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Entry version 77 (03 Jul 2019)
Sequence version 1 (19 Jul 2004)
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Protein

Rho GTPase-activating protein 32

Gene

arhgap32

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein 32
Alternative name(s):
Rho-type GTPase-activating protein 32
Rho/Cdc42/Rac GTPase-activating protein RICS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:arhgap32
Synonyms:rics
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-1002479 arhgap32

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003452051 – 1940Rho GTPase-activating protein 32Add BLAST1940

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q6GPD0

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6GPD0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini154 – 248PX; atypicalAdd BLAST95
Domaini262 – 324SH3PROSITE-ProRule annotationAdd BLAST63
Domaini375 – 570Rho-GAPPROSITE-ProRule annotationAdd BLAST196

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1069 – 1074Poly-Pro6
Compositional biasi1107 – 1110Poly-Pro4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal PX domain interacts specifically with phosphatidylinositides.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PX domain-containing GAP family.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K20647

Database of Orthologous Groups

More...
OrthoDBi
1300981at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07298 PX_RICS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit
3.30.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042139 PX_ARHGAP32
IPR036871 PX_dom_sf
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00620 RhoGAP, 1 hit
PF07653 SH3_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00324 RhoGAP, 1 hit
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350 SSF48350, 1 hit
SSF50044 SSF50044, 1 hit
SSF64268 SSF64268, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50238 RHOGAP, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6GPD0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGGTDAAAF AAFPSIHAVP STSGRMVTGS KLDELERIMK SSLHLEEDDF
60 70 80 90 100
VPELPRSIHP RERPDWEETI SAMARGADIT VPGEIQIPAE LPLRSCGSTA
110 120 130 140 150
SMKVKNVKKL SFTKGHFPKL AECAHFHYEN VDFGSIQLTL TEDQNEVNRN
160 170 180 190 200
GCESKELVFL VQIACQGRSW IVKRSYEDFR VLDKHLHLCI YDRRFSQLSE
210 220 230 240 250
LPRSDSVKDN PELVTQMLMA YLSRLSAIAG NKINCGPALT WMEIDNKGNH
260 270 280 290 300
LLVHEESSIN VPAIAAAHVI KRYNAQAPDE LSFEVGDIVS VIDMPPKELT
310 320 330 340 350
TWWRGKHGFQ VGFFPSECVE LINDKVPQSM TNSVPKPVSR KHGKLITFLR
360 370 380 390 400
TFMKSRPSKQ KLKQRGILRE RVFGCDLGEH LLNSGQDVPQ VLRSCTEFIE
410 420 430 440 450
KHGVVDGIYR LSGIASNIQK LRHEFDSEQI PDLTKDVYIQ DIHCVGSLCK
460 470 480 490 500
LYFRELPNPL LTYQLYEKFS DAVSAASDEE RLVKIHDVIQ QLPPPHYRTL
510 520 530 540 550
EFLMRHLSRL ATYCSITNMH TKNLAIVWAP NLLRSKQIES ACFSGTAAFM
560 570 580 590 600
EVRIQSVVVE FILNHVEVLF SAKLSSVIRE GAGHTSLSRP KSLLVSSPST
610 620 630 640 650
KLLSLEEAQA RTQAQINSPV VGDSRYIEVG EGPAALQGRF HTVIDFPSER
660 670 680 690 700
KRPPSKMKKS PVGSWRSFFN IGKSSSSSSM SKRKLQRNPS EPLEMKSMAF
710 720 730 740 750
AGGRDSSAMR SAKSEESLSS LHAADGESKL FRPRRPRSSS DALSASYNGD
760 770 780 790 800
LLDSCNRCNS YDNLPRDHDS DGDEGLIHVP AMLSGRSPED EDLSPPDIGM
810 820 830 840 850
ATLDFDPMSF QCSPHQLDSE GPDNFFQLDI FASNGKDKLQ SGTQNPGSVT
860 870 880 890 900
GCEPLSPFQD KVISPFLSPD RSPSTDKVSK TASFAEKFVQ ALSPKMGRKA
910 920 930 940 950
VRSPPLTISD PVSISLPSRV SEMIGSMPGN SAASQSIIWN RESSTNSRES
960 970 980 990 1000
ETYYGCKLVD ANLSSSSATA DPWSTVTPVI TCNQDGREDK AGIFTHGFPQ
1010 1020 1030 1040 1050
PLESSDLEYI ENYNLELGTT NVAAAYQNDD TELSRANQNK AHPPNSPQGA
1060 1070 1080 1090 1100
SASESPQELS HVSSVSIIPP PPPPKNPARM LALALAESAQ QASANKKPSF
1110 1120 1130 1140 1150
MQFMDLPPPP SVPEDKPLLE FSPKMSPEPL RSGPATPAAS PPVISRKTSP
1160 1170 1180 1190 1200
ATPPSTTSSF SVTTIHHSPV KNYNPLAGQM PTAVTPGLSP SSNQVFASVP
1210 1220 1230 1240 1250
DMLHSETIKM NSIIPSEAFT TGIPVTPPTE KTKESSRAPH LHQRSESFPS
1260 1270 1280 1290 1300
HPAYSTAKPT PPVRTMDSRL ATAMHSNFND SITANNYHSF LNTMMLPSSL
1310 1320 1330 1340 1350
EDALPRHNYS PHLKTGNIDE EGVNYRQTYL SHNKQDDPAD LGDLYRQPYI
1360 1370 1380 1390 1400
SPGKSENAEI GNAYRHPYPS NTESESLKEP LEPFLHHKPA VAPKTYRAET
1410 1420 1430 1440 1450
LLPHIPPQVY GSRCDTPSSA FYGTYINQAK HPRSRNKPDY MPSMSPGVRS
1460 1470 1480 1490 1500
YTEDTSSYPT IRRVQSLHVP MQTLPPPIRT VPISRTEVPP DDDPAYCPRP
1510 1520 1530 1540 1550
LYQYKQCPPF NSQSDYHVTQ LQPYFENGRV HYRYSPYSGG PTYFSSDSNF
1560 1570 1580 1590 1600
YDMDPYGTLR LRQLPLYPSR DFASYTTRLQ PKATYRSQGL PPYPRGTLRE
1610 1620 1630 1640 1650
HNFISRDVPP ALPPEHPRPL HISWDMEDMD RYRLQSLRRE NKARQRAKGP
1660 1670 1680 1690 1700
VMSQYDNVTP SLVEDVAGLD VIHLRSRSDP GKTPGLLSVA ETKDVRYPGR
1710 1720 1730 1740 1750
TEGDERTTYP PPVFGNGHQD KPSLPQKQSG SSRSRMQHDI STEQHSQDTL
1760 1770 1780 1790 1800
HRQPSEGRNG PPIPPVDYNA KGMPNPPDPT SYHSSANKYN LTQQEPMRLN
1810 1820 1830 1840 1850
HKELRLTEDI ERSHTRPADN QHRDCYREEQ AQFASVVPPP KPERSHSLRA
1860 1870 1880 1890 1900
HNPAVLERDP SIFYPYQTLH AKRQSTINTV SQYDNLSDYH SIPHHRTTNQ
1910 1920 1930 1940
STPNAFPLPH GRTYSTALGQ GAFLAAELAL QRPETKIHVE
Length:1,940
Mass (Da):216,024
Last modified:July 19, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E3BCF52E0D00D33
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC073211 mRNA Translation: AAH73211.1

NCBI Reference Sequences

More...
RefSeqi
NP_001085694.1, NM_001092225.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
444120

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:444120

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC073211 mRNA Translation: AAH73211.1
RefSeqiNP_001085694.1, NM_001092225.1

3D structure databases

SMRiQ6GPD0
ModBaseiSearch...

Proteomic databases

PRIDEiQ6GPD0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi444120
KEGGixla:444120

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
444120
XenbaseiXB-GENE-1002479 arhgap32

Phylogenomic databases

KOiK20647
OrthoDBi1300981at2759

Family and domain databases

CDDicd07298 PX_RICS, 1 hit
Gene3Di1.10.555.10, 1 hit
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR042139 PX_ARHGAP32
IPR036871 PX_dom_sf
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00620 RhoGAP, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00324 RhoGAP, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
SSF50044 SSF50044, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50238 RHOGAP, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHG32_XENLA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6GPD0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 19, 2004
Last modified: July 3, 2019
This is version 77 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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