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Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

CAGL0E03850g

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

Protein has several cofactor binding sites:

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (CAGL0E03850g), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (CAGL0J00847g), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SDH2)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Ligand2Fe-2SUniRule annotation, 3Fe-4SUniRule annotation, 4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayi
UPA00223;UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
Ordered Locus Names:CAGL0E03850gImported
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)Imported
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome E

Organism-specific databases

CGDiCAL0129068 CAGL0E03850g
EuPathDBiFungiDB:CAGL0E03850g

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi284593.XP_445854.1

Structurei

3D structure databases

ProteinModelPortaliQ6FV90
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 1182Fe-2S ferredoxin-typeInterPro annotationAdd BLAST82
Domaini160 – 1904Fe-4S ferredoxin-typeInterPro annotationAdd BLAST31

Sequence similaritiesi

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3049 Eukaryota
COG0479 LUCA
HOGENOMiHOG000160590
InParanoidiQ6FV90
KOiK00235
OMAiESWIHTN
OrthoDBiEOG092C401C

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di1.10.1060.10, 1 hit
3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR006058 2Fe2S_fd_BS
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR012675 Beta-grasp_dom_sf
IPR009051 Helical_ferredxn
IPR004489 Succ_DH/fum_Rdtase_Fe-S
IPR025192 Succ_DH/fum_Rdtase_N
PfamiView protein in Pfam
PF13085 Fer2_3, 1 hit
SUPFAMiSSF46548 SSF46548, 1 hit
SSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR00384 dhsB, 1 hit
PROSITEiView protein in PROSITE
PS00197 2FE2S_FER_1, 1 hit
PS51085 2FE2S_FER_2, 1 hit
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6FV90-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIRRGVLSLG ISGRRLMSTE APRLKTFKIY RWNPDQPEVK PKLQEFKVDL
60 70 80 90 100
NECGPMVLDA LLKIKDEQDA SLTFRRSCRE GICGSCAMNI GGRNTLACLC
110 120 130 140 150
KIDQDTSKQA KIYPLPHMFI VKDLVPDLTN FYQQYKSIKP YLQRKDYPAD
160 170 180 190 200
GKEVLQSIED RKKLDGLYEC ILCACCSTSC PSYWWNQEEY LGPAVLMQAY
210 220 230 240 250
RWLVDSRDQA TQERKDMLNN SMSLYRCHTI MNCTKTCPKG LNPGESIAKI

KQQLAF
Length:256
Mass (Da):29,417
Last modified:July 19, 2004 - v1
Checksum:i8D916A723F04F9A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380951 Genomic DNA Translation: CAG58773.1
RefSeqiXP_445854.1, XM_445854.1

Genome annotation databases

EnsemblFungiiCAG58773; CAG58773; CAGL0E03850g
GeneIDi2887279
KEGGicgr:CAGL0E03850g

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380951 Genomic DNA Translation: CAG58773.1
RefSeqiXP_445854.1, XM_445854.1

3D structure databases

ProteinModelPortaliQ6FV90
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284593.XP_445854.1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG58773; CAG58773; CAGL0E03850g
GeneIDi2887279
KEGGicgr:CAGL0E03850g

Organism-specific databases

CGDiCAL0129068 CAGL0E03850g
EuPathDBiFungiDB:CAGL0E03850g

Phylogenomic databases

eggNOGiKOG3049 Eukaryota
COG0479 LUCA
HOGENOMiHOG000160590
InParanoidiQ6FV90
KOiK00235
OMAiESWIHTN
OrthoDBiEOG092C401C

Enzyme and pathway databases

UniPathwayi
UPA00223;UER01006

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di1.10.1060.10, 1 hit
3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR006058 2Fe2S_fd_BS
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR012675 Beta-grasp_dom_sf
IPR009051 Helical_ferredxn
IPR004489 Succ_DH/fum_Rdtase_Fe-S
IPR025192 Succ_DH/fum_Rdtase_N
PfamiView protein in Pfam
PF13085 Fer2_3, 1 hit
SUPFAMiSSF46548 SSF46548, 1 hit
SSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR00384 dhsB, 1 hit
PROSITEiView protein in PROSITE
PS00197 2FE2S_FER_1, 1 hit
PS51085 2FE2S_FER_2, 1 hit
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ6FV90_CANGA
AccessioniPrimary (citable) accession number: Q6FV90
Entry historyiIntegrated into UniProtKB/TrEMBL: July 19, 2004
Last sequence update: July 19, 2004
Last modified: December 20, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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