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UniProtKB - Q6GIU7 (NORA_STAAR)
Protein
Quinolone resistance protein NorA
Gene
norA
Organism
Staphylococcus aureus (strain MRSA252)
Status
Functioni
Involved in quinolone resistance. May constitute a membrane-associated active efflux pump of hydrophilic quinolones (By similarity).
By similarityGO - Molecular functioni
- xenobiotic transmembrane transporter activity Source: InterPro
Keywordsi
Biological process | Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Quinolone resistance protein NorA |
Gene namesi | Name:norA Ordered Locus Names:SAR0748 |
Organismi | Staphylococcus aureus (strain MRSA252) |
Taxonomic identifieri | 282458 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 5 – 25 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 42 – 62 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 69 – 89 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 99 – 119 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 129 – 149 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 157 – 177 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 201 – 221 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 239 – 259 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 269 – 289 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 293 – 313 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 331 – 351 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 355 – 375 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000173371 | 1 – 388 | Quinolone resistance protein NorAAdd BLAST | 388 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
HOGENOMi | CLU_001265_10_11_9 |
OMAi | LYADSFH |
OrthoDBi | 626204at2 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR004734, Multidrug-R IPR001958, Tet-R_TetA/multi-R_MdtG |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
PRINTSi | PR01035, TCRTETA |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00880, 2_A_01_02, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6GIU7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNKQIFVLYF NIFLIFLGIG LVIPVLPVYL KDLGLTGSDL GLLVAAFALS
60 70 80 90 100
QMIISPFGGT LADKLGKKLI ICIGLILFSV SEFMFAVGHN FSVLMLSRVI
110 120 130 140 150
GGMSAGMVMP GVTGLIADVS PSHQKAKNFG YMSAIINSGF ILGPGIGGFM
160 170 180 190 200
AEVSHRMPFY FAGALGILAF IMSVVLIHDP KKSTTSGFQK LEPQLLTKIN
210 220 230 240 250
WKVFITPAIL TLVLAFGLSA FETLYSLYTS YKVNYSPKDI SIAITGGGIF
260 270 280 290 300
GALFQIYFFD KFMKYFSELT FIAWSLIYSV IVLVLLVIAD GYWTIMVISF
310 320 330 340 350
AVFIGFDMIR PAITNYFSNI AGDRQGFAGG LNSTFTSMGN FIGPLIAGAL
360 370 380
FDVHIEAPIY MAIGVSLAGV VIVLIEKQHR AKLKQQDL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX571856 Genomic DNA Translation: CAG39758.1 |
RefSeqi | WP_001041283.1, NC_002952.2 |
Genome annotation databases
KEGGi | sar:SAR0748 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX571856 Genomic DNA Translation: CAG39758.1 |
RefSeqi | WP_001041283.1, NC_002952.2 |
3D structure databases
SMRi | Q6GIU7 |
ModBasei | Search... |
Genome annotation databases
KEGGi | sar:SAR0748 |
Phylogenomic databases
HOGENOMi | CLU_001265_10_11_9 |
OMAi | LYADSFH |
OrthoDBi | 626204at2 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR004734, Multidrug-R IPR001958, Tet-R_TetA/multi-R_MdtG |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
PRINTSi | PR01035, TCRTETA |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00880, 2_A_01_02, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NORA_STAAR | |
Accessioni | Q6GIU7Primary (citable) accession number: Q6GIU7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | July 19, 2004 | |
Last modified: | February 23, 2022 | |
This is version 101 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |