP00000354822.3; NM_017523.5; NP_059993.2

UCSC genome browser

More...UCSCi		uc002gdn.4, human [Q6GPH4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99699 mRNA Translation: CAA68030.1 Frameshift.
EF028165 mRNA Translation: ABM74556.1
EF028166 mRNA Translation: ABM74557.1
AK290276 mRNA Translation: BAF82965.1
AK292710 mRNA Translation: BAF85399.1
AK292848 mRNA Translation: BAF85537.1
CH471108 Genomic DNA Translation: EAW90288.1
CH471108 Genomic DNA Translation: EAW90289.1
BC032776 mRNA Translation: AAH32776.1 Different initiation.
BC073156 mRNA Translation: AAH73156.1
BX649188 mRNA Translation: CAE46206.1
CCDSiCCDS11080.1 [Q6GPH4-1]
CCDS11081.1 [Q6GPH4-2]
RefSeqiNP_059993.2, NM_017523.3 [Q6GPH4-1]
NP_954590.1, NM_199139.2 [Q6GPH4-2]
XP_005256765.1, XM_005256708.2 [Q6GPH4-6]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LXWNMR-A251-301[»]
BMRBiQ6GPH4
SMRiQ6GPH4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120121, 36 interactors
IntActiQ6GPH4, 16 interactors
STRINGi9606.ENSP00000354822

PTM databases

iPTMnetiQ6GPH4
PhosphoSitePlusiQ6GPH4

Genetic variation databases

BioMutaiXAF1
DMDMi74736479

Proteomic databases

MassIVEiQ6GPH4
MaxQBiQ6GPH4
PaxDbiQ6GPH4
PeptideAtlasiQ6GPH4
PRIDEiQ6GPH4
ProteomicsDBi66307 [Q6GPH4-1]
66308 [Q6GPH4-2]
66309 [Q6GPH4-3]
66310 [Q6GPH4-4]
66311 [Q6GPH4-5]
66312 [Q6GPH4-6]
66313 [Q6GPH4-7]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23838, 251 antibodies from 30 providers

The DNASU plasmid repository

More...DNASUi		54739

Genome annotation databases

EnsembliENST00000346752; ENSP00000341029; ENSG00000132530 [Q6GPH4-2]
ENST00000361842; ENSP00000354822; ENSG00000132530
ENST00000571673; ENSP00000461196; ENSG00000132530 [Q6GPH4-4]
ENST00000574962; ENSP00000458229; ENSG00000132530 [Q6GPH4-3]
GeneIDi54739
KEGGihsa:54739
MANE-SelectiENST00000361842.8; ENSP00000354822.3; NM_017523.5; NP_059993.2
UCSCiuc002gdn.4, human [Q6GPH4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54739
DisGeNETi54739

GeneCards: human genes, protein and diseases

More...GeneCardsi		XAF1
HGNCiHGNC:30932, XAF1
HPAiENSG00000132530, Low tissue specificity
MIMi606717, gene
neXtProtiNX_Q6GPH4
OpenTargetsiENSG00000132530
PharmGKBiPA162409299
VEuPathDBiHostDB:ENSG00000132530

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QQRU, Eukaryota
GeneTreeiENSGT00530000063869
HOGENOMiCLU_066148_0_0_1
InParanoidiQ6GPH4
OMAiWHEAKCQ
OrthoDBi1113262at2759
PhylomeDBiQ6GPH4
TreeFamiTF331416

Enzyme and pathway databases

PathwayCommonsiQ6GPH4
ReactomeiR-HSA-909733, Interferon alpha/beta signaling
SignaLinkiQ6GPH4
SIGNORiQ6GPH4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54739, 2 hits in 1038 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		XAF1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		XAF1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54739
PharosiQ6GPH4, Tbio

Protein Ontology

More...PROi		PR:Q6GPH4
RNActiQ6GPH4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000132530, Expressed in right ovary and 219 other tissues
ExpressionAtlasiQ6GPH4, baseline and differential
GenevisibleiQ6GPH4, HS

Family and domain databases

Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR031220, XAF1
IPR041386, XAF1_C
IPR013083, Znf_RING/FYVE/PHD
IPR001293, Znf_TRAF
PANTHERiPTHR16295:SF17, PTHR16295:SF17, 1 hit
PfamiView protein in Pfam
PF18608, XAF1_C, 1 hit
PROSITEiView protein in PROSITE
PS50145, ZF_TRAF, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXAF1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6GPH4
Secondary accession number(s): A2T931
, A2T932, A8K2L1, A8K9Y3, D3DTM6, Q6MZE8, Q8N557, Q99982
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 19, 2004
Last modified: February 23, 2022
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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