Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 112 (26 Feb 2020)
Sequence version 1 (19 Jul 2004)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Chromatin-remodeling ATPase INO80

Gene

INO80

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi747 – 754ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Hydrolase
Biological processDNA damage, DNA repair, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chromatin-remodeling ATPase INO80By similarity (EC:3.6.4.-By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:INO80
Ordered Locus Names:CAGL0E05038g
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284593 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002428 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome E

Organism-specific databases

Candida Genome Database

More...
CGDi
CAL0128574 CAGL0E05038g

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:CAGL0E05038g

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000743211 – 1484Chromatin-remodeling ATPase INO80Add BLAST1484

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q6FV37

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the INO80 chromatin-remodeling complex.

PROSITE-ProRule annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5478.XP_445907.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6FV37

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini493 – 618DBINOPROSITE-ProRule annotationAdd BLAST126
Domaini734 – 906Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST173
Domaini1299 – 1463Helicase C-terminalPROSITE-ProRule annotationAdd BLAST165

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili404 – 462Sequence analysisAdd BLAST59

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi857 – 860DEAQ box4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DBINO region is involved in binding to DNA.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0388 Eukaryota
ENOG410XP0A LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000315_26_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6FV37

KEGG Orthology (KO)

More...
KOi
K11665

Identification of Orthologs from Complete Genome Data

More...
OMAi
YDAGEMK

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10810, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020838 DBINO
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR031047 Ino80
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N

The PANTHER Classification System

More...
PANTHERi
PTHR45685:SF2 PTHR45685:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13892 DBINO, 1 hit
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51413 DBINO, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6FV37-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLSALLNND DPVEDTKLYL ESLNREMDRL IKRDQLELMY QDWKFANYQE
60 70 80 90 100
FELISEWNTQ CKELVGDGND LQNNDLMTEE VHLDDLYDNI QRIRNEWKDY
110 120 130 140 150
ESYKETRSQL LSKSIQAKPI KHRRRRRTKL EMEAAANLAA LSQMGTTDVK
160 170 180 190 200
TPEIINDHGN RSKASRSDTT NKTDNTMAGI NSPTSDVDSG HKDELDQTKL
210 220 230 240 250
IKKQEASSST NSAASVTASV ANGIVEDQKD EAERTIEANR IGSNMQNSDQ
260 270 280 290 300
DTMDDLKKTN DPSSDIDSDA NTSVNDGSDE NLSNKLDSDD LHSEPADNEE
310 320 330 340 350
EPVSSDAEKD QAENINQTDE SEEEIIVKEY DDNNDEDFAP EIKKPKPNGK
360 370 380 390 400
IVTINSDRPK IVRELIKLRN KGKAPKSSKR RYTAVNITEY SPTEKKISVK
410 420 430 440 450
ITLKQMHVKK LKKILQDARK AEEKRLQEEA KQIADQESPR KRRKIDRSEN
460 470 480 490 500
TKQEDEDDKE DDDLDGLPTY GMKMSLKDAK AIQRHYDNTY TMIWKDMARK
510 520 530 540 550
DCMKISRLVQ QIQSTRALNY KKTSSLCARE ARKWQTRNFK QVKDFQTRAR
560 570 580 590 600
KGIREMANFW KKNEREERDL KKKAEREALE LAKKEEEEKE SKRQAKKLNF
610 620 630 640 650
LLTQTELYSH FIGRKIKTSA LEGNEVAEED EDNYDLTTTA PNKNDFHAID
660 670 680 690 700
FDNENDEQLK LKAAQNASNA LAETRAKAKA FDDAHRQQQS TESDDEEEMN
710 720 730 740 750
FQNPTSLGEI TIEQPKMLAC TLKEYQLKGL NWLANLYDQG INGILADEMG
760 770 780 790 800
LGKTVQSISV LAHLAEHHNI WGPFLVVTPA STLHNWVNEI SKFVPQFKIL
810 820 830 840 850
PYWGSANDRK VLRKFWDRKN LRYSEKSPFH VMITSYQMVV ADASYLQKMK
860 870 880 890 900
WQYMILDEAQ AIKSSQSSRW KNLLSFHCRN RLLLTGTPIQ NNMQELWALL
910 920 930 940 950
HFIMPSLFDS HDEFNEWFSR DIESHAEGNS SLNQQQLRRL HMILKPFMLR
960 970 980 990 1000
RIKKNVQSEL GDKIEIDVMC DLTQRQTKLY QVLKSQMSSN YDAIENAAAE
1010 1020 1030 1040 1050
GSDIAGGGNS DQSIINAVMQ FRKVCNHPDL FERADINSPF SFTSFGKTSS
1060 1070 1080 1090 1100
LISSSIATSG GLTETISELM YSSTNPINCA IPKLIYEDLI LPNYNNSIDI
1110 1120 1130 1140 1150
MEKLLLSDFS IYDPVNNKEM CQYLGLLTGL AYGSFRKIHK SNYFERIINL
1160 1170 1180 1190 1200
KKESKQSSQN LITVVSNAND LIADSIVHAD TNLPNLTGIR NDIYHNDYLN
1210 1220 1230 1240 1250
SIQPGYCPKV VAPPINFNVN GSLNFTNKMS SYLFNPVITT ALSSIPPPTQ
1260 1270 1280 1290 1300
YNMFVKKCIP IEEFPISEMY PNPLNKHFSS NISMPSMDRF ITESAKLKKL
1310 1320 1330 1340 1350
DELLVELKKN DHRVLIYFQM TKMMDLMEEY LTYRQYNHIR LDGSSKLEDR
1360 1370 1380 1390 1400
RDLVHDWQTN PEIFIFLLST RAGGLGINLT AADTVIFYDS DWNPTIDSQA
1410 1420 1430 1440 1450
MDRAHRLGQT KQVTVYRLLV RGTIEERMRD RAKQKEQVQQ VVMEGKTKDT
1460 1470 1480
NIQTTHTRPE HEQLTPKSLS SEPEATNNLI TVKN
Length:1,484
Mass (Da):170,540
Last modified:July 19, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA6CB2876E014F1F2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR380951 Genomic DNA Translation: CAG58826.1

NCBI Reference Sequences

More...
RefSeqi
XP_445907.1, XM_445907.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
CAG58826; CAG58826; CAGL0E05038g

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2887378

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cgr:CAGL0E05038g

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380951 Genomic DNA Translation: CAG58826.1
RefSeqiXP_445907.1, XM_445907.1

3D structure databases

SMRiQ6FV37
ModBaseiSearch...

Protein-protein interaction databases

STRINGi5478.XP_445907.1

Proteomic databases

PRIDEiQ6FV37

Genome annotation databases

EnsemblFungiiCAG58826; CAG58826; CAGL0E05038g
GeneIDi2887378
KEGGicgr:CAGL0E05038g

Organism-specific databases

CGDiCAL0128574 CAGL0E05038g
EuPathDBiFungiDB:CAGL0E05038g

Phylogenomic databases

eggNOGiKOG0388 Eukaryota
ENOG410XP0A LUCA
HOGENOMiCLU_000315_26_2_1
InParanoidiQ6FV37
KOiK11665
OMAiYDAGEMK

Family and domain databases

Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR020838 DBINO
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR031047 Ino80
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PANTHERiPTHR45685:SF2 PTHR45685:SF2, 1 hit
PfamiView protein in Pfam
PF13892 DBINO, 1 hit
PF00271 Helicase_C, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51413 DBINO, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINO80_CANGA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6FV37
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 19, 2004
Last modified: February 26, 2020
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again