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Protein

Macrolide export ATP-binding/permease protein MacB

Gene

macB

Organism
Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) (Rochalimaea henselae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi46 – 53ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Macrolide export ATP-binding/permease protein MacBUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:macBUniRule annotation
Ordered Locus Names:BH15460
OrganismiBartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) (Rochalimaea henselae)
Taxonomic identifieri283166 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
Proteomesi
  • UP000000421 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei285 – 305HelicalUniRule annotationAdd BLAST21
Transmembranei532 – 552HelicalUniRule annotationAdd BLAST21
Transmembranei593 – 613HelicalUniRule annotationAdd BLAST21
Transmembranei625 – 645HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002699211 – 660Macrolide export ATP-binding/permease protein MacBAdd BLAST660

Proteomic databases

PaxDbiQ6G1V5
PRIDEiQ6G1V5

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi283166.BH15460

Structurei

3D structure databases

ProteinModelPortaliQ6G1V5
SMRiQ6G1V5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 248ABC transporterUniRule annotationAdd BLAST239

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Macrolide exporter (TC 3.A.1.122) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D6C Bacteria
COG0577 LUCA
COG1136 LUCA
HOGENOMiHOG000208217
KOiK05685
OMAiLNTDDIR
OrthoDBiPOG091H023H

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003838 ABC_permease_dom
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR017911 ABC_transptr_macrolide_ATP-bd
IPR025857 MacB_PCD
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00005 ABC_tran, 1 hit
PF02687 FtsX, 1 hit
PF12704 MacB_PCD, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit
PS51267 MACB, 1 hit

Sequencei

Sequence statusi: Complete.

Q6G1V5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKAKQADAVL VLENIVRKFP AGETFVTVLK DINLTIKRGE MVAIVGASGS
60 70 80 90 100
GKSTLMNILG CLDRPTFGRY WISGKETASL SADELSALRR NHFGFIFQRY
110 120 130 140 150
HLLNELTALG NVEIPAVYAG YAPEVRRKRA EDLLTRLGMR DRIHHRPNQL
160 170 180 190 200
SGGQQQRVSI ARALMNNAEV ILADEPTGAL DKKSGQEVLR ILDELHQEGR
210 220 230 240 250
TIIMVTHDMQ VAERADRIIE ISDGEIIADN VSKVAKTKTD SQALYGKQVL
260 270 280 290 300
KDQKTLGFFR SFAERFREAF VMALLAMNAH RMRTFLTMLG VIIGIGAIIA
310 320 330 340 350
MVALGNGTRE KILENFKSLG SNTLTILPGK SLSDPQAEKI TSLVEADAEA
360 370 380 390 400
LSKLPYVSGV TPQMSASSTI RFGSVEADVV IAGVGEQYFQ TQGLNAVQGR
410 420 430 440 450
LFDQKSVHDR AIDLVIEKEA LAVLFPHSHE SPLGKVVHVG NVPVRIVGVI
460 470 480 490 500
DPQHNGGTSS TLQVYLPYTT VQTRFLGTTQ VRAITVKIAD TVDSNLAETM
510 520 530 540 550
VRRFLIMRHG EEDFFIRNSQ LFRDRIMEST HILTLLVSSI AAISLIVGGI
560 570 580 590 600
GVMNIMLVTV SERINEIGVR MAVGARQSDI LQQFLIEAIL VCVIGGGLGI
610 620 630 640 650
LFGMSIGGLF LLFKAPIHLI YTIDSIILSL TFSTLIGVCF GFSPARQASR
660
LDPVVALSRD
Length:660
Mass (Da):72,232
Last modified:July 19, 2004 - v1
Checksum:i440391550AF991B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX897699 Genomic DNA Translation: CAF28309.1
RefSeqiWP_011181312.1, NZ_LRIJ02000001.1

Genome annotation databases

EnsemblBacteriaiCAF28309; CAF28309; BH15460
GeneIDi29621770
KEGGibhe:BH15460

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX897699 Genomic DNA Translation: CAF28309.1
RefSeqiWP_011181312.1, NZ_LRIJ02000001.1

3D structure databases

ProteinModelPortaliQ6G1V5
SMRiQ6G1V5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi283166.BH15460

Proteomic databases

PaxDbiQ6G1V5
PRIDEiQ6G1V5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAF28309; CAF28309; BH15460
GeneIDi29621770
KEGGibhe:BH15460

Phylogenomic databases

eggNOGiENOG4105D6C Bacteria
COG0577 LUCA
COG1136 LUCA
HOGENOMiHOG000208217
KOiK05685
OMAiLNTDDIR
OrthoDBiPOG091H023H

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003838 ABC_permease_dom
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR017911 ABC_transptr_macrolide_ATP-bd
IPR025857 MacB_PCD
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00005 ABC_tran, 1 hit
PF02687 FtsX, 1 hit
PF12704 MacB_PCD, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit
PS51267 MACB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMACB_BARHE
AccessioniPrimary (citable) accession number: Q6G1V5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 19, 2004
Last modified: October 10, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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