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Entry version 139 (17 Jun 2020)
Sequence version 1 (19 Jul 2004)
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Protein

Fatty-acid amide hydrolase 2

Gene

FAAH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:17015445, PubMed:19926788). Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by O-aryl carbamates and alpha-keto heterocytes.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=7.9 µM for anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine)1 Publication
  2. KM=4.3 µM for palmitoylethanolamine (N-hexadecanoylethanolamine)1 Publication
  1. Vmax=0.20 nmol/min/mg enzyme for palmitoylethanolamine (N-hexadecanoylethanolamine) (at pH 9.0)1 Publication
  2. Vmax=1.21 nmol/min/mg enzyme for palmitoylethanolamine (N-hexadecanoylethanolamine) (at pH 9.0)1 Publication
  3. Vmax=0.46 nmol/min/mg enzyme for anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine) (at pH 9.0)1 Publication
  4. Vmax=0.71 nmol/min/mg enzyme for anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine) (at pH 9.0)1 Publication

pH dependencei

Optimum pH is around 9.0.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei131Charge relay systemBy similarity1
Active sitei206Charge relay systemBy similarity1
Active sitei230Acyl-ester intermediateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.5.1.4 2681
3.5.1.99 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2142753 Arachidonic acid metabolism

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001059

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fatty-acid amide hydrolase 2 (EC:3.5.1.992 Publications)
Alternative name(s):
Amidase domain-containing protein
Anandamide amidohydrolase 2
Oleamide hydrolase 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAAH2
Synonyms:AMDD
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000165591.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26440 FAAH2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300654 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6GMR7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei11 – 31HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Lipid droplet, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
158584

Open Targets

More...
OpenTargetsi
ENSG00000165591

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162385543

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6GMR7 Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1628475

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1401

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAAH2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74757585

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002919931 – 532Fatty-acid amide hydrolase 2Add BLAST532

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6GMR7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6GMR7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6GMR7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6GMR7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6GMR7

PeptideAtlas

More...
PeptideAtlasi
Q6GMR7

PRoteomics IDEntifications database

More...
PRIDEi
Q6GMR7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66301

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6GMR7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6GMR7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in kidney, liver, lung, prostate, heart and ovary.1 Publication1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165591 Expressed in pituitary gland and 134 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6GMR7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6GMR7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000165591 Tissue enhanced (pancreas, pituitary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127693, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000364035

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q6GMR7

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6GMR7 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6GMR7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi48 – 51Poly-Leu4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the amidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1212 Eukaryota
COG0154 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162502

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009600_16_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6GMR7

KEGG Orthology (KO)

More...
KOi
K19176

Identification of Orthologs from Complete Genome Data

More...
OMAi
PINFAYT

Database of Orthologous Groups

More...
OrthoDBi
852596at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6GMR7

TreeFam database of animal gene trees

More...
TreeFami
TF313781

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.1300.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020556 Amidase_CS
IPR023631 Amidase_dom
IPR036928 AS_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01425 Amidase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF75304 SSF75304, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00571 AMIDASES, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6GMR7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPSFTARIQ LFLLRALGFL IGLVGRAALV LGGPKFASKT PRPVTEPLLL
60 70 80 90 100
LSGMQLAKLI RQRKVKCIDV VQAYINRIKD VNPMINGIVK YRFEEAMKEA
110 120 130 140 150
HAVDQKLAEK QEDEATLENK WPFLGVPLTV KEAFQLQGMP NSSGLMNRRD
160 170 180 190 200
AIAKTDATVV ALLKGAGAIP LGITNCSELC MWYESSNKIY GRSNNPYDLQ
210 220 230 240 250
HIVGGSSGGE GCTLAAACSV IGVGSDIGGS IRMPAFFNGI FGHKPSPGVV
260 270 280 290 300
PNKGQFPLAV GAQELFLCTG PMCRYAEDLA PMLKVMAGPG IKRLKLDTKV
310 320 330 340 350
HLKDLKFYWM EHDGGSFLMS KVDQDLIMTQ KKVVVHLETI LGASVQHVKL
360 370 380 390 400
KKMKYSFQLW IAMMSAKGHD GKEPVKFVDL LGDHGKHVSP LWELIKWCLG
410 420 430 440 450
LSVYTIPSIG LALLEEKLRY SNEKYQKFKA VEESLRKELV DMLGDDGVFL
460 470 480 490 500
YPSHPTVAPK HHVPLTRPFN FAYTGVFSAL GLPVTQCPLG LNAKGLPLGI
510 520 530
QVVAGPFNDH LTLAVAQYLE KTFGGWVCPG KF
Length:532
Mass (Da):58,304
Last modified:July 19, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1D83E34BFF186E5E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti98K → R in BAB71007 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK055766 mRNA Translation: BAB71007.1
AL928898 Genomic DNA No translation available.
AL590394 Genomic DNA No translation available.
AL606754 Genomic DNA No translation available.
Z83745 Genomic DNA No translation available.
BC048279 mRNA Translation: AAH48279.1
BC073922 mRNA Translation: AAH73922.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14375.1

NCBI Reference Sequences

More...
RefSeqi
NP_777572.2, NM_174912.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000374900; ENSP00000364035; ENSG00000165591

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
158584

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:158584

UCSC genome browser

More...
UCSCi
uc004dvc.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055766 mRNA Translation: BAB71007.1
AL928898 Genomic DNA No translation available.
AL590394 Genomic DNA No translation available.
AL606754 Genomic DNA No translation available.
Z83745 Genomic DNA No translation available.
BC048279 mRNA Translation: AAH48279.1
BC073922 mRNA Translation: AAH73922.1
CCDSiCCDS14375.1
RefSeqiNP_777572.2, NM_174912.3

3D structure databases

SMRiQ6GMR7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127693, 1 interactor
STRINGi9606.ENSP00000364035

Chemistry databases

BindingDBiQ6GMR7
ChEMBLiCHEMBL1628475
GuidetoPHARMACOLOGYi1401
SwissLipidsiSLP:000001059

PTM databases

iPTMnetiQ6GMR7
PhosphoSitePlusiQ6GMR7

Polymorphism and mutation databases

BioMutaiFAAH2
DMDMi74757585

Proteomic databases

EPDiQ6GMR7
jPOSTiQ6GMR7
MassIVEiQ6GMR7
MaxQBiQ6GMR7
PaxDbiQ6GMR7
PeptideAtlasiQ6GMR7
PRIDEiQ6GMR7
ProteomicsDBi66301

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
13026 133 antibodies

Genome annotation databases

EnsembliENST00000374900; ENSP00000364035; ENSG00000165591
GeneIDi158584
KEGGihsa:158584
UCSCiuc004dvc.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
158584
DisGeNETi158584
EuPathDBiHostDB:ENSG00000165591.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAAH2
HGNCiHGNC:26440 FAAH2
HPAiENSG00000165591 Tissue enhanced (pancreas, pituitary gland)
MIMi300654 gene
neXtProtiNX_Q6GMR7
OpenTargetsiENSG00000165591
PharmGKBiPA162385543

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1212 Eukaryota
COG0154 LUCA
GeneTreeiENSGT00940000162502
HOGENOMiCLU_009600_16_1_1
InParanoidiQ6GMR7
KOiK19176
OMAiPINFAYT
OrthoDBi852596at2759
PhylomeDBiQ6GMR7
TreeFamiTF313781

Enzyme and pathway databases

BRENDAi3.5.1.4 2681
3.5.1.99 2681
ReactomeiR-HSA-2142753 Arachidonic acid metabolism

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
158584 2 hits in 413 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FAAH2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
158584
PharosiQ6GMR7 Tchem

Protein Ontology

More...
PROi
PR:Q6GMR7
RNActiQ6GMR7 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000165591 Expressed in pituitary gland and 134 other tissues
ExpressionAtlasiQ6GMR7 baseline and differential
GenevisibleiQ6GMR7 HS

Family and domain databases

Gene3Di3.90.1300.10, 1 hit
InterProiView protein in InterPro
IPR020556 Amidase_CS
IPR023631 Amidase_dom
IPR036928 AS_sf
PfamiView protein in Pfam
PF01425 Amidase, 1 hit
SUPFAMiSSF75304 SSF75304, 1 hit
PROSITEiView protein in PROSITE
PS00571 AMIDASES, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFAAH2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6GMR7
Secondary accession number(s): Q86VT2, Q96N98
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 19, 2004
Last modified: June 17, 2020
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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