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UniProtKB - Q6GLK6 (ACSF3_XENLA)
Protein
Malonate--CoA ligase ACSF3, mitochondrial
Gene
acsf3
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates.
By similarityCatalytic activityi
- This reaction proceeds in the forwardBy similarity direction.
- EC:6.2.1.n3By similarityThis reaction proceeds in the forwardBy similarity direction.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 459 | ATPBy similarity | 1 | |
Binding sitei | 473 | ATPBy similarity | 1 | |
Binding sitei | 565 | ATPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 205 – 213 | ATPBy similarity | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- malonyl-CoA synthetase activity Source: RHEA
GO - Biological processi
- fatty acid metabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Ligase |
Biological process | Fatty acid metabolism, Lipid metabolism |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Malonate--CoA ligase ACSF3, mitochondrialBy similarity (EC:6.2.1.n3By similarity)Alternative name(s): Acyl-CoA synthetase family member 3 |
Gene namesi | Name:acsf3By similarity |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-964816, acsf3.S |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 19 | MitochondrionSequence analysisAdd BLAST | 19 | |
ChainiPRO_0000315802 | 20 – 578 | Malonate--CoA ligase ACSF3, mitochondrialAdd BLAST | 559 |
Proteomic databases
PRIDEi | Q6GLK6 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 394 – 413 | DisorderedSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the ATP-dependent AMP-binding enzyme family.Curated
Keywords - Domaini
Transit peptideFamily and domain databases
Gene3Di | 3.30.300.30, 1 hit 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q6GLK6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRVGAFLGRS LFSCSHVRGA LVRRRTPQHS CSFHISKPRS LSHVVPVFSR
60 70 80 90 100
APLFSERTAM VDQHGKHTYK DLYIRSQALS KMIIQLLGNP SHNNTPERVS
110 120 130 140 150
FLCPNNSSYV VCQWAVWMSG AIAVPLCKSH PPSELKYVLQ DSQSALVVAE
160 170 180 190 200
ESYTNVLSPL AEQLGIPVLT MSGSQNLHPS ELLQEIKISQ LDLDWKDRGA
210 220 230 240 250
MIIYTSGTTG RPKGVLSTHY NLYSMVTALV NEWGWTKEDS ILHVLPLHHV
260 270 280 290 300
HGVVNKLMCP LWVGATCVIL PEFCPKTVWQ HFLGRDVPSI NIFMAVPTIY
310 320 330 340 350
SKLIAYYEQH FTHSNVREFV RAACQERIRL MVSGSSALPV PVLERWQEIT
360 370 380 390 400
GHTLLERYGM TEIGMALTNP LHGPRVPGAV GAPLPGVEVR TVTQNPRKEG
410 420 430 440 450
TSYTTHAQGD STGTMVSVGL ENREGELQVR GPAVFKEYWN KRLDTQEAFT
460 470 480 490 500
SDGWFKTGDT AMYKDGTYWI LGRTSVDIIK SGGYKVSALE VERHLLGHPS
510 520 530 540 550
ITDVAVIGAP DVTWGQRVAA IVKLRDGHAL SLQELKEWAR AVMAPYCIPA
560 570
ELIRVEEIPR NQMGKINKKQ LLVHFYPQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC074473 mRNA Translation: AAH74473.1 |
RefSeqi | NP_001086314.2, NM_001092845.1 |
Genome annotation databases
GeneIDi | 444743 |
KEGGi | xla:444743 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC074473 mRNA Translation: AAH74473.1 |
RefSeqi | NP_001086314.2, NM_001092845.1 |
3D structure databases
SMRi | Q6GLK6 |
ModBasei | Search... |
Proteomic databases
PRIDEi | Q6GLK6 |
Protocols and materials databases
DNASUi | 444743 |
Genome annotation databases
GeneIDi | 444743 |
KEGGi | xla:444743 |
Organism-specific databases
CTDi | 444743 |
Xenbasei | XB-GENE-964816, acsf3.S |
Family and domain databases
Gene3Di | 3.30.300.30, 1 hit 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ACSF3_XENLA | |
Accessioni | Q6GLK6Primary (citable) accession number: Q6GLK6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | July 19, 2004 | |
Last modified: | February 23, 2022 | |
This is version 63 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |