UniProtKB - Q6GEG5 (MOBA_STAAR)
Protein
Probable molybdenum cofactor guanylyltransferase
Gene
mobA
Organism
Staphylococcus aureus (strain MRSA252)
Status
Functioni
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.UniRule annotation
Catalytic activityi
- EC:2.7.7.77UniRule annotation
Cofactori
Mg2+UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 18 | GTPUniRule annotation | 1 | |
Binding sitei | 65 | GTPUniRule annotation | 1 | |
Metal bindingi | 97 | MagnesiumUniRule annotation | 1 | |
Binding sitei | 97 | GTPUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 6 – 8 | GTPUniRule annotation | 3 |
GO - Molecular functioni
- GTP binding Source: UniProtKB-UniRule
- metal ion binding Source: UniProtKB-KW
- molybdenum cofactor guanylyltransferase activity Source: UniProtKB-EC
GO - Biological processi
- Mo-molybdopterin cofactor biosynthetic process Source: UniProtKB-KW
Keywordsi
Molecular function | Transferase |
Biological process | Molybdenum cofactor biosynthesis |
Ligand | GTP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | SAUR282458:G1G3O-2553-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Probable molybdenum cofactor guanylyltransferaseUniRule annotation (EC:2.7.7.77UniRule annotation)Short name: MoCo guanylyltransferaseUniRule annotation Alternative name(s): GTP:molybdopterin guanylyltransferaseUniRule annotation Mo-MPT guanylyltransferaseUniRule annotation Molybdopterin guanylyltransferaseUniRule annotation Molybdopterin-guanine dinucleotide synthaseUniRule annotation Short name: MGD synthaseUniRule annotation |
Gene namesi | Name:mobAUniRule annotation Ordered Locus Names:SAR2353 |
Organismi | Staphylococcus aureus (strain MRSA252) |
Taxonomic identifieri | 282458 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › |
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000134914 | 1 – 199 | Probable molybdenum cofactor guanylyltransferaseAdd BLAST | 199 |
Family & Domainsi
Domaini
The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.UniRule annotation
Sequence similaritiesi
Belongs to the MobA family.UniRule annotation
Phylogenomic databases
HOGENOMi | CLU_055597_2_0_9 |
OMAi | SVCYVQA |
OrthoDBi | 2019898at2 |
Family and domain databases
CDDi | cd02503, MobA, 1 hit |
Gene3Di | 3.90.550.10, 1 hit |
HAMAPi | MF_00316, MobA, 1 hit |
InterProi | View protein in InterPro IPR025877, MobA-like_NTP_Trfase IPR013482, Molybde_CF_guanTrfase IPR029044, Nucleotide-diphossugar_trans |
Pfami | View protein in Pfam PF12804, NTP_transf_3, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6GEG5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKAIILAGGH SVRFGKPKAF AEVNGETFYS RVIKTLESTN MFNEIIISTN
60 70 80 90 100
AQLATQFKYP NVVIDDENHN DKGPLAGIYT IMKQHPEEEL FFVVSVDTPM
110 120 130 140 150
ITGKAVSTLY QFLVSHLIEN HLDVAAFKED GRFIPTIAFY SPNALGAITK
160 170 180 190
ALHSDNYSFK NVYHELSTDY LDVRDVDAPS YWYKNINYQH DLDALIQKL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX571856 Genomic DNA Translation: CAG41334.1 |
RefSeqi | WP_000643988.1, NC_002952.2 |
Genome annotation databases
EnsemblBacteriai | CAG41334; CAG41334; SAR2353 |
KEGGi | sar:SAR2353 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX571856 Genomic DNA Translation: CAG41334.1 |
RefSeqi | WP_000643988.1, NC_002952.2 |
3D structure databases
SMRi | Q6GEG5 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | CAG41334; CAG41334; SAR2353 |
KEGGi | sar:SAR2353 |
Phylogenomic databases
HOGENOMi | CLU_055597_2_0_9 |
OMAi | SVCYVQA |
OrthoDBi | 2019898at2 |
Enzyme and pathway databases
BioCyci | SAUR282458:G1G3O-2553-MONOMER |
Family and domain databases
CDDi | cd02503, MobA, 1 hit |
Gene3Di | 3.90.550.10, 1 hit |
HAMAPi | MF_00316, MobA, 1 hit |
InterProi | View protein in InterPro IPR025877, MobA-like_NTP_Trfase IPR013482, Molybde_CF_guanTrfase IPR029044, Nucleotide-diphossugar_trans |
Pfami | View protein in Pfam PF12804, NTP_transf_3, 1 hit |
SUPFAMi | SSF53448, SSF53448, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MOBA_STAAR | |
Accessioni | Q6GEG5Primary (citable) accession number: Q6GEG5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 21, 2004 |
Last sequence update: | July 19, 2004 | |
Last modified: | February 10, 2021 | |
This is version 91 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |