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Entry version 100 (07 Oct 2020)
Sequence version 1 (19 Jul 2004)
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Protein

Inactive rhomboid protein 1

Gene

rhbdf1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor binding
Biological processProtein transport, Transport

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S54.952

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inactive rhomboid protein 1
Short name:
iRhom1
Alternative name(s):
Rhomboid family member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rhbdf1
ORF Names:zgc:91984
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-040704-75, rhbdf1a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 413CytoplasmicSequence analysisAdd BLAST413
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei414 – 434HelicalSequence analysisAdd BLAST21
Topological domaini435 – 661LumenalSequence analysisAdd BLAST227
Transmembranei662 – 682HelicalSequence analysisAdd BLAST21
Topological domaini683 – 693CytoplasmicSequence analysisAdd BLAST11
Transmembranei694 – 714HelicalSequence analysisAdd BLAST21
Topological domaini715 – 716LumenalSequence analysis2
Transmembranei717 – 737HelicalSequence analysisAdd BLAST21
Topological domaini738 – 748CytoplasmicSequence analysisAdd BLAST11
Transmembranei749 – 769HelicalSequence analysisAdd BLAST21
Topological domaini770 – 774LumenalSequence analysis5
Transmembranei775 – 795HelicalSequence analysisAdd BLAST21
Topological domaini796 – 805CytoplasmicSequence analysis10
Transmembranei806 – 826HelicalSequence analysisAdd BLAST21
Topological domaini827 – 857LumenalSequence analysisAdd BLAST31

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003401111 – 857Inactive rhomboid protein 1Add BLAST857

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi585N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6GMF8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000036541, Expressed in heart and 25 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6GMF8, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000053094

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6GMF8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S54 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2290, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156278

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011531_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6GMF8

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6GMF8

TreeFam database of animal gene trees

More...
TreeFami
TF312988

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1540.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022764, Peptidase_S54_rhomboid_dom
IPR035952, Rhomboid-like_sf
IPR022241, Rhomboid_SP

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01694, Rhomboid, 1 hit
PF12595, Rhomboid_SP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6GMF8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAELRRDSTS SLQRKKPPWL KLDIPTAHVS VDEVPAFVPP VKRQGFHRSA
60 70 80 90 100
SMPVETSHFH SPQRDIIDHR RAAFQRQSSI TQTIKRGTAD WFGVSKDGDA
110 120 130 140 150
TQKWQRKSLR HCSLRYGKLK PQVIREMELP SQDNISLTST ETPPPLYVPS
160 170 180 190 200
SQHGMQKIVD PLARGRAFRM VEEVDGYSVP QTPITPGAAS ICSFNSSRSG
210 220 230 240 250
LNRIPRRRKR ESVAKMSFRA AAALVKGRSL REGTLRRAHR RSFTPASFIE
260 270 280 290 300
EDVVDFPDEL DTSFFARDIM MHEEMSTFHD EVFESPSDST MKDVDSKQLD
310 320 330 340 350
ESELTGSALD KSELEKSHLM LPLERGWRKV KEKTPAPPKI RLKQEVVSVN
360 370 380 390 400
GQRRGQRIGL PVKKLFAREK RPYGLGMVGK LTNRTYRKRI DSYVKKQIED
410 420 430 440 450
MDDHRPFFTY WITFVHILIT ILAVCIYGIA PVGFSQHETV DSVLRNKGVY
460 470 480 490 500
ENVKFVQQEN FWIGPSSEAL IHLGAKFSPC MRRDNQVHEL IKKKQELERN
510 520 530 540 550
SACCVRNDRS GCLQTSEEEC SSTLAVWVKW PQHPSVPQLD GVARQHGSVC
560 570 580 590 600
HQDPRTCTEP ASVSPHEWPD DITKWPICTK YNSGNHTNLP HIDCTITGRP
610 620 630 640 650
CCIGTKGRCE ITSREYCDFM KGYFHEEATL CSQVHCMDDV CGLLPFLNPE
660 670 680 690 700
VPDQFYRLWL SLFLHAGILH CLVSVCFQMT ILRDLEKLAG WLRISIIYIL
710 720 730 740 750
SGITGNLASA IFLPYRAEVG PAGSQFGILA CLFVELIQSW QILAQPWRAF
760 770 780 790 800
TKLLCVVLFL FAFGLLPWID NFAHISGFIS GFFLSFAFLP YISFGRLDMY
810 820 830 840 850
RKRCQIIIFL VVFLGLFAGL VVLFYVHPIK CEWCELLTCI PFTDKFCEKY

DLNAHLH
Length:857
Mass (Da):97,841
Last modified:July 19, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA3C0611249B48132
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QJA8E9QJA8_DANRE
Rhomboid 5 homolog 1a (Drosophila)
rhbdf1a rhbdf1
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC074097 mRNA Translation: AAH74097.1

NCBI Reference Sequences

More...
RefSeqi
NP_001002228.1, NM_001002228.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000053095; ENSDARP00000053094; ENSDARG00000036541

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
798402

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:798402

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC074097 mRNA Translation: AAH74097.1
RefSeqiNP_001002228.1, NM_001002228.1

3D structure databases

SMRiQ6GMF8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000053094

Protein family/group databases

MEROPSiS54.952

Proteomic databases

PaxDbiQ6GMF8

Genome annotation databases

EnsembliENSDART00000053095; ENSDARP00000053094; ENSDARG00000036541
GeneIDi798402
KEGGidre:798402

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
798402
ZFINiZDB-GENE-040704-75, rhbdf1a

Phylogenomic databases

eggNOGiKOG2290, Eukaryota
GeneTreeiENSGT00940000156278
HOGENOMiCLU_011531_1_1_1
InParanoidiQ6GMF8
PhylomeDBiQ6GMF8
TreeFamiTF312988

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q6GMF8

Gene expression databases

BgeeiENSDARG00000036541, Expressed in heart and 25 other tissues
ExpressionAtlasiQ6GMF8, baseline and differential

Family and domain databases

Gene3Di1.20.1540.10, 1 hit
InterProiView protein in InterPro
IPR022764, Peptidase_S54_rhomboid_dom
IPR035952, Rhomboid-like_sf
IPR022241, Rhomboid_SP
PfamiView protein in Pfam
PF01694, Rhomboid, 1 hit
PF12595, Rhomboid_SP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHDF1_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6GMF8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 19, 2004
Last modified: October 7, 2020
This is version 100 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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