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Protein
Submitted name:

Nr4a1 protein

Gene

nr4a1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi236 – 311Nuclear receptorPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotationImported
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DRE-198693 AKT phosphorylates targets in the nucleus
R-DRE-383280 Nuclear Receptor transcription pathway

Names & Taxonomyi

Protein namesi
Submitted name:
Nr4a1 proteinImported
Submitted name:
Nuclear receptor subfamily 4, group A, member 1Imported
Gene namesi
Name:nr4a1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 23

Organism-specific databases

ZFINiZDB-GENE-040704-11 nr4a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSDARG00000000796

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000001911

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini236 – 311Nuclear receptorInterPro annotationAdd BLAST76
Domaini336 – 571NR LBDInterPro annotationAdd BLAST236

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG4217 Eukaryota
ENOG410YWNC LUCA
GeneTreeiENSGT00760000118887
HOGENOMiHOG000230925
HOVERGENiHBG052663
KOiK04465
OMAiCLREHMS
TreeFamiTF315716

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR003070 Nuc_orph_rcpt
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01284 NUCLEARECPTR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6GMG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTCVQSQHGV QSYESSLFSS EFLNPDFTSR LAMDVTEQRE QLSAPSLPSI
60 70 80 90 100
TSLVGGYVGE FDTYSCQIAT GAASTCVGST SGQLDSFKLD DLQVYGCYPG
110 120 130 140 150
TFALSYLDET LSSSGGSNCF GSPASAPSPS TPGYQHMSAW DSTFGPCSPD
160 170 180 190 200
EGCWGSEKPL NQAASFFTFG HVTADELSPL GQMQSQIPDQ DPFSHTPQHG
210 220 230 240 250
SPLPFSPLSL EQGSRDGSGL MDGHLSPKVR SPTGNEGRCA VCGDNASCQH
260 270 280 290 300
YGVRTCEGCK GFFKRTVQKN AKYVCLANKD CPVDKRRRNR CQFCRFQKCL
310 320 330 340 350
AVGMVKEVVR TDSLKGRRGR LPSKPKAVQD SVSVSSPVNI IASLVTAHID
360 370 380 390 400
SNPASANLDY SKYQESTSGL PEKEDANDIQ QFYDLLTGSM DVIRKWAGSI
410 420 430 440 450
PGFSAFCKED QELLLESAFV ELFILRLAYR SNPETDKLIF CNGVVLHRTQ
460 470 480 490 500
CVRSFGDWID SIMEFSQSLH RLNLDISAFS CLATLVIITD RHGLKEPKRI
510 520 530 540 550
EDFQNRLITC LRDHVSTSAL EVGRPNSLSR LLSKLPELRT LCTQGLQRIF
560 570
YLKLEDLVPP PPIVDKIFMD TLPF
Length:574
Mass (Da):63,044
Last modified:July 19, 2004 - v1
Checksum:iFB0CF30BAABF587C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU041363 Genomic DNA No translation available.
CU469363 Genomic DNA No translation available.
BC074092 mRNA Translation: AAH74092.1
BC164696 mRNA Translation: AAI64696.1
RefSeqiNP_001002173.1, NM_001002173.1
UniGeneiDr.9243

Genome annotation databases

EnsembliENSDART00000000876; ENSDARP00000001911; ENSDARG00000000796
ENSDART00000157479; ENSDARP00000141471; ENSDARG00000000796
GeneIDi431720
KEGGidre:431720

Similar proteinsi

Entry informationi

Entry nameiQ6GMG3_DANRE
AccessioniPrimary (citable) accession number: Q6GMG3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 19, 2004
Last sequence update: July 19, 2004
Last modified: June 20, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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