UniProtKB - Q6G1R9 (TRMD_BARHE)
Protein
tRNA (guanine-N(1)-)-methyltransferase
Gene
trmD
Organism
Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) (Rochalimaea henselae)
Status
Functioni
Specifically methylates guanosine-37 in various tRNAs.UniRule annotation
Catalytic activityi
- guanosine37 in tRNA + S-adenosyl-L-methionine = H+ + N1-methylguanosine37 in tRNA + S-adenosyl-L-homocysteineUniRule annotationEC:2.1.1.228UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 111 | S-adenosyl-L-methionine; via amide nitrogenUniRule annotation | 1 |
GO - Molecular functioni
- tRNA (guanine(37)-N(1))-methyltransferase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Methyltransferase, Transferase |
Biological process | tRNA processing |
Ligand | S-adenosyl-L-methionine |
Names & Taxonomyi
Protein namesi | Recommended name: tRNA (guanine-N(1)-)-methyltransferaseUniRule annotation (EC:2.1.1.228UniRule annotation)Alternative name(s): M1G-methyltransferaseUniRule annotation tRNA [GM37] methyltransferaseUniRule annotation |
Gene namesi | Name:trmDUniRule annotation Ordered Locus Names:BH15820 |
Organismi | Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) (Rochalimaea henselae) |
Taxonomic identifieri | 283166 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000060331 | 1 – 232 | tRNA (guanine-N(1)-)-methyltransferaseAdd BLAST | 232 |
Proteomic databases
PaxDbi | Q6G1R9 |
PRIDEi | Q6G1R9 |
Interactioni
Subunit structurei
Homodimer.
UniRule annotationProtein-protein interaction databases
STRINGi | 283166.BH15820 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q6G1R9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q6G1R9 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 131 – 136 | S-adenosyl-L-methionine bindingUniRule annotation | 6 |
Sequence similaritiesi
Belongs to the RNA methyltransferase TrmD family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0336, Bacteria |
OMAi | ILCGHYK |
Family and domain databases
Gene3Di | 1.10.1270.20, 1 hit 3.40.1280.10, 1 hit |
HAMAPi | MF_00605, TrmD, 1 hit |
InterProi | View protein in InterPro IPR029028, Alpha/beta_knot_MTases IPR002649, tRNA_m1G_MeTrfase_bac IPR023148, tRNA_m1G_MeTrfase_C IPR029026, tRNA_m1G_MTases_N IPR016009, tRNA_MeTrfase_TRMD/TRM10 |
PANTHERi | PTHR46417, PTHR46417, 1 hit |
Pfami | View protein in Pfam PF01746, tRNA_m1G_MT, 1 hit |
PIRSFi | PIRSF000386, tRNA_mtase, 1 hit |
SUPFAMi | SSF75217, SSF75217, 1 hit |
TIGRFAMsi | TIGR00088, trmD, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6G1R9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKFQARVLTL YPEMFPGFLG CSLAGQALKQ GIWSLETVQI RDFALDKHHS
60 70 80 90 100
VDDTPAGGGA GMVMRADVLA AALDSCPNDS PRLLMSPRGR LLNQAYARSL
110 120 130 140 150
ARSSGVTLVC GRFEGVDERI IEARELEEVS IGDYILSGGE TAALVLLDAI
160 170 180 190 200
VRLLPGVMGN EISAKCESFE NGLLEHPQYT RPAVFEGRGI PPVLTSGHHK
210 220 230
AIANWRQQQA ESLTRQRRPD LYALYNKNRQ KT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX897699 Genomic DNA Translation: CAF28345.1 |
RefSeqi | WP_011181348.1, NZ_LRIJ02000001.1 |
Genome annotation databases
EnsemblBacteriai | CAF28345; CAF28345; BH15820 |
GeneIDi | 29621535 |
KEGGi | bhe:BH15820 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX897699 Genomic DNA Translation: CAF28345.1 |
RefSeqi | WP_011181348.1, NZ_LRIJ02000001.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3IEF | X-ray | 2.50 | A/B | 1-232 | [»] | |
SMRi | Q6G1R9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 283166.BH15820 |
Proteomic databases
PaxDbi | Q6G1R9 |
PRIDEi | Q6G1R9 |
Genome annotation databases
EnsemblBacteriai | CAF28345; CAF28345; BH15820 |
GeneIDi | 29621535 |
KEGGi | bhe:BH15820 |
Phylogenomic databases
eggNOGi | COG0336, Bacteria |
OMAi | ILCGHYK |
Miscellaneous databases
EvolutionaryTracei | Q6G1R9 |
Family and domain databases
Gene3Di | 1.10.1270.20, 1 hit 3.40.1280.10, 1 hit |
HAMAPi | MF_00605, TrmD, 1 hit |
InterProi | View protein in InterPro IPR029028, Alpha/beta_knot_MTases IPR002649, tRNA_m1G_MeTrfase_bac IPR023148, tRNA_m1G_MeTrfase_C IPR029026, tRNA_m1G_MTases_N IPR016009, tRNA_MeTrfase_TRMD/TRM10 |
PANTHERi | PTHR46417, PTHR46417, 1 hit |
Pfami | View protein in Pfam PF01746, tRNA_m1G_MT, 1 hit |
PIRSFi | PIRSF000386, tRNA_mtase, 1 hit |
SUPFAMi | SSF75217, SSF75217, 1 hit |
TIGRFAMsi | TIGR00088, trmD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRMD_BARHE | |
Accessioni | Q6G1R9Primary (citable) accession number: Q6G1R9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2005 |
Last sequence update: | July 19, 2004 | |
Last modified: | December 2, 2020 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families