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Protein

Probable malate:quinone oxidoreductase 1

Gene

mqo1

Organism
Staphylococcus aureus (strain MSSA476)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase 2 (mqo), Probable malate:quinone oxidoreductase 1 (mqo1)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandFAD, Flavoprotein

Enzyme and pathway databases

UniPathwayi
UPA00223;UER01008

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate:quinone oxidoreductase 1UniRule annotation (EC:1.1.5.4UniRule annotation)
Alternative name(s):
MQO 1UniRule annotation
Malate dehydrogenase [quinone] 1UniRule annotation
Gene namesi
Name:mqo1UniRule annotation
Ordered Locus Names:SAS2256
OrganismiStaphylococcus aureus (strain MSSA476)
Taxonomic identifieri282459 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001287451 – 492Probable malate:quinone oxidoreductase 1Add BLAST492

Proteomic databases

PRIDEiQ6G6V5

Structurei

3D structure databases

ProteinModelPortaliQ6G6V5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000109379
KOiK00116

Family and domain databases

Gene3Di3.50.50.60, 2 hits
HAMAPiMF_00212 MQO, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR006231 MQO
PfamiView protein in Pfam
PF06039 Mqo, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR01320 mal_quin_oxido, 1 hit

Sequencei

Sequence statusi: Complete.

Q6G6V5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTQHSKTDV ILIGGGIMSA TLGTLLKELS PEKNIKVFEK LAQPGEESSN
60 70 80 90 100
VWNNAGTGHS ALCELNYTKE GKDGTVDCSK AIKINEQYQI SKQFWAYLVK
110 120 130 140 150
TGQLDNPDRF IQAVPHMSFV IGEDNVAFIK SRVATLKKSV LFEKMKLSQD
160 170 180 190 200
EEEMKSWVPL MIEGRKSDEP IALTYDETGT DVNFGALTAK LFENLEQRGV
210 220 230 240 250
GIQYKQNVLD IKKQKSGAWL VKVKDLETNE TTTYESDFVF IGAGGASLPL
260 270 280 290 300
LQKTGIKQSK HIGGFPVSGL FLRCTNQEVI DRHHAKVYGK AAVGAPPMSV
310 320 330 340 350
PHLDTRFVDG KRSLLFGPFA GFSPKFLKTG SHMDLIKSVK PNNIVTMLSA
360 370 380 390 400
GIKEMSLTKY LVSQLMLSND ERMDDLRVFF PNAKNEDWEV ITAGQRVQVI
410 420 430 440 450
KDTEDSKGNL QFGTEVITSD DGTLAALLGA SPGASTAVDI MFDVLQRCYR
460 470 480 490
DEFKGWEPKI KEMVPSFGYR LTDHEDLYHK INEEVTKYLQ VK
Length:492
Mass (Da):54,786
Last modified:December 21, 2004 - v2
Checksum:i8D31D1A84F26D441
GO

Sequence cautioni

The sequence CAG44069 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571857 Genomic DNA Translation: CAG44069.1 Different initiation.
RefSeqiWP_000211366.1, NC_002953.3

Genome annotation databases

KEGGisas:SAS2256

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX571857 Genomic DNA Translation: CAG44069.1 Different initiation.
RefSeqiWP_000211366.1, NC_002953.3

3D structure databases

ProteinModelPortaliQ6G6V5
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6G6V5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGisas:SAS2256

Phylogenomic databases

HOGENOMiHOG000109379
KOiK00116

Enzyme and pathway databases

UniPathwayi
UPA00223;UER01008

Family and domain databases

Gene3Di3.50.50.60, 2 hits
HAMAPiMF_00212 MQO, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR006231 MQO
PfamiView protein in Pfam
PF06039 Mqo, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR01320 mal_quin_oxido, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMQO1_STAAS
AccessioniPrimary (citable) accession number: Q6G6V5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: October 10, 2018
This is version 71 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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