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UniProtKB - Q6GNY1 (MIB1_XENLA)
Protein
E3 ubiquitin-protein ligase mib1
Gene
mib1
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors (By similarity).
By similarityCatalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 85 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 88 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 100 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 103 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 109 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 112 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 118 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 122 | Zinc 2PROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 80 – 132 | ZZ-typePROSITE-ProRule annotationAdd BLAST | 53 | |
Zinc fingeri | 820 – 855 | RING-type 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Zinc fingeri | 867 – 902 | RING-type 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Zinc fingeri | 964 – 997 | RING-type 3PROSITE-ProRule annotationAdd BLAST | 34 |
GO - Molecular functioni
- ubiquitin-protein transferase activity Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- Notch signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Transferase |
Biological process | Notch signaling pathway, Ubl conjugation pathway |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: E3 ubiquitin-protein ligase mib1 (EC:2.3.2.27)Alternative name(s): Mind bomb homolog 1 RING-type E3 ubiquitin transferase mib1Curated |
Gene namesi | Name:mib1 |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-1001398, mib1.L |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytoskeleton
- centriolar satellite By similarity
Cytoskeleton
- microtubule organizing center Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000055946 | 1 – 1011 | E3 ubiquitin-protein ligase mib1Add BLAST | 1011 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 74 | MIB/HERC2 1PROSITE-ProRule annotationAdd BLAST | 69 | |
Domaini | 143 – 221 | MIB/HERC2 2PROSITE-ProRule annotationAdd BLAST | 79 | |
Repeati | 430 – 460 | ANK 1Add BLAST | 31 | |
Repeati | 463 – 492 | ANK 2Add BLAST | 30 | |
Repeati | 496 – 525 | ANK 3Add BLAST | 30 | |
Repeati | 529 – 558 | ANK 4Add BLAST | 30 | |
Repeati | 562 – 591 | ANK 5Add BLAST | 30 | |
Repeati | 595 – 627 | ANK 6Add BLAST | 33 | |
Repeati | 631 – 661 | ANK 7Add BLAST | 31 | |
Repeati | 665 – 694 | ANK 8Add BLAST | 30 | |
Repeati | 698 – 729 | ANK 9Add BLAST | 32 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 936 – 963 | Sequence analysisAdd BLAST | 28 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 80 – 132 | ZZ-typePROSITE-ProRule annotationAdd BLAST | 53 | |
Zinc fingeri | 820 – 855 | RING-type 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Zinc fingeri | 867 – 902 | RING-type 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Zinc fingeri | 964 – 997 | RING-type 3PROSITE-ProRule annotationAdd BLAST | 34 |
Keywords - Domaini
ANK repeat, Coiled coil, Repeat, Zinc-fingerPhylogenomic databases
OMAi | CCGGIGR |
OrthoDBi | 220300at2759 |
Family and domain databases
CDDi | cd02339, ZZ_Mind_bomb, 1 hit |
Gene3Di | 1.25.40.20, 3 hits 3.30.40.10, 3 hits 3.30.60.90, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR042056, MIB1/2_ZZ IPR010606, Mib_Herc2 IPR037252, Mib_Herc2_sf IPR040847, SH3_15 IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR000433, Znf_ZZ IPR043145, Znf_ZZ_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 3 hits PF06701, MIB_HERC2, 2 hits PF18346, SH3_15, 2 hits PF00569, ZZ, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 9 hits SM00184, RING, 3 hits SM00291, ZnF_ZZ, 1 hit |
SUPFAMi | SSF159034, SSF159034, 2 hits SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 6 hits PS51416, MIB_HERC2, 2 hits PS50089, ZF_RING_2, 3 hits PS01357, ZF_ZZ_1, 1 hit PS50135, ZF_ZZ_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6GNY1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGSRNNRVM VEGVGARVAR GPDWKWGKQD GGEGHVGTVR SFESPEEVVV
60 70 80 90 100
VWDNGTAANY RCSGAYDLRI MDSAPTGIKH DGTMCDTCRQ QPIIGIRWKC
110 120 130 140 150
AECTNYDLCT VCYHGDKHHL RHRFYRITTP GSERVLLESR RKSKKITARG
160 170 180 190 200
IFAGARVVRG VDWQWEDQDG GNGRRGKVTE IQDWSASSPH SAAYVLWDNG
210 220 230 240 250
AKNLYRVGFE GMSDLKCVQD AKGGSFYRDH CPVLGEQNGN RNPGGLLIGD
260 270 280 290 300
LVNIDLELEI VQSLQHGHGG WTDGMFETLT TTGTVCGIDE DHDIVVQYPS
310 320 330 340 350
GNRWTFNPAV LTKANVVRSG DAAQGAEGGT SPFQVGDLVQ ICYDIERIKL
360 370 380 390 400
LQRGHGEWAE AMLPTLGKVG RVQQIYSDND LKVEVCGTSW TYNPAAVSRV
410 420 430 440 450
ASVGSAISNA TGERLSQLLK KLFETQESGD LNEELVKAAA NGDVAKVDDL
460 470 480 490 500
LKRQDVDVNG QCAGHTAMQA ASQNGHVDIL KLLLKHSVDV EAEDKDGDRA
510 520 530 540 550
VHHAAFGDEG TVIEVLQRGG ADLNARNKRR QTPLHIAVNK GHLQVVKKLL
560 570 580 590 600
DFSCHPSLQD SEGDTPLHDA ISKKRDDILA VLLEAGADVT ITNNNGFNAL
610 620 630 640 650
HHAALRGNPS AMRVLLSKLP RPWIVDEKKD DGYTALHLAA LNNHVEVAEL
660 670 680 690 700
LVHQGSANLD IQNVNQQTAL HLAVERQHTQ IVRLLVRAEA KLDIQDKDGD
710 720 730 740 750
TPLHEALRHH TLSQLRQLQD MQDVGKVDTT TWEPSKNTLI MGLGTQGAEK
760 770 780 790 800
KSAASIACFL AANGADLAVR NKKGQSPLDL CPDPNLCKTL AKCHKEKSSG
810 820 830 840 850
QVGSHSPSMI NNDSETLEEC MVCSDLKRDT LFGPCGHIAT CSLCSPRVKK
860 870 880 890 900
CLLCKEQVQS RTKIEECVVC SDKKAAVLFQ PCGHMCACEN CASLMKKCVQ
910 920 930 940 950
CRAVVERRVP FVMCCSGKGT EDVADDIAGG NIPALQKDKD NTNVNADVQK
960 970 980 990 1000
LQQQLQDIKE QTMCPVCLDR LKNMIFMCGH GTCQLCGDRM SECPICRKAI
1010
ERRILLYSMS C
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC073370 mRNA Translation: AAH73370.1 |
RefSeqi | NP_001085805.1, NM_001092336.1 |
Genome annotation databases
GeneIDi | 444232 |
KEGGi | xla:444232 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC073370 mRNA Translation: AAH73370.1 |
RefSeqi | NP_001085805.1, NM_001092336.1 |
3D structure databases
SMRi | Q6GNY1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 102395, 1 interactor |
Protocols and materials databases
DNASUi | 444232 |
Genome annotation databases
GeneIDi | 444232 |
KEGGi | xla:444232 |
Organism-specific databases
CTDi | 444232 |
Xenbasei | XB-GENE-1001398, mib1.L |
Phylogenomic databases
OMAi | CCGGIGR |
OrthoDBi | 220300at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Family and domain databases
CDDi | cd02339, ZZ_Mind_bomb, 1 hit |
Gene3Di | 1.25.40.20, 3 hits 3.30.40.10, 3 hits 3.30.60.90, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR042056, MIB1/2_ZZ IPR010606, Mib_Herc2 IPR037252, Mib_Herc2_sf IPR040847, SH3_15 IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR000433, Znf_ZZ IPR043145, Znf_ZZ_sf |
Pfami | View protein in Pfam PF12796, Ank_2, 3 hits PF06701, MIB_HERC2, 2 hits PF18346, SH3_15, 2 hits PF00569, ZZ, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 9 hits SM00184, RING, 3 hits SM00291, ZnF_ZZ, 1 hit |
SUPFAMi | SSF159034, SSF159034, 2 hits SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 6 hits PS51416, MIB_HERC2, 2 hits PS50089, ZF_RING_2, 3 hits PS01357, ZF_ZZ_1, 1 hit PS50135, ZF_ZZ_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MIB1_XENLA | |
Accessioni | Q6GNY1Primary (citable) accession number: Q6GNY1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2005 |
Last sequence update: | July 19, 2004 | |
Last modified: | February 23, 2022 | |
This is version 102 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |