Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 126 (17 Jun 2020)
Sequence version 1 (19 Jul 2004)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Putative peptidyl-tRNA hydrolase PTRHD1

Gene

PTRHD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative peptidyl-tRNA hydrolase PTRHD1 (EC:3.1.1.29)
Alternative name(s):
Peptidyl-tRNA hydrolase domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTRHD1
Synonyms:C2orf79
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000184924.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:33782 PTRHD1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617342 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6GMV3

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
391356

Open Targets

More...
OpenTargetsi
ENSG00000184924

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162379611

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6GMV3 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PTRHD1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74736452

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003218181 – 140Putative peptidyl-tRNA hydrolase PTRHD1Add BLAST140

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6GMV3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6GMV3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6GMV3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6GMV3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6GMV3

PeptideAtlas

More...
PeptideAtlasi
Q6GMV3

PRoteomics IDEntifications database

More...
PRIDEi
Q6GMV3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66305

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q6GMV3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6GMV3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6GMV3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184924 Expressed in thyroid gland and 206 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6GMV3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000184924 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
133896, 33 interactors

Protein interaction database and analysis system

More...
IntActi
Q6GMV3, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000330389

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6GMV3 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6GMV3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PTH2 family. PTRHD1 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3305 Eukaryota
ENOG4111N6W LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00500000044959

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_119261_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6GMV3

Identification of Orthologs from Complete Genome Data

More...
OMAi
TQACHAA

Database of Orthologous Groups

More...
OrthoDBi
1557083at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6GMV3

TreeFam database of animal gene trees

More...
TreeFami
TF353726

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1490.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023476 Pep_tRNA_hydro_II_dom_sf
IPR002833 PTH2
IPR042237 PTRHD1

The PANTHER Classification System

More...
PANTHERi
PTHR46194 PTHR46194, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01981 PTH2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF102462 SSF102462, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6GMV3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHRGVGPAFR VVRKMAASGA EPQVLVQYLV LRKDLSQAPF SWPAGALVAQ
60 70 80 90 100
ACHAATAALH THRDHPHTAA YLQELGRMRK VVLEAPDETT LKELAETLQQ
110 120 130 140
KNIDHMLWLE QPENIATCIA LRPYPKEEVG QYLKKFRLFK
Length:140
Mass (Da):15,805
Last modified:July 19, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3AD1C82F3A9CF80B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07854752C → Y Found in a family with early-onset autosomal recessive parkinsonism and intellectual disability; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs781442277EnsemblClinVar.1
Natural variantiVAR_07854853H → Y Found in a family with early-onset autosomal recessive parkinsonism and intellectual disability; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1057519631EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH471053 Genomic DNA Translation: EAX00745.1
BC073803 mRNA Translation: AAH73803.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33156.1

NCBI Reference Sequences

More...
RefSeqi
NP_001013685.1, NM_001013663.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000328379; ENSP00000330389; ENSG00000184924

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
391356

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:391356

UCSC genome browser

More...
UCSCi
uc002rfm.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471053 Genomic DNA Translation: EAX00745.1
BC073803 mRNA Translation: AAH73803.1
CCDSiCCDS33156.1
RefSeqiNP_001013685.1, NM_001013663.1

3D structure databases

SMRiQ6GMV3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi133896, 33 interactors
IntActiQ6GMV3, 4 interactors
STRINGi9606.ENSP00000330389

PTM databases

iPTMnetiQ6GMV3
PhosphoSitePlusiQ6GMV3

Polymorphism and mutation databases

BioMutaiPTRHD1
DMDMi74736452

Proteomic databases

EPDiQ6GMV3
jPOSTiQ6GMV3
MassIVEiQ6GMV3
MaxQBiQ6GMV3
PaxDbiQ6GMV3
PeptideAtlasiQ6GMV3
PRIDEiQ6GMV3
ProteomicsDBi66305
TopDownProteomicsiQ6GMV3

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
13171 14 antibodies

The DNASU plasmid repository

More...
DNASUi
391356

Genome annotation databases

EnsembliENST00000328379; ENSP00000330389; ENSG00000184924
GeneIDi391356
KEGGihsa:391356
UCSCiuc002rfm.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
391356
DisGeNETi391356
EuPathDBiHostDB:ENSG00000184924.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PTRHD1
HGNCiHGNC:33782 PTRHD1
HPAiENSG00000184924 Low tissue specificity
MIMi617342 gene
neXtProtiNX_Q6GMV3
OpenTargetsiENSG00000184924
PharmGKBiPA162379611

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3305 Eukaryota
ENOG4111N6W LUCA
GeneTreeiENSGT00500000044959
HOGENOMiCLU_119261_0_1_1
InParanoidiQ6GMV3
OMAiTQACHAA
OrthoDBi1557083at2759
PhylomeDBiQ6GMV3
TreeFamiTF353726

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
391356 1 hit in 787 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
391356
PharosiQ6GMV3 Tdark

Protein Ontology

More...
PROi
PR:Q6GMV3
RNActiQ6GMV3 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000184924 Expressed in thyroid gland and 206 other tissues
GenevisibleiQ6GMV3 HS

Family and domain databases

Gene3Di3.40.1490.10, 1 hit
InterProiView protein in InterPro
IPR023476 Pep_tRNA_hydro_II_dom_sf
IPR002833 PTH2
IPR042237 PTRHD1
PANTHERiPTHR46194 PTHR46194, 1 hit
PfamiView protein in Pfam
PF01981 PTH2, 1 hit
SUPFAMiSSF102462 SSF102462, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTRD1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6GMV3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 19, 2004
Last modified: June 17, 2020
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again