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Protein

Galactose-6-phosphate isomerase subunit LacB

Gene

lacB

Organism
Staphylococcus aureus (strain MRSA252)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-galactose 6-phosphate = D-tagatose 6-phosphate.UniRule annotation

Pathwayi: D-galactose 6-phosphate degradation

This protein is involved in step 1 of the subpathway that synthesizes D-tagatose 6-phosphate from D-galactose 6-phosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Galactose-6-phosphate isomerase subunit LacB (lacB), Galactose-6-phosphate isomerase subunit LacA (lacA)
This subpathway is part of the pathway D-galactose 6-phosphate degradation, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-tagatose 6-phosphate from D-galactose 6-phosphate, the pathway D-galactose 6-phosphate degradation and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processLactose metabolism

Enzyme and pathway databases

UniPathwayi
UPA00702;UER00714

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose-6-phosphate isomerase subunit LacBUniRule annotation (EC:5.3.1.26UniRule annotation)
Gene namesi
Name:lacBUniRule annotation
Ordered Locus Names:SAR2285
OrganismiStaphylococcus aureus (strain MRSA252)
Taxonomic identifieri282458 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002081381 – 171Galactose-6-phosphate isomerase subunit LacBAdd BLAST171

Interactioni

Subunit structurei

Heteromultimeric protein consisting of LacA and LacB.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ6GEN5
SMRiQ6GEN5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LacAB/RpiB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000226301
KOiK01819
OMAiTYSAHQG

Family and domain databases

Gene3Di3.40.1400.10, 1 hit
HAMAPiMF_01556 LacB, 1 hit
InterProiView protein in InterPro
IPR004784 LacB
IPR003500 RpiB_LacA_LacB
IPR036569 RpiB_LacA_LacB_sf
PANTHERiPTHR30345 PTHR30345, 1 hit
PfamiView protein in Pfam
PF02502 LacAB_rpiB, 1 hit
PIRSFiPIRSF005384 RpiB_LacA_B, 1 hit
SUPFAMiSSF89623 SSF89623, 1 hit
TIGRFAMsiTIGR01119 lacB, 1 hit
TIGR00689 rpiB_lacA_lacB, 1 hit

Sequencei

Sequence statusi: Complete.

Q6GEN5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIALGCDHI VTDTKMRVSE FLKSKGHEVI DVGTYDFTRT HYPIFGKKVG
60 70 80 90 100
EQVVSGNADL GVCICGTGVG INNAVNKVPG VRSALVRDMT SALYAKEELN
110 120 130 140 150
ANVIGFGGRI IGELLMCDII DAFINAEYKP TEENKKLIAK IKHLETSNAD
160 170
QADPHFFDEF LEKWDRGEYH D
Length:171
Mass (Da):18,951
Last modified:July 19, 2004 - v1
Checksum:i10617F0F28536A13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA Translation: CAG41263.1

Genome annotation databases

EnsemblBacteriaiCAG41263; CAG41263; SAR2285
KEGGisar:SAR2285

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571856 Genomic DNA Translation: CAG41263.1

3D structure databases

ProteinModelPortaliQ6GEN5
SMRiQ6GEN5
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG41263; CAG41263; SAR2285
KEGGisar:SAR2285

Phylogenomic databases

HOGENOMiHOG000226301
KOiK01819
OMAiTYSAHQG

Enzyme and pathway databases

UniPathwayi
UPA00702;UER00714

Family and domain databases

Gene3Di3.40.1400.10, 1 hit
HAMAPiMF_01556 LacB, 1 hit
InterProiView protein in InterPro
IPR004784 LacB
IPR003500 RpiB_LacA_LacB
IPR036569 RpiB_LacA_LacB_sf
PANTHERiPTHR30345 PTHR30345, 1 hit
PfamiView protein in Pfam
PF02502 LacAB_rpiB, 1 hit
PIRSFiPIRSF005384 RpiB_LacA_B, 1 hit
SUPFAMiSSF89623 SSF89623, 1 hit
TIGRFAMsiTIGR01119 lacB, 1 hit
TIGR00689 rpiB_lacA_lacB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLACB_STAAR
AccessioniPrimary (citable) accession number: Q6GEN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 19, 2004
Last modified: October 10, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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