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Protein

Palmitoyltransferase PFA3

Gene

PFA3

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Palmitoyltransferase specific for VAC8. Palmitoylates VAC8 at one or more of its N-terminal cysteine residues, which is required for its proper membrane localization (By similarity).By similarity

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Palmitoyltransferase PFA3 (EC:2.3.1.225)
Alternative name(s):
Protein fatty acyltransferase 3
Gene namesi
Name:PFA3
Ordered Locus Names:CAGL0D02508g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome D

Organism-specific databases

EuPathDBiFungiDB:CAGL0D02508g

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicSequence analysisAdd BLAST13
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Topological domaini35 – 37LumenalSequence analysis3
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Topological domaini59 – 147CytoplasmicSequence analysisAdd BLAST89
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21
Topological domaini169 – 188LumenalSequence analysisAdd BLAST20
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 332CytoplasmicSequence analysisAdd BLAST123

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002129521 – 332Palmitoyltransferase PFA3Add BLAST332

Post-translational modificationi

Autopalmitoylated.By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

STRINGi284593.XP_445524.1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 154DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1315 Eukaryota
COG5273 LUCA
HOGENOMiHOG000246777
InParanoidiQ6FW70
KOiK20028
OMAiHHCPWFA
OrthoDBiEOG092C524D

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q6FW70-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLVNNFSKL FPRCLTTGLY LWSLYAIVVC IHVIRARVVL PLVFTIAMVA
60 70 80 90 100
LYTYAKLIYV GPGTTKEYSI LRVYDLNAAE SGFELPPEML VKRSYTQKRN
110 120 130 140 150
GRFRVCKSCS SWKPDRCHHC STCNVCVLKM DHHCPWFAGC VGYRNQKFFI
160 170 180 190 200
QFLIYCTVYS ILVLILSSME IYTWFKGEFF EVELINFTLL SLWLLALVVS
210 220 230 240 250
ISITIFTVFS ISQVCQNQTT IELYSLRRYN EEVAFLNEFS NEPIKGTINI
260 270 280 290 300
FDLGKKLINW EEVMGYSLIE WALPISRRPS SLDLEGSHSH GLFFNVNKNV
310 320 330
SKTMNESVDL QDRLLRRLTP RSSLDVDRSN FV
Length:332
Mass (Da):38,432
Last modified:July 19, 2004 - v1
Checksum:i929FA622615E2318
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380950 Genomic DNA Translation: CAG58435.1
RefSeqiXP_445524.1, XM_445524.1

Genome annotation databases

EnsemblFungiiCAG58435; CAG58435; CAGL0D02508g
GeneIDi2886970
KEGGicgr:CAGL0D02508g

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380950 Genomic DNA Translation: CAG58435.1
RefSeqiXP_445524.1, XM_445524.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284593.XP_445524.1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG58435; CAG58435; CAGL0D02508g
GeneIDi2886970
KEGGicgr:CAGL0D02508g

Organism-specific databases

EuPathDBiFungiDB:CAGL0D02508g

Phylogenomic databases

eggNOGiKOG1315 Eukaryota
COG5273 LUCA
HOGENOMiHOG000246777
InParanoidiQ6FW70
KOiK20028
OMAiHHCPWFA
OrthoDBiEOG092C524D

Family and domain databases

InterProiView protein in InterPro
IPR001594 Palmitoyltrfase_DHHC
PfamiView protein in Pfam
PF01529 DHHC, 1 hit
PROSITEiView protein in PROSITE
PS50216 DHHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPFA3_CANGA
AccessioniPrimary (citable) accession number: Q6FW70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 19, 2004
Last modified: September 27, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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