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Protein

Spliceosome-associated protein CWC27 homolog

Gene

cwc27

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity.By similarity

Caution

Despite the fact that it belongs to the cyclophilin-type PPIase family, it has probably no peptidyl-prolyl cis-trans isomerase activity.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Spliceosome-associated protein CWC27 homologCurated
Alternative name(s):
Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homologBy similarity
Short name:
PPIase CWC27By similarity
Gene namesi
Name:cwc27
Synonyms:sdccag10
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-942799 cwc27

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003136531 – 477Spliceosome-associated protein CWC27 homologAdd BLAST477

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Part of the activated spliceosome B/catalytic step 1 spliceosome, one of the forms of the spliceosome which has a well-formed active site but still cannot catalyze the branching reaction and is composed at least of 52 proteins, the U2, U5 and U6 snRNAs and the pre-mRNA. Recruited during early steps of activated spliceosome B maturation, it is probably one of the first proteins released from this complex as he matures to the spliceosome C complex.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6GLX7
SMRiQ6GLX7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 166PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST156

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili308 – 381Sequence analysisAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi252 – 280Asp-richAdd BLAST29

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG097993
KOiK12737

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6GLX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNIYIQEPP SNGKVLLKTT AGEIDIELWS KEAPKACRNF VQLCLEGYYD
60 70 80 90 100
NTIFHRVVPE FIIQGGDPTG TGTGGESVFG KPFRDEFHSR LRFNRRGLVA
110 120 130 140 150
MANAGPHDNG SQFFFTLGRA DELNNKHTIF GKVTGDTIYN ILRLAEVDIG
160 170 180 190 200
EDERPVNPHK IKCTEVLFNP FDDIIPRIDK KTKKDEEEEG KKSKAKGTKN
210 220 230 240 250
FNLLSFGEEA EEDEEEVNEV SKVMRGKSKS SHDLLKDDPR LSSVPAVERE
260 270 280 290 300
KDSQSADSDK DEDEMSDDDD EEEDDEMDSD EKHQMKDRIS NKLRKDPSKS
310 320 330 340 350
IKQAENSDEA EERKSSRSEE LRREARQLKR ELKAAKEKKE NNIKESETAK
360 370 380 390 400
EAENTVANSA LEEYLKEKEK YEEVRKKNTN KGVSREQQTL ALLDRFKSKL
410 420 430 440 450
TQAITEPPKE EEASDVDEEN DKGWLSHVLQ FEEKSGKVKD ANMQDEDTFE
460 470
IYDPRNPVNK RRREESKKIM KQKKERR
Length:477
Mass (Da):54,875
Last modified:July 19, 2004 - v1
Checksum:iAD5032026CE472D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC074317 mRNA Translation: AAH74317.1
RefSeqiNP_001086199.1, NM_001092730.1
UniGeneiXl.13268

Genome annotation databases

GeneIDi444628
KEGGixla:444628

Similar proteinsi

Entry informationi

Entry nameiCWC27_XENLA
AccessioniPrimary (citable) accession number: Q6GLX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 19, 2004
Last modified: July 18, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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