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Protein

Brain-specific angiogenesis inhibitor 1-associated protein 2

Gene

Baiap2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-2029482 Regulation of actin dynamics for phagocytic cup formation
R-RNO-4420097 VEGFA-VEGFR2 Pathway
R-RNO-5663213 RHO GTPases Activate WASPs and WAVEs

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-specific angiogenesis inhibitor 1-associated protein 2
Short name:
BAI-associated protein 2
Short name:
BAI1-associated protein 2
Alternative name(s):
Insulin receptor substrate protein of 53 kDa
Short name:
IRSp53
Short name:
Insulin receptor substrate p53
Insulin receptor tyrosine kinase substrate protein p53
Gene namesi
Name:Baiap2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi619814 Baiap2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi17Y → F: Loss of phosphorylation; when associated with F-115 and F-178. 1 Publication1
Mutagenesisi115Y → F: Loss of phosphorylation; when associated with F-17 and F-178. 1 Publication1
Mutagenesisi178Y → F: Loss of phosphorylation; when associated with F-17 and F-115. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000648181 – 535Brain-specific angiogenesis inhibitor 1-associated protein 2Add BLAST535

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei262PhosphoserineBy similarity1
Modified residuei324PhosphoserineBy similarity1
Modified residuei326PhosphoserineCombined sources1
Modified residuei337PhosphoserineBy similarity1
Modified residuei341PhosphothreonineBy similarity1
Modified residuei347PhosphoserineBy similarity1
Modified residuei361PhosphothreonineBy similarity1
Modified residuei367PhosphoserineCombined sources1
Modified residuei385PhosphoserineBy similarity1
Modified residuei396PhosphoserineBy similarity1
Modified residuei455PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine residues by INSR in response to insulin treatment.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6GMN2
PRIDEiQ6GMN2

PTM databases

iPTMnetiQ6GMN2
PhosphoSitePlusiQ6GMN2

Expressioni

Tissue specificityi

Ubiquitous.2 Publications

Gene expression databases

BgeeiENSRNOG00000004049 Expressed in 10 organ(s), highest expression level in brain
GenevisibleiQ6GMN2 RN

Interactioni

Subunit structurei

Homodimer. Interacts with CDC42 and RAC1 that have been activated by GTP binding. Binds TIAM1. Interacts with ATN1, ADGRB1, DIAPH1, EPS8, SHANK1, SHANK2, SHANK3, WASF1 and WASF2. Interacts with ENAH after recruitment of CDC42 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Lin7bQ9Z2523EBI-6997402,EBI-7001699

GO - Molecular functioni

Protein-protein interaction databases

BioGridi250757, 7 interactors
CORUMiQ6GMN2
IntActiQ6GMN2, 8 interactors
MINTiQ6GMN2
STRINGi10116.ENSRNOP00000005687

Structurei

3D structure databases

ProteinModelPortaliQ6GMN2
SMRiQ6GMN2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 250IMDPROSITE-ProRule annotationAdd BLAST250
Domaini375 – 438SH3PROSITE-ProRule annotationAdd BLAST64

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 251By similarityAdd BLAST251

Domaini

The IMD domain forms a coiled coil. The isolated domain can induce actin bundling and filopodia formation. In the absence of G-proteins intramolecular interaction between the IMD and the SH3 domain gives rise to an auto-inhibited state of the protein. Interaction of the IMD with RAC1 or CDC42 leads to activation (By similarity).By similarity
The SH3 domain interacts with ATN1, ADGRB1, WASF1, WASF2, SHANK1, DIAPH1 and ENAH.By similarity

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiENOG41110CD LUCA
GeneTreeiENSGT00390000005995
HOGENOMiHOG000038005
HOVERGENiHBG054462
InParanoidiQ6GMN2
KOiK05627
OMAiPLWQQSC
OrthoDBiEOG091G05ZV
PhylomeDBiQ6GMN2

Family and domain databases

CDDicd11915 SH3_Irsp53, 1 hit
Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR013606 I-BAR_dom
IPR030128 IRSp53
IPR027681 IRSp53/IRTKS/Pinkbar
IPR035594 Irsp53_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR14206 PTHR14206, 1 hit
PTHR14206:SF3 PTHR14206:SF3, 1 hit
PfamiView protein in Pfam
PF08397 IMD, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51338 IMD, 1 hit
PS50002 SH3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6GMN2-1) [UniParc]FASTAAdd to basket
Also known as: IRS-58

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLSRSEEMH RLTENVYKTI MEQFNPSLRN FIAMGKNYEK ALAGVTFAAK
60 70 80 90 100
GYFDALVKMG ELASESQGSK ELGDVLFQMA EVHRQIQNQL EEMLKAFHNE
110 120 130 140 150
LLTQLEQKVE LDSRYLSAAL KKYQTEQRSK GDALDKCQAE LKKLRKKSQG
160 170 180 190 200
SKNPQKYSDK ELQYIDAISN KQGELENYVS DGYKTALTEE RRRFCFLVEK
210 220 230 240 250
QCAVAKNSAA YHSKGKELLA QKLPLWQQAC ADPNKIPDRA AQLMQQMANS
260 270 280 290 300
NGSILPSALS ASKSNLVISD PIPGAKPLPV PPELAPFVGR MSAQENVPVM
310 320 330 340 350
NGVAGADSED YNPWADRKAA QPKSLSPPQS QSKLSDSYSN TLPVRKSVTP
360 370 380 390 400
KNSYATTENK TLPRSSSMAA GLERNGRMRV KAIFSHAAGD NSTLLSFKEG
410 420 430 440 450
DLITLLVPEA RDGWHYGESE KTKMRGWFPF SYTRVLDSDG SDRLHMSLQQ
460 470 480 490 500
GKSSSTGNLL DKDDLALPPP DYGTSSRAFP SQTAGTFKQR PYSVAVPAFS
510 520 530
QGLDDYGARS VSRNPFANVH LKPTVTNDRS APLLS
Length:535
Mass (Da):59,183
Last modified:July 19, 2004 - v1
Checksum:i606CED16E5DFD212
GO
Isoform 2 (identifier: Q6GMN2-2) [UniParc]FASTAAdd to basket
Also known as: IRSp53S, BAIAP2-alpha

The sequence of this isoform differs from the canonical sequence as follows:
     513-535: RNPFANVHLKPTVTNDRSAPLLS → SGSGTLVSTV

Show »
Length:522
Mass (Da):57,542
Checksum:iCCFF96819E52B999
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015510513 – 535RNPFA…APLLS → SGSGTLVSTV in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037934 mRNA Translation: AAK72488.1
BC074009 mRNA Translation: AAH74009.1
RefSeqiNP_476544.1, NM_057196.1 [Q6GMN2-2]
XP_006247931.1, XM_006247869.3 [Q6GMN2-1]
UniGeneiRn.95155

Genome annotation databases

EnsembliENSRNOT00000005687; ENSRNOP00000005687; ENSRNOG00000004049 [Q6GMN2-1]
ENSRNOT00000068437; ENSRNOP00000060172; ENSRNOG00000004049 [Q6GMN2-2]
GeneIDi117542
KEGGirno:117542

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037934 mRNA Translation: AAK72488.1
BC074009 mRNA Translation: AAH74009.1
RefSeqiNP_476544.1, NM_057196.1 [Q6GMN2-2]
XP_006247931.1, XM_006247869.3 [Q6GMN2-1]
UniGeneiRn.95155

3D structure databases

ProteinModelPortaliQ6GMN2
SMRiQ6GMN2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250757, 7 interactors
CORUMiQ6GMN2
IntActiQ6GMN2, 8 interactors
MINTiQ6GMN2
STRINGi10116.ENSRNOP00000005687

PTM databases

iPTMnetiQ6GMN2
PhosphoSitePlusiQ6GMN2

Proteomic databases

PaxDbiQ6GMN2
PRIDEiQ6GMN2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005687; ENSRNOP00000005687; ENSRNOG00000004049 [Q6GMN2-1]
ENSRNOT00000068437; ENSRNOP00000060172; ENSRNOG00000004049 [Q6GMN2-2]
GeneIDi117542
KEGGirno:117542

Organism-specific databases

CTDi10458
RGDi619814 Baiap2

Phylogenomic databases

eggNOGiENOG41110CD LUCA
GeneTreeiENSGT00390000005995
HOGENOMiHOG000038005
HOVERGENiHBG054462
InParanoidiQ6GMN2
KOiK05627
OMAiPLWQQSC
OrthoDBiEOG091G05ZV
PhylomeDBiQ6GMN2

Enzyme and pathway databases

ReactomeiR-RNO-2029482 Regulation of actin dynamics for phagocytic cup formation
R-RNO-4420097 VEGFA-VEGFR2 Pathway
R-RNO-5663213 RHO GTPases Activate WASPs and WAVEs

Miscellaneous databases

PROiPR:Q6GMN2

Gene expression databases

BgeeiENSRNOG00000004049 Expressed in 10 organ(s), highest expression level in brain
GenevisibleiQ6GMN2 RN

Family and domain databases

CDDicd11915 SH3_Irsp53, 1 hit
Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR013606 I-BAR_dom
IPR030128 IRSp53
IPR027681 IRSp53/IRTKS/Pinkbar
IPR035594 Irsp53_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR14206 PTHR14206, 1 hit
PTHR14206:SF3 PTHR14206:SF3, 1 hit
PfamiView protein in Pfam
PF08397 IMD, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51338 IMD, 1 hit
PS50002 SH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBAIP2_RAT
AccessioniPrimary (citable) accession number: Q6GMN2
Secondary accession number(s): Q923H3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 19, 2004
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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