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Entry version 94 (08 May 2019)
Sequence version 1 (19 Jul 2004)
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Protein

Iron-regulated surface determinant protein B

Gene

isdB

Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Seems to function as the primary receptor for hemoglobin since its inactivation inhibits the ability of S.aureus to bind hemoglobin. Binds hemoglobin in a dose-dependent way. Required for S.aureus growth using hemoglobin as the sole iron source. Also required for virulence. IsdA and/or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processVirulence
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
SAUR282458:G1G3O-1171-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.39.1.1 the gram-positive bacterial hemoglobin receptor (isd) family
9.A.39.1.2 the gram-positive bacterial hemoglobin receptor (isd) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Iron-regulated surface determinant protein B
Alternative name(s):
Fur-regulated protein B
Staphylococcal iron-regulated protein H
Staphylococcus aureus surface protein J
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:isdB
Synonyms:frpB, sasJ, sirH
Ordered Locus Names:SAR1102
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStaphylococcus aureus (strain MRSA252)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri282458 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

  • cell wall PROSITE-ProRule annotation; Peptidoglycan-anchor PROSITE-ProRule annotation
  • Note: Anchored to the cell wall by sortase A (By similarity).By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cell wall, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 40Sequence analysisAdd BLAST40
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000029256941 – 620Iron-regulated surface determinant protein BAdd BLAST580
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000292570621 – 652Removed by sortasePROSITE-ProRule annotationAdd BLAST32

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei620Pentaglycyl murein peptidoglycan amidated threoninePROSITE-ProRule annotation1

Keywords - PTMi

Peptidoglycan-anchor

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q6GHV7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Repressed by fur in the presence of iron (By similarity). Transcriptionally up-regulated by hydrogen peroxide and to a lesser extent by hypochlorous acid and human neutrophil azurophilic granule proteins.By similarity1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6GHV7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini151 – 276NEAT 1PROSITE-ProRule annotationAdd BLAST126
Domaini348 – 465NEAT 2PROSITE-ProRule annotationAdd BLAST118

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi12 – 23YSIRK-G/S signaling motifBy similarityAdd BLAST12
Motifi617 – 621LPXTG sorting signalPROSITE-ProRule annotation5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IsdB family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000280077

Identification of Orthologs from Complete Genome Data

More...
OMAi
KADNNTY

Database of Orthologous Groups

More...
OrthoDBi
962011at2

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06920 NEAT, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019948 Gram-positive_anchor
IPR019929 Iron-reg_IsdB
IPR019931 LPXTG_anchor
IPR006635 NEAT_dom
IPR037250 NEAT_dom_sf
IPR005877 YSIRK_signal_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00746 Gram_pos_anchor, 1 hit
PF05031 NEAT, 2 hits
PF04650 YSIRK_signal, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00725 NEAT, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF158911 SSF158911, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03657 IsdB, 1 hit
TIGR01168 YSIRK_signal, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50847 GRAM_POS_ANCHORING, 1 hit
PS50978 NEAT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q6GHV7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNKQQKEFKS FYSIRKSSLG VASVAISTLL LLMSNGEAKA AEETGVTNTE
60 70 80 90 100
AQPKTEAVAS PTTTTTEKAP EAKPVAKPVA NAVSVSNKEV VAPTTETKEA
110 120 130 140 150
KEVKAVKEVK APKEAKEEKP AAKADNNTYP ILNQELREAI KNPAIKDKDH
160 170 180 190 200
SAPNSRPIDF EMKKKDGTQQ FYHYASSVKP ARVIFTDSKP EIELGLQSGQ
210 220 230 240 250
FWRKFEVYEG DKKLPIKLVS YDTVKDYAYI RFSVSNGTKA VKIVSSTHFN
260 270 280 290 300
NKEEKYDYTL MEFAQPIYNS ADKFKTEEDY KAEKLLAPYK KAKTLERQVY
310 320 330 340 350
ELNKIQDKLP EKLKAEYKKK LEETKKALDE QVKSAITEFQ NVQPTNEKMT
360 370 380 390 400
DLQDTKYVVY ESVENNESMM DAFVKHPIKT GMLNGKKYMV METTNDDYWK
410 420 430 440 450
DFMVEGQRVR TISKDAKNNT RTIIFPYVEG KTLYDAIVKV HVKTIDYDGQ
460 470 480 490 500
YHVRIVDKEA FTKANADKTN KKEQQDNSAK KETTPAMPSK PTTPPVEKES
510 520 530 540 550
QKQDSQKDDN KQSPSVEKEN DASSESGKDK MPVTKPAKAE VESSSTTPTK
560 570 580 590 600
VVSTTQNVAK PTTASSETTK DVVQTSAGSS EAKDSAPLQK ANIKNTNDGH
610 620 630 640 650
TQSQNNKNTQ ENKAKSLPQT GEESNKDMTL PLMALIALSS IVAFVLPRKR

KN
Length:652
Mass (Da):72,999
Last modified:July 19, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i28FF303EF6103428
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX571856 Genomic DNA Translation: CAG40104.1

NCBI Reference Sequences

More...
RefSeqi
WP_001041573.1, NC_002952.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAG40104; CAG40104; SAR1102

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sar:SAR1102

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA Translation: CAG40104.1
RefSeqiWP_001041573.1, NC_002952.2

3D structure databases

SMRiQ6GHV7
ModBaseiSearch...

Protein family/group databases

TCDBi9.A.39.1.1 the gram-positive bacterial hemoglobin receptor (isd) family
9.A.39.1.2 the gram-positive bacterial hemoglobin receptor (isd) family

Proteomic databases

PRIDEiQ6GHV7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG40104; CAG40104; SAR1102
KEGGisar:SAR1102

Phylogenomic databases

HOGENOMiHOG000280077
OMAiKADNNTY
OrthoDBi962011at2

Enzyme and pathway databases

BioCyciSAUR282458:G1G3O-1171-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q6GHV7

Family and domain databases

CDDicd06920 NEAT, 1 hit
InterProiView protein in InterPro
IPR019948 Gram-positive_anchor
IPR019929 Iron-reg_IsdB
IPR019931 LPXTG_anchor
IPR006635 NEAT_dom
IPR037250 NEAT_dom_sf
IPR005877 YSIRK_signal_dom
PfamiView protein in Pfam
PF00746 Gram_pos_anchor, 1 hit
PF05031 NEAT, 2 hits
PF04650 YSIRK_signal, 1 hit
SMARTiView protein in SMART
SM00725 NEAT, 2 hits
SUPFAMiSSF158911 SSF158911, 2 hits
TIGRFAMsiTIGR03657 IsdB, 1 hit
TIGR01168 YSIRK_signal, 1 hit
PROSITEiView protein in PROSITE
PS50847 GRAM_POS_ANCHORING, 1 hit
PS50978 NEAT, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiISDB_STAAR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6GHV7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 19, 2004
Last modified: May 8, 2019
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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